• During gastrulation anterior endoderm (AE) provides cardiogenic signals that act on adjacent mesoderm , resulting in induction of cardiac precursors. (xenbase.org)
  • Subsequently cardiogenic mesoderm generates a FGF signal that acts on adjacent AE to induce foregut organ specification. (xenbase.org)
  • In response to ligation of monomorphic regions of MHC class II antigens with monoclonal antibody CR3/43, human leukocytes retrodifferentiate into a variety of heterogeneous stem cell types belonging to the mesoderm, ectoderm or endoderm lineage, depending on culture media and conditions. (eurekaselect.com)
  • These include embryonic disc and bilaminar disc formation, epiblast lumenogenesis, polarized amniogenesis, anterior-posterior symmetry breaking, primordial germ-cell specification, polarized yolk sac with visceral and parietal endoderm formation, extra-embryonic mesoderm expansion that defines a chorionic cavity and a connecting stalk, and a trophoblast-surrounding compartment demonstrating syncytium and lacunae formation. (nature.com)
  • The fertilized oocyte is totipotent, with resultant blastomeres capable of generating all three primary germ layers, ectoderm, mesoderm, and endoderm, in addition to the extra embryonic tissues. (conditionmed.org)
  • Epithelia (ectoderm and endoderm) form the majority of the "ductless" endocrine glands like gastrointestinal and skin associated "ducted" glands. (edu.au)
  • Here, we employed a human pancreatic differentiation platform complemented with an shRNA screen in human pluripotent stem cells (PSCs) to identify potential drivers of early endoderm and pancreatic development. (mdpi.com)
  • Here we show the differentiation of patient specific iPSCs derived from a patient with SFTPB deficiency into lung organoids with mesenchymal and epithelial cell populations from both the proximal and distal portions of the human lung. (nature.com)
  • Although many differentiation protocols in the literature have been successful in mimicking lung development from stem cells, there has not been an examination of how a specific mutation impacts the differentiation process including its effects on the early endoderm, as well as the proximal and distal lung epithelial cell populations in the lung organoids. (nature.com)
  • Differentiation of several also organs involves a epithelial/mesenchye interaction, seen in repeated in many differentiation of many different tissues. (edu.au)
  • The posterior download drawing made easy dragons fantasy unleash your of self-containing die in reading beobachten stem and andere with Organ-derived Periodontal differentiation. (it-dresden.net)
  • Purposefully using this process, called "embryonic programming", can improve animal performances when a specific challenge is encountered later in life. (biomedcentral.com)
  • Tissue development is a key process for life starting from the earliest embryonic stages during which cells differentiate into later organs composing an entire body. (exeter.ac.uk)
  • He suggested that during embryonic development the organs formed successively in an epigenetic manner. (biologydiscussion.com)
  • In the prepubertal period, normal external genitalia and age-appropriate developmental milestones often mask abnormalities of the internal reproductive organs. (medscape.com)
  • Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. (thermofisher.com)
  • The robustness and efficacy of the retrodifferentiation process in generating unprecedented quantities of stem cells belonging to the three germ layers will enable organ and tissue reconstruction ex vivo, using bio-printing and various scaffold materials. (eurekaselect.com)
  • Only gradually did these "globules" organise into rudiments (germ layers) which, in turn, took on the characteristics of the various organs of the embryo. (biologydiscussion.com)
  • The complete human digestive system is made up of the gastrointestinal tract plus the accessory organs of digestion (the tongue, salivary glands, pancreas, liver and gallbladder). (wikipedia.org)
  • LN metastases resist T cell-mediated cytotoxicity, induce antigen-specific regulatory T cells, and generate tumor-specific immune tolerance that subsequently facilitates distant tumor colonization. (stanford.edu)
  • The endocrine glands produce hormones, which are distributed by the vascular system to the many body tissues, subsequently these organs are richly vascularized. (edu.au)
  • I then developed effective methods to differentiate PSCs into specific lineages by providing the extracellular signal(s) that specify a given lineage while inhibiting the signals that induce the alternate fate(s), enabling the generation of highly-pure human heart and bone (Loh & Chen et al. (stanford.edu)
  • Cerberus and hhex are required in anterior endoderm for liver and cardiac specification. (xenbase.org)
  • Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network. (xenbase.org)
  • LN metastases have the potential to seed additional tissues and can induce metastatic tolerance, a process by which tumor-specific immune tolerance in LNs promotes further disease progression. (stanford.edu)
  • The endocrine system resides within specific endocrine organs and both organs and tissues with other specific functions. (edu.au)
  • Hormones "orchestrate" responses in other tissues, including other endocrine organs, and these overall effects can be similar or different in different tissues. (edu.au)
  • Here, using genomic approaches and epistasis experiments, we define the Sox17 -governed endoderm GRN in Xenopus gastrulae. (xenbase.org)
  • A) Endoderm expression of sox17a and sox17b in NF10.5 Xenopus tropicalis gastrula . (xenbase.org)
  • We show that Sox17 functionally interacts with the canonical Wnt pathway to specify and pattern the endoderm while repressing alternative mesectoderm fates. (xenbase.org)
  • They are 3-dimensional, complex, multicellular structures that can be derived from patient specific human induced pluripotent stem cells (hiPSCs). (nature.com)
  • Infection of iPSCs with lentiviral inserts is a highly efficient process since stem cells grow quickly, remain undifferentiated in specific cell culture conditions and can establish fully infected clones within 2-3 passages. (nature.com)
  • The structures of many sequence-specific protein-DNA com- plexeshavenowbeensolved,and while some proteicnasusethemeltingofoneormorebasepairs, most recognition occurs in the context of a closed duplex. (top5binarybrokers.com)
  • Sox17 is a key transcriptional regulator of definitive endoderm development, and yet, its genomic targets remain largely uncharacterized. (xenbase.org)
  • This current page provides a general introduction to the endocrine system, use the links below to explore development of specific endocrine organs. (edu.au)
  • During the development of this organ, highly differentiated, information-processing structures are formed - such as the cerebrum in the telencephalon, the tectum in the mesencephalon and the cerebellum in the rhombencephalon - which all have to be wired up with the information-generating sensory systems. (silverchair.com)
  • Matsushita S, Ishii Y, Scotting PJ, Kuroiwa A, Yasugi S. Pre-gut endoderm of chick embryos is regionalized by 1.5 days of development. (arizona.edu)
  • Our findings establish Sox17 as a tissue -specific modifier of Wnt responses and point to a novel paradigm where genomic specificity of Wnt/β-catenin transcription is determined through functional interactions between lineage-specific Sox TFs and β-catenin/Tcf transcriptional complexes. (xenbase.org)
  • To establish the importance of specific cell signaling pathways to the production of pro-inflammatory cytokines from LPS-stimulated human monocytes, the NF-B inhibitor, Bay11, the p38 inhibitor, SB203580, the PI3K inhibitor, LY294002, and 607737-87-1 supplier the JNK inhibitor, SP 600125, were added to adherent human monocytes cultured in RPMI 1640 made up of 10% AB+ serum in flat bottom 96 well plates. (morainetownshipdems.org)
  • B) qPCR showing fold difference in expression between Gata4 treated animal caps and control animal caps grown to st. 33, induction of expression of myl7 , nr1h5 , hhex and marker of endoderm foxa2 is shown. (xenbase.org)
  • Also, most of the newly found microRNAs show tissue-specific expression. (pharmaceuticalintelligence.com)
  • The GI tract includes all structures between the mouth and the anus, forming a continuous passageway that includes the main organs of digestion, namely, the stomach, small intestine, and large intestine. (wikipedia.org)
  • Finally, we explore the most recent understanding of germ layer-specific metabolic remodeling. (conditionmed.org)
  • This suggested that autophagy was related to the chicken immune system or gender-specific differences, if not really both [31, 42]. (immune-source.com)
  • Instead, a specific subset of ISGs that includes Parp9 remains activated by the unphosphorylated form of ISGF3 that enhances nDNA damage and repair responses. (regenerativemedicine.net)
  • Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. (nature.com)
  • Stem cell research endeavors to generate specific subtypes of classically defined "cell types. (stanford.edu)
  • We identified a novel way of spreading Wnt proteins in vertebrates: Wnt molecules are mobilized on specific cell protrusions known as cytonemes. (exeter.ac.uk)
  • These effects extend to human cancers and other murine cancer models, implicating a conserved systemic mechanism by which malignancies spread to distant organs. (stanford.edu)
  • In a comparative analysis between the human microRNA datasets and the chimpanzee, gorilla, orangutan, macaque, mouse, fruit fly, and mouse genomes, Dr. Rigoutsos and colleagues discovered that almost 95% of the newly unveiled microRNAs were primate-specific, and over 56% of them were found only in humans. (pharmaceuticalintelligence.com)
  • The definitive diagnosis of all ovarian cysts is made based on histologic analysis. (medscape.com)
  • After an accurate diagnosis is rendered, many treatment options exist, and they are usually tailored to the specific müllerian anomaly. (medscape.com)
  • See also specific endocrine organ pages for more specific search options. (edu.au)
  • The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines. (wikipedia.org)
  • Prosthogonimiasis poses a threat to the reproductive system of poultry and wild birds, which are the definitive hosts of the parasite causing this disease. (bvsalud.org)
  • As it is very difficult to determine the specific impact of individual parameters in a complex biological system by a purely experimental approach, we interact with mathematicians using computational modelling. (exeter.ac.uk)
  • Metastasis to lymph nodes (LNs) is a common feature of disease progression in most solid organ malignancies. (stanford.edu)