Oral midazolam. Medical search. Frequent questions

Intravenous sedation was required in two (6%) of the children in the midazolam+ketamine group, and in eight (27%) in the midazolam alone group. (druglib.com)
The combination of oral midazolam and ketamine led to deeper sedation than midazolam alone, with less children requiring intravenous sedation. (druglib.com)
Midazolam is effective for status epilepticus or when intravenous access cannot be obtained, and has advantages of being water-soluble, having a rapid onset of action and not causing metabolic acidosis from the propylene glycol vehicle (which is not required due to its solubility in water), which occurs with other benzodiazepines. (wikipedia.org)
Intravenous midazolam is indicated for procedural sedation (often in combination with an opioid, such as fentanyl), preoperative sedation, for the induction of general anesthesia, and for sedation of people who are ventilated in critical care units. (wikipedia.org)
On day 8, intravenous and oral doses of midazolam were administered 2 hours after the final clarithromycin dose. (nih.gov)
0.05) difference in the urinary excretion of 1'-hydroxymidazolam after intravenous and oral dosing on day 1 or day 8, indicating that the oral dose was completely absorbed into the gut wall. (nih.gov)
Intravenous midazolam has been associated with respiratory depression and respiratory arrest, especially when used for sedation in noncritical care settings. (nih.gov)
Intravenous midazolam should be used only in hospital or ambulatory care settings, including physicians' and dental offices, that provide for continuous monitoring of respiratory and cardiac function, e.g, pulse oximetry. (nih.gov)
Midazolam hydrochloride injection is a water-soluble benzodiazepine available as a sterile, nonpyrogenic parenteral dosage form for intravenous or intramuscular injection. (nih.gov)
IV sedation - Intravenous injection of drugs like midazolam induces a deeper sedation while monitoring vital signs. (cdhp.org)

The findings indicate that rapidly acting oral benzodiazepines such as midazolam provide safe, effect alternatives to i.v. diazepam for conscious sedation in outpatients undergoing minor surgical procedures. (ox.ac.uk)
Long-term use for the management of epilepsy is not recommended due to the significant risk of tolerance (which renders midazolam and other benzodiazepines ineffective) and the significant side effect of sedation. (wikipedia.org)
Medical References on Benzodiazepines, side-effects and risks A Aarskog D. Association between Maternal Intake of Diazepam and Oral Clefts. (benzo.org.uk)

Buccal and intranasal midazolam may be both easier to administer and more effective than rectally administered diazepam in the emergency control of seizures. (wikipedia.org)
Objectives Based on the 2010 Israeli Medical Association recommendations, young children with suspected urinary tract infection (UTI) are mildly sedated with oral or intranasal midazolam to reduce the distress associated with urethral catheterisation (UC). (bmj.com)
Conclusions In this cohort of febrile infants, sedation with oral or intranasal midazolam reduced the risk of culture contamination during UC without causing serious adverse events. (bmj.com)

Ratings by the surgeon indicated superior anxiolysis following midazolam and significantly more patients expressed a preference for oral midazolam sedation. (ox.ac.uk)
While similar probabilities of obtaining anxiolysis were found, adequate sedation, calm behavior during child's separation from parents, low levels of fear during face mask adaptation, and cooperative behavior during peripheral venous cannulation were more likely with midazolam-ketamine combinations. (bjan-sba.org)
The initial pediatric dose of midazolam for sedation/anxiolysis/amnesia is age, procedure, and route dependent (see DOSAGE AND ADMINISTRATION for complete dosing information). (nih.gov)

Midazolam is a benzodiazepine. (mayoclinic.org)
Midazolam, sold under the brand name Versed among others, is a benzodiazepine medication used for anesthesia and procedural sedation, and to treat severe agitation. (wikipedia.org)
midazolam should not be used for longer than 72 hours due to risks of tachyphylaxis, and the possibility of development of a benzodiazepine withdrawal syndrome, as well as neurological complications. (wikipedia.org)
Chemically, midazolam HCl is 8-chloro-6(2-fluorophenyl)-1-methyl-4 H -imidazo[1,5-a][1,4]benzodiazepine hydrochoride. (nih.gov)
Midazolam is a short-acting benzodiazepine central nervous system (CNS) depressant. (nih.gov)
Midazolam is a short-acting benzodiazepine central nervous system depressant available as an injection, tablet, or oral syrup. (ijpc.com)

