• Classical Complement Pathway) Phagocytosis - by opsonizing antigens. (wikipedia.org)
  • Also, serum antibodies recognized in these people show restricted ability to opsonise epitomized bacterial antigens. (alliedacademies.org)
  • Thus, blockade of activating FcγR inhibits binding of opsonized antigens, induction of effector functions and secretion of pro-inflammatory cytokines by macrophages, and degranulation of granulocytes. (academie-medecine.fr)
  • In conditions such as like ITP that is autoantibody-mediated, IVIG Fc fragmentmediated competitive blockade of activating FcγR might inhibit: binding of opsonized antigens, induction of effector functions and secretion of pro-inflammatory cytokines by macrophages, and degranulation of granulocytes [1, 12]. (academie-medecine.fr)
  • Attack by phagocytic cells can be facilitated when antigens are coated with antibody (Ab), which is produced as part of acquired immunity, or when complement proteins opsonize antigens. (msdmanuals.com)
  • Other exposed cells after priming with serum opsonized zymosan (SOZ) were analyzed for their ability to produce superoxide anion and hydrogen-peroxide. (cdc.gov)
  • Finally, while the phagocytosis of inert latex particles by human blood monocytes is not affected by the presence of ethanol [ 3362 ], the phagocytosis of opsonized red cells by Kupffer cells is slightly impaired by ethanol [ 3363 ]. (nanomedicine.com)
  • Phagocytosis of opsonized Escherichia coli and leukocyte expression of constitutive toll-like receptor 4 (TLR4) were evaluated via flow cytometry. (avma.org)
  • As an example, we provide an experimental protocol for studying phagocytosis of opsonized Streptococcus pyogenes using the THP-1 cell line. (lu.se)
  • ingestion of unopsonized zymosan, opsonized P. aeruginosa, EIgG, and E (IgM)C occurred in the presence or absence of glucose as did-ingestion of unopsonized P. aeruginosa by polymorphonuclear leukocytes. (jci.org)
  • Incubation with anti-CD64 F(ab')2 inhibits Fibrocyte differentiation(10) and blocks phagocytosis of antibody-opsonized platelets (11). (ancell.com)
  • To systematically investigate the relationship of opsonising antibodies with protection using a large panel of sera, we also have established a reporter system to measure opsonizing antibodies against FMDV. (forschung3r.ch)
  • Macrophage eliminating assay Macrophages had been challenged at an MOI of 2 with fixed stage opsonized with 10% regular mouse serum for 20 min. (mingsheng88.org)
  • Fc receptor-dependent antibody functions are important components of the immune response that provide mechanisms for clearance of infected host cells, immune complexes, or opsonized pathogens. (frontiersin.org)
  • and a host of innate immune cells capable of differential responses to opsonized particles and present at different sites. (eurekaselect.com)
  • The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil. (bvsalud.org)
  • The ability of some cells to phagocytize opsonized polystyrene latex microspheres was evaluated. (cdc.gov)
  • Antibody 10.1 blocks binding of Fc gamma RI to immunoglobin opsonized cells (1, 9). (ancell.com)
  • Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. (qedbio.com)
  • Frequencies of these cells also correlated with higher plasma parasite-specific opsonizing Abs. (elsevierpure.com)
  • C3b has most important opsonizing activity. (wikipedia.org)
  • Dissociation of opsonized particle phagocytosis and respiratory burst activity in an Epstein-Barr virus-infected myeloid cell line. (umassmed.edu)
  • A main conclusion from was that opsonizing activity was clearly much broader than neutralizing activity suggesting that non-neutralizing IgG could also complex with FMDV to infect bovine MoDC or activate pDC. (forschung3r.ch)
  • We and others, have also shown that the complement system has a critical, non-redundant roles in creating and maintaining a non-inflammatory intravascular environment by tagging and opsonizing circulating foreign or abnormally folded host proteins with C1q, MBL, C3b and C4b. (hhs.gov)
  • Classical Complement Pathway) Phagocytosis - by opsonizing antigens. (wikipedia.org)
  • Nonopsonized or opsonized bacteria were incubated with neutrophils as described in the legend for Fig. phagocytosed, but only in the presence of opsonizing antibody, suggesting that Fc receptor-mediated signaling may be needed for phagocytosis. (synanet2020.com)
  • In this study we examined the role of virulence factors and of the presence or absence of opsonizing antibodies in phagocytosis by human neutrophils. (synanet2020.com)
  • This must be compared to the opsonizing antibodies that promote the specific phagocytosis of extra-cellular bacteria. (ssrn.com)
  • Phagocytosis of platelets opsonized with differently glycosylated anti-HLA hIgG1 by monocyte-derived macrophages" Thijs L, Gesture Vidarsson, et al. (ancell.com)
  • The functionality of these cells was assessed by examining their ability to phagocytose opsonized targets, produce cytokines, eicosanoids and intracellular cAMP measured by enzyme immunoassays, and gene expression of proteins, enzymes and receptors essential for eicosanoid generation and phagocytosis measured by real time RT-PCR. (biomedcentral.com)
  • However, even though the young AMs produced a skewed eicosanoid profile, neither the inhibition of PGE 2 by aspirin nor the addition of exogenous LTB 4 rescued the defective opsonized phagocytosis. (biomedcentral.com)
  • Examination of a receptor responsible for mediating opsonized phagocytosis showed a significant decrease in the gene expression levels of the Fcgamma receptor in young (day 7) AMs compared to adult AMs. (biomedcentral.com)
  • These results suggest that elevated production of PGE 2 and decreased production of LTB 4 do not contribute to impaired opsonized macrophage phagocytosis and highlight an important difference between young and adult AMs. (biomedcentral.com)
  • Incubation with anti-CD64 F(ab')2 inhibits Fibrocyte differentiation(10) and blocks phagocytosis of antibody-opsonized platelets (11). (ancell.com)
  • We also observed that p110α was required for phagocytosis of IgG and serum opsonized particles in differentiated U-937 cells. (ubc.ca)
  • AMs phagocytose antibody opsonized pathogens via engagement of their Fcγ receptors. (biomedcentral.com)
  • The results of in vitro C3 uptake studies evaluating the effect of IVIG on the clearance of pre-opsonized cells suggest that IVIG produces a kinetic depression of C3 uptake and modifies the process of complement fragment deposition on erythrocytes. (medscape.com)
  • The intracellular BCG elimination coincided with the induction of NO production, which was more pronounced in cells infected with opsonized BCG compared to those infected with the non-opsonized bacteria. (scirp.org)
  • This article summarizes recent evidence in the literature on the peculiar features that render memory NK cells an attractive tool for antitumor immunotherapy, including their long-term survival and in vivo persistence, the resistance to tumor-dependent immunosuppressive microenvironment, the amplified functional responses to IgG-opsonized tumor cells, and in vitro expansion capability. (hindawi.com)
  • additionally, NK cells are potently activated by CD16 or Fc γ RIIIa (low-affinity Fc receptor for IgG)-dependent recognition of IgG-opsonized targets. (hindawi.com)
  • AMs from young animals (day 7 and 14) were defective in their ability to phagocytose opsonized targets and produce tumor necrosis factor (TNF)- α. (biomedcentral.com)
  • It can be diagnosed using serum-opsonized E.coli as a stimulus in dihydrorhodamine (DHR) assay. (nih.gov)
  • Polymer coating and retargeting with bFGF further reduced rates of clearance for both viruses, suggesting protection against both neutralizing and opsonizing factors. (ox.ac.uk)