• Stem cells can repair and even replace diseased cells in organs and tissues. (quantumday.com)
  • Induced stem cells are generated by modifying the genetic structure of a normal cell to activate its stem cell properties. (quantumday.com)
  • In the new study, this structure spontaneously emerged from human embryonic stem cells (hESCs)-cells derived from human embryos that are capable of developing into a variety of tissues-thanks to the cell culture methods optimized by Sasai and his team. (quantumday.com)
  • For instance, the hESC-derived optic cup is much larger than the optic cup that Sasai and collaborators previously derived from mouse embryonic stem cells, suggesting that these cells contain innate species-specific instructions for building this eye structure. (quantumday.com)
  • Application of various small molecules and recombinant proteins to mouse embryonic stem cells at specific time points in vitro has enabled recapitulation of developmental cues with subsequent formation of inner ear organoids. (springer.com)
  • Role of Otx2 in Embryonic Stem Cells (ESCs): Otx2 is an intrinsic determinant required to maintain the ESC metastable state by antagonizing ground state pluripotency and promoting commitment to differentiation. (cnr.it)
  • Finally, it remains to be determined whether iPSC can recreate the 3D histo-architecture of the neural retina (NR) in vitro beyond a rudimentary stratification 22 . (nature.com)
  • Moreover, it has recently been shown that mouse and human ES cells can develop into a three-dimentional (3D) optic cup in culture that remarkably resembles the embryonic vertebrate eye 20 , 21 . (nature.com)
  • Baker C, Bronner-Fraser M (2001) Vertebrate cranial placodes I. Embryonic induction. (springer.com)
  • In vertebrate eyes, the retinal pigment epithelium (RPE) provides structural and functional homeostasis to the retina. (molcells.org)
  • However, to fulfill this promise, a remaining challenge is to induce human iPSC to recreate in vitro key structural and functional features of the native retina, in particular the presence of photoreceptors with outer-segment discs and light sensitivity. (nature.com)
  • However, it is still unclear to what extent hiPSC may be capable of recapitulating in vitro the cellular and molecular features of the native retina, especially regarding photoreceptor differentiation and functional maturation. (nature.com)
  • The requirements for the successful culture of organoids in vitro differ significantly from those of traditional monolayer cell cultures. (mdpi.com)
  • The present in vitro study suggests that the avian pineal organ is made up of multiple types of cells with different immunore-activity at the ontogenic state (from embryonic day 9 to day 14), before it acquires the final photoendocrinal nature of the mature state. (bioone.org)
  • Synthetic materials could be suitable as scaffolding for tissue because, unlike natural tissues, they remain stable in the organism long enough for the body to form new natural structures. (mpg.de)
  • Moreover, the effect of all these factors is linked in natural tissues and varies from organ to organ," Britta Trappmann explains. (mpg.de)
  • The intense, focused light of lasers with these colors can be used for a wide variety of unique therapeutic interventions: making incisions, cauterizing and sealing wounds, and selectively heating or even vaporizing specific regions of organs and tissues. (nationalacademies.org)
  • To understand the multifaced aspects of Parkinson's disease, it may be desirable to expand the complexity of these models, to include different brain regions, vasculature, immune cells as well as additional diverse organ-specific organoids such as gut and intestine. (nature.com)
  • particular BiologyThe Life Sciences Institute asks an colourful retina, biology present interest. (cutechabeads.com)
  • Gestational age is the primary determinant of organ maturity. (msdmanuals.com)
  • In humans, injuries and diseases can result in irreversible tissue or organ loss. (unimore.it)
  • Using lab-created tissue to heal or replace damaged organs is one of the great visions for the future of medicine. (mpg.de)
  • During development, light-sensitive tissue lining the back of the eye, called the retina, forms from a structure known as the optic cup. (quantumday.com)
  • An organoid is a 3D organization of cells that can recapitulate some of the structure and function of native tissue. (mdpi.com)
  • 1991), and the original name for the temporary organ of repair, 'granulation tissue' (Hunter, 1787), is derived from the prominence of its vessels. (docksci.com)
  • The amount of this intrinsic absorption can be used to determine the physiological health of an organ-for example, whether the tissue is getting sufficient oxygenated blood flow. (nationalacademies.org)
  • This is a human ES cell-derived optic cup generated in our self-organization culture (culture day 26). (quantumday.com)
  • Eiraku M, Takata N, Ishibashi H et al (2011) Self-organizing optic-cup morphogenesis in three-dimensional culture. (springer.com)
  • Alström syndrome (AS) is characterised by metabolic deficits, retinal dystrophy, sensorineural hearing loss, dilated cardiomyopathy and multi-organ fibrosis. (springer.com)
  • A team headed by biomedical engineer Dr Britta Trappmann from the Max Planck Institute for Molecular Biomedicine in Münster, Germany, has developed a cell culture system in which, for the first time, a functional blood vessel system is able to grow within a framework made of synthetic materials. (mpg.de)
  • Studies using Xenopus cell-free extracts, oocytes, eggs, embryos, larval stages, and adult frogs have yielded important insights into a multitude of key biological processes-from mechanisms underlying the cell cycle to embryonic development to human disease. (cshlpress.com)
  • Within the backdrop of embryogenesis, inner ear development follows an intricate pathway of signaling cues and morphological changes, leading to its complex final three-dimensional (3D) structure. (springer.com)
  • Tubulogenesis is crucial during organ development and the vascular system, particularly in blood vessel formation and function. (uic.edu)
  • Role of Otx1 in corticogenesis, pituitary functions and sense organs development. (cnr.it)
  • Following the characterization of their direct binding capabilities by SPR, Alpha-LISA, and thermal shift assays, we will determine which molecules selectively prevent Gα12 binding to α-SNAP and inhibit vWF secretion and thrombosis in cultured human endothelial cells, in the isolated mouse lung, and in the db/db mouse model of T2DM. (uic.edu)
  • Deregulation of this receptor results in many diseases and its total knockout is embryonic lethal. (uic.edu)
  • A tentacle or bothrium is one of usually two or more elongated flexible organs present in animals, especially invertebrates. (absoluteastronomy.com)
  • Additional tip cell formation is stopped through lateral inhibition of surrounding cells, which subsequently develop into stalk cells that form the initial structure of the new vessel. (uic.edu)
  • Organoid versions incorporate multiple organ-specific cell types, recapitulating body organ advancement and function. (phytid.org)
  • Ultimately, expression of kidney-specific proteins and replication of 3D tubular structure by organoid constituents were used for validation. (phytid.org)
  • [3] It is a common misconception that all albino animals have characteristic pink or red eyes (resulting from the lack of pigment in the iris allowing the blood vessels of the retina to be visible), however this is not the case for some forms of albinism. (wikipedia.org)
  • Macrophages are widespread and reside in many different organs, where they fulfill different functions. (frontiersin.org)
  • At both high (x ray) and low (radio frequency [RF]) energies the body is mostly transparent, thus allowing the non-invasive imaging of the internal structure of organs and bones. (nationalacademies.org)
  • Perhaps as a consequence, no photoreceptor-light response has been observed in such cultures either. (nature.com)