Oral radiotherapy anticancer drugs or radiation. Medical search. Frequent questions

This combination of chemotherapy and radiotherapy has a special role in tumor down staging and in sphincter preservation for lower rectal tumors. (wjgnet.com)
Ondansetron is indicated for the management of nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy, and for the prevention and treatment of post-operative nausea and vomiting. (seagullindia.com)

Although FAP has limited expression in normal adult tissues, it is highly expressed in the tumor microenvironment of many solid cancers - a characteristic that makes it an ideal target for anticancer therapy. (doaj.org)
In this study, we constructed a nano-drug delivery system (NPF@DOX) targeting FAP to increase the therapeutic efficiency of synergistic chemo-photothermal therapy against OSCC.Methods: We utilized PEGylated nano-graphene oxide (NGO) to link doxorubicin (DOX) and fluorescently-labeled, FAP-targeted peptide chains via hydrogen bonding and π-π bonding to enhance the targeting capability of NPF@DOX. (doaj.org)
6. Palliative radiation therapy completed ≤ 7 days prior to start of study drugs. (astrazenecaclinicaltrials.com)
7. No other anti-cancer therapy (chemotherapy, immunotherapy, hormonal anti-cancer radiotherapy [except for palliative local radiotherapy]), biological therapy or other novel agent is permitted while the patient is receiving study medication. (astrazenecaclinicaltrials.com)
The FDA has granted Fast Track and Breakthrough Therapy designations to avasopasem for the reduction of severe oral mucositis induced by radiotherapy. (galeratx.com)
The Company's second product candidate, rucosopasem manganese (rucosopasem), is in clinical-stage development to augment the anti-cancer efficacy of stereotactic body radiation therapy in patients with non-small cell lung cancer and locally advanced pancreatic cancer. (galeratx.com)
Due to its ability to induce cell cycle arrest, ionizing radiation is used on abnormal growths in the human body such as cancer cells, in radiation therapy. (wikipedia.org)
Most cancer cells are fully treated with some type of radiotherapy, however some cells such as stem cell cancer cells show a reoccurrence when treated by this type of therapy. (wikipedia.org)
In medicine, medical diagnostic methods such as CT scans and radiation therapy expose the individual to ionizing radiation. (wikipedia.org)
Treatment with arginine, one of the amino-acid building blocks of proteins, enhanced the effectiveness of radiation therapy in cancer patients with brain metastases, in a proof-of-concept, randomized clinical trial from investigators at Weill Cornell Medicine and Angel H. Roffo Cancer Institute. (news-medical.net)
The study, published Nov. 5 in Science Advances, reported the results of administering arginine, which can be delivered in oral form, prior to standard radiation therapy in 31 patients who had brain metastases. (news-medical.net)
However, the results, and arginine's apparent mechanism of action, suggest that the amino acid might be useful more broadly as an anticancer therapy. (news-medical.net)
Finally, neoadjuvant therapy consisting of Capecitabine plus radiation therapy, for locally advanced rectal cancer was analysed. (wjgnet.com)
The US Food and Drug Administration (FDA) has granted a third so-called Breakthrough Therapy Designation for the investigational oral. (lymphomainfo.net)
The U.S. Food and Drug Administration has announced that it has granted "Breakthrough Therapy Designation" for the investigational agent. (lymphomainfo.net)
I did not have any other choice, The side effects of radiation therapy were exceptionally difficult (vomiting, oral cavity inflammation, sore throat). (cancerherbal.com)
They also reported that DC therapy in combination free base inhibitor database with an oral fluoropyrimidine, S-1, enhanced sponsor immune reactions and elicited a designated anticancer effect, as compared to DCs only in tumor-bearing mice (14), and that DC vaccine combined with gemcitabine and/or S-1 probably prolonged the survival of individuals with advanced pancreatic malignancy (15). (opioid-receptors.com)
When the tumor comes with an nearly spherical form, 3-dimensional conformal radiotherapy (3DCRT) or stereotactic body radio-therapy (SBRT) can be used rather than tomotherapy, since each one of these rays modalities yield related excellent conformal dose distributions. (opioid-receptors.com)
The aim of the present study was, therefore, to investigate the cytostatic and cytotoxic impact of the new iron chelator deferasirox (DFX) on human GBM cells in well-defined clinical situations represented by radiation therapy and mild-hypoxia. (biomedcentral.com)
Participants should have progressive disease after prior radiation therapy and one prior line of alkylating chemotherapy for their disease. (astrazenecaclinicaltrials.com)
Radiation therapy is one of the most important options for cancer treatment. (emergency.co.jp)
Depending on the type and stage of cancer, initial treatment, preoperative radiation therapy, postoperative radiation therapy, and symptomatic treatment are provided. (emergency.co.jp)
It is more precise than regular x-ray therapy and can deliver higher doses of radiation to cancerous tissue, minimizing damage to surrounding normal tissue. (emergency.co.jp)
Compared to other radiation therapy modalities, heavy particle therapy tends to reduce complications. (emergency.co.jp)
It enhances the effect of radiation therapy and destroys cancer cells more effectively. (emergency.co.jp)
Radiation therapy is used to stimulate the immune system to attack cancer cells. (emergency.co.jp)
Radiation therapy uses high-powered energy beams or particles to target cancer cells and kill them. (mountsinai.org)
Buy Zofran 4 mg online: Zofran 4 mg is a medication used alone or with other drugs to prevent nausea and vomiting caused by cancer drug treatment and radiation therapy. (seagullindia.com)
This study is comparing safety and effectiveness of a new drug called giredestrant compared to standard hormone therapy in people with early-stage, ER-positive breast cancer. (facingourrisk.org)
This study is looking at how well the drug elimusertib (a type of targeted therapy known as an ATR inhibitor) works when combined with chemotherapy for treating people with advanced cancers, including urothelial, ovarian, gastric, endometrial, triple-negative breast cancer and others. (facingourrisk.org)
The FDA has already granted Breakthrough Therapy and Fast Track Designations to avasopasem for the reduction of SOM induced by radiotherapy. (medical-xprt.com)
Radiation therapy is frequently used to treat early stage and inoperable locally advanced prostate cancer. (crowebrothers.com)
The outcome of radiation therapy can be greatly improved if higher doses of radiation are applied, especially for patients with unfavorable tumors (i.e., stage T Tracking them for years. (crowebrothers.com)
2. Prior chemotherapy, immunotherapy (tumour vaccine, cytokine or growth factor given to control the cancer) or other anti-cancer therapy within less than 2 weeks before study drug administration, or any persistent unresolved toxicity from such previous therapy that, according to the judgement of the investigator, may pose a risk for the subject if taking part in the study. (who.int)
3. Prior definitive radiation therapy within less than 4 weeks and prior palliative radiotherapy within less than 2 weeks before study drug administration. (who.int)
Advanced head and neck squamous cell carcinoma (HNSCC) is treated with radiotherapy, chemotherapy, targeted therapy or a combination of these treatments. (researchsquare.com)
Findings were categorized by type of treatment (radiotherapy, chemotherapy, targeted therapy, or combination therapy). (researchsquare.com)
Radiation therapy can be used for HNSCC patients with advanced pathological stage. (biomedcentral.com)
Various anti-DNA-PKcs strategies have been developed and tested in preclinical studies to exploit the benefit of DNA-PKcs inhibition in sensitization of radiotherapy and in combined modality therapy with other antitumor agents. (amegroups.org)
In patients with cancer who have undergone antineoplastic therapy, the development of acute or late oral complications are common. (bvsalud.org)
The aim of the present work was to present the current oral complications of antineoplastic therapy as well as the importance of the dentists' performance in this context. (bvsalud.org)
Drug therapy-Adverse effects. (bvsalud.org)
8. Meraw SJ, Reeve CM. Dental considerations and treatment of the oncology patient receiving radiation therapy. (bvsalud.org)
10. Garg AK, Malo M. Manifestations and treatment of xerostomia and associated oral effects secondary to head and neck radiation therapy. (bvsalud.org)

