Optic disc atrophy. Medical search. Frequent questions

The fundus appearance is varaible ranging from normal in the early stages, with only subtle temporal optic nerve pallor, macular pigment migration and atrophy or a bull's-eye maculopathy, to peripheral retinal pigment epithelium atrophy, intra retinal pigmentation migration, arteriolar attenuation, and optic disc pallor as disease progresses. (orpha.net)
Fundus examination can be normal at the early stages with only subtle temporal optic disc pallor or may show macular pigment migrations and atrophy or a bull's-eye maculopathy. (orpha.net)
Late stage findings include peripheral retinal pigment epithelium atrophy, intraretinal pigment migration, arteriolar attenuation, and optic disc pallor. (orpha.net)
hence this condition is also referred to as optic nerve head pallor . (targetwoman.com)
This 47 year-old woman was seen for bilateral optic disc pallor. (neuroophthalmology.ca)
Examination by a neurologist documented mild temporal pallor of the optic discs, Automated perimetry 5 and 4 years ago showed some scattered relative depression OS, and visual evoked potentials showed prolonged p100 latencies bilaterally. (neuroophthalmology.ca)
Fundoscopy shows optic discs with diffuse pallor and cupping. (neuroophthalmology.ca)
The company also noted that patients diagnosed with the disease present with bilateral, slowly progressing visual impairment, temporal pallor of the optic disc, central visual field defects, and abnormalities in color vision. (ophthalmologytimes.com)

Inflammation of the optic nerve called optic neuritis . (targetwoman.com)
The role of intravenous steroids is a proven treatment in case of optic neuritis or arthritic anterior ischemic optic neuropathy. (stemcellcareindia.com)
Multiple sclerosis causes optic neuritis, which is an inflammation (swelling) of the optic nerve. (stemcellcareindia.com)
Optic neuritis, an inflammation or swelling that affects the optic nerve area, this is the reason of multiple sclerosis. (stemcellcareindia.com)
Optic disc edema may also occur from many conditions other than papilledema, including central retinal artery or vein occlusion, congenital structural anomalies and optic neuritis, and anterior ischemic optic neuropathy. (surajeyeinstitute.org)
Central scotomaand cecocentral scotoma is in optic neuritis and toxic optic neuropathy. (surajeyeinstitute.org)
The authors feel this may be a case of optic perineuritis (peri-optic neuritis). (biomedcentral.com)
Isolated disk edema (eg, caused by optic neuritis or ischemic optic neuropathy) without the retinal findings indicative of elevated cerebrospinal fluid pressure is not considered papilledema (unless the intracranial pressure is elevated on concurrent lumbar puncture). (msdmanuals.com)

SEATTLE, Washington - Treatment with pegcetacoplan (Syfovre, Apellis Pharmaceuticals) produced clinically meaningful reductions in the growth of geographic atrophy (GA) lesions through month 30, according to interim results presented at the annual meeting of the American Society of Retina Specialists. (medscape.com)

Till date there is no proven treatment for optic atrophy. (stemcellcareindia.com)
What treatment for optic atrophy can an IALVS eye doctor provide? (ialvs.com)
Presently, there is no cure or effective treatment for optic atrophy. (ialvs.com)

Optic nerve heads (ONH) had a myopic tilt, extensive peripapillary atrophy temporally and a cup-to-disc ratio of 0.15 right eye and 0.25 left eye without evidence of clinic nerve fiber layer defects. (reviewofoptometry.com)
The fundus demonstrates many signs characteristic to high myopia including a tilted disc, peripapillary atrophy, and macular atrophy. (eyerounds.org)

Primary congenital glaucoma (PCG) is characterized by elevated intraocular pressure (IOP), enlargement of the globe ( buphthalmos ), edema, and opacification of the cornea with rupture of Descemet's membrane (Haab's striae), thinning of the anterior sclera and iris atrophy, anomalously deep anterior chamber, and structurally normal posterior segment except for progressive glaucomatous optic atrophy. (beds.ac.uk)
An objective test that would detect the presence and progression of glaucomatous optic atrophy in the eyes of children with PCG would be desirable. (bmj.com)

