• We have recently reported that mechanical manipulation of human adipose tissue without modification of tissue composition, structure and histology, that was totally comparable to that of the original source (see Experimental procedure for details), increased significantly the number of stromal cells bearing the expression of beta-tubulin III. (neurogelenmarche-usa.org)
  • Human adipose tissue-derived stem cells (hASCs) are attractive cells for therapeutic applications and are currently being evaluated in multiple clinical trials. (biomedcentral.com)
  • This protocol is used to answer key questions related to the function of human adipose progenitors in the vascular microenvironment. (jove.com)
  • We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
  • Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)
  • We conducted a comprehensive analysis of the metabolomes and lipidomes of biopsy-proven IgG4-ROD (n = 22) and orbital MALT lymphoma (n = 21) specimens and matched adjacent microscopically normal adipose tissues using liquid chromatography time-of-flight mass spectrometry. (elsevierpure.com)
  • Under physiological conditions, the main- PPARγ mutation has been shown to link to familial partial lipody- tenance of normal adipose tissue mass is mainly the result of a strophy, a clinical disorder characterized by the loss of adipose balance of lipid storage and lipolysis (Bouchard et al. (deepdyve.com)
  • 1. Activation of adipose tissue and related mesenchymal stem cells: promotion of anti-inflammatory properties through SOX2 transcription factor and HuR RNA-binding protein modulation. (neurogelenmarche-usa.org)
  • It stimulates proliferation, cytokine, and hyaluronan production, and thyrotropin receptor expression by orbital fibroblasts. (eur.nl)
  • The aim of this study was to investigate the effect of PDGF-BB on adipocyte differentiation by orbital fibroblasts. (eur.nl)
  • Orbital fibroblasts from five healthy controls and nine GO patients were collected. (eur.nl)
  • Adipogenesis was induced by culturing orbital fibroblasts in differentiation medium, either in the presence or absence of PDGF-BB. (eur.nl)
  • 0.05) in orbital fibroblasts. (eur.nl)
  • Platelet-derived growth factor-BB enhances adipogenesis in orbital fibroblasts, and, thus, may contribute to adipose tissue expansion in GO. (eur.nl)
  • Orbital pre-adipocytes and fibroblasts also express the TSH receptor, resulting in expanded retro-orbital tissue and causing exophthalmos and limited eye movement. (frontiersin.org)
  • In this study, we investigated the role of PLC-γ and the therapeutic effect of the PLC-specific inhibitor U73122 using orbital fibroblasts from patients with Graves' orbitopathy (GO). (bvsalud.org)
  • Methods: The expression of phospholipase C gamma 1 (PLCG1) and phospholipase C gamma 2 (PLCG2) was evaluated using polymerase chain reaction in GO and normal orbital tissues/fibroblasts. (bvsalud.org)
  • The primary cultures of orbital fibroblasts were treated with non-toxic concentrations of U73122 with or without interleukin (IL)-1ß to determine its therapeutic efficacy. (bvsalud.org)
  • We investigated the pathogenic role of a specific adipokine, adipsin, known as complement factor D in Graves' orbital fibroblasts. (bvsalud.org)
  • Adipsin protein production was analyzed in primary cultured orbital fibroblasts under insulin growth factor (IGF)-1, CD40 ligand (CD40L) stimulation, and adipogenesis. (bvsalud.org)
  • The aim of this study was to investigate the effect of PDGF-BB on adipocyte differentiation by orbital fibroblasts.METHODS: Orbital fibroblasts from five healthy controls and nine GO patients were collected. (eyehospital.nl)
  • Fibroblast growth factor receptor inhibitors reduce adipogenesis of orbital fibroblasts and enhance myofibroblastic differentiation in Graves' orbitopathy[J]. Ocul Immunol Inflamm, 2021, 29(1): 193-202. (csu.edu.cn)
  • Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves ophthalmopathy. (thieme-connect.de)
  • Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtype. (thieme-connect.de)