Itraconazole, a common triazole anti-fungal drug in widespread clinical use, has evidence of clinical activity that is of interest in oncology. (ecancer.org)
Based on these findings we should continue to investigate arginine in combination with radiotherapy but also in combination with chemotherapy or immunotherapy, and even arginine on its own,' said senior author Dr. Leandro Cerchietti, an associate professor of medicine in the Division of Hematology and Medical Oncology, who participated in designing and implementing the trial at Angel H. Roffo Cancer Institute in Argentina where he was an attending oncologist. (news-medical.net)
PI Shen is an early career post-doctoral researcher with particular expertise in DIPG cell culture and xenograft models, cancer cell biology, drug discovery, radiation oncology. (thecurestartsnow.org)
Each drug will affect each patient differently, and anyone receiving Velcade is urged to report any and all Velcade side effects to their oncology team immediately. (lymphomainfo.net)
Advances in Radiation Oncology. (elsevierpure.com)
International Journal of Radiation Oncology Biology Physics. (elsevierpure.com)
Physics and Imaging in Radiation Oncology. (elsevierpure.com)
We use a broad range of standard and state-of-the-art treatment options including surgery, radiation, medical oncology, including molecular targeted therapies, and immunotherapy. (mountsinai.org)
The Company also recently announced that detailed results from the ROMAN trial will be presented in an oral presentation at the upcoming 2022 American Society of Clinical Oncology (ASCO) Annual Meeting on Friday, June 3, 2022. (medical-xprt.com)
Benjamin P.C. Chen, PhD. Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, 2201 Inwood Rd., Rm. (amegroups.org)
Principles and practice of radiation oncology. (bvsalud.org)

