Organ dysfunction after ischemia and reperfusion injuries ischemia reperfusion. Medical search. Frequent questions

During vascular anastomosis* 1 in kidney transplantation procedures, kidneys removed from donors and stored after cooling are exposed to the risk of second warm ischemic injury* 2 due to heating by contact with a surgeon or donor's tissues. (screen.co.jp)
Made of a special gel material, this thermal isolation bag is an instrument shaped like a drawstring pouch bag and wraps an organ to be transplanted during kidney transplantation to properly hold it, blocking contact heat and physical stimuli from the surgeons or patient. (screen.co.jp)
The clinical trial is expected to confirm that OrganPocket provides greater reliability in organ protection during transplantation procedures. (screen.co.jp)
Organ shortage continues to limit the lives of patients who require liver transplantation. (jci.org)
Cold ischemia and subsequent reperfusion injury are non-immunologic cornerstones in the development of graft injury after heart transplantation. (frontierspartnerships.org)
Chronic allograft injury (CAI), consisting of vasculopathy and interstitial fibrosis, affects approximately 50% of patients after 10 years and limits long-term survival following heart transplantation ( 1 ). (frontierspartnerships.org)
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have made intermediate-term survival after lung transplantation an achievable goal. (ersjournals.com)
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have contributed to increase the 1‐yr patient survival after lung transplantation (LTx) to 70-80% 1 . (ersjournals.com)
A shift in the nature of complications from early to late graft dysfunction has been similarly observed after transplantation of other solid organs 2 . (ersjournals.com)
Ischaemic reperfusion (I/R) occurs during surgical procedures, including hepatic resection and liver transplantation (LT) [ 1 ]. (ijbs.com)
When after an ischemic event reperfusion is induced, which happens for instance during organ transplantation or resuscitation after cardiac arrest, this reperfusion can paradoxically cause additional damage to the affected tissue. (tu-dresden.de)
The consortium brings together six partners with highly complementary expertise in (oxi-)lipidomics, bioinformatics, drug discovery, immunology, organ transplantation, pre-clinical and clinical research in a highly interdisciplinary approach. (tu-dresden.de)
TORONTO, Feb. 15, 2022 - Revive Therapeutics Ltd. ("Revive" or the "Company") (OTCQB: RVVTF) (CSE: RVV) (FRANKFURT:31R), a specialty life sciences company focused on the research and development of therapeutics for medical needs and rare disorders, is pleased to announce that the U.S. Food and Drug Administration ("FDA") has granted Orphan Drug Designation ("ODD") for Bucillamine for the prevention of ischemia-reperfusion injury ("IRI") during liver transplantation. (dailymushroom.co)
Michael Frank, CEO of Revive commented: "We are very pleased to receive orphan drug designation from the FDA for Bucillamine for the prevention of ischemia-reperfusion injury during liver transplantation. (dailymushroom.co)
Liver ischemia-reperfusion injury is a major complication of liver transplantation and is one of the leading causes for post-surgery hepatic dysfunction leading to an increased risk of post-operative morbidity and mortality. (dailymushroom.co)
Revive's cannabinoid pharmaceutical portfolio focuses on rare inflammatory diseases and the company was granted FDA orphan drug status designation for the use of Cannabidiol (CBD) to treat autoimmune hepatitis (liver disease) and to treat ischemia and reperfusion injury from organ transplantation. (dailymushroom.co)
In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
During my research fellowship in Madison at the University of Wisconsin with Dr. F.O. Belzer in 1986-1988 I became interested in organ donation, ischaemia & reperfusion injury and preservation in transplantation. (ox.ac.uk)
I also served the European Society for Organ Transplantation as Secretary and was elected President of ESOT in 2009. (ox.ac.uk)
Organ transplantation saves the lives of thousands of patients every year and is now recognised as the treatment of choice for end stage organ failure. (ox.ac.uk)
Despite the increasing awareness of the importance of organ transplantation both amongst the medical community and the general public, a gulf remains between the supply and clinical need for life saving organs. (ox.ac.uk)
In an attempt to address this issue, the transplantation community has been turning to living donor organ transplantation and to organs previously considered unsuitable for donation. (ox.ac.uk)
In addition, if we can identify markers to predict outcome of transplantation, this would help transplant teams in deciding the suitability of specific organs for individual patients and better guide post-operative management. (ox.ac.uk)
To increase the number and quality of retrieved organs for transplantation by optimising donor management and resuscitating and preserving marginal organs. (ox.ac.uk)
Cardiac transplantation relies on organs procured from Brain Dead Donors (DBD). (whiterose.ac.uk)
Donation after Circulatory Death (DCD) organs are being increasingly used for renal, liver and lung transplantation. (whiterose.ac.uk)
He invented the approach of Therapeutic Mitochondria Transplantation (TMT) at Harvard Medical School as a means to ameliorate ischemia-reperfusion injury. (cellvie.bio)
He has since expanded on these observations to demonstrate safety and efficacy of mitochondrial transplantation for ischemia-reperfusion injury along with methodologies for mitochondria preparation and delivery. (cellvie.bio)
Short-term survival following heart transplantation has improved with the evolution of transplant immunology & immunosuppressive therapy, advances in organ preservation & surgical techniques, as well as diagnosis & management of acute rejection. (lidsen.com)

