• Effects of p27 Kip1 -gene disruption include ongoing cell proliferation in postnatal and adult mouse organ of Corti at time points well after mitosis normally has ceased during embryonic development. (pnas.org)
  • We demonstrate that disruption of the p27 Kip1 -gene in a knock-out mouse model promotes cell division in the postnatal and adult mouse organ of Corti well after terminal mitosis is normally completed at embryonic day 14 ( 11 ). (pnas.org)
  • In the absence of p27(Kip1), mitotically active cells are still observed in the organ of Corti of postnatal day 6 animals, suggesting that the persistence of p27(Kip1) expression in mature supporting cells may contribute to the maintenance of quiescence in this tissue and, possibly, to its inability to regenerate. (biologists.org)
  • In the postembryonic and adult mammalian auditory sensory epithelium, the organ of Corti, no hair-cell regeneration has ever been observed. (pnas.org)
  • This finding may provide an important pathway for inducing hair-cell regeneration in the mammalian hearing organ. (pnas.org)
  • CONCLUSIONS/SIGNIFICANCE: The lack of dedifferentiation amongst supporting cells and their replacement by cells from the outer side of the organ of Corti are factors that may need to be considered in any attempt to promote endogenous hair cell regeneration. (biomedsearch.com)
  • Regeneration of lost organ of Corti hair cells through forced cell cycle re-entry of supporting cells or through manipulation of stem cells, both avenues towards a permanent cure, require a more complete understanding of normal inner ear development, specifically the balance of proliferation and differentiation required to form and to maintain hair cells. (mdpi.com)
  • Lastly, we detail the translational significance of our findings and what future work must be performed to make the ultimate hearing aid: the regeneration of the organ of Corti. (mdpi.com)
  • The data were also separated into recovery times of 0 days (acute) and >0 days (chronic) and the apical and basal halves of the organ of Corti (OC). (cdc.gov)
  • The purpose of this study is to design a simple and robust method to quantitatively determine the distribution of the inner and outer hair cells at the organ of Corti in the mouse cochlea. (csic.es)
  • Matt Nadol J.B., Jr., Synaptic morphology of inner and outer hair cells of the human organ of Corti, Journal of electron microscopy technique, 15, 187-196, 1990. (auditory.org)
  • In normal hearing subjects, the majority of the auditory signals that reach the organ of Corti in the first place come from the outer ear. (wikipedia.org)
  • The mammalian auditory organs have a dual sensory system (inner vs. outer hair cells) with distinctly different cellular organizations and innervation patterns. (nih.gov)
  • In humans, the organ of Corti contains 3,500 inner hair cells and 15,000 outer hair cells that are stimulated and highly sensitive to sounds. (wisegeek.com)
  • A major reason we can perceive faint sounds and communicate in noisy environments is that the outer hair cells of the organ of Corti enhance the sound-evoked motions inside the cochlea. (spie.org)
  • The Organ of Corti includes three rows of outer hair cells and one row of inner hair cells. (statpearls.com)
  • Outer hair cells (OHC): (German: äußere Haarzellen) They stand next to each other in three rows of cells on the outside of the organ of corti. (doccheck.com)
  • In the organ of corti there are about 15,000 hair cells and also many supporting cells (German: Stützzellen), like phalangeal (Deiters) cells and inner and outer pillar cells. (doccheck.com)
  • The Organ of Corti contains inner hair cells and outer hair cells. (hubpages.com)
  • In this model the active pressure is equal on both sides of the Organ of Corti and this produces very fast propagating pressure waves which generate extra activity within the cochlea and emissions through the middle/outer ear. (wikipedia.org)
  • In the mammalian cochlea, amplification occurs in the outer hair cells of the Organ of Corti. (wikipedia.org)
  • The membrane that extends from the margin of the bony shelf of the cochlea to its outer wall and on which the sensory cells of the organ of Corti rest. (thefreedictionary.com)