and the Company's ability to achieve its goal of transforming radiotherapy in cancer treatment with its selective dismutase mimetics. (galeratx.com)
With submission of this NDA, we achieved an important milestone towards our goal of transforming radiotherapy, potentially bringing patients with HNC the first approved drug for SOM and relief from its tremendous burden," said Mel Sorensen, M.D., President and Chief Executive Officer of Galera Therapeutics. (biogeneratorventures.com)

Additionally, the drug uptake efficiency in vitro, photo-thermal properties, release performance, and anti-tumor effects of NPF@DOX were evaluated and further demonstrated in vivo.Results: Data derived from FT-IR, UV-Vis, and TEM implied successful construction of the NPF@DOX nano-drug delivery system. (doaj.org)
Overloading a high-NO tumor with much more NO prior to radiation treatment could weaken the tumor's ability to repair radiation-induced DNA damage, she added-;and indeed her preclinical experiments in mice confirmed this effect. (news-medical.net)
Capecitabine (Xeloda ® ) is an oral fluoropyrimidine which is produced as a pro-drug of fluorouracil, and shows improved tolerability and intratumor drug concentrations following its tumor-specific conversion to the active drug. (wjgnet.com)
The depth of the radiation source can be adjusted according to the location of the tumor. (emergency.co.jp)
In Privo's Phase I / II safety and efficacy study in patients with squamous cell carcinoma of the oral cavity and lips, PRV111 demonstrated compelling results meeting all primary and secondary endpoints, including the ability to reduce tumor size by over 70% in a single week. (afcr.org)
Then we aim radiation beams at the tumor from several directions. (mountsinai.org)
PAVO is an open-label Phase II study investigating if the study drug, a PARP inhibitor called niraparib (Zejula), is safe and effective for certain people who have been diagnosed with an advanced solid tumor with either an inherited or tumor PALB2 mutation. (facingourrisk.org)
SOM can adversely affect cancer treatment outcomes by causing interruptions in radiotherapy, which may compromise the otherwise good prognosis for tumor control in many of these patients. (medical-xprt.com)
It has been suggested that radiation sensitivity and chemosensitivity of cancer cells may play an important role in the local control of the tumor following these therapies. (researchsquare.com)

However, the efficacy of traditional treatments is hindered by systemic toxicity, limited therapeutic effects, and drug resistance. (doaj.org)
The promising results have prompted the team to start and plan further studies of arginine on its own or in combination with other anticancer treatments. (news-medical.net)
Where chemo- and radiotherapy treatments fail, turmeric was able to keep up its cancer-fighting effects. (radiation.news)
The researchers found detectable levels of curcuminoids in the tumors, which made them jump to the conclusion that oral treatments may alter the tumor's energy metabolism. (radiation.news)
In addition to its standalone treatments, Privo is planning to combine its products with immunotherapy to improve immunotherapy's outcome as 70% to 85% of patients taking immunotherapy drugs fail to respond to the treatment. (afcr.org)
Standard of care surgical/radiation treatments for OC can severely damage a patient's ability to speak, chew, and swallow. (afcr.org)
Zofran (ondansetron) is used to relieve nausea and vomiting commonly associated with cancer treatments like chemotherapy and radiation. (seagullindia.com)
There are no FDA-approved treatments for radiotherapy-induced SOM, which affects over 40,000 patients with head and neck cancer undergoing radiotherapy in the U.S. alone, and we are enthusiastically working to bring this potential treatment to patients as quickly as possible. (medical-xprt.com)
Treatment of HNSCCs includes one of the surgery, radiotherapy or chemotherapy treatments or a combination of these treatments. (researchsquare.com)

