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  • midline
  • During development, the axons of retinal ganglion cell (RGC) neurons must decide whether to cross or avoid the midline at the optic chiasm to project to targets on both sides of the brain. (ox.ac.uk)
  • Unexpectedly, the NRP1 ligand involved is not an axon guidance cue of the class 3 semaphorin family, but VEGF164, the neuropilin-binding isoform of the classical vascular growth factor VEGF-A. VEGF164 is expressed at the chiasm midline and is required for normal contralateral growth in vivo. (ox.ac.uk)
  • These findings have identified a permissive midline signal for axons at the chiasm midline and provide in vivo evidence that VEGF-A is an essential axon guidance cue. (ox.ac.uk)
  • Axons
  • These effects on both axon populations suggest that GAP-43 does not mediate pathfinding specifically for one or the other axon population but is more consistent with a model in which the initial pathfinding defect at the chiasm/tract transition zone leads to axons backing up into the chiasm, resulting in circular trajectories and eventual random axon exit into one or the other optic tract. (jneurosci.org)
  • spinal cord
  • A high-definition multileaf collimator, or beam-shaping device, shapes the dose so that it closely matches the shape of the targeted tumor, in order to precisely carry out delicate radiosurgical procedures near critical structures like the optic chiasm , brain stem, or spinal cord. (thefreedictionary.com)
  • radiation
  • A 41-year-old man had rapidly progressive visual loss caused by a malignant glioma that developed in the optic chiasm eight years after radiation therapy for a recurrent prolactinoma. (jamanetwork.com)
  • hemisphere
  • Past the optic chiasm , everything from the left visual field is now processed in the right hemisphere and everything from the right visual field is now processed in the left hemisphere. (thefreedictionary.com)
  • Structures
  • In this patient, due to adherence to the vital structures, such as cavernous sinus and optic chiasm , we could not resect the capsule of the tumor totally to avoid possible additional neurologic complications. (thefreedictionary.com)
  • opposite
  • Here, approximately one-half of the nerve fibres from each eye continue on the same side of the brain, and the remaining nerve fibres cross over at the chiasm to join fibres from the opposite eye on the other side of the brain. (britannica.com)
  • development
  • From day 3 of optic chiasm development onward, positive detection of BCIP/NBT-levamisole at the chiasm (Fig 1) indicates the presence of LR AP (a characteristic previously only attributed to IAP). (arvojournals.org)
  • similar
  • 12 Similar to the previous scan Similar to the previous scan (at 9th month of therapy) (at 9th month of therapy) 15 Normal cranial MRI findings, The lesion on the level of except for a 2-3 mm optic chiasm disappeared. (thefreedictionary.com)