SynthesisMethyleneArylPyridineReactionBiological activitiesMedicinalStructuralSyntheticMoleculesCyclizationAdsorptionExperimentalInteractionStudyMethodsGreenEfficientPyridine derivativesCompoundsSynthesis of novelHydrazineAntimicrobialFlavonoidsHeterocyclicMolecularIngredientsActivityPotentialAgentsStudyDataQuality
Synthesis6
- these have included dihydroxylation of the coumarin double bond, and the synthesis of 4- benzylaminocoumarin derivatives as potential intermediates. (ru.ac.za)
- Synthesis of Some Chalcone and Their Heterocyclic Derivatives as Potential Antimicrobial Agents: A Review. (ajrconline.org)
- Chalcones is an α, β -unsaturated ketones, which acts as significant precursors for the synthesis of bioactive compounds and major constitutes of the natural products. (chemmethod.com)
- A number of synthetic routes have been reported for the synthesis of chalcones, while their general synthesis involves Claisen-Schmidt condensation under homogeneous conditions in the presence of acid or base [20-22]. (chemmethod.com)
- A novel metal-free synthesis of indenone derivatives mediated by CBr4 and diethyl phosphonate is reported. (researchgate.net)
- The synthesis and properties of a series of unsymmetrical thienopentalenes are explored, including both monoareno and diareno derivatives. (researchgate.net)
Methylene1
- T. C. Egbosiuba, A. S. Abdulkareem, and A. S. Kovo, "Ultrasonic enhanced adsorption of methylene blue onto the optimized surface area of activated carbon: Adsorption isotherm, kinetics and thermodynamics," Chem. (edu.iq)
Aryl2
- Structure-activity relationship (SAR) has contributed to the improvement of anticancer properties of chalcones by substituting aryl rings and introducing heterocyclic moieties [18-19]. (chemmethod.com)
- A series of 2-chloro-5-[(4-chlorophenyl)sulfamoyl]- N -(alkyl/aryl)-4-nitrobenzamide derivatives (5a - 5v) has been synthesized and confirmed by physicochemical(R f , melting point) and spectral means (IR, 1 HNMR, 13 CNMR). (biomedcentral.com)
Pyridine3
- Oxidation of 1,4-DHPs accounts for one of the easiest ways of accessing pyridine derivatives. (wikipedia.org)
- As such, particular attention has been paid to developing methods of aromatization to yield pyridine derivatives under milder and efficient conditions. (wikipedia.org)
- Upon metabolism, 1,4-DHP based antihypertensive drugs undergo oxidation by way of cytochrome P-450 in the liver and are thus converted to their pyridine derivatives. (wikipedia.org)
Reaction3
- respectively, at 70 °C with pressure under microwave reaction condition to afford the corresponding 2-hydroxyphenylcyanopyridone, 2-hydroxyphenyl acetylcyclohexanone, and thieno[2,3-c]chromen-4-one derivatives respectively. (dntb.gov.ua)
- Moreover, the reaction of chalcone 3 with hydrogen peroxide with stirring affords the corresponding chromen-4-one derivative. (dntb.gov.ua)
- The reaction of various salicylaldehyde derivatives with tert-butyl acrylate In the presence of 1,4- diazabicyclo[2.2.2]octane (DABCO) has afforded a series of Baylis-Hillman adducts in moderate yield. (ru.ac.za)
Biological activities2
- Rozmer Z and Perjési P. Naturally occurring chalcones and their biological activities. (syncsci.com)
- The , β -unsaturated ketones as well as their synthetic derivatives show numerous biological activities [1]. (chemmethod.com)
Medicinal3
- Chalcone: a privileged structure in medicinal chemistry. (syncsci.com)
- Imidazole derivatives have occupied a unique place in the field of medicinal chemistry. (ajrconline.org)
- The medicinal properties of chalcones are because of the presence of α, β - unsaturated double bond, absence of conjugation double bond functionality with carbonyl carbon, and inactivity of chlcone [2]. (chemmethod.com)
Structural1
- Mahapatra DK, Bharti SK and Asati V. Anti-cancer chalcones: Structural and molecular target perspectives. (syncsci.com)
Synthetic2