  • Caused by inflammation, cellular proliferation and increased growth of extraocular muscles and retro-orbital connective and adipose tissues due to the actions of thyroid stimulating antibodies and cytokines released by cytotoxic T lymphocytes (killer cells). (capsulehealth.one)
  • Orbital exenteration is the surgical removal of the contents of the orbit and the periorbital soft tissue, including the eye, extraocular muscles, optic nerve, periorbita, orbital adipose tissue, eyelids, and periorbital skin. (entokey.com)
  • 2004). Indeed, autologous transplant of adipose tissue is an established therapeutic procedure used for the repair of a variety of tissue damage. (neurogelenmarche-usa.org)
  • The adult stem cells used were autologous and were extracted from infraumbilical adipose tissue prior to abdominoplasty. (rbcp.org.br)
  • Therefore, this study was designed to investigate the regeneration of articular cartilage and subchondral bone, using three-dimensional constructs of autologous adipose. (koreamed.org)
  • This study hypothesizes that enhanced intestinal permeability may aggravate orbital inflammation and, thus, increase myofibroblast differentiation and the degree of fibrosis. (frontiersin.org)
  • Benign and malignant tumours of adipose differentiation represent a large category of soft tissue tumours, many of which are frequently encountered in diagnostic pathology [ 1 ]. (biomedcentral.com)
  • Results: Adipsin gene expression was significantly elevated in GO tissue and increased after the stimulation of IGF-1 and CD40L, as well as adipocyte differentiation in GO cells. (bvsalud.org)
  • analyses, as well as others (8-11), support the hypothesis that adipose tissue-secreted factors may indeed be potent modulators of inflammation-related disorders such as obe- sity, type 2 diabetes, metabolic syndrome, atherosclerosis, inflammatory bowel disease, thyroid-associated (Graves') ophthalmopathy, breast cancer, and nonalcoholic fatty liver disease. (123dok.org)
  • The subsequent translocation of bacterial compounds to the systemic circulation may aggravate inflammatory processes within the orbital tissue and, as a consequence, augment the proportion of activated myofibroblasts, which actively secrete extracellular matrix leading to retro-orbital tissue expansion. (frontiersin.org)
  • These findings warrant further exploration to assess the correlation between specific inflammatory pathways in the orbital tissue and the gut microbiota composition and may pave the way for new microbiota-targeting therapies. (frontiersin.org)
  • Our discoveries here reported indicate a clear method of tissue activation that stimulates anti-inflammatory properties in human fat recovered by liposuction with an accompanying reduction in the production of known inflammatory cytokines such as TNFalfa. (neurogelenmarche-usa.org)
  • Fat tissue accumulation is, as a matter of fact, considered an inflammatory process. (neurogelenmarche-usa.org)
  • Pro- and anti-inflammatory factors were assessed in lipoaspirate tissue obtained from the same group off patients and subjected to such specific mechanical force for a variable number of minutes. (neurogelenmarche-usa.org)
  • The results show that the application of a 97 x g force eliminates the typical adipose tissue expression of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha). (neurogelenmarche-usa.org)
  • Such a mechanically induced modification of the fat tissue inflammatory status might have much broader implications as it is suggested by the dramatically enhanced leptin expression(Figure 1), the food desire suppressor produced by fat and this suggest further in vivo application of such force to body surfaces where such an hormone plays a crucial role. (neurogelenmarche-usa.org)
  • Purpose: Graves' orbitopathy (GO) is an orbital manifestation of autoimmune Graves' disease, and orbital fibroblast is considered a target cell, producing pro-inflammatory cytokines and/or differentiating into adipocytes. (bvsalud.org)
  • Adipose tissue has been focused on as an endocrine and inflammatory organ secreting adipokines. (bvsalud.org)
  • This study aims to construct a competing endogenous RNA (ceRNA) network for this disease and clarify the infiltration patterns of inflammatory cells in orbital tissue to further explore the pathogenesis of GO. (csu.edu.cn)