4 Myopic maculopathy, a consequence of high myopia, may involve Bruch membrane lacquer cracks, chorioretinal and macular atrophy, and choroidal neovascularization. (optometryadvisor.com)

Neural progenitor cells delivered to the vitreous can add into the ganglion cell layer of the retina, turn on neurofilament genes, and migrate into the host's optic nerve. (stemcellcareindia.com)
A retina simulation disc can be put onto the back of the viewer, and a student with an ophthalmoscope can look inside the viewer as if looking into an eye. (gilai.com)

Anterior optic ischemic neuropathy is a form of stroke that affects the optic nerve. (stemcellcareindia.com)

Over a few days, optic disc edema develops, sometimes associated with flame hemorrhages of the swollen disc or nearby cotton-wool exudates. (molvis.org)
Q.2 Which of the following features are associated with disc edema? (surajeyeinstitute.org)
Q.3 What ophthalmic examinations will you perform on a patient suspected of or having disc edema? (surajeyeinstitute.org)
Optic disc edema arises from the blockage of retrograde and orthograde axoplasmic transport in the optic nerve. (surajeyeinstitute.org)
The evaluation of patients with optic disc edema: A retrospective study. (surajeyeinstitute.org)
A rare case of optic disc edema associated with cutaneous larva migrans is presented. (biomedcentral.com)
A 45-year-old Caucasian man, a naturalist, from the UK developed cutaneous larva migrans while in Kenya and presented to us with visual disturbance secondary to unilateral optic disc edema. (biomedcentral.com)
To the best of our knowledge, optic disc edema associated with cutaneous larva migrans has not been previously reported. (biomedcentral.com)
This case highlights the importance of taking relevant history of recent travel to endemic areas affected by the nematodes in patients presenting with optic disc edema, and pertinent questioning regarding non-ocular symptoms, including skin lesions. (biomedcentral.com)
We report a case of cutaneous larva migrans associated with unilateral optic disc edema, which resolved after a single dose of ivermectin. (biomedcentral.com)
Visual symptoms, skin lesions and optic disc edema resolved over the course of two to three weeks. (biomedcentral.com)
On last review, visual acuity was 6/6 in both eyes, color vision and visual fields were normal and there was complete resolution of disc edema (Figures 2 and 3 ). (biomedcentral.com)
13. Optic nerve edema. (who.int)

Optic disc drusen was noted in 48% of study eyes by EDI-OCT but was not found to be predictive of visual outcome. (bmj.com)
Interestingly, a high proportion of study eyes had optic disc drusen, which was not associated with vision loss, but can be a diagnostic challenge in distinguishing true papilledema from pseudopapilledema. (bmj.com)
Objective To assess the performance of a deep learning system (DLS) to discriminate between optic disc drusen (ODD) and papilledema caused by intracranial hypertension, using standard color ocular fundus photographs collected in a large international multi-ethnic population. (medrxiv.org)
External-testing was subsequently performed on an independent dataset (221 patients) including 207 images with ODD (96 visible and 111 buried), provided by 3 centers of the Optic Disc Drusen Studies Consortium, and 214 images of papilledema (92 mild-to-moderate and 122 severe) from a previously validated study. (medrxiv.org)
or pseudo swollen disks (eg, optic nerve drusen), requires a thorough ophthalmologic evaluation. (msdmanuals.com)

Macula: In the right eye, there was patchy chorioretinal atrophy with a small retinal hemorrhage in the superotemporal macula near a lacquer crack. (eyerounds.org)
There was chorioretinal atrophy extending into the inferonasal macula. (eyerounds.org)
In the left eye, there was dense chorioretinal atrophy along the inferior arcade. (eyerounds.org)
Extensive chorioretinal atrophy in the inferonasal periphery of the left eye with extension into the inferior macula. (eyerounds.org)
Current fundus examination of the right eye revealed pale optic disc, occluded retinal vessels, and diffuse chorioretinal atrophy (Fig. 2 ). (springeropen.com)