- In vitro antiproliferative and antiangiogenic effects of synthetic chalcone analogues. (syncsci.com)
- Usually, the coagulants can be either inorganic coagulants (e.g., aluminum sulfate (Al 2 (SO 4 ) 3 ), ferric chloride (FeCl 3 ), and poly aluminum chloride), synthetic organic polymers (e.g., polyacrylamide derivatives and polyethylene imine), or naturally occurring coagulants (e.g., chitosan and microbial coagulants). (degruyter.com)
Molecules1
- Being a polar and ionisable aromatic compound, it improves pharmacokinetic characteristics of lead molecules and thus used as a remedy to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. (ajrconline.org)
Cyclization2
- it easily undergoes cyclization to produce additional derivatives likes flavanones [3]. (chemmethod.com)
- Diareno pentalene derivatives were accessed via gold-catalyzed cyclization of di. (researchgate.net)
Adsorption1
- Zirconium phosphosilicate and zirconium phosphate has been synthesized and their composition has been determined.204Tl, 114mIn and 85+89Sr have been used as tracers for optimizing the ideal conditions in the adsorption. (ajrconline.org)
Experimental1
- The experimental conditions were optimized. (atlantis-press.com)
Interaction2
- Also, the compounds were optimized through DFT/B3LYP/6-31G (d,p) basis set and identification of their physical descriptors, whereas the compound 12 was confirmed through X-Ray single structure with Hirsh field analysis of the compound to know the hydrogen electrostatic bond interaction, and correlated with the optimized structure by comparing their bond length, bond angle, FT-IR, and NMR, which gave excellent correlation. (dntb.gov.ua)
- Study on the interaction of some (E)-2-benzyldenebenzosuberone derivatives with serum albumin by UV-Vis method, inhibitory effect on topoisomerase. (syncsci.com)
Study3
- An early study into the mechanism using 13C and 15N NMR indicated the intermediacy of the chalcone 6 and enamine 3. (wikipedia.org)
- To the best of our knowledge, for the first time, we reported the force degradation study and toxicological properties of synthesized chalcones by ICH guidelines. (chemmethod.com)
- With the aim of setting up a cost-effective and high purity production of resveratrol derivatives, hairy root lines were established from Vitis vinifera cv Pinot Noir 40024 to study the organ-specific production of various stilbenes. (omicsdi.org)
Methods2
- The broad range of availability of chalcone in the nature and their significant biological activity chalcones of the analytical methods play a vital role for the isolation and purification of the desired compounds [23]. (chemmethod.com)
- The proposed methods are optimized and validated as per the International Conference on Harmonization (ICH) guidelines. (ajrconline.org)
Green1
- Enantioenriched, highly functionalized cyclopropane derivatives were prepared by a simple and green approach using monosaccharide‐based chiral crown ethers as phase transfer catalysts. (researchgate.net)
Efficient1
- Starting with resolving agent screening, an efficient enantioseparation method was developed and optimized using (R,R)-(1-naphthyl)-spiro-TADDOL as the resolving agent. (researchgate.net)
Pyridine derivatives5
- Oxidation of 1,4-DHPs accounts for one of the easiest ways of accessing pyridine derivatives. (wikipedia.org)
- As such, particular attention has been paid to developing methods of aromatization to yield pyridine derivatives under milder and efficient conditions. (wikipedia.org)
- Upon metabolism, 1,4-DHP based antihypertensive drugs undergo oxidation by way of cytochrome P-450 in the liver and are thus converted to their pyridine derivatives. (wikipedia.org)
- 13. Design, synthesis, molecular modeling and biological evaluation of novel 1H-pyrazolo[3,4-b]pyridine derivatives as potential anticancer agents. (nih.gov)
- 18. Design, synthesis and cytotoxicity studies of novel pyrazolo[1, 5-a]pyridine derivatives. (nih.gov)
Compounds4