We believe in avasopasem's potential to bring meaningful benefit to patients with head and neck cancer suffering from severe oral mucositis. (galeratx.com)
The Company intends to gain an understanding from the FDA of its evaluation of avasopasem for radiotherapy-induced severe oral mucositis (SOM) in patients with head and neck cancer undergoing standard-of-care treatment and next steps to support an NDA resubmission. (galeratx.com)
Avasopasem manganese (avasopasem, or GC4419) is a selective small molecule dismutase mimetic in development for the reduction of radiation-induced severe oral mucositis (SOM) in patients with locally advanced head and neck cancer (HNC) and for the reduction of radiation-induced esophagitis in patients with lung cancer. (medical-xprt.com)

A dendritic cell (DC)-based vaccine was coupled with intensity-modulated radiotherapy (IMRT) or other conformal radiotherapy (RT), assuming minimal immunosuppression by such RT modalities. (opioid-receptors.com)

Galera Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing a pipeline of novel, proprietary therapeutic candidates that have the potential to transform radiotherapy in cancer. (galeratx.com)

Immunocompromised patients are often treated prophylactically with triazole anti-fungal drugs, including ITZ, particularly if there is a risk of aspergillosis . (ecancer.org)
Nearly 78 percent had a complete or partial response in their brain tumors over the follow-up period of up to four years, while only 22 percent of the 32 patients who received a placebo prior to radiotherapy had such a response. (news-medical.net)
In the clinical trial, patients were treated with high-dose arginine or placebo oral suspensions an hour before radiotherapy for their brain metastases-;tumors in the brain that represent the spread from primary tumors elsewhere, such as the lungs. (news-medical.net)
The US Food and Drug Administration today has approved an expanded use of Imbruvica (ibrutinib) in patients with. (lymphomainfo.net)
In truth, chemo- and radiotherapy can boost cancer stem cell production and accelerate a patients' death. (radiation.news)
In Japan, research and development of radiation technology in cancer treatment is active, and medical teams with advanced technology and expertise provide optimal treatment for patients. (emergency.co.jp)
It is particularly suitable for pediatric cancer patients because it minimizes the effects of radiation on the growing tissue. (emergency.co.jp)
The TAPUR Study aims to describe the safety and efficacy of Food and Drug Administration (FDA)-approved, targeted anticancer drugs prescribed for treatment of patients with advanced cancer that has a potentially actionable genomic alteration. (facingourrisk.org)
The Company looks forward to continuing to work with the FDA to bring this potential new treatment to patients with head and neck cancer receiving radiotherapy. (medical-xprt.com)
Approximately 42,000 patients with head and neck cancer undergo standard-of-care radiotherapy every year in the U.S. and are at risk of experiencing SOM. (medical-xprt.com)
In patients with head and neck cancer, radiotherapy is a mainstay of treatment. (medical-xprt.com)
Approximately 70 percent of patients receiving radiotherapy for head and neck cancer develop SOM, defined by the inability to eat solid food or drink liquids. (medical-xprt.com)
There is currently no drug approved to prevent or treat SOM for these patients. (medical-xprt.com)
There are currently no FDA-approved drugs to reduce SOM for these patients. (biogeneratorventures.com)
Approximately 42,000 patients with HNC undergo standard-of-care radiotherapy every year in the U.S. and are at risk of developing SOM. (biogeneratorventures.com)
Dr. Sorensen continued, "Further, the reduction in cisplatin-related chronic kidney disease in patients treated with avasopasem reported in October may offer added clinical benefit to the large number of patients with HNC who receive cisplatin with their radiotherapy. (biogeneratorventures.com)
The Phase 3 ROMAN trial (GTI-4419-301) was a randomized, double-blind, placebo-controlled trial in 455 patients designed to evaluate the ability of avasopasem to reduce radiation-induced SOM in patients with locally advanced HNC, receiving seven weeks of standard-of-care radiotherapy plus cisplatin. (biogeneratorventures.com)
Patients were randomized to one of the two treatment groups (3:2) to receive 90 mg of avasopasem or placebo by infusion on the days they receive their radiation treatment. (biogeneratorventures.com)
Therefore, knowing the genetic variations (polymorphisms) will be effective in predicting the response to treatment, and accordingly, we can determine which patients will benefit from chemo- or radiotherapy (Ansell et al. (researchsquare.com)
Recent studies have shown that simultaneous radiotherapy and chemotherapy can improve patient survival, but it is not tolerated by many patients. (biomedcentral.com)
Prevention of oral complications in cancer patients. (bvsalud.org)
In this article, we describe the mechanisms via which interactions between herbs and prescription drugs may occur, and highlight four popular herbs and a medicinal mushroom commonly used by cancer patients, along with reports of their interactions with standard drugs. (cancernetwork.com)
We highlight four popular herbs and a medicinal mushroom commonly used by cancer patients-turmeric, green tea, ginger, ashwagandha, and reishi mushroom-along with reports of their interactions with standard drugs. (cancernetwork.com)
We conclude by emphasizing the need to inform patients and physicians about herb-drug interactions and how to advise patients on appropriate use of herbal supplements to minimize the risk for interactions. (cancernetwork.com)