The aim of study was to evaluate the efficacy of dexmedetomidine and fentanyl-midazolam combination on awake fiberoptic intubation in oral cancer surgery. (anesthesiologyjournal.in)
Group-FM (30 pt): Received an infusion of fentanyl 2 µg /kg and midazolam 0.02mg/kg IV in 10ml of normal saline. (anesthesiologyjournal.in)
Dexmedetomidine is more effective than fentanyl-midazolam during AFOI, as it provides better intubation condition, hemodynamics stability and sedation. (anesthesiologyjournal.in)
This study assessed the effects of sedation using a combination of fentanyl, midazolam and medetomidine in comparison to ketamine. (biomedcentral.com)
This study compared the effects of a combination of fentanyl-midazolam-medetomidine (FMM), followed by reversal with naloxone and atipamezole, with ketamine (KET) in rhesus macaques. (biomedcentral.com)
midazolam 2mg before subarachnoid block with hyperbaric Bupivacaine 0.5% 2.5-3ml and fentanyl 15mcg in the operation theatre (OT). (who.int)

Midazolam can be given by mouth, intravenously, by injection into a muscle, by spraying into the nose, or through the cheek. (wikipedia.org)
weight range, 45 to 100 kg) received simultaneous doses of midazolam intravenously (0.05 mg/kg over 30 minutes) and orally (4 mg of a stable isotope, 15N3-midazolam). (nih.gov)

Midazolam is superior to diazepam in impairing memory of endoscopy procedures, but propofol has a quicker recovery time and a better memory-impairing effect. (wikipedia.org)
However, for long-term sedation, lorazepam is preferred due to its long duration of action, and propofol has advantages over midazolam when used in the ICU for sedation, such as shorter weaning time and earlier tracheal extubation. (wikipedia.org)
Oral midazolam for children and patient-controlled propofol show very promising results. (lww.com)

Rapid onset of sedation was seen after midazolam, while the pattern and duration of postoperative sedation, as measured by standard psychometric tests, indicated slower recovery after midazolam than after diazepam. (ox.ac.uk)
Effect of oral low dose clonidine premedication on postoperative pain in patients undergoing abdominal hysterectomy: a randomized placebo controlled clinical trial. (druglib.com)
Objective: This study aimed to determine the effect of oral midazolam inpreventing postoperative EA in children. (bvsalud.org)

Objectives: The objective of this study was to explore potential drug-drug/food interactions of ciprofloxacin and grapefruit juice, known hepatic cytochrome P450 (CYP) 1A2 inhibitors, on single-dose oral pharmacokinetics of riluzole, a substrate of CYP 1A2 enzymes. (researchgate.net)

Objective: We aimed to examine if changes in oxygen saturation and pulse rate of pediatric patients during conscious sedation with midazolam and nitrous oxide are associated with child's behavior, midazolam dose, the type and duration of the treatment and demographic parameters. (tau.ac.il)
Study Design: This study was a retrospective chart review of consecutive pediatric patients, aged 2.5-12.5 years, who had undergone conscious sedation for dental treatment with oral midazolam (with or without nitrous oxide) between January 2011 and September 2015 at the Department of Pediatric Dentistry of Tel Aviv University. (tau.ac.il)
Conclusions: Poor behavior of pediatric patients does not affect oxygen saturation, but it increases the pulse rate of children under sedation with midazolam and nitrous oxide. (tau.ac.il)
A systematic literature search was conducted using Medline, Cochrane, EMBASE, CENTRAL, and Web of Science for randomized controlled trials comparing oral combinations of midazolam and ketamine with midazolam alone as preanesthetic medication in elective surgical pediatric patients. (bjan-sba.org)
Comparative evaluation of midazolam and butorphanol as oral premedication in pediatric patients. (nih.gov)
In pediatric patients, up to 85% had no recall of pictures shown after receiving intramuscular midazolam compared with 5% of the placebo controls. (nih.gov)