  • Finally, inflammatory or infectious processes associated with refractory orbital pain (e.g., invasive fungal infections such as mucormycosis) may be indications for orbital exenteration. (entokey.com)
  • Weber-Christian disease (WCD) is an inflammatory disease whose main histological feature is lobular panniculitis of adipose tissue. (qxmd.com)
  • The main function of Interleukin (IL)-17 appears to be the regulation of local tissue inflammation via the coordinated expression of pro-inflammatory cytokines and chemokines. (biomedcentral.com)
  • The influx of macrophages and accumulation of T-cells and myofibroblast were quantified in orbital connective tissue. (frontiersin.org)
  • Macrophage influx was positively linked to the extent of T cell influx and fibroblast activation within GO-affected orbital tissues. (frontiersin.org)
  • 2011). Stem cell frequency appears to be significantly higher in adipose tissue than in other tissues such as bone marrow (Bieback et al. (neurogelenmarche-usa.org)
  • The location of panniculitis determines the clinical presentation, being the subcutaneous adipose tissue the most frequent one, followed by liver, spleen, bone marrow and mesenteric adipose tissue. (qxmd.com)
  • The frontal bone also presents an orbital surface and an intracranial surface that is not discussed in this article. (medscape.com)
  • The superciliary ridges are prominences of the frontal bone above the orbital margins that meet in the midline in the glabella. (medscape.com)
  • Two distinct cohorts of GO patients were studied, one of which was a unique cohort consisting of blood, fecal, and retro-orbital tissue samples. (frontiersin.org)
  • Moreover, serum LBP levels significantly correlated with the abundance of specific Gram-negative gut bacteria, linking the gut to local orbital inflammation. (frontiersin.org)
  • Autoimmune hyperthyroid disorder that classically comprises hyperthyroidism with a diffuse goitre, eye disease characterized by inflammation and involvement of intra-orbital structures, dermopathy to as pretibial myxoedema, and rare involvement of the nails, fingers and long bones known as acropachy. (capsulehealth.one)
  • There is a recent line of research favoring hypothetic allergic mechanisms in the genesis of atherosclerosis and, consequently, coronary artery disease (CAD), among which Interleukin (IL)-17 appears to be a key cytokine regulating local tissue inflammation. (biomedcentral.com)
  • Immunohistochemical staining of normal (axillary) BAT and subcutaneous/abdominal white adipose tissue (WAT) as well as a wide range of benign and malignant primary soft tissue tumours (n = 171) was performed using a rabbit polyclonal antibody to UCP1. (biomedcentral.com)
  • All TED patients completing an 8-dose course of teprotumumab between January 2020 and September 2022 and all patients undergoing bony orbital decompression from January 2017 to December 2019 were included. (bvsalud.org)
  • In some cases, not only the orbital and periorbital soft tissue but also the bony orbital walls must be removed. (entokey.com)
  • The association found between the amount of visceral fat and circulating levels of eotaxin on the one hand, and IMT on the other, could reinforce the hypothesis that IL-17, released by the visceral adipose tissue, induces eotaxin secretion via the smooth muscle cells present in the atheromatosus vessels. (biomedcentral.com)
  • Oro-orbital tumours. (midlandeye.com)
  • Palato-Orbital Tumours. (midlandeye.com)
  • UCP1 has also been found in other tissues (e.g. smooth muscle) but whether it is expressed in non-adipose benign and malignant soft tissue tumours is unknown. (biomedcentral.com)
  • UCP1 was not expressed in WAT or other adipose tumours with the exception a few tumour cells in pleomorphic liposarcoma. (biomedcentral.com)
  • UCP1 is strongly expressed in BAT but not WAT and is found in all hibernomas and a few pleomorphic liposarcomas but not in other adipose tumours. (biomedcentral.com)
  • In specific subtypes of benign and malignant adipose tumours there may be lipoblasts and/or atypical adipose cells with large or small, single or multiple, fat vacuoles as well as cells with pleomorphic or spindle-shaped nuclei [ 1 ]. (biomedcentral.com)