It is also worth noting that human toxicity from chronic DCA exposure is influenced by subject age, and oral administration of DCA is far better tolerated in young children than adults. (thecurestartsnow.org)
It was defined as "the effect of herbs, other plants, or plant extracts on the activity, metabolism, or toxicity of drugs. (cancernetwork.com)

They concluded that curcumin could inhibit cancer cell growth and induce cell death in certain subpopulations of glioblastoma tumors, making it an attractive therapeutic agent which should be considered as a potent anticancer treatment, the researcher said. (radiation.news)
The anticancer properties of DFO and deferiprone have been tested particularly for brain tumors. (biomedcentral.com)
Because of its proximity to surrounding vital tissues and organs, it is also effective for the head and neck region, including the oral cavity, nasopharynx, and brain tumors. (emergency.co.jp)
Head and neck squamous cell carcinoma (HNSCC), which includes a group of heterogeneous tumors from the squamous epithelium of the oral cavity, oropharynx, larynx and hypopharynx, is the seventh most common cancer in the world [ 1 ]. (biomedcentral.com)

Despite recent advances in imaging, surgery, radiation, and systemic therapies, overall survival (OS) has improved only 5% in the last decade. (afcr.org)
This service harnesses the power of AI to engineer antibodies with unmatched precision, paving the way for targeted therapies, personalized medicine, and cutting-edge protein drug design. (medical-xprt.com)
7. Squier CA. Oral complications of cancer therapies. (bvsalud.org)

These disturbances in the integrity and function of the buccal cavity are due to the fact that radiotherapy and chemotherapy are incapable of destroying tumoral cells without injuring normal cells. (bvsalud.org)
A growing body of research shows that human papil- cancers of the oral cavity, oropharynx, hypopharynx, lar- lomavirus (HPV) is a common and increasing cause of ynx, sinonasal tract, and nasopharynx. (cdc.gov)
Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)

This disease is traditionally treated through a combination of surgery, radiotherapy, and chemotherapy. (doaj.org)
Treatment of breast cancer depends on type of cancer and the stage and involves chemotherapy , radiation or surgery. (healthresource4u.com)
Glioblastoma is an aggressive, fast-growing form of brain cancer which is usually treated with chemotherapy, surgery, and radiation. (radiation.news)
Currently adjuvant treatment is used after recovery from surgery such as radiation and chemotherapy. (afcr.org)
This includes people undergoing surgery or radiation near the bladder or urinary tract, as well as people with a bladder condition (neurogenic bladder) caused by an injury to the spinal cord . (rxlist.com)
Zofran is an antiemetic prescription drug that is prescribed to prevent nausea and vomiting due to pregnancy, surgery, and cancer medications or procedures. (seagullindia.com)
7. Major surgery within 4 weeks before the first dose of the study drug or minor surgery within 1 week (subject must also have recovered from any surgery-related toxicities to less than CTCAE Grade 2). (who.int)
In the treatment of HNSCC, TNM staging is routinely used as the basis for selecting an appropriate treatment plan including surgery, radiotherapy and/or chemotherapy. (biomedcentral.com)
High-grade glioma (HGG) are optimally treated with maximum safe surgery, followed by radiotherapy (RT) and/or systemic chemotherapy (CT). (surgicalneurologyint.com)