  • Only β II and β IV tubulin are found in inner and outer pillar cells, while β I , β II , and β IV tubulin are present in Deiters cells, and β I , β II and β III tubulin are found in organ of Corti dendrites. (elsevier.com)
  • Only βII and βIV tubulin are found in inner and outer pillar cells, while βI, βII, and βIV tubulin are present in Deiters cells, and βI, βII and βIII tubulin are found in organ of Corti dendrites. (elsevier.com)
  • Scanning electron micrographs of the organ of Corti at 3 weeks of age reveal disorganized and splayed stereocilia of outer hair cells and, less severely, of inner hair cells along with degeneration of hair cells that yields a disorganized hair cell pattern. (jax.org)
  • The primary sensory receptors for hearing, the inner hair cells, are found within the organ of Corti as are the outer hair cells, which primarily facilitate the sensory response of the inner hair cells. (nap.edu)
  • Focal lesions involve substantial loss of outer hair cells (OHCs) only, inner hair cells (IHCs) only, or both OHCs and IHCs (i.e., combined lesions) in a specific region of the organ of Corti (OC). (cdc.gov)
  • However, the mammalian auditory sensory epithelium, the organ of Corti, thus far has shown no ability to regenerate hair cells, and it has not proved possible to isolate the relevant factors or to produce the appropriate conditions to provoke supporting-cell proliferation in the organ of Corti ( 13 - 15 ). (pnas.org)
  • The organ of Corti has an epithelium composed of hair cells and supporting cells. (rrnursingschool.biz)
  • Intracellular measurements of the resting cell membrane potentials of guinea pig Corti's organ were made in order to determine the sensitivity of this cell potential to anoxic hypoxia (a lowered oxygen state due to lack of respiratory oxygen) and to establish differences according to cell types or morphologic regions of the sensory epithelium. (elsevier.com)
  • The organ of Corti, the auditory sensory organ in mammals, is a highly specialized epithelium in structure ( Fig. 1 A ) and function. (jneurosci.org)
  • The vibration pattern of the organ was complex and changed with frequency. (mit.edu)
  • The current vibration noise floor for native organ of Corti tissue is 0.03 nm in this frequency range. (spie.org)
  • The sensitive hair cells of the organ of Corti may have about 100 tiny stereocilia which in the resting state are leaning on each other in a conical bundle. (gsu.edu)
  • Such information is needed to therapeutically guide organ of Corti hair cell development in flat epithelia and generate the correct arrangement of different hair cell types, orientation of stereocilia, and the delayed loss of the kinocilium that are all essential for hearing, while avoiding driving hair cells toward a vestibular fate. (frontiersin.org)
  • It causes the stapes to vibrate resulting in a traveling wave along the organ of Corti propagating from base towards apex. (diva-portal.org)
  • Organotypic Cultures of the Organ of Corti. (pnas.org)
  • In this study, we measure the in vivo vibrations of the organ of Corti via round window in live anaesthetized guinea pigs using PSFDOCT. (spie.org)
  • The aims of this study were: 1) to establish primary cultures and subcultures from dissociated organ of Corti obtained from adult guinea pigs, and 2) to characterize these mixed cell populations with specific markers in three different culture conditions, regarding cell cycle status. (arquivosdeorl.org.br)
  • C-E′) Surface preparation of the organ of Corti of P2 (C-C′) and adult (D-E′) mice immunostained for plastin 1 and counterstained with fluorescently labelled phalloidin. (nih.gov)
  • frequency portion of the spiral ganglion / organ of the Corti. (auditory.org)
  • The OHCs have unique electromotile properties and play an important role in hearing sensitivity and frequency discrimination by locally amplifying sound-elicited vibrations of the organ of Corti. (nih.gov)
  • From these observations it is not far to the conclusion that our sense of hearing judges equal distances between excitation points of the organ of Corti as practically equal steps of pitch, while actually their frequency relation is exponential . (huygens-fokker.org)