A double-blind, randomised, placebo-controlled trial of oral midazolam plus oral ketamine for sedation of children during laceration repair. (druglib.com)
OBJECTIVES: To compare the efficacy of oral midazolam alone with a combination of oral midazolam and ketamine in children requiring laceration repair. (druglib.com)
INTERVENTIONS: Using a computer-generated sequence, children were randomly assigned in blocks of four to one of two groups: oral midazolam (0.5 mg/kg) plus oral placebo and oral midazolam (0.5 mg/kg) plus oral ketamine (5 mg/kg). (druglib.com)
29 were assigned for treatment with midazolam and 31 for the combination of midazolam and ketamine. (druglib.com)
VAS assessment by a parent was 4.5±3.3 mm in the midazolam+ketamine group versus 4.4±2.7 mm in the midazolam alone group (mean difference 0.1, CI -1.9 to 1.71). (druglib.com)
Sedation Score during procedure was lower in the midazolam+ketamine group (mean difference 1.14, 95% CI 0.67 to 1.6). (druglib.com)
CONCLUSIONS: No difference was found in pain assessment during local anaesthetic injection between the group treated with midazolam and ketamine, and the group treated with midazolam alone. (druglib.com)
This study compared the effects of oral combinations of midazolam and ketamine with oral midazolam alone for pediatric preanesthetic medication. (bjan-sba.org)

For women not receiving oral contraceptives (n = 6) a significant gender-related difference was observed for systemic and oral clearance and for area under the curve and elimination half-life after oral administration. (nih.gov)
0.05) reduction in the systemic clearance of midazolam from 28 +/- 9 L/hr to 10 +/- 3 L/hr occurred after clarithromycin administration. (nih.gov)
Conclusions: Co-administration of ciprofloxacin with riluzole increases the systemic levels of riluzole and thereby the oral pharmacokinetic properties of riluzole while co-administration of grapefruit juice with riluzole has no significant effect. (researchgate.net)
Systemic exposure (area under the plasma concentration-time curve) to single-dose apalutamide increased 68% with gemfibrozil but was relatively unchanged with itraconazole (study A). Apalutamide reduced systemic exposure to midazolam ↓92%, omeprazole ↓85%, S-warfarin ↓46%, fexofenadine ↓30%, rosuvastatin ↓41%, and pioglitazone ↓18% (study B). After a single dose, apalutamide is predominantly metabolized by CYP2C8, and less by CYP3A4. (springer.com)
d9-Caffeine exhibited a prolonged systemic and brain exposure time in rats as compared to caffeine following oral administration. (bvsalud.org)

In a randomized double-blind, parallel groups study, 40 patients undergoing surgical removal of impacted 3rd molar teeth received either midazolam 15 mg orally followed at 35 min by i.v. saline, or oral placebo followed at 35 min by i.v. diazepam 10 mg (Diazemuls). (ox.ac.uk)
Measurements of IOP were performed before, and 15 and 30 min after sedation with orally administered midazolam (1 mg/kg) given as preoperative medication, and 5 and 15 min after induction of general anaesthesia. (uni-regensburg.de)

Oral midazolam was administered according to the patients'weight, either at 0.4 mg/kg, 0.5 mg/kg or at a maximum dose of 10 mg. (tau.ac.il)
If the child is receiving an oral suspension of clarithromycin, use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons. (medbroadcast.com)
The effects of midazolam on the CNS are dependent on the dose administered, the route of administration, and the presence or absence of other medications. (nih.gov)
This study is a single-center, open-label, 3-group, fixed-sequence drug-drug interaction study to assess the effect of coadministration of multiple-dose itraconazole or diltiazem on the single-dose PK of AZD3293 and the effects of coadministration of single- and multiple-dose AZD3293 on the single-dose PK of midazolam. (astrazenecaclinicaltrials.com)
On Day 8, a single dose of AZD3293 will be coadministered as an oral solution after the morning dose of itraconazole. (astrazenecaclinicaltrials.com)
The children were randomly assigned to receive either a syrup of paracetamol 10 mg/kg with injectable midazolam 0.5 mg/kg added to the syrup (Group A) or a placebo in the form of paracetamol syrup (Group B) at a dose of 10 mg/kg 30 min before induction of anesthesia. (bvsalud.org)
Group P will receive oral capsule pregabalin 75 mg Q12hrly from the 1st dose for next 60 hrs. (who.int)