The evidence for these anticancer effects, in vitro , in vivo , and clinical are summarised, and the putative mechanisms of their action outlined. (ecancer.org)
However, Hsp90 interferes with a number of molecules that up-regulate the intracellular level of survivin, raising the question that clinical use of Hsp90 inhibitors may indirectly induce survivin expression and subsequently enhance cancer anti-drug responses. (biomedcentral.com)
Exploratory analyses, such as time to SOM onset and SOM incidence at various landmarks of radiotherapy delivered, further demonstrated the clinical benefit of avasopasem in reducing the burden of SOM. (biogeneratorventures.com)
Exploratory analyses, such as time to SOM onset and SOM incidence at various landmarks of radiotherapy delivered, also demonstrated the clinical benefit of avasopasem in reducing the burden of SOM, along with a reduction in long-term loss of kidney function associated with concurrent cisplatin. (biogeneratorventures.com)
To fully appreciate the clinical impact, both the drug and the herb must be studied together in humans. (cancernetwork.com)

Oral squamous cell carcinoma (OSCC) is a malignant disease with serious impacts on human health and quality of life worldwide. (doaj.org)
Therefore, we aimed to demonstrate the potential anticancer effects of Sangju honey on human oral squamous cell carcinoma (OSCC), particularly focusing on epithelial-mesenchymal transition (EMT) and apoptotic and mitogen-activated protein kinase (MAPK) signaling pathways. (jcpjournal.org)
However, based on recommendations by key opinion leaders and as a proof of concept, the company has conducted several studies in oral squamous cell carcinoma or oral cancer. (afcr.org)
Squamous cell carcinoma is not only the most common oral malignancy in cats, it has one of the poorest outcomes. (vin.com)
While sun exposure is an important risk factor for squamous cell carcinoma on the ears and nose, the owner's cigarette smoking habits turn out to be one of the most important risk factors for the oral squamous cell carcinoma. (vin.com)
The use of flea collars was associated with a five-fold increase in the development of oral squamous cell carcinoma, although the study that found this correlation was not able to differentiate between different types of flea collars. (vin.com)
Regular feeding of canned food, especially tuna fish, was associated with increased risk for the development of oral squamous cell carcinoma. (vin.com)
In humans, poor oral hygiene has been associated with an increased risk for oral squamous cell carcinoma, so it is speculated to be the basis of the canned food correlation in cats as well. (vin.com)

Advances in medical imaging have resulted in increased exposure of humans to low doses of ionizing radiation. (wikipedia.org)

