• Adherence reaction mediated through the CR receptors on phagocytes lead to stimulation of phagocytosis, activation of metabolism and secretory function and movement of phagocytes into the inflammatory site. (dadamo.com)
  • Our results show that maternal dietary n-3 PUFA deficiency increases microglia-mediated phagocytosis of synaptic elements in the rodent developing hippocampus, partly through the activation of 12/15-lipoxygenase (LOX)/12-HETE signaling, altering neuronal morphology and affecting cognitive performance of the offspring. (nature.com)
  • The functions of complement include the attraction of inflammatory cells, opsonization to promote phagocytosis, immune complex clearance and direct microbial killing through the formation of the membrane attack complex (MAC). (abcam.com)
  • This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins.It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. (joplink.net)
  • Opsonization of the deposits with anti-Aβ IgG 6E10 enhanced microglial chemotaxis to and phagocytosis of Aβ, as well as exacerbated microglial secretion of the pro-inflammatory cytokines TNF-α and IL-6. (biomedcentral.com)
  • Indomethacin, a common nonsteroidal anti-inflammatory drug (NSAID), had no effect on microglial chemotaxis or phagocytosis, but did significantly inhibit the enhanced production of IL-6 after Aβ opsonization. (biomedcentral.com)
  • Overall, opsonization with Aβ antibody enhanced microglial migration to and phagocytosis of Aβ. (biomedcentral.com)
  • MBL may also influence phagocytosis in the absence of complement activation through. (silverchair.com)
  • Immunoglobulin G binds to viruses, bacteria, as well as fungi and facilitates their destruction or neutralization via agglutination (and thereby immobilizing them), activation of the compliment cascade, and opsonization for phagocytosis. (rockland.com)
  • The interaction between lectins and carbohydrates have been shown to be involved in such activities as opsonization of microorganisms, phagocytosis, cell adhesion and migration, cell activation and differentiation, and apoptosis. (tamu.edu)
  • Complement activation generates membrane attack complex (MAC). (biomedcentral.com)
  • Pharmacological inhibition of C3 activation can modify all outcomes of complement cascade activation (opsonization, inflammation and membrane attack complex formation), irrespective of which complement pathway is activated. (guidetoimmunopharmacology.org)
  • the classical pathway initiated by antibodies bound to the surface of foreign bodies and the alternative and lectin pathways that provide an antibody-independent mechanism for complement activation, induced by the presence of bacteria and other micro-organisms. (abcam.com)
  • Mouse IgG2b is composed of two heavy chains and two light chains, and it is involved in opsonization, complement activation, and antibody-dependent cell-mediated cytotoxicity. (thermofisher.com)
  • The Fc fragment mediates opsonization, antibody dependent cellular cytotoxicity (ADCC), and complement activation through binding to Fc receptors such as CD16, CD32, CD64, and the complement factor C1. (biolegend.com)
  • 8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
  • Previously, the IgG1 ch14.18 (dinutuximab) antibody was reformatted into the IgA1 isotype, which abolishes neuropathic pain and induces efficient neutrophil-mediated antibody-dependent cellular cytotoxicity (ADCC) via activation of the Fc alpha receptor (FcαRI/CD89). (bmj.com)
  • The production of such "class switched" antibodies is important for optimizing the immune response to particular antigens, since the antibody class defines its effector functions, such as complement activation, opsonization, neutralization of bacterial toxins and mast cell activation. (fu-berlin.de)
  • C1q attaches to antibodies bound on the pathogen surface, leading to the activation of C1s. (abcam.com)
  • Mediates a process known as opsonization which refers to antibodies coating a pathogenic cell to lure the phagocyte toward the antigenic surface of the pathogen. (bioexplorer.net)
  • Activated microthrombotic pathway mediates platelet activation and exocytosis of unusually large von Willebrand factor multimers (ULVWF) from ECs and initiates microthrombogenesis. (biomedcentral.com)