  • In addition, as UCP1 has been reported in other cell types, we have examined whether UCP1 is expressed in a wide range of non-adipose benign and malignant soft tissue tumours. (biomedcentral.com)
  • We have also determined whether tumour markers other than UCP1 can be used to distinguish hibernoma from other adipose/non-adipose soft tissue tumours. (biomedcentral.com)
  • When an "eyelid-sparing" orbital exenteration may be possible, the skin of the upper and lower eyelids should be carefully examined, and the degree of laxity and redundant skin should be noted as this skin will be used to line the orbit. (entokey.com)
  • Methods: The messenger RNA (mRNA) expression of multiple adipokines was investigated in adipose tissues harvested from GO and healthy subjects. (bvsalud.org)
  • GD is the most common form of hyperthyroidism ( 1 ) and up to 40% [CI 0.32 - 0.48] of GD patients have clinically apparent abnormalities of orbit soft tissue, known as Graves' orbitopathy (GO) or thyroid eye disease (TED) ( 2 ). (frontiersin.org)
  • The most common indication for orbital exenteration is a malignancy of the eye, orbit, ocular adnexa, or periocular region for which salvage of the globe is not possible. (entokey.com)
  • During the physical examination in a patient being considered for orbital exenteration, the tumor should be carefully evaluated, and its exact location within the orbit, ocular adnexal structures, paranasal sinuses, or nasal cavity should be noted. (entokey.com)
  • The eye orbit is the part of the facial skeleton that contains the eye, the muscles that move it as well as the adipose tissue. (craniofacial.org)
  • Moreover, dasatinib reduced PPAR-γ mRNA expression in cultured GO orbital tissue. (eur.nl)
  • [ 1 ] The eyes, more specifically, the periorbital tissues are vital in the expression of emotion but also are telling of age, gender, and beauty. (medscape.com)
  • Although under-eye pubbiness is the most common aesthetic problem of the periocular area, caused by the herniation of the orbital fat, there is a category of patients whose problem is the concavity of this area and the accentuation of the "tear lines" or the presence of dark circles (periorbital melanosis). (drberbecarzeca.ro)
  • The lateral orbital margin is visible and palpable in its extent, and the frontozygomatic suture frequently may be felt as a small depression some 10 mm superior to the lateral canthus. (medscape.com)
  • The superior margin of the zygomatic arch is generally palpable, extending between the lateral orbital rim and the anterior border of the tragus. (medscape.com)
  • The superficial fat space contains the nasolabial fat pad, the superior, inferior, and lateral orbital fat pads, the temporal and forehead fat pads, the jowl fad pad, and the medial, middle, and lateral cheek fat pads. (nih.gov)
  • UCP1 expression in a few non-adipose soft tissue sarcomas may possibly reflect origin of tumour cells from a common mesenchymal stem cell precursor and/or developmental pathway. (biomedcentral.com)
  • 1999). Recent studies have shown that the potentiality of tissue regeneration can be enhanced using adipose derived stem cells (hADSCs) (see Gimble et al. (neurogelenmarche-usa.org)
  • This study aimed to assess whether the use of adult stem cells from adipose tissue is beneficial to skin healing. (rbcp.org.br)
  • Skin healing results after implantation of adult stem cells derived from adipose tissue were satisfactory. (rbcp.org.br)
  • The use of hASCs for therapeutic applications has grown substantially in the last years, because the use of stem cells from adult tissues circumvent some ethical issues associated with the application of embryonic stem cells, and because of their accessibility via isolation from lipoaspirates, a disposable byproduct of cosmetic surgery. (biomedcentral.com)
  • BACKGROUND: In recent years, researchers discovered that menstrual blood-derived stem cells (MenSCs) have the potential to differentiate into a wide range of tissues including the chondrogenic lineage. (koreamed.org)