Recent literature suggests a genetic component for non-arteritic anterior ischemic optic neuropathy (NAION). (molvis.org)
Anterior ischemic optic neuropathy (AION) occurs in two forms: arteritic and nonarteritic (NAION). (molvis.org)
This condition is also called optic atrophy and optic neuropathy. (stemcellcareindia.com)
An hereditary syndrome in which a person loses vision in one eye and then the other (known as Leber's inherited optic neuropathy). (stemcellcareindia.com)
Stroke, known as anterior ischemic optic neuropathy. (stemcellcareindia.com)
This condition is known as Leber's optic neuropathy. (stemcellcareindia.com)
Zuchner S, et al: Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2. (neuroophthalmology.ca)
Voo I, et al: Hereditary motor and sensory neuropathy type VI with optic atrophy. (neuroophthalmology.ca)
According to the company, ADOA is an autosomal dominant inherited optic neuropathy, and about 80% of ADOA is caused by mutations in the OPA1 gene. (ophthalmologytimes.com)
Our most advanced investigational gene therapy drug candidate, NR082, used for the treatment of Leber's hereditary optic neuropathy (LHON) associated with mtND4 mutation (ND4-LHON), has been granted orphan drug designation (ODD) by the U.S. FDA and the European Medicines Agency (EMA). (ophthalmologytimes.com)
We report a case of papilledema without the typical symptoms of arteritic anterior ischemic optic neuropathy, ultimately diagnosed as a subtype of giant cell arteritis, which has not been reported previously in Korea. (jkos.org)
Magnetic resonance imaging revealed no specific findings, leading to a diagnosis of anterior ischemic optic neuropathy. (jkos.org)
Assess for pupil constriction during accommodation and for relative afferent pupillary defect to look for associated optic neuropathy. (eyewiki.org)
caused by multiple sclerosis), a congenital problem in which the optic nerve does not form properly, stroke of the optic nerve, and Leber's hereditary optic neuropathy (a genetic condition in which the patient loses vision in one eye, and then in the other). (ialvs.com)
Magnetic resonance images (MRI) revealed no intra-orbital pathologies or optic neuropathy but demonstrated a clearly delineated air-filled space of the left anterior clinoid process (ACP). (openaccesspub.org)
One patient with an at-risk optic disc on monthly treatment developed ischemic optic neuropathy after six injections. (medscape.com)

The distal muscle atrophy in the lower extremities leads to the classic finding of pes cavus (high arched foot) and hammer toes demonstrated in this case. (neuroophthalmology.ca)
Similarly, experimental studies using botulinum neurotoxin type A to induce masticatory muscle atrophy reported decreased craniofacial growth and development 5-6 . (bvsalud.org)

The CNVM has resolved and there is some mild outer retinal atrophy in the area (arrow). (eyerounds.org)

What are the symptoms of optic atrophy? (ialvs.com)

HSMN, type VI, which we believe this patient to have, is an autosomal dominantly inherited axonal sensorimotor polyneuropathy associated with optic atrophy. (neuroophthalmology.ca)
Interestingly, MFN2 shows functional overlap with the OPA1 gene, the protein underlying the most common form of autosomal dominant optic atrophy. (neuroophthalmology.ca)
Neurophth Therapeutics today announced the Australian Therapeutic Goods Administration (TGA) has registered and approved its candidate drug, NFS-05, for clinical trials targeting autosomal dominant optic atrophy (ADOA). (ophthalmologytimes.com)

Although optic atrophy affects one eye, bilateral optic atrophy can also occur when the illness damages the nerves of the both eyes. (targetwoman.com)

and the refraction has become myopic, and astigmatic, being - 2 D as measured on the vertical vessels of the disc, and - 3.5 D as measured on the horizontal. (ox.ac.uk)
If there is optic atrophy, the optic disc will be pale because of insufficient blood flow through the blood vessels. (ialvs.com)

In the case of optic atrophy, something is interfering with the optic nerve's ability to transmit these signals. (stemcellcareindia.com)

Glaucomatocyclitic crisis is characterized by a slight decrease in vision, elevated IOP, and open anterior chamber angles, with normal visual fields and optic nerve appearance. (medscape.com)
Anatomic configurations that predispose the optic nerve to injury include type 2 (nerve course adjacent to the sphenoid sinus causing an indentation of the sinus wall, without contacting any posterior ethmoid cell) or type 3 (nerves course through the sphenoid sinus), bone dehiscence over the optic nerve, and anterior clinoid process pneumatization (ACPP) with and without ipsilateral optic nerve protrusion. (openaccesspub.org)
Pneumatization occurs when a paranasal sinus, often the sphenoid or ethmoid sinus, extends into the anterior clinoid process via the inferior or anterior root otherwise known as the optic strut. (openaccesspub.org)