  • 4 , 13 Complement plays a crucial role in host defense against foreign bodies by promoting phagocyte-mediated clearance of cell debris through activation of an inflammatory response, opsonization of pathogens, and lysis of susceptible bacteria and cells. (jrheum.org)
  • Complement is activated via 3 routes leading to opsonization of the bacteria that are subsequently recoginized by phagocytes. (evasionutrecht.nl)
  • Another inflammatory process associated with postprandial lipaemia is the activation of the complement system. (silverchair.com)
  • Excessive or uncontrolled activation of the complement system plays a key role in a wide range of autoimmune and inflammatory diseases. (guidetoimmunopharmacology.org)
  • Different fragments, released from individual components during complement activation, operate by a non-cytolytic mechanism through specific receptors present on various cell types. (dadamo.com)
  • Thus, the aim of this work is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, its mechanism of action, and to elucidate molecular mechanisms involved in endotoxin's recognition by the immune system and cell activation. (bvsalud.org)
  • Activation of the complement cascade, with the formation of the effector MAC unit, results in cytotoxic and cytolytic reactions. (dadamo.com)
  • Mannan-binding lectin (MBL) and MBL-associated serine proteases (MASPs) are involved in the initial step of the lectin pathway of complement activation. (abcam.com)
  • Following these cleavage events, complement pathway activation continues as in the classical pathway. (abcam.com)
  • The alternative pathway of complement activation is in a constant state of low-level activation (known as tickover). (abcam.com)
  • Therefore, the objective of this study is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, as well as to elucidate molecular mechanisms involved in its recognition by the immune system and in cell activation. (bvsalud.org)
  • Activation of the complement system generates potent chemoattractants and leads to the opsonization of cells for immune clearance. (rcsb.org)
  • It is also involved in the regulation of immune responses, including the activation of T cells and the inhibition of B cell activation. (thermofisher.com)
  • The activation phase is when re-exposure of antigen causes the release of contents of basophils and mast cells. (periobasics.com)
  • Inhibition of IgE-mediated mast cell activation by the paired Ig-like receptor PIR-B. J Clin Invest. (southernbiotech.com)
  • Additionally, cortisol facilitates the activation of glycogen phosphorylase, which is necessary for adrenaline to have an effect on glycogenolysis. (wikipedia.org)
  • Understanding the mechanistic basis of the central complement-activation step and microbial immune evasion strategies targeting this step will aid in the development of complement therapeutics. (rcsb.org)
  • 125 I-labeled C3 was bound to the particles during opsonization. (rupress.org)
  • 45 Ca was not bound to the particles during opsonization. (rupress.org)
  • The binding of MBL to mannose and N-acetyl glucosamine in micro-organisms leads to the activation of MASPs, which subsequently cleave C4 and C2. (abcam.com)
  • Activation of the complement system occurs through the classical (CP), lectin (LP), or alternative (AP) pathways. (jrheum.org)
  • The three principal activation pathways of the complement system (the classical, lectin and alternative pathways) converge on complement peptide C3, making it a central target for drug development in the search for immune system modulators for the treatment of complement-mediated disorders. (guidetoimmunopharmacology.org)
  • 1. Yang J, Wang L, Zhang H, Qiu L, Wang H, Song L. C-type lectin in Chlamys farreri (CfLec-1) mediating immune recognition and opsonization. (southernbiotech.com)
  • Cell-to-cell interactions set off a cascade of events that may result in T- or B-cell activation and, ultimately, host defense. (medscape.com)
  • 2008). While size and surface composition influences uptake, surface charge plays a major role in immune activation as well as membrane and uptake activities(Frohlich, 2012). (freedissertation.com)
  • After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. (abcam.com)
  • 2004). Coating and charge of a nanoparticle can play a major role in activation as well as size and surface area(Aggarwal, Hall, McLeland, Dobrovolskaia, & McNeil, 2009). (freedissertation.com)
  • C3 plays a central role in the activation of the complement system. (abcam.com)