We further discuss how injuries alter tissue environments and how this primes mononuclear phagocytes to enforce this particular environment, for example, to support host defense and pathogen clearance, to support the resolution of inflammation, to support epithelial and mesenchymal healing, and to support the resolution of fibrosis to the smallest possible scar. (hindawi.com)
When there is increased demand in the setting of inflammation, ischemia-reperfusion injury, and organ dysfunction, endogenous arginine production falls short, and external supplementation may be necessary. (nih.gov)
They include ischemia and reperfusion injury, systemic inflammation, and vascular dysfunction. (medscape.com)
An UCCAO caused a slight cerebral ischemia (cerebral blood flow [CBF] 70%) without hypotension (MABP 85 mmHg), systemic inflammation, multiple organs injuries, or neurological injury. (medsci.org)
An HS caused a moderate cerebral ischemia (52% of the original CBF levels), a moderate hypotension (MABP downed to 22 mmHg), systemic inflammation, and peripheral organs injuries. (medsci.org)
However, combined an UCCAO and an HS caused a severe cerebral ischemia (18% of the original CBF levels), a moderate hypotension (MABP downed to 17 mmHg), systemic inflammation, peripheral organs damage, and neurological injury, which can be attenuated by whole body cooling. (medsci.org)
The Q-CABG study aims to explore the efficacy of quercetin to reduce inflammation, myocardial injury and senescence in patients undergoing CABG following an acute coronary syndrome. (frontiersin.org)
Inflammation has emerged as a central mediator of endothelial dysfunction, and by extension, vascular disease ( 1 ). (frontiersin.org)
The authors found that liver grafts with absent carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) exhibited increased ischemia-reperfusion injury inflammation and decreased function in wild-type recipients. (jci.org)
Lung inflammation is induced by renal ischemia and reperfusion injury as part of the systemic inflammatory syndrome. (phypha.ir)
Acute inflammation is your body's natural way of healing and repairing itself when it comes into contact with a harmful pathogen (bacteria or virus), allergens (from food, pollen, dust etc.), or you have an injury. (water-for-health.co.uk)
ALA can prevent I/R injury by reducing the production of free radicals, scavenging free radicals, and reducing inflammation. (geronova.com)
Trim8 knockout relieved hepatocyte injury triggered by I/R. Silencing of Trim8 expression alleviated hepatic inflammation responses and inhibited apoptosis in vitro and in vivo . (ijbs.com)
Using optical coherence tomography (OCT) we have recently shown that the retina and choroid are thinned in patients with CKD and this thinning relates to the degree of kidney dysfunction as well as inflammation and endothelial dysfunction. (ed.ac.uk)

Additionally, in contrast with findings from Langendorff models of ischemia-reperfusion, there is a marked augmentation of CICR in isolated cells. (whiterose.ac.uk)

Effects of ischemic acute kidney injury on lung water balance: nephrogenic pulmonary edema? (phypha.ir)
Kidney-lung cross-talk and acute kidney injury. (phypha.ir)
9. Doi K, Ishizu T, Fujita T, Noiri E. Lung injury following acute kidney injury: kidney-lung crosstalk. (phypha.ir)
Remote organ failure in acute kidney injury. (phypha.ir)
Such ischemia-reperfusion injuries (IRI) are a serious complication, responsible for a variety of clinically important conditions including stroke and acute kidney injury. (tu-dresden.de)
Approximately 20% of patients with acute brain injury (ABI) also experience acute kidney injury (AKI), which worsens their outcomes. (beds.ac.uk)
Acute kidney injury (AKI) in intensive care units (ICUs) is an independent risk factor for death. (beds.ac.uk)
A 42-year-old male patient (height: 165 cm, weight: 61.7 kg) was admitted due to acute kidney injury with dyspnea. (anesth-pain-med.org)
Clinical evidence suggests that tissue injury in both acute kidney injury and heart failure has immune-mediated inflammatory consequences that can initiate remote organ dysfunction. (biomedcentral.com)
Clinical evidence suggests that tissue injury such as acute kidney injury (AKI) is not an isolated event and it has become apparent that much of the increased risk of death is derived from distant complications [ 5 , 6 ]. (biomedcentral.com)