  • The grafting of adipose tissue in the infraorbital area also has regenerative effects due to the presence of stem cells in adipose tissue. (drberbecarzeca.ro)
  • The addition of stem cells provided by the adipose tissue and the enriched stem cell (PRP) plasma will ensure a faster recovery and better skin quality in the infraorbital region. (drberbecarzeca.ro)
  • The indications for orbital exenteration can be divided into four general categories: tumors of the eyelid or conjunctiva for which salvage of the globe is not possible, intraocular tumors with extension to the orbital soft tissue, orbital extension of tumors of the paranasal sinuses or nasal cavity, and orbital extension from intracranial processes. (entokey.com)
  • Orbital exenteration may not be appropriate in patients with widespread metastatic disease, patients with tumors expected to have a high likelihood of local-regional recurrence despite orbital exenteration, elderly patients with multiple medical comorbidities, or patients with a short life expectancy. (entokey.com)
  • We have suspected that mechanical forces may be of key relevance in adult tissue plasticity as it occurs during embryogenesis, tissue remodeling and mitotic and motile behavior of cells (Vogel et al, 2006). (neurogelenmarche-usa.org)
  • and (2) through the paracrine release of trophic factors to induce tissue repair by endogenous cells [ 6 ]. (biomedcentral.com)
  • Abdelaziz BA, Baher W, Hafez MS, El Ebiary FH (2019) Effect of Curcumin on the Plasticity of Inguinal Adipose Tissue in Experimental Model of Hypothyroidism in Rat: Histological Study. (gavinpublishers.com)
  • The "endo-" of endosonography refers to the examination of tissue within hollow organs, with reference to the usual ultrasonography procedure which is performed externally or transcutaneously. (lookformedical.com)
  • At multiple regression, IMT was predicted, other than by age, by the amount of the visceral adiposity, expressed as visceral adipose tissue at ultrasonography, and by serum eotaxin. (biomedcentral.com)
  • Perivascular adipose tissue surrounds blood vessels and regulates cardiovascular physiology. (jove.com)
  • 2010). Senp2 also regulates fatty acid metabolism in skeletal Downloaded from https://academic.oup.com/jmcb/article-abstract/10/3/258/4763638 by Ed 'DeepDyve' Gillespie user on 26 June 2018 Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1 j 259 muscle (Koo et al. (deepdyve.com)
  • PURPOSE: To explore if orbital fat-to-muscle ratio (FMR) is predictive of whether surgical decompression or teprotumumab leads to greater proptosis reduction in thyroid eye disease (TED). (bvsalud.org)
  • In this study, we have sought to determine whether UCP1 is expressed in specific benign and malignant adipose tumour subtypes. (biomedcentral.com)
  • Orbital exenteration may also be indicated for certain nonmalignant neoplasms, such as neurofibromatosis causing severe orbital displacement, immobility, and blindness or extensive lymphangioma causing disfigurement or orbital pain. (entokey.com)
  • In effect, a wide range of exported secretory proteins, dubbed adipokines, have been identified as constituents of the adipose proteome (adipokinome). (123dok.org)
  • Extraskeletal chondromas are benign soft tissue tumor of hyaline cartilage. (koreamed.org)
  • UCP1 was variably expressed by tumour cells in a few non-adipose sarcomas including leiomyosarcoma, rhabdomyosarcoma, alveolar soft part sarcoma, synovial sarcoma and clear cell sarcoma. (biomedcentral.com)
  • Orbital exenteration can be required for treatment of squamous cell carcinoma, basal cell carcinoma, sebaceous carcinoma, conjunctival melanoma, uveal melanoma with extrascleral or orbital extension, epithelial cancers such as adenoid cystic carcinoma of the lacrimal gland, rhabdomyosarcoma, and other rare sarcomas. (entokey.com)
  • The superior orbital margin forms a well-marked prominence that may be palpated along its length. (medscape.com)
  • Recent work has seen organoids gain prominence as a valuable model for studying tissue development, drug discovery, and potential clinical applications. (mdpi.com)
  • Adipocyte Senp2 de﫿ciency resulted in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feed- ing. (deepdyve.com)