Research shows that 83% of adult patients with myopic maculopathy have signs of diffuse peripapillary choroidal atrophy as children. (optometryadvisor.com)
Patients without these findings must have diffuse choroidal thickening-as seen using ultrasonography-with fluorescein angiographic abnormalities, including focal areas of delayed choroidal perfusion, multifocal pinpoint leakage, areas of placoid hyperfluorescence, pooling of subretinal fluid, and optic nerve staining. (medscape.com)

Optic nerve damage can range from a slight reduction in upper nasal peripheral visual field to total blindness. (pharmacology2000.com)

This article examines chance-corrected intraobserver and interobserver agreement for horizontal and vertical cup:disc ratios and width of the narrowest remaining neuroretinal rim on stereo, color, fundus photographs. (nih.gov)
Participants The study included 4,508 color fundus images in 2,180 patients from 30 neuro-ophthalmology centers (19 countries) participating in the Brain and Optic Nerve Study with Artificial Intelligence (BONSAI) Group. (medrxiv.org)
Fundus examination showed the presence of a swollen optic disc in the left eye (Figure 1 ). (biomedcentral.com)

Presently, risk factors with strongest evidence for conversion of ocular hypertension (OH) to glaucoma, or presence and progression of open-angle glaucoma (OAG), include older age, thinner central corneal thickness (CCT), greater cup-to-disc ratio (C/D ratio), and higher intraocular pressure (IOP). (hindawi.com)

11 ACPP is not associated with any predictors that might be recognized preoperatively 12 and has no reported pathologic consequences despite its proximity to the internal carotid artery, the ophthalmic artery, and the optic nerve. (openaccesspub.org)

Early diagnosis and prompt o ptic nerve atrophy stem cell treatment in Delhi India can help the patients with compressive and toxic neuropathies. (stemcellcareindia.com)
To evaluate the effect of one lesson of continuing medical education (CME) of subjective assessment of optic nerve head appearance on sensitivity and specificity for the diagnosis of glaucoma. (biomedcentral.com)
Ophthalmologists and residents in ophthalmology attending an international glaucoma meeting arranged at Malmö University Hospital, Malmö, Sweden, were asked to grade optic nerve head (ONH) photographs of healthy and glaucomatous subjects at two sessions separated by a lecture on glaucoma diagnosis by ONH assessment. (biomedcentral.com)

If you face any of these symptoms seek medical attention immediately as any progression of optic atrophy leads to vision loss. (targetwoman.com)

Note: If OCT is not available, the following exclusion criteria will apply: vertical cup/disc ratio by fundoscopy greater than or equal to 0.80 with a corresponding visual field defect in the superior and inferior hemifield, and/or visual field loss within 5 degrees of fixation in at least one hemifield. (who.int)

Optic disc morphology in myopic primary open-angle glaucoma. (jocgp.com)

Ophthalmologist will examine the eyes with an ophthalmoscope and the doctor may recommend few more tests, if he suspects optic atrophy. (targetwoman.com)
However ophthalmologist diagnose the underlying condition or disorder that is causing optic atrophy and treat them. (targetwoman.com)
An ophthalmologist determines the condition of optic nerve using an instrument. (stemcellcareindia.com)

Funduscopic examination OD was remarkable for peripapillary subretinal hemorrhage-view of the optic nerve head was obscured by retinal hemorrhage, retinal whitening superior to macula indicative of a branch arterial occlusion and scattered intraretinal and blot hemorrhages associated with the deeper retinal capillary plexus. (optometrytimes.com)

The gold standard for monitoring glaucoma in adults and children includes intraocular pressure measurements, monitoring of the optic nerve cup-to-disc ratio and visual fields. (bmj.com)