- First, the dataset of compounds was optimized using the density functional theory (DFT) approach. (nih.gov)
- The optimized compounds were then submitted to the first screening, which was done by the pKCM web server to look for drug-likeness and the PyRx to look for binding affinity. (nih.gov)
- Key physicochemical properties were calculated (absorption, distribution, metabolism, excretion and toxicity), to determine the bioavailability of the designed compounds and to perform a preselection of 12 derivatives which were then optimized and studied by molecular docking with the receptor PBP3 (4bjp) from Escherichia coli . (journals.cz)
- The pyrimidine series were synthesized starting by the reaction of chalcones and guanidine, giving rise to the corresponding amonopyrimidines, which were then reacted with aromatic and heteroaromatic aldehydes to obtain the acyclic azomethine compounds. (journals.cz)
Synthesis of novel1
- 9. Eco-friendly synthesis of novel cyanopyridine derivatives and their anticancer and PIM-1 kinase inhibitory activities. (nih.gov)
Hydrazine2
- The derivatives were afforded by refluxing mixtures of chalcones and phenylhydrazine, hydrazine hydrate, and / or acetic acid in DMSO or ethanol at low temperatures between 40-60°C in an oil-bath. (phcogcommn.org)
- The dihydropyrazole derivatives were obtained from the reaction of chalcones with one equivalent of hydrazine derivatives by one-step cyclocondensations. (journals.cz)
Antimicrobial1
- To combat the antimicrobial and anticancer drug resistance by pathogens and cancerous cells, efforts has been made to study the pharmacological activities of newly synthesized N -(4-(4-bromophenyl)thiazol-2-yl)-2-chloroacetamide derivatives. (biomedcentral.com)
Flavonoids1
- Dietary flavonoids and synthetic derivatives have a well-known potential for biomedical applications. (degruyter.com)
Heterocyclic1
- Vit-B3 or nicotinic acid or niacin with the formula C 6 H 5 NO 2 ( Figure 1 ) is a carboxylic acid derivative of pyridine heterocyclic scaffold, in which it could be available as a single standing structure or in combination with other structures [ 19 ]. (jmchemsci.com)
Molecular1
- The molecular structures of the synthesized derivatives were confirmed by their physicochemical properties and spectroanalytical data (NMR, IR and elemental). (biomedcentral.com)
Ingredients1
- In recent years, the interest in bio-additives has been increased by optimizing the use of organic additives or new ingredients arising from biotechnological processes, which leads to the application of living organisms and their metabolites in diverse industries. (vetmedmosul.com)
Activity3
- Based on these findings, we recommend that compound 7 should undergo further structural modification in order to optimize its anti-microbial activity. (phcogcommn.org)
- 2. Design and synthesis of thienopyrimidine urea derivatives with potential cytotoxic and pro-apoptotic activity against breast cancer cell line MCF-7. (nih.gov)
- 17. Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity. (nih.gov)
Potential1
- Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents. (sinica.edu.tw)
Agents1
- This condition could be prevented by the application of antioxidant therapeutic agents such as hydrazone derivatives with potent antioxidant activities. (springeropen.com)
Study2
- An early study into the mechanism using 13C and 15N NMR indicated the intermediacy of the chalcone 6 and enamine 3. (wikipedia.org)
- It is believed that the outcome of this study could be utilized to support the ongoing research in similar area with better quality and greater probability of success, consequently optimizing the resources in subsequent in vitro, in vivo, non-clinical and clinical development. (bvsalud.org)
Data1
- NMR data was described in detail for each derivative. (phcogcommn.org)
Quality1
- In conclusion, an optimized light spectrum improves the value and quality of cannabis. (karger.com)