Intraoperative tissue hypoperfusion and re-reperfusion injury, which generate reactive oxygen species (ROS), are suggested to induce delirium. (mdpi.com)
Reperfusion injury and reactive oxygen species: the evolution of a concept. (phypha.ir)
Participation of reactive oxygen species in diabetes-induced endothelial dysfunction. (nel.edu)

Eighty male and female rats were assigned into 8 groups, 4 groups in each gender including: sham, renal ischemia for 45min by clamping renal vessels followed by 3, 24 or 48h reperfusion. (phypha.ir)
Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats. (phypha.ir)
The protective effect of erythropoietin on renal injury induced by abdominal aortic-ischemia-reperfusion in rats. (phypha.ir)
Effect of acetylcholine and ischaemia/reperfusion injury on the heart of rats with STZ-induced experimental diabetes. (nel.edu)
Knezl V, Kysel'ová Z, Zúrová-Nedelcevová J, Navarová J, Tribulová N, Drímal J. Effect of acetylcholine and ischaemia/reperfusion injury on the heart of rats with STZ-induced experimental diabetes. (nel.edu)
1. Zaets SB, Xu DZ, Lu Q, Feketova E, Berezina TL, Gruda M, Malinina IV, Deitch EA, Olsen EH: Recombinant factor XIII diminishes multiple organ dysfunction in rats caused by gut ischemia-reperfusion injury Shock 2009;31(6):621-626. (ajbm.net)
Rats, subjected to bilateral renal ischemia (45 min) followed by reperfusion (6 h), were administered EUK-134 (0.3 and 3 mg/kg, i.v.) prior to and during reperfusion, after which biochemical and histological indicators of renal dysfunction and injury were measured. (scienceopen.com)

Involved inflammatory cells produce cytokines and chemokines, and generate ROS, further contributing to graft dysfunction. (jci.org)
Hepatic I/R is an important cause of liver damage and is also the underlying cause of graft dysfunction in marginal organs. (ijbs.com)

If biological tissues are exposed to body temperature without blood flow (warm ischemia), cellular homeostasis is not maintained due to the lack of oxygen and nutrients, and so disabling substances are released outside the cell. (screen.co.jp)

While extending criteria for liver organs provides a needed resource, tissue damage from prolonged ischemic injury can result in early allograft dysfunction and consequent rejection. (jci.org)
Scavenging peroxynitrite using seleno-organic compounds like ebselen provides renoprotection against ischemic injury. (scienceopen.com)
Because of the increased ability of the immature myocardium to rely on anaerobic glycolysis, it can withstand ischemic injury better than adult myocardium can. (medscape.com)

SCREEN will place the medical device on the market and continue research and development, aiming to expand the intended for use to organs other than kidneys. (screen.co.jp)
This product has been notified to the authority as a medical device, and SCREEN will manufacture and market the product, and is planning to conduct research and development aiming to expand the product's application to organs other than kidneys. (screen.co.jp)
In animal studies, LA has been found to be effective in reducing I/R injury in the liver, kidneys, and heart. (geronova.com)
CBD was shown to protect against ischemia/reperfusion injury of the kidneys and liver. (havnlife.com)
The CRS classification system includes a vast array of acute or chronic conditions in these two important organs, where the primary failing organ can be either the heart or the kidneys. (biomedcentral.com)

