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  • reduced glucocorticoid dose
  • Despite receiving a reduced glucocorticoid dose, patients in the mepolizumab group, as compared with those in the placebo group, had a relative reduction of 32% in the annualized rate of exacerbations (1.44 vs. 2.12, P=0.04) and a reduction of 0.52 points with respect to asthma symptoms (P=0.004), as measured on the Asthma Control Questionnaire 5 (in which the minimal clinically important difference is 0.5 points). (nih.gov)
  • concomitant
  • Early onset in life Acute or sudden onset Concomitant sharp pain or cholinergic urticaria over the entire body Absence of other autonomic dysfunction Elevated serum IgE levels Marked response to glucocorticoids Preserved apocrine sweating (adrenergic innervation) The overwhelming majority of reported AIGA patients are Japanese, but whether AIGA is truly rare in whites or has been simply underreported by Western physicians remains unclear. (wikipedia.org)
  • bisphosphonate
  • The first three cases of bisphosphonate-associated osteonecrosis of the jaw were spontaneously reported to the FDA by an oral surgeon in 2002, with the toxicity being described as a potentially late toxicity of chemotherapy. (wikipedia.org)
  • In 2003 and 2004, three oral surgeons independently reported to the FDA information on 104 cancer patients with bisphosphonate-associated osteonecrosis of the jaw seen in their referral practices in California, Florida, and New York. (wikipedia.org)
  • In terms of severity most cases of ONJ in oral bisphosphonate users are stage 1-2 and tend to progress to resolution with conservative measures such as oral chlorhexidine rinses. (wikipedia.org)
  • Humans
  • In 2013 the European Medicines Agency's Committee on Medicinal Products for Human Use (CHMP) recommended that a ban be imposed on the use of oral ketoconazole for systemic use in humans throughout the European Union, after concluding that the risk of serious liver injury from systemic ketoconazole outweighs its benefits. (wikipedia.org)
  • contraceptive
  • In females, the most common use of MPA is as an oral or depot-injected contraceptive and also as the progestin component of menopausal hormone therapy to prevent endometrial hyperplasia and cancer. (wikipedia.org)
  • Acanthosis nigricans has been linked to the use of nicotinic acid, glucocorticoid use, combined oral contraceptive pills, and growth hormone therapy. (wikipedia.org)
  • The estrogen dosage in third-generation contraceptive pills (including those containing gestodene) is lower than that in second-generation oral contraceptives, reducing the likelihood of weight gain, breast tenderness, and migraine. (wikipedia.org)
  • Women who take oral contraceptives containing gestodene are 5.6 times as likely to develop venous thromboembolism than women who do not take any contraceptive pill, and 1.6 times as likely to develop venous thromboembolism compared to women taking oral contraceptives containing levonorgestrel. (wikipedia.org)
  • glucose
  • The name glucocorticoid (glucose + cortex + steroid) is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure (see structure to the right). (wikipedia.org)
  • The name "glucocorticoid" derives from early observations that these hormones were involved in glucose metabolism. (wikipedia.org)
  • Third-generation oral contraceptives are also suitable for use in patients with diabetes or lipid disorders because they have minimal impact on blood glucose levels and the lipid profile. (wikipedia.org)
  • nucleus
  • The activated GR can then regulate gene expression via one of two pathways: Transactivation The first (direct) pathway is called transactivation whereby the activated GR dimerizes, is translocated into the nucleus and binds to specific sequences of DNA called glucocorticoid response elements (GREs). (wikipedia.org)
  • patients
  • In a randomized, double-blind trial involving 135 patients with severe eosinophilic asthma, we compared the glucocorticoid-sparing effect of mepolizumab (at a dose of 100 mg) with that of placebo administered subcutaneously every 4 weeks for 20 weeks. (nih.gov)
  • The cost-effectiveness of bone protection in patients using oral glucocorticoids. (ox.ac.uk)
  • Many patients receive an NSAID and at least one DMARD, sometimes with low-dose oral glucocorticoids. (wikipedia.org)
  • Oral dosing for patients with subclinical hypothyroidism is 1 µg/kg/day. (wikipedia.org)
  • effects
  • However, the regular use of systemic glucocorticoids can result in serious and often irreversible adverse effects. (nih.gov)
  • Glucocorticoids are distinguished from mineralocorticoids and sex steroids by their specific receptors, target cells, and effects. (wikipedia.org)
  • Glucocorticoid effects may be broadly classified into two major categories: immunological and metabolic. (wikipedia.org)
  • Excessive glucocorticoid levels resulting from administration as a drug or hyperadrenocorticism have effects on many systems. (wikipedia.org)
  • Glucocorticoids have multiple effects on fetal development. (wikipedia.org)
  • In vivo evidence on whether particular SEGRAMs can elicit similar effects than classic glucocorticoid in cancer pathologies is currently lacking. (wikipedia.org)
  • Current preclinical tests show that the SEGRAMs available so far would elicit fewer side effect or at least less grave side effects than classic glucocorticoids would. (wikipedia.org)
  • However, the ratio of progestogenic to androgenic effects of gestodene is distinctly higher than that of levonorgestrel, and the increase in sex hormone-binding globulin (SHBG) levels (a marker of androgenicity) produced by oral contraceptives containing gestodene is slightly less than that produced by oral contraceptives containing desogestrel (which is known to be one of the more weakly androgenic 19-nortestosterone derivatives). (wikipedia.org)
  • bioavailability
  • Fluoxymesterone has approximately 80% oral bioavailability, unlike testosterone, as the C17α methyl group of fluoxymesterone inhibits first-pass metabolism. (wikipedia.org)
  • Grapefruit juice may double bioavailability of oral budesonide. (wikipedia.org)
  • administration
  • They are usually given intravenously, shortly before administration of the chemotherapeutic agent, although some authors have argued that oral administration may be preferred. (wikipedia.org)
  • An oral formulation was approved on August 22, 2008 for prevention of acute CINV alone, as a large clinical trial did not show oral administration to be as effective as IV use against delayed CINV. (wikipedia.org)
  • placebo
  • The median percentage reduction from baseline in the glucocorticoid dose was 50% in the mepolizumab group, as compared with no reduction in the placebo group (P=0.007). (nih.gov)
  • levels
  • The dependency on age remained when correcting, in a multiple linear regression analysis, for 1CTP levels at admission, weight, sex, and daily maintenance dose of inhaled glucocorticoids. (diva-portal.org)
  • intravenous
  • Time to event ranged from 23-39 months and 42-46 months with high dose intravenous and oral bisphosphonates. (wikipedia.org)
  • estimated an incidence of osteonecrosis of the jaw of 1.15% for intravenous bisphosphonates and 0.04% for oral bisphosphonates. (wikipedia.org)
  • clinical
  • These case series were published as peer-reviewed articles - two in the Journal of Oral and Maxillofacial Surgery and one in the Journal of Clinical Oncology. (wikipedia.org)
  • lower
  • This is about 10,000 times lower than the oral dosage of progesterone required to inhibit ovulation (300 mg/day). (wikipedia.org)