Rucosopasem was granted Orphan Drug Designation by the FDA for the treatment of pancreatic cancer. (galeratx.com)
Additionally, based on the properties summarised previously, it is proposed that itraconazole may synergise with a range of other drugs to enhance the anti-cancer effect, and some of these possible combinations are presented in the supplementary materials accompanying this paper. (ecancer.org)
Moreover the efficacy of Capecitabine on metastatic colorectal cancer, either alone or in various combinations with other active drugs such as Irinotecan and Oxaliplatin was also assessed. (wjgnet.com)
Velcade is the brand name of an anti-cancer drug called bortezomib . (lymphomainfo.net)
My skin that was darkened by the radiation regained its original complexion, and further examinations showed that all cancer cells had disappeared. (cancerherbal.com)
At the functional level, down-regulation of survivin by siRNA further increased the drug sensitivity to 17-AAG in the tested cancer cell lines. (biomedcentral.com)
Instead, targeting Hsp90 with small molecule inhibitors will induce the over-expression of survivin in certain cancer cell lines and subsequently enhances the ability of cell survival in drug-treated situations. (biomedcentral.com)
For example, over-expression of survivin has been shown to induce drug resistance against anti-mitotic compounds by stabilizing microtubule network in vincristine/colchicine-resistant oral cancer cells and down-regulation of it restores drug sensitivity to those compounds in the same cell line [ 9 ]. (biomedcentral.com)
Interestingly, a recent report suggests that over-expression of survivin may also enhance DNA double-strand breaks (DBD) repair capability in radiation-treated oral cancer cells by up-regulating the molecular sensor of DNA damage, Ku70 [ 11 ]. (biomedcentral.com)
Though the study had its limitations and further research will be needed to address bioavailability issues in humans and find the ideal dose, another study , published in the journal Nutrition and Cancer , discovered that it is possible to get a bioactive dose of curcumin into human glioblastoma cancer cells via oral delivery methods. (radiation.news)
Depending on the type of cancer, the radiation source is temporarily or permanently implanted in the body. (emergency.co.jp)
It is more precise than regular X-ray irradiation and delivers a higher dose of radiation to cancer tissue. (emergency.co.jp)
This is a special cancer treatment in which a boron drug is administered to the cancer patient, followed by neutron irradiation of the cancer tissue. (emergency.co.jp)
A combination of radiotherapy and anticancer drugs is used to increase the sensitivity of cancer cells. (emergency.co.jp)
Cancer AND drug name. (clinicaltrialsregister.eu)
Oral cancer (OC) is an underserved disease which is often overlooked by the medical community, yet it is the 6th most common and deadliest cancer in the world and claims the life of 1 American every hour. (afcr.org)
According to the Oral Cancer Foundation, approximately 50,000 Americans were diagnosed with oral and oropharyngeal cancer in 2020, resulting in 9,700 deaths and is increasing among all population segments due to the rising prevalence of oral human papillomavirus (HPV). (afcr.org)
Although radiotherapy to treat prostate cancer can be highly effective, damage to nearby healthy tissues is common. (crowebrothers.com)
Colorectal Cancer Prostate Cancer Oral Cancer. (crowebrothers.com)
A compound derived from feverfew daisies can boost radiotherapy for the treatment of prostate cancer. (crowebrothers.com)
Research published in the Journal of Medicinal Food demonstrated the anticancer effects of feverfew extracts on two human breast cancer cell lines (Hs605T and MCF-7) and one human cervical cancer cell line (SiHa). (crowebrothers.com)

Some cases have been associated with resistance to radiotherapy or chemotherapy and local recurrence. (researchsquare.com)

Our team of pulmonologists, thoracic surgeons, medical oncologists, and radiation oncologists works together to give you the best possible care. (mountsinai.org)

Galera's selective dismutase mimetic product candidate avasopasem manganese (avasopasem) is being developed for radiation-induced toxicities. (galeratx.com)
Galera's selective dismutase mimetic product candidate avasopasem manganese (GC4419, also referred to as avasopasem) is being evaluated for radiotherapy-induced toxicities. (medical-xprt.com)

Here we tested whether roscovitine, an inhibitor of cyclin-dependent kinases (CDKs), which hereby also blocks homologous recombination (HR), can be used to enhance the radiation sensitivity of HNSCC cell lines. (oncotarget.com)

8. Immunosuppressive doses of systemic medications, such as steroids or absorbed topical steroids (doses >10 mg/day prednisone or equivalent) within 2 weeks before study drug administration. (who.int)

More importantly, our data demonstrated that the anti-tumour effect of DCA can be further enhanced by the addition of other clinically available drugs, thereby maximising the cell-killing effect of RT. (thecurestartsnow.org)

Very few herbs and drugs have been studied in this way, however, and much of the current knowledge rests on data from in vitro, animal, and in silico models. (cancernetwork.com)

The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is the key component of the non-homologous end-joining (NHEJ) pathway for DNA double-strand break (DSB) repair and is required for cellular resistance to ionizing radiation (IR) ( 1 , 2 ). (amegroups.org)

Thus, it is a potential anticancer agent for human OSCC. (jcpjournal.org)

Ionizing radiation can cause biological effects which are passed on to offspring through the epigenome. (wikipedia.org)

The trial was designed to gauge the effectiveness of arginine as a 'radiosensitizer' that enhances the effects of radiation treatment. (news-medical.net)
To improve the therapeutic effectiveness, therefore, combination with radiotherapy (RT) and chemotherapy is currently under consideration. (opioid-receptors.com)

All of these exist as low frequency radiation which can come from wireless cellular devices or through electrical appliances which induce extremely low frequency radiation (ELF). (wikipedia.org)

We often use combinations of two or more drugs. (mountsinai.org)

In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repair genes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)