Optic atrophy is a serious eye disorder that is caused by a underlying disease or condition. (targetwoman.com)
You can now cure this disease with optic nerve transplant stem cell. (stemcellcareindia.com)
However, early detection of this condition can help prevent further damage from the disease that caused optic atrophy. (ialvs.com)

Optic disk swelling resulting from causes that do not involve increased intracranial pressure (eg, malignant hypertension, central retinal vein occlusion) is not considered papilledema. (msdmanuals.com)

Q.1 Ans D The term "papilledema" describes optic disc swelling resulting from increased intracranial pressure. (surajeyeinstitute.org)
Papilledema is swelling of the optic disk due to increased intracranial pressure. (msdmanuals.com)

Ophthalmoscopic examination reveals engorged and tortuous retinal veins, a hyperemic and swollen optic disk (optic nerve head), and retinal hemorrhages around the disk but not into the retinal periphery. (msdmanuals.com)

Optic disc photographs on presentation and automated perimetry, SD-OCT and EDI-OCT imaging on final follow-up visit were statistically analysed to identify patient characteristics and anatomic findings associated with irreversible vision loss. (bmj.com)
Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. (jocgp.com)

Interobserver agreement was also substantial (kappas of 0.71 for horizontal cup:disc ratio, 0.74 for vertical cup:disc ratio, and 0.58 for the neuroretinal rim). (nih.gov)

Optic atrophy is the result of the fibres of optic nerve failing to transmit the visual information to the brain due to the damaged optic nerve which may result in problems with vision. (targetwoman.com)
Optic atrophy refers to the loss or damage of the fibres of the optic nerve. (targetwoman.com)
The optic nerve contains nerve fibres that transmit impulses to the brain. (stemcellcareindia.com)

A congenital problem is improper optic nerve growth (the person is born with it). (stemcellcareindia.com)

However, There were still 8.0 % (5/62) of the patients with poor outcomes, including optic disc atrophy in 3 patients and stent-interior thrombosis in 2 patients, which occurred 6.3 months after stenting. (benthamscience.com)

The 22 discs include normal retinas and retinas with different diseases and disfigurations: retinitis with pigmentosa, neororetinitis, optic atrophy etc. (gilai.com)

A bundle of fibers make up the optic nerve, and these fibers transmit impulses to the brain. (ialvs.com)

The optic nerve fiber is made of axons from the retinal ganglion cells, that usually doesn't regenerate after an injury, resulting in a lifelong visual loss. (stemcellcareindia.com)
Q.2 Ans A, B, and D. Signs of optic disc swelling include elevation and blurring of the disc margins, visual field loss, and eventually optic disc atrophy. (surajeyeinstitute.org)
Afterwards, there was no improvement in visual acuity, and optic nerve atrophy occurred. (jkos.org)
2. Severe retinal nerve fiber layer thinning of the optic nerve in the superior and inferior quadrant analysis by OCT with a corresponding visual field defect in the superior and inferior hemifield, and/or visual field loss within 5 degrees of fixation in at least one hemifield. (who.int)
6. Optic atrophy with a reproducible visual field defect detected by confrontation visual field testing. (who.int)

Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. (jocgp.com)

Anatomy44

Organisms10

Diseases77

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment72

Psychiatry and Psychology6

Phenomena and Processes29

Disciplines and Occupations5

Technology, Industry, Agriculture2

Information Science5

Named Groups3

Health Care22

Geographicals2

Pallor8

Neuritis8

Geographic Atrophy1

Treatment for optic atrophy3

Peripapillary atrophy2

Glaucomatous optic atrophy2

Macular1

Retina2

Ischemic neuropathy1

Edema13

Drusen5

Chorioretinal atrophy5

Neuropathy16

Muscle atrophy2

Outer retinal1

Symptoms of optic1

Autosomal3

Bilateral optic1

Vessels2

Case of optic1

Anterior3

Diffuse2

Peripheral1

Fundus3

Corneal1

Ophthalmic1

Diagnosis3

Progression1

Fundoscopy1

Myopic1

Ophthalmologist3

Hemorrhage1

Intraocular1

Disease3

Occlusion1

Papilledema2

Swollen optic1

Perimetry2

Ratio1

Fibres3

Congenital problem1

Outcomes1

Retinitis1

Transmit1

Visual5

Nerve fiber1