Cooling the whole body should have effects on multiple pathways and multiple organs that might be affected by the shock state. (medscape.com)
Cooling the whole body should have effects on multiple pathways and multiple organs that might be affected by the shock state and help temporize things until you can stabilize the patient, warm them back up, and avoid that period of injury. (medscape.com)
The Hellman Group studies TLR-dependent pathways expressed by macrophages as well as non-conventional inflammatory cells, including endothelial cells, in Inflammatory Critical Illness, focusing on their roles in coagulopathy, vascular permeability, neutrophil trafficking to organs, and organ injury and failure. (ucsf.edu)
We are now further exploring these observations, testing the basic hypotheses that ERK1/2 and ERK5 regulate TLR-dependent and TLR-independent activation of endothelial inflammatory pathways and contribute to endothelial dysfunction in septic shock and organ failure. (ucsf.edu)
The goals are to further delineate the downstream pathways leading to coagulopathy and organ failure, and identify potential therapeutic targets to mitigate these deleterious outcomes without negatively impacting bacterial clearance. (ucsf.edu)
4. The effects of TLR2 activation on the vascular endothelium, including on endothelial inflammatory responses, leucocyte trafficking, coagulation pathways and permeability: Endothelial cell (EC) activation, coagulopathy, and vascular leak contribute to sepsis-induced organ failure. (ucsf.edu)
Tao Q, Tianyu W, Jiangqiao Z, Zhongbao C, Xiaoxiong M, Long Z, Jilin Z. Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways. (ijbs.com)
In conclusion, our study demonstrates that Trim8 deficiency plays a protective role in hepatic I/R injury by inhibiting the activation of TAK1-dependent signalling pathways. (ijbs.com)
I/R injury, through the liberation of radical oxygen species and the activation of inflammatory pathways, induces cellular injury and mi-crocirculatory damage, which translate to organ dysfunc-tion, morbidity, and increased health care costs [7, 8]. (123dok.net)
By addressing these injury mechanisms in donor and recipient, through understanding the pathways of injury and applying therapeutics and new biomedical technologies we attempt to prevent organ injury, improving allograft function and short and long-term organ survival. (ox.ac.uk)
To identify pathways of injury and apply targeted interventions to repair donor organ injury. (ox.ac.uk)
Organ failure in the heart or kidney can initiate various complex metabolic, cell-mediated and humoral pathways affecting distant organs, contributing to the high therapeutic costs and significantly higher morbidity and mortality. (biomedcentral.com)
Heart performance and kidney function are closely interconnected and communication between these organs occurs through a variety of bidirectional pathways. (biomedcentral.com)

Ischemia-reperfusion (I/R) injury is a common complication of surgery, and a major cause of organ dysfunction, especially in the liver. (geronova.com)
Acute lung injury (ALI) is a leading complication in patients with extensive burns. (ajbm.net)

Cardiogenic shock in the MI setting was usually fatal until the advent of acute reperfusion therapy with balloon angioplasty, but even today with modern PCI and intra-aortic balloon pumping, mortality is about 50%, note the viewpoint's authors, led by Dr Brian M Stegman (Duke University Medical Center, Durham, NC). (medscape.com)
I/R is a common pathological disorder leading to acute liver injury, a potentially life-threatening clinical condition with high morbidity, mortality, and prolonged patient hospitalization. (ijbs.com)
Severe burn injury in Europe: a systematic review of the incidence, etiology, morbidity, and mortality. (ajbm.net)
Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. (ajbm.net)
The nature and severity of abdominal injuries vary widely depending on the mechanism and forces involved, thus generalizations about mortality and need for operative repair tend to be misleading. (msdmanuals.com)
Cardiopulmonary bypass (CPB) induces a systemic inflammatory response which is thought to be a significant cause of postoperative organ dysfunction and mortality. (peertechzpublications.com)
The early postoperative period in CABG patients is associated with systemic inflammatory response syndrome (SIRS), which is complicated with multiple organ dysfunction and high mortality in 5%-16% of cases (EACTA 2007 data) [ 1 , 2 ]. (hindawi.com)
Retransplantation is the definitive treatment for severe CAV, however, the paucity of organs along with increased mortality associated with retransplantation makes it a less desirable option. (lidsen.com)
Primary analysis focused on the association between syndecan-1 levels and the development of ARDS, other organ dysfunction (Brussels criteria), or in-hospital mortality. (springeropen.com)
Measurement of syndecan-1 levels in sepsis patients might be useful for identifying patients at high risk of organ dysfunction and mortality as well as those who could benefit from therapies targeted at protecting or restoring the glycocalyx. (springeropen.com)