This treatment delivers a high dose of radiation to cancerous tissue with minimal damage to surrounding normal tissue. (emergency.co.jp)

Prevention and treatment of the consequences of head and neck radiotherapy. (bvsalud.org)

Based on the agreement with the U.S. Food and Drug Administration (FDA) on Special Protocol Assessments for two phase 3 studies with ceftobiprole - one in Staphylococcus aureus bacteremia (SAB) and one in acute bacterial skin and skin structure infections (ABSSSI) - Basilea is in preparation to initiate these studies. (basilea.com)
Pharmacyclics has announced that the company has submitted a New Drug Application (NDA) to the US Food and Drug Administration (FDA) for. (lymphomainfo.net)
These informations and statements have not been evaluated by the Food and Drug Administration (FDA). (cancerherbal.com)
free base inhibitor database Thus far, the DC-based vaccine has had some success, as sipuleucel-T (Dendreon Co., Seattle, WA, USA) was authorized as the 1st anticancer vaccine by the US Food and Drug Administration in 2010 2010 (5). (opioid-receptors.com)
These products, however, are not regulated as drugs by the US Food and Drug Administration (FDA). (cancernetwork.com)

Proton beams can reach depths where radiation has the greatest effect when focused on cancerous tissue. (emergency.co.jp)

The National Council on Radiation Protection and Measurements along with many other scientific committees have ruled in favor of continued use of medical imaging as the reward far outweighs the minimal risk obtained from these imaging techniques. (wikipedia.org)

As radiotherapy is the main treatment for GBM, the combination of DFX and X-ray beam irradiation was also investigated. (biomedcentral.com)
Treatment generally consists of surgical resection when possible, followed by a combination of external beam radiotherapy with concomitant administration of the orally active alkylating agent temozolomide (TMZ). (biomedcentral.com)

The effects of radiation on cells has been found to be dependent on the dosage of the radiation, the location of the cell in regards to tissue, and whether the cell is a somatic or germ line cell. (wikipedia.org)
The ionizing radiation from these techniques can cause many other detrimental effects in cells including changes in gene expression and halting the cell cycle. (wikipedia.org)
The extent of how radiation effects cells depends on the type of cell and the dosage of the radiation. (wikipedia.org)
Radiotherapy-Adverse effects. (bvsalud.org)

The results of this study showed evidence of an association between high cariogenic risk and great severity of oral disease in the studied group of young women and low calcium intake. (medscape.com)
6. Female subjects who are sexually active and able to bear children must agree to use highly effective methods of contraception during the study and for 2 days after the last dose of study drug. (nih.gov)
One study is focused on tongue cancers and the other on high-risk oral dysplasia. (afcr.org)
Radiopharmaceuticals (strontium, samarium) within less than 8 weeks before study drug administration. (who.int)

In line with this, for HPV negative but not for HPV positive cell lines, treatment with roscovitine resulted in a pronounced enhancement of the radiation-induced G2 arrest as well as a significant increase in radiosensitivity. (oncotarget.com)

Okamoto (12,13) reported that a relatively low dose of 5-FU led to the enhancement of anticancer immunity mediated from the induction of helper T-cell type-1 cytokines (such as interferon- and interleukin-12) and natural-killer cell activity in individuals with oral malignancy. (opioid-receptors.com)

Examples include High grade oral and cervical dysplasias. (afcr.org)

Oral sequelae of head and neck radiotherapy. (bvsalud.org)

Anatomy8

Organisms2

Diseases53

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment83

Phenomena and Processes35

Disciplines and Occupations9

Technology, Industry, Agriculture4

Information Science5

Health Care28

Chemotherapy and radiotherapy2

Therapy44

Oncology11

Goal of transforming2

Tumor9

Treatments9

Mucositis3

Conformal1

Therapeutics1

Patients24

Toxicity2

Tumors4

Therapies3

Cavity3

Surgery9

Clinical5

Squamous8

Doses of ionizing1

Cancer21

Recurrence1

Thoracic1

Avasopasem2

Sensitivity1

Systemic1

Clinically1

Vitro1

Resistance1

OSCC1

Biological1

Effectiveness2

Induce1

Combinations1

Antioxidant1

High-dose1

Prevention1

Food and Drug Admin5

Beams1

Minimal1

Combination2

Effects4

Study4

Arrest1

Enhancement1

Cervical1

Head1