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  • crush
  • At 16 weeks of age, baseline images of fluroescent retinal neurons were collected using a blue-light confocal scanning laser ophthalmoscope and then all mice received unilateral optic nerve crush. (arvojournals.org)
  • The mean proportions of fluorescent retinal neurons remaining in the control group following optic nerve crush were 45±24, 35±19, 21±18, and 18±9 percent, at weeks 1 through 4, respectively. (arvojournals.org)
  • myelin
  • Myelin is the fatty substance that covers and protects nerves. (news-medical.net)
  • Anoxic injury of mammalian central white matter Decreased susceptibility in myelin-deficient optic nerve. (docme.ru)
  • One characteristic of white matter that may contribute to its susceptibility to anoxic injury is the presence of myelin. (docme.ru)
  • To test the hypothesis that myelination, or associated events, confer susceptibility to anoxia, we analyzed the effects of anoxia on isolated optic nerves from the myelin-deficient (md) rat. (docme.ru)
  • Peripheral
  • Moreover, tissue maturation, its activation in peripheral versus central nervous system (PNS versus CNS) and the context of injury influence cellular NF-κB functions. (biologists.org)
  • researchers
  • In mouse experiments, the researchers saw a dramatic elevation of zinc after injury to the optic nerve -- surprisingly, not in the damaged retinal ganglion cells themselves but in cells that communicate with them, interneurons known as amacrine cells. (eurekalert.org)
  • Damage
  • Damage to the optic nerve typically causes permanent and potentially severe loss of vision, as well as an abnormal pupillary reflex , which is diagnostically important. (stem-cell-center.com)
  • After bowel surgery, more than half of the patients suffer from irreparable nerve damage. (medicalxpress.com)
  • canal
  • Studies have shown that forces applied to the frontal bone and malar eminences are transferred and concentrated in the area near the optic canal. (clinicaltrials.gov)
  • trauma
  • Very recently it has been shown the cytokine hormone erythropoietin (EPO) that had been long known and used as a valuable agent to promote hematopoiesis has been protective in experimental models of mechanical trauma, neuroinflammation, cerebral and retinal ischemia, and even in a human stroke trial, and most notably in optic nerve transection. (clinicaltrials.gov)
  • brain
  • Fifty patients suffered from brain injury, whereas 26 had no intracranial pathology and served as control individuals. (biomedsearch.com)
  • or =8 [n = brain injury. (biomedsearch.com)
  • Finally, invasive ICP measurement using an intraparenchymal catheter was performed in patients with severe brain injury. (biomedsearch.com)
  • 0.0001) in patients with severe brain injury as compared with patients with moderate brain injury (4.2 +/- 1.2 mm and 12.0 +/- 3.6 mmHg) and compared with control individuals (3.6 +/- 0.6 mm and 10.3 +/- 3.1 mmHg). (biomedsearch.com)
  • In the patients with severe brain injury, ONSD measurements correlated with invasive ICP values (r = 0.68, P = 0.002). (biomedsearch.com)
  • Retinal ganglion cells are nerves that transmit information from the eye to the brain. (nih.gov)
  • The visual information it sends to the brain is not as crisp since some of the "wires" within the nerve are lost. (healthtap.com)
  • induction
  • In addition to RelA activation in astrocytes, optic nerve axonotmesis caused a hitherto unrecognized induction of RelA in growth-inhibitory oligodendrocytes. (biologists.org)
  • evaluation
  • Hence, optic nerve sonography may serve as an additional diagnostic tool that could alert clinicians to the presence of elevated ICP, whenever invasive ICP evaluation is contraindicated and/or is not available. (biomedsearch.com)
  • control
  • Acutely isolated optic nerves from 19- to 21-day-old md rats and control optic nerves from unaffected male littermates were maintained in vitro at 3 7 T , and exposed to a standard 60-minute period of anoxia. (docme.ru)
  • The compound action potential was nearly abolished within 3 to 6 minutes after onset of anoxia in control optic nerves, while optic nerves from md rats displayed a slower decrease in compound action potential amplitude during anoxia, with a distinct action potential present even after 60 minutes of anoxia. (docme.ru)