February 6, 2012 (Boston, Massachusetts) - Therapeutic hypothermia can help preserve the brain during cardiac arrest, so maybe it could protect organs throughout the body in other conditions that threaten their blood supply--such as cardiogenic shock. (medscape.com)
When combined with an HS, an UCCAO is associated with ischemic neuronal injury in the ipsilateral hemisphere of adult rat brain, which can be attenuated by therapeutic hypothermia. (medsci.org)
Sex effects and the time of reperfusion may be the important factors to consider clinical therapeutic of renal IRI as well as its impact on remote organs. (phypha.ir)
Ferroptosis, a recently described form of regulated necrotic cell death, has emerged as a common underlying pathomechanism of tissue IRI, and represents a most promising therapeutic target to prevent extensive IRI-driven cell loss, tissue dysfunction and necroinflammation. (tu-dresden.de)
Despite accumulating evidence regarding its mechanisms and potential therapeutic approaches, hepatic I/R is still a leading cause of organ dysfunction, morbidity, and resource utilization, especially in those patients with underlying parenchymal abnormali-ties. (123dok.net)
Therapeutic strategies tackling I/R injury could not only improve post-surgical organ function, but also allow a reduction in the risk of cancer recurrence. (123dok.net)
Objective: To develop a model of in-vivo cardiac arrest and resuscitation in order to characterize the biology of the associated myocardial dysfunction and test potential therapeutic strategies. (whiterose.ac.uk)

15. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. (phypha.ir)
Shock Shock is a state of organ hypoperfusion with resultant cellular dysfunction and death. (msdmanuals.com)
By understanding the links between Ca2+, electrical excitability and energy production, we hope to understand the cellular basis of cardiac arrhythmias, ischemia-reperfusion injury, and sudden death. (hopkinsmedicine.org)
Nonalcoholic steatohepatitis, identified by increased liver enzyme tests in the absence of other causes of liver injury, is definitively diagnosed via a biopsy finding of fat accumulation (steatosis) in the liver as well as microscopic findings of cellular injury to the cells in the organ. (innovatebiopharma.com)

Remote effect of kidney ischemiareperfusion injury on pancreas: role of oxidative stress and mitochondrial apoptosis. (phypha.ir)
Inhibition of oxidative stress in renal ischemia-reperfusion injury. (phypha.ir)
Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)
Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. (scienceopen.com)
We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R. (scienceopen.com)
The findings emphasize the role of concomitant oxidative and nitrosative stress and the role of peroxynitrite in the ensuing renal dysfunction. (scienceopen.com)
In these pathological conditions, CBD decreased organ damage and dysfunction, oxidative and nitrative stress, and inflammatory processes, among others. (havnlife.com)

Improved understanding of the mechanism of lung injury during brain death and during transition from donor to recipient may one day lead to techniques and preservation solutions that prevent ischemia-reperfusion injury. (medscape.com)
We assessed whether donor preservation with S-NO-HSA affects isograft injury and myocardial expression of GATA2 as well as miR-126-3p, which are considered protective against vascular and endothelial injury. (frontierspartnerships.org)
There is substantial evidence that endothelial injury during organ procurement and preservation, caused by ischemia and subsequent reperfusion, results in endothelial dysfunction. (frontierspartnerships.org)
Besides endothelial dysfunction, the progression of interstitial and perivascular fibrosis consecutively leads to impaired diastolic and systolic graft function, thus preservation of endothelial and vascular function is certainly a clinically desirable goal. (frontierspartnerships.org)
Complications following LT occur commonly and may derive from pretransplant recipient condition, graft-specific factors (including preservation and ischemia-reperfusion injury), technical or intraoperative complications, the immunologic response to the graft, or infection. (musculoskeletalkey.com)
Changes in donor organ allocation policies and improved organ preservation allowing broader geographic distribution have also increased potential access for children to donor liver grafts. (musculoskeletalkey.com)
I am currently focusing on the establishment of two consortia: the Consortium on Organ Preservation In Europe (COPE) and on the Consortium on Quality in Organ Donation (QUOD? (ox.ac.uk)
By increasing organ quality including ex vivo preservation and resuscitation as well as by conditioning the recipient we also aim to make previously unusable organs transplantable. (ox.ac.uk)

However, chronic allograft dysfunction in the form of bronchiolitis obliterans remains a major hurdle that threatens both the quality of life and long-term survival of the recipients. (ersjournals.com)
After successful reduction of early complications, chronic allograft dysfunction has become the major obstacle to long-term survival. (ersjournals.com)

This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. (medsci.org)
However, it is not known whether resuscitation after a [ 10 - 12 ] HS can cause cerebral injury and concomitant neurological dysfunction, and its potential mechanisms. (medsci.org)
Specifically, the researchers from Dresden, München, Regensburg and Essen aim to identify and validate common ferroptotic signatures and molecular mechanisms in organs mostly affected by IRI such as brain, liver, lung and kidney. (tu-dresden.de)
Putative pathophysiological mechanisms linking I/R injury and liver cancer recurrence include an increased implantation of circulating cancer cells in the ischemic liver and the upregulation of proliferation and angiogenic factors following the ischemic insult. (123dok.net)
Exposure to warm ischaemia, a heightened pro-inflammatory and pro-coagulatory state, increased immunogenicity and ischaemia reperfusion injury are central mechanisms resulting in organ injury and eventually will lead to chronic transplant dysfunction. (ox.ac.uk)
Rational strategies can then be devised to correct dysfunction during the progression of disease through a comprehensive understanding of basic mechanisms. (hopkinsmedicine.org)

New experimental data have emerged in recent years focusing on the interactive effects of kidney and lung dysfunction, and providing evidence that kidney-lung crosstalk occurs and can be bidirectionally deleterious. (biomedcentral.com)

These processes result from a complex inflammatory response that is initiated through the innate immune system by interactions between host cells and microbes or endogenous host factors that are released during injury or cell death. (ucsf.edu)
Bucillamine, a cysteine derivative that contains two donatable thiol groups, in the context of IRI is capable of replenishing the thiol group in glutathione, thereby reactivating this endogenous defense against oxidant injury. (dailymushroom.co)

Increasing pressure reduces blood flow to abdominal organs and impairs pulmonary, cardiovascular, renal, and gastro-intestinal (GI) function, causing obstructive shock, multiple organ dysfunction syndrome and death. (wikipedia.org)
High levels of inflammatory markers, such as C-reactive protein, were associated with left ventricular dysfunction ( 2 ), higher cardiovascular event rates ( 3 ) and worse clinical prognosis ( 4 ) following an acute myocardial infarction, independent of traditional risk factors. (frontiersin.org)
The anti-inflammatory action of molecular hydrogen, along with its other capabilities, has the potential to positively affect various diseases, including metabolic syndrome, cardiovascular disease and organ injury. (water-for-health.co.uk)
Using mouse models of ischaemia-reperfusion injury, we are investigating the cardiovascular and renal sequelae of AKI and examining new experimental medicine strategies to reduce the risks of developing these. (ed.ac.uk)
Positive effects of CBD were observed in experimental models of heart diseases, stroke, neonatal hypoxic ischemic encephalopathy, sepsis-related encephalitis, cardiovascular complications of diabetes, and liver and kidney ischemia / reperfusion . (havnlife.com)

The most relevant goal, they write, would be to "improve cardiac function and hemodynamics and reduce end-organ damage from prolonged hypoperfusion. (medscape.com)

The primary endpoint examines the effects of quercetin on blood inflammatory cytokines and markers of myocardial injury and senescence in this patient population. (frontiersin.org)
Activation of Kupffer cells and neutrophils leads to release of inflammatory cytokines and free radicals, which further aggravate liver injury [ 4 , 5 ]. (ijbs.com)
4. Koo DJ, Chaudry IH, Wang P. Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis. (ajbm.net)
Ischemia - reperfusion injury also appears to be associated with tight junction dysfunction, while many cytokines, bacterial toxins, infections, and drugs have also been implicated in tight junction injury or destruction. (innovatebiopharma.com)
Inflammatory dysregulation resulting from each organ failure results in rising levels of circulating chemokines, cytokines and activated lymphocytes [ 17 ]. (biomedcentral.com)

11. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. (phypha.ir)

Clinical assessment reveals that patients after surgery of cardiopulmonary bypass or coronary bypass experience postoperative cognitive dysfunction. (medsci.org)
Cardiac surgery with cardiopulmonary bypass (CPB) is associated with a systemic inflammatory response syndrome (SIRS) that is known to be one of the main causes of postoperative organ dysfunction (1). (peertechzpublications.com)

In the oncological setting, there are growing concerns regarding the deleterious impact of I/R injury on the risk of post-surgical tumor recurrence. (123dok.net)
the liver, I/R injury is at the source of poor outcomes after surgical procedures such as hepatectomy and liver trans-plantation [7]. (123dok.net)
Several factors such as contact of blood with foreign surfaces, surgical trauma, ischemia reperfusion to the organs, and release of endotoxin have been widely documented to cause SIRS after CPB. (peertechzpublications.com)
These include bowel obstruction, traumatic intra-abdominal injuries and intra-abdominal bleeding, recent liver transplant, aerophagia, abdominal mass, and increased abdominal perfusion or re-perfusion often associated with fluid resuscitation or in the post-surgical setting. (acep.org)

Hearts from DCD donors have not been utilized as there is a fear that they will have sustained irreversible myocardial injury post cardiac arrest. (whiterose.ac.uk)
Conclusions: Cardiac arrest and reperfusion lead to calcium cardiac memory, which support cardiomyocyte contractility in the face of post arrest myofilament calcium sensitivity. (whiterose.ac.uk)

Sepsis and multiple organ failure are leading causes of death in the Intensive Care Unit. (ucsf.edu)
3. The role of TLR2 in bacterial sepsis and organ injury: My lab has been investigating the bacterial lipoproteins in the context of sepsis for over a decade. (ucsf.edu)
Genetic determinants and ethnic disparities in sepsis-associated acute lung injury. (ajbm.net)
She became junior faculty in 2015 and now has her own research program aimed at investigating immunomodulatory therapies for the prevention of infection and sepsis following a severe burn injury. (vumc.org)
Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. (springeropen.com)
The extent of endothelial glycocalyx degradation is associated with non-pulmonary organ dysfunction in subjects with sepsis and is associated with ARDS but only in the subgroup with non-pulmonary sepsis. (springeropen.com)
Both pulmonary and non-pulmonary sepsis can lead to ARDS with pulmonary sepsis (due to pneumonia or aspiration of gastric contents) resulting in direct injury to the lung and non-pulmonary sepsis resulting in indirect injury to the lung [ 22 ]. (springeropen.com)
In a mouse model of non-pulmonary sepsis, glycocalyx degradation contributed to acute lung injury, and human studies have shown an association between glycocalyx degradation and development of pulmonary edema [ 27 , 28 ], findings that support an association between glycocalyx degradation and ARDS. (springeropen.com)

In the organ crosstalk, the combination of AKI with acute lung injury remains a formidable challenge for clinicians treating critically ill patients. (biomedcentral.com)

Tight junction dysfunction has been implicated in a host of disease states, including a variety of autoimmune diseases. (innovatebiopharma.com)

To investigate the effect of acetylcholine (ACh) and ischaemia/reperfusion injury on functional changes and dysrhythmias of th. (nel.edu)

Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs. (researchgate.net)
Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
Although limited, there is growing clinical evidence that I/R injury and liver quality are associated with the risk of post-sur-gical cancer recurrence. (123dok.net)

All solid organs and most other tissues harbor a network of DC or macrophages (Table 1 ). (hindawi.com)
The enhanced lung and renal tissues damages were depended to reperfusion time in both genders. (phypha.ir)

Research in our lab has incorporated mitochondrial energetics, Ca2+ dynamics, and electrophysiology to provide tools for studying how defective function of one component of the cell can lead to catastrophic effects on whole cell and whole organ function. (hopkinsmedicine.org)

The influence of low dose streptozotocin diabetes on intestinal and vascular injury induced by mesenteric ischaemia/reperfusio. (nel.edu)

During the last decades, research has focused on the cell-type-specific properties of these cells in culture, which then led to an immunocentric view of their role in disease like if they were primed like T cells to infiltrate target organs to cause tissue damage and drive progressive scaring [ 2 , 3 ]. (hindawi.com)

These sequelae of renal ischemia are a result of endothelial dysfunction, which is most probably responsible for the 'no-reflow' phenomenon and further aggravation of tubular ischemia during the early reperfusion period. (scienceopen.com)

Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma. (ajbm.net)
16. ANGPT2 Genetic Variant Is Associated with Trauma-associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio. (ajbm.net)
injury may be confined to the abdomen or be accompanied by severe, multisystem trauma. (msdmanuals.com)
Bladder Trauma External bladder injuries are caused by either blunt or penetrating trauma to the lower abdomen, pelvis, or perineum. (msdmanuals.com)
Approach to the Trauma Patient Injury is the number one cause of death for people aged 1 to 44. (msdmanuals.com)
Penetrating trauma to the chest below the fourth intercostal space (or nipple line) should also be evaluated as a potential abdominal wound because of the location of abdominal organs within the chest during the respiratory cycle. (msdmanuals.com)

The effect of Trim8 on hepatic I/R injury was analysed via pathological and molecular analyses. (ijbs.com)

A resuscitation from an HS regards as a reperfusion insult which may induce neurological injury in patients with an UCCAO disease. (medsci.org)
The resuscitation after an HS causes a reperfusion or reoxygenation insult [ 2 - 4 ], gut injury, and multiple organ dysfunctions [ 5 , 6 ]. (medsci.org)

Ascorbic acid is an excellent antioxidant and may reduce organ damage by inhibiting the production of ROS. (mdpi.com)

However, his kidney injury worsened and progressed to chronic kidney disease. (anesth-pain-med.org)

The severity of IRI induced- lung insult can be affected by gender and reperfusion time alteration. (phypha.ir)
This overview provides information on the pathophysiology of the inducible nitric oxide synthase/nitric oxide (iNOS/NO) system in the injury to cultured renal tubular epithelia, freshly isolated proximal tubules, and the whole organ after hypoxic or ischemic insult. (scienceopen.com)

Patient outcomes following a minor polytrauma are often worse than those with a single severe injury. (medsci.org)
This article summarizes the epidemiology and outcomes of AKI in neurocritically ill adults admitted to the ICU, focusing on prevalent ABI conditions like traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), and acute stroke. (beds.ac.uk)

To connect the artery, vein, or the ureter of a donor organ to the recipient side in transplant surgery. (screen.co.jp)

[ 5 ] Finally, the shortage of organ donors must be addressed because too many patients die on the waiting list and never receive a second chance at life. (medscape.com)
Deceased donors have a physiologically abnormal state resulting in significant organ damage even prior to retrieval. (ox.ac.uk)

Serial perioperative blood samples were collected for quantification of amino acids, arginase, nitric oxide metabolites, and markers of organ function (lactate, Pao 2 /Fio 2 ratio, and creatinine clearance). (nih.gov)
The nitric oxide donor S-nitroso-human-serum-albumin (S-NO-HSA) is known to attenuate myocardial ischemia-reperfusion (I/R)-injury. (frontierspartnerships.org)
Recent studies have demonstrated that supplementation of nitric oxide (NO), or increased expression of endothelial NO-synthase (eNOS) protects against both IR-injury and fibrosis ( 5 , 6 ). (frontierspartnerships.org)
In conclusion, the intricate relations between endothelial and epithelial cells, based in part on the relations between endothelial and inducible nitric oxide synthases, are perturbed in renal ischemia primarily as a result of endothelial dysfunction precipitating epithelial injury. (scienceopen.com)

The gut is the most sensitive to intra-abdominal hypertension, and it develops evidence of end-organ damage before alterations are observed in other systems. (wikipedia.org)
This ensures swift delivery of leukocytes (a type of white blood cell) to the area of injury to remove the toxins and repair any damage. (water-for-health.co.uk)
Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)

Perioperative organ dysfunction was evaluated by cardiac surgery scorring (CASUS) system. (peertechzpublications.com)

The metabolic and inflammatory changes associated with AKI likely contribute to prolonged brain injury and edema. (beds.ac.uk)
Fenestrated capillaries are commonly found in organs with high metabolic activity or involved in absorption and filtration processes. (labtestsguide.com)

later, vascular injury was noted during the Each sample was divided into 2 × 5 mL por- annual medical examination. (who.int)
the blood in the second vascular injury. (who.int)

Anatomy28

Organisms13

Diseases53

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Psychiatry and Psychology1

Phenomena and Processes37

Disciplines and Occupations1

Information Science2

Health Care14

Transplantation29

Inflammation14

Models of ischemia-reperfusion1

Acute kidney10

Reactive oxygen3

Rats7

Graft dysfunction2

Warm ischemia1

Ischemic injury3

Kidneys5

Pathways13

Complication2

Mortality10

Therapeutic7

Cellular4

Oxidative7

Preservation8

Allograft dysfunction2

Mechanisms6

Lung dysfunction1

Endogenous2

Cardiovascular5

Hypoperfusion1

Cytokines5

Apoptosis1

Postoperative2

Surgical4

Cardiac arrest2

Sepsis8

Crosstalk1

Autoimmune1

Investigate the effect1

Clinical3

Tissues2

Mitochondrial1

Mesenteric1

Tissue damage1

Sequelae1

Trauma6

Pathological1

Resuscitation2

Antioxidant1

Chronic1

Insult2

Outcomes2

Donor organ1

Donors2

Nitric oxide4

Damage3

Perioperative1

Metabolic2

Vascular injury2