  • Although less fat stor- adqcKO pose lipid storage in adipocyte-speci﫿c Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
  • Therefore, adipocyte-speci﫿c remain in adipose tissues. (deepdyve.com)
  • Interestingly, lesions in IgG4-ROD were uniquely enriched in arachidonic metabolism, whereas those in orbital MALT lymphoma were enriched in tricarboxylic acid cycle metabolism. (elsevierpure.com)
  • Fat grafting is a technique in which harvested adipose tissue is injected underneath the skin for the reconstruction of traumatic, oncologic, or congenital defects. (nih.gov)
  • It affects both soft and hard tissue (facial skeleton). (wikipedia.org)
  • Phenotypic features include soft-tissue and skeletal hypertrophy and regional macrodontia. (wikipedia.org)
  • The main cause of eyelid edema and ecchymosis after rhinoplasty is soft tissue damage at the osteotomy site [ 2 ]. (e-ceo.org)
  • Considering the risk of periosteal injury and the manipulation of the surrounding soft tissue during osteotomy, lateral osteotomy can be done with or without periosteal elevation (subperiosteal tunneling) [ 3 ]. (e-ceo.org)
  • The bones of the forehead form the scaffold on which the soft tissues are draped. (medscape.com)
  • Gravity causes descent of the facial soft tissues and creates unflattering folds and shadows (e.g., nasolabial folds, tear troughs, marionette lines, etc.), contributing to an aged appearance. (nih.gov)
  • Conclusion,2,This study has constructed a ceRNA regulatory network (MALAT1-MIR21-DDX5) in GO orbital tissue, clarifying the downregulation of the proportion of CD4,+, stationary memory T cells and their positive regulatory relationship with ceRNA components, further revealing the pathogenesis of GO. (csu.edu.cn)
  • To identify tissue metabolomic profiles in biopsy specimens with IgG4-related ophthalmic disease (IgG4-ROD) and mucosa-associated lymphoid tissue (MALT) lymphoma and investigate their potential implication in the disease pathogenesis and biomarkers. (elsevierpure.com)
  • The goal of this protocol is to test the ability of progenitor cells derived from human perivascular adipose tissue to differentiate into multiple cell lineages. (jove.com)
  • At sacrifice, the inguinal adipose tissue was dissected and processed for different histological, ultrastructure, immunohistochemically and morphometric analyses. (gavinpublishers.com)
  • Cross Sectional Analysis of Adipose Tissue and Fatty Liver Prevalence in association with sugar sweetened beverages consumption. (pjmhsonline.com)
  • Insuf﫿cient adipose lipid storage is asso- ciated with many pathological conditions including hyperlipidemia, insulin resistance, and type 2 diabetes. (deepdyve.com)
  • Congenital hemifacial enlargement in which mature lipocytes invade adjacent tissue. (wikipedia.org)
  • The fat is infiltrating with no clear separation from the adjacent tissue. (wikipedia.org)
  • The increased intestinal permeability was accompanied by augmented expression of genes marking immune cell infiltration and encoding key proteins for immune cell adhesion, antigen presentation, and cytokine signaling in the orbital tissue. (frontiersin.org)
  • Downregulated adipose tissue expression of browning genes with increased environmental temperatures. (medscape.com)
  • In most instances, orbital exenteration is only appropriate for patients in whom the possibility of cure is likely enough to justify this radical procedure. (entokey.com)
  • Orbital exenteration not only results in loss of the eye and its function but also causes significant facial disfigurement. (entokey.com)
  • For such patients, palliative radiation therapy, other palliative medical treatments, or various degrees of debulking may offer a better quality of life than orbital exenteration. (entokey.com)
  • A careful examination for signs of local or regional disease spread is essential because orbital exenteration may not be appropriate in patients with regional lymph node or distantorgan metastasis. (entokey.com)
  • We show that a population of multipotent progenitors can be derived successfully from perivascular adipose tissue from patients with cardiovascular disease. (jove.com)