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Administration, