• Eflornithine, sold under the brand name Vaniqa among others, is a medication used to treat African trypanosomiasis (sleeping sickness) and excessive hair growth on the face in women. (wikipedia.org)
  • A hair removal cream called eflornithine (vaniqa) can suppress hair growth when a person uses it regularly. (tribuntech.com)
  • Nifurtimox-eflornithine combination treatment (NECT) is an effective regimen for the treatment of second stage gambiense African trypanosomiasis. (wikipedia.org)
  • In 2009, results from a pivotal clinical trial sponsored by DNDi and Médecins Sans Frontières (MSF) showed that NECT, a combined treatment of Bayer's nifurtimox and Sanofi's eflornithine, was a safe and effective treatment for sleeping sickness. (dndi.org)
  • NECT has significant practical benefits in comparison to eflornithine: there are fewer intravenous infusions (14 instead of 56), treatment length is shorter, and it is more cost effective than using eflornithine alone. (dndi.org)
  • There is limited data comparing fexinidazole to NECT but fexinidazole is preferred in low resource settings given the ease of administration as an oral drug. (cdc.gov)
  • The NECT combination regimen appears to be more effective and less toxic than eflornithine monotherapy. (cdc.gov)
  • Efficacy and Safety of Fexinidazole Compared to Nifurtimox-Eflornithine Combination Therapy (NECT) in Patients With Late-stage Human African Trypanosomiasis (HAT) Due to T.b. (who.int)
  • Any contraindication to imidazole products (known hypersensitivity to imidazoles) and NECT (known hypersensitivity to eflornithine). (who.int)
  • Eflornithine is also called difluoromethylornithine or DFMO. (msf.org)
  • Participants were randomly assigned to undergo oral treatment with DFMO at one of five doses or placebo for 3 months, with 3 additional months of follow-up. (medscape.com)
  • MINNEAPOLIS, April 06, 2023 (GLOBE NEWSWIRE) -- Panbela Therapeutics, Inc . (Nasdaq: PBLA), a clinical stage biopharmaceutical company developing disruptive therapeutics for the treatment of patients with cancer today announced that an abstract about CPP-1X (also known as DFMO or Eflornithine) research, has been accepted for poster presentation at the Endocrine Society meeting, which will be held June 15-18, 2023. (mammothtimes.com)
  • Drugs used in the treatment of polycystic ovarian syndrome (PCOS) include metformin (off-label use), spironolactone, eflornithine (topical cream to treat hirsutism), and oral contraceptives. (medscape.com)
  • Sleeping sickness, or trypanosomiasis, is treated with pentamidine or suramin (depending on subspecies of parasite) delivered by intramuscular injection in the first phase of the disease, and with melarsoprol and eflornithine intravenous injection in the second phase of the disease. (wikipedia.org)
  • It's sold under the name eflornithine as an intravenous treatment for African sleeping sickness (trypanosomiasis) and as a cream for unwanted hair growth in women. (medscape.com)
  • Shampoos, topical eflornithine (for hirsutism) and minoxidil (for alopecia) are considered to pose a negligible risk to a breastfeeding infant. (sps.nhs.uk)
  • After its introduction to the market in the 1980s, eflornithine has replaced melarsoprol as the first line medication against Human African trypanosomiasis (HAT) due to its reduced toxicity to the host. (wikipedia.org)
  • If eflornithine is prescribed to a patient with Human African trypanosomiasis caused by a trypanosome that contains a mutated or ineffective TbAAT6 gene, then the medication will be ineffective against the disease. (wikipedia.org)
  • Many medications like CLOMIPHENE, an oral drug, are taken in the first part of the menstrual cycle to improve ovulation and help become pregnant. (pcosrelief.org)
  • There has been great progress for these two diseases in recent years, with the delivery of fexinidazole , the first all-oral treatment for sleeping sickness developed by DNDi and Sanofi, and the approval in the US of moxidectin for river blindness. (dndi.org)
  • In 2018-9, DND i and partners, in particular Sanofi, delivered the first all-oral treatment for sleeping sickness, fexinidazole, that is currently being implemented in endemic countries. (dndi.org)
  • Eflornithine is also effective in combination with other drugs, such as melarsoprol and nifurtimox. (wikipedia.org)
  • Another randomized control trial in Uganda compared the efficacy of various combinations of these drugs and found that the nifurtimox-eflornithine combination was the most promising first-line theory regimen. (wikipedia.org)
  • When administering nifurtimox-eflornithine combined therapy, the dosage of nifurtimox in children and adults is 5 mg/kg every 8 hours for 10 days. (msf.org)
  • Buy Eflora Cream 13.9% - 15gm (Eflornithine), Eflornithine is used topically as hair removal cream for the treatment of excessive hair on the face of women (Hirsutism). (onlinegenericmedicine.com)
  • Eflornithine is used topically as hair removal cream for the treatment of excessive hair on the face of women (Hirsutism). (onlinegenericmedicine.com)
  • In 2002, the UK CSM warned that preparations containing cyproterone and ethinylestradiol should not be used solely for contraception, but for treatment of severe acne that had not responded to oral antibac-terials, or for moderately severe hirsutism, and that they should be withdrawn 3 or 4 cycles after the treated condition has completely resolved. (pocketdrugguide.com)
  • Eflornithine Hydrochloride works by inhibiting an enzyme called ornithine decarboxylase, which is involved in the production of hair. (onlinegenericmedicine.com)
  • It may take several weeks of regular use to see the full effects of Eflornithine Hydrochloride. (onlinegenericmedicine.com)
  • This phase II trial studies how well irinotecan hydrochloride, temozolomide, and dinutuximab work with or without eflornithine in treating patients with neuroblastoma that has come back (relapsed) or that isn't responding to treatment (refractory). (ucbraid.org)
  • Eflornithine Cream patient information, description, dosage and directions. (tribuntech.com)
  • Treatment with combined oral contraceptives or metformin is suggested, using patient characteristics and preferences to guide decision-making. (bvsalud.org)
  • Oral medication, especially contraceptives are also used in the treatment. (cypruscrownivf.com)
  • Oral contraceptives containing a combination of estrogen and progestin increase sex hormone-binding globulin (SHBG) levels and thereby reduce the free testosterone level. (medscape.com)
  • However, the use of oral contraceptives may be associated with an increased risk of thrombosis and metabolic abnormalities. (medscape.com)
  • When low-dose cyproterone is given with ethinylestradiol to women, adverse effects associated with combined oral contraceptives may occur. (pocketdrugguide.com)
  • Combined oral contraceptives are associated with a small increased risk of cardiovascular disease. (pocketdrugguide.com)
  • A review by the authorities in New Zealand considered the risk to be at least as great as with third-generation oral contraceptives, a conclusion further supported by a study in that country of the contraceptives used by women discharged from hospital with a diagnosis of deep-vein thrombosis or pulmonary embolism. (pocketdrugguide.com)
  • However, others' have questioned some study results, concluding that preparations containing cyproterone are not associated with a risk in excess of that associated with conventional combined oral contraceptives including those containing levonorgestrel. (pocketdrugguide.com)
  • Eflornithine is not effective in the treatment of Trypanosoma brucei rhodesiense due to the parasite's low sensitivity to the drug. (wikipedia.org)
  • But a second all-oral, and importantly single-dose treatment, acoziborole , is now being tested in Phase II/III clinical studies in DRC and Guinea. (dndi.org)
  • Pregnancy must be ruled out before oral contraceptive therapy is started. (medscape.com)
  • It is sometimes combined with the oral contraceptive pill. (kerryskinclinic.ie)
  • oral contraceptive pill (OCP) - progesterone only, or combined, or else 12 week cycles of medroxyprogesterone acetate 5mg BD followed by 1 week break - NOT contraceptive! (scottishpaeds.org.uk)
  • Patients unable to take oral medication. (who.int)
  • An oral contraceptive containing ethinyl estradiol and a progestin with minimal androgenic activity, such as norgestimate, norethindrone, or desogestrel, should be selected. (medscape.com)
  • Flynpovi is a combination of CPP-1X (eflornithine) and sulindac with a dual mechanism inhibiting polyamine synthesis and increase polyamine export and catabolism. (wkrn.com)
  • The purpose of this study was to assess the safety and feasibility of delivering an experimental approach called GliAtak which uses AdV-tk, an adenoviral vector containing the Herpes Simplex thymidine kinase gene, plus an oral anti-herpetic prodrug, valacyclovir, in combination with standard of care radiation. (mountaintoday.in)
  • Resistance to eflornithine has increased the use of melarsoprol despite its toxicity, which has been linked to the deaths of 5% of recipient HAT patients. (wikipedia.org)
  • Focusing on FAP patients with lower gastrointestinal tract anatomy in the recent Phase 3 trial comparing Flynpovi to single agent eflornithine and single agent sulindac, FAP patients with lower GI anatomy (patients with an intact colon, retained rectum or surgical pouch), Flynpovi showed statistically significant benefit compared to both single agents (p≤0.02) in delaying surgical events in the lower GI for up to four years. (wkrn.com)
  • Women with menstrual irregularities are treated with oral contraceptive pills (OCPs). (dibesity.com)
  • The Programme of Work 2009 of the Global Polio Eradication Initiative was constructed in order to inform this new strategy by evaluating new tactical innovations in each disease-endemic area,2 conducting clinical trials of new oral poliovirus vaccine formulations and facilitating an independent evaluation of major barriers to interrupting poliovirus transmission. (who.int)
  • Typically, drugs that inhibit cell growth are considered candidates for cancer therapy, so eflornithine was naturally believed to have potential utility as an anti-cancer agent. (wikipedia.org)
  • Withdrawal bleeding can be induced with medroxyprogesterone (Provera) given for 5-10 days before the start of oral contraceptive therapy. (medscape.com)
  • The gene TbAAT6, conserved in the genome of Trypanosomes, is believed to be responsible for the transmembrane transporter that brings eflornithine into the cell. (wikipedia.org)
  • The loss of this gene due to specific mutations causes resistance to eflornithine in several trypanosomes. (wikipedia.org)
  • CPP-1X (eflornithine) is being developed as a single agent tablet or high dose power sachet for several indications including prevention of gastric cancer and recent onset Type 1 diabetes. (wkrn.com)
  • Eflornithine blocks the production of chemicals called polyamines that are important in the growth of cancer cells. (ucbraid.org)
  • By inhibiting ODC, eflornithine inhibits cell growth and division of both cancerous and noncancerous cells. (wikipedia.org)
  • Eflornithine is a hair growth inhibitor that works by inhibiting an enzyme located in the hair follicle (base of hair) that is involved in hair growth. (onlinegenericmedicine.com)
  • In regions of the world where the disease is common eflornithine is provided for free by the World Health Organization. (wikipedia.org)
  • Eflornithine should only be used if the potential benefits justify the potential risk to the baby. (onlinegenericmedicine.com)
  • Eflornithine was developed in the 1970s and came into medical use in 1990. (wikipedia.org)