In the final stages of end-of-life care, midazolam is routinely used at low doses via subcutaneous injection to help with agitation, restlessness or anxiety in the last hours or days of life. (wikipedia.org)
At higher doses during the last weeks of life, midazolam is considered a first line agent in palliative continuous deep sedation therapy when it is necessary to alleviate intolerable suffering not responsive to other treatments, but the need for this is rare. (wikipedia.org)
Sedative Doses of Midazolam Depress Hypoxic Ventilatory Responses in Humans. (benzo.org.uk)

In study B, 23 patients with castration-resistant prostate cancer received probes for CYP3A4 (midazolam), CYP2C9 (warfarin), CYP2C19 (omeprazole), and CYP2C8 (pioglitazone), and transporter substrates for P-glycoprotein (P-gp) (fexofenadine) and breast cancer resistance protein (BCRP)/organic anion transporting polypeptide (OATP) 1B1 (rosuvastatin) at baseline and after repeat once-daily administration of apalutamide 240 mg to steady state. (springer.com)

Midazolam is used to produce sleepiness or drowsiness and to relieve anxiety before surgery or certain procedures. (mayoclinic.org)
Sedation using midazolam can be used to relieve anxiety and manage behaviour in children undergoing dental treatment. (wikipedia.org)
The results showed that both sedation methods used produced beneficial effects and were safe in reducing pre-operatory anxiety, showing no significant cardiovascular or respiratory effects, and midazolam 7.5 mg P.O. was more effective in reducing the salivary cortisol. (bvsalud.org)
Oral sedatives - Anti-anxiety pills and medications like Halcion taken before the procedure. (cdhp.org)

Oral midazolam availability was significantly increased from 0.31 +/- 0.1 to 0.75 +/- 0.2 after clarithromycin dosing. (nih.gov)
These data indicate that in addition to the liver, the intestine is a major site of the interaction between oral midazolam and clarithromycin. (nih.gov)

Midazolam is available as a generic medication. (wikipedia.org)

Midazolam is also given to produce amnesia (loss of memory) so that the patient will not remember any discomfort or undesirable effects that may occur after a surgery or procedure. (mayoclinic.org)

Midazolam is also sometimes used in newborns who are receiving mechanical ventilation, although morphine is preferred, owing to its better safety profile for this indication. (wikipedia.org)
Rescue Analgesia will be provided with oral oxycodone 5mg TDS and Morphine S/C 4-5mg, in escalating manner as per patient requirement. (who.int)

At oral argument, Justice Samuel Alito accused defense attorneys of mounting a "guerilla war against the death penalty" by blocking state efforts to get execution drugs. (themarshallproject.org)
A home care kit includes (VHA pan flu plan, Appendix D-4) thermometers, nonsteroidal antiinflammatory drugs or acetaminophen, cough suppressants, oral rehydration mix packs, a medical mask, printed home instructions about caring for someone with influenza, a list of contact information, and a list of signs or symptoms that should prompt a call or visit to a healthcare center. (cdc.gov)

A benefit of midazolam is that in children it can be given in the cheek or in the nose for acute seizures, including status epilepticus. (wikipedia.org)
We are pleased to announce that OPS has been appointed as one of the select distributors of the newly licensed Epistatus (Midazolam) Oromucosal Solutions, from Veriton Pharma Ltd. Epistatus is indicated for the treatment of prolonged and acute convulsive seizures in infants, toddlers and children aged from 3 months to 18 years. (oxfordpharmacystore.co.uk)
Therefore, we investigated the effects of oral midazolam on IOP in children. (uni-regensburg.de)
In all of the cooperative children, IOP measurement was possible after sedation with midazolam. (uni-regensburg.de)
Sedation with midazolam can be assumed to be an applicable, well-tolerated, safe method for IOP measurements in children. (uni-regensburg.de)
One of the most successful textbooks in pediatric dentistry, this expert resource provides superior, comprehensive coverage of oral care for infants, children, teenagers, and medically compromised individuals. (google.nl)
Prophylactic midazolam and clonidine for emergence from agitation in children after emergence from sevoflurane anesthesia: a meta-analysis. (druglib.com)

Group P will receive oral capsule pregabalin 75mg one hour preoperatively and Group C will not receive any premedication preoperatively. (who.int)

Midazolam should not be administered by rapid injection in the neonatal population. (nih.gov)

Although, in clinical practice, IV administration of CIP is not recommended for routine use in the management of CRS, this route was herein chosen because oral bioavailability of CIP is only around 20% in rats (Hwang et al. (researchgate.net)

Blood and urine samples were assayed for midazolam, 15N3-midazolam, and metabolites by gas chromatography-mass spectrometry. (nih.gov)
Diclofenac is 100% absorbed after oral administration compared to IV administration as measured by urine recovery. (nih.gov)

Each enteric-coated tablet for oral administration contains 75 mg of diclofenac sodium. (nih.gov)
Mean IOP was 11.2±0.3 mmHg before sedation, 10.9±0.2 mmHg at 15 min, and 10.7±0.3 mmHg 30 min after administration of midazolam. (uni-regensburg.de)
Clonidine hydrochloride extended-release tablets are a centrally acting alpha 2 -adrenergic agonist available as a 0.1 mg extended-release tablet for oral administration. (druglib.com)
DIFICID (fidaxomicin) is a macrolide antibacterial drug for oral administration. (rxlist.com)

Realizou-se estudo split-mouth, no qual vinte e oito pacientes do gênero masculino foram submetidos à extração de terceiros molares inferiores sob anestesia local e sedação com midazolam e óxido nitroso associado ao oxigênio. (bvsalud.org)
Este estudo comparou os efeitos de combinações orais de midazolam e cetamina com midazolam oral sozinho para medicação pré-anestésica pediátrica. (bjan-sba.org)

Awake fiberoptic intubation (AFOI) is the principal techniques in the management of difficult airway in oral cancer surgery. (anesthesiologyjournal.in)

Embora tenham sido encontradas probabilidades semelhantes de obter ansiólise, sedação adequada, comportamento calmo durante a separação da criança dos pais, baixos níveis de medo durante a adaptação da máscara facial e comportamento cooperativo durante a canulação venosa periférica foram mais prováveis com combinações de midazolam-cetamina. (bjan-sba.org)

Midazolam is sometimes used in neonatal intensive care units. (wikipedia.org)

Midazolam, in combination with an antipsychotic drug, is indicated for the acute management of schizophrenia when it is associated with aggressive or out-of-control behaviour. (wikipedia.org)

Compared with controls, cases had lower odds of UCC (OR=0.39, 95% CI 0.21 to 0.73).Serious adverse events related to midazolam were not recorded. (bmj.com)

It was carried out a split-mouth study, in which twenty- eight male patients underwent lower third molar extraction under local anesthesia and sedation with midazolam and nitrous oxide associated with oxygen. (bvsalud.org)

60 patients of age group 18-60 years with American Society of Anaesthesiologist I and II posted for oral cancer surgery under general anaesthesia were randomly divided into two groups of 30 each in this prospective randomised and comparative study. (anesthesiologyjournal.in)
Results Two cohorts of patients who underwent UC were compared, 164 female infants who were sedated with midazolam (case subjects) and 173 who were not (controls). (bmj.com)
One hundred and forty-one patients were treated with oral midazolam and 23 received the drug intranasally. (bmj.com)
L'objectif de ce travail était d'évaluer la prise en charge de ces patients dans le service d'anesthésie et de réanimation. (bvsalud.org)

Likewise, intestinal and oral availability were significantly increased from 0.42 +/- 0.2 to 0.83 +/- 0.2 and from 0.74 +/- 0.1 to 0.90 +/- 0.04, respectively. (nih.gov)

Midazolam must never be used without individualization of dosage. (nih.gov)

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology4

Phenomena and Processes1

Health Care4

Intravenous10

Benzodiazepines3

Intranasal midazolam3

Anxiolysis3

Benzodiazepine6

Fentanyl6

Intravenously2

Propofol3

Postoperative3

Pharmacokinetics1

Pediatric patients6

Ketamine8

Systemic5

Orally2

Dose7

Doses3

CYP3A41

Anxiety4

Clarithromycin2

Medication1

Procedure1

Morphine2

Drugs2

Children7

Premedication1

Injection1

Route1

Urine2

Administration4

Estudo2

Awake1

Foram1

Neonatal1

Combination1

Adverse1

Anesthesia1

Patients4

Significantly1

Dosage1