  • Nuttall, AL & Lawrence, M 1979, ' Intracellular Potential Changes of Corti's Organ With Anoxia ', Archives of Otolaryngology , vol. 105, no. 10, pp. 574-578. (elsevier.com)
  • Evidence is accumulating that cisplatin interferes with the antioxidant defense system of Corti's organ. (elsevier.com)
  • Conclusions: Organotypic culture of Corti's organ has been validated as a model for studying cisplatin toxicity and for screening otoprotective molecules. (elsevier.com)
  • Transverse section of Corti's organ from the central coil of cochlea. (usf.edu)
  • Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea. (biomedsearch.com)
  • Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning. (researchmap.jp)
  • Our method of cellular mapping is effective for system-level phenotyping of the organ of Corti under both physiological and pathological conditions. (researchmap.jp)
  • Therefore, Dallos and Evans (1995a) proposed that extracellular potential changes within the organ of Corti could drive cellular motor proteins. (elsevier.com)
  • Nerve fibers in the human organ of Corti. (nih.gov)
  • In the adult organ of Corti, each of the five major cell types synthesizes a different subset of isotypes. (elsevier.com)
  • It contains the Organ of Corti. (prezi.com)
  • Movement of the stapes sets up pressure waves in the fluids inside the cochlea, which contains the organ of Corti, the sensory organ for hearing, spiraling from base to apex. (nap.edu)
  • Highlighting the differences from vestibular organs and defining what is known about the regulation of these differences will help focus future research directions toward successful restoration of an organ of Corti following long-term hair cell loss. (frontiersin.org)
  • (B) The organ of Corti evolved out of an outgrowth of the saccule into the lagenar duct and requires expression of several genes to form organ of Corti-specific hair cell subtypes and distribution. (frontiersin.org)
  • High-fidelity detection and analysis of all hair cell positions along the entire longitudinal axis of the organ of Corti were performed automatically by machine learning-based pattern recognition. (researchmap.jp)
  • The establishment of organ of Corti cultures is essential for the investigation of factors that affect hair cell and precursors cell functions and survival. (arquivosdeorl.org.br)
  • 4. The external spiral bundle increases its fiber count when internal and tunnel spiral bundles were present in the organ of Corti. (nih.gov)
  • 8. In some cases medial fibers showed a torpedo-like deformity in the tunnel of Corti. (nih.gov)
  • We modeled the tunnel of Corti as an elastic tube and showed that it can support a traveling wave. (mit.edu)
  • The tunnel of Corti wave could travel without significant attenuation for distances larger than the wavelength of the cochlear traveling wave at its peak. (mit.edu)
  • Here we report that the cyclin-dependent kinase inhibitor p27 Kip1 is selectively expressed in the supporting-cell population of the organ of Corti. (pnas.org)
  • The absence of any proliferative capacity in the organ of Corti may indicate that the supporting-cell population has attained a terminally differentiated state. (pnas.org)
  • Therefore, this investigation has been directed at the potential role of cell-cycle inhibition in the supporting-cell population of the organ of Corti. (pnas.org)
  • Wnt signaling then instructs vestibular organ formation in both sensory and nonsensory regions ( Rakowiecki and Epstein, 2013 ). (jneurosci.org)
  • The studies demonstrate how the regular surface architecture of the organ of Corti is altered after exposure to noise. (sciencemag.org)
  • HCoV-EMC productively replicated in human bronchial and lung ex vivo organ cultures. (asm.org)
  • Treatment of human lung tissue ex vivo organ cultures with type I IFNs (alpha and beta IFNs) at 1 h postinfection reduced the replication of HCoV-EMC, suggesting a potential therapeutic use of IFNs for treatment of human infection. (asm.org)
  • In order to understand the role of OHC motility in cochlear micromechanics we developed a technique to measure the mechanical responses within the organ of Corti (OC) due to OHC forces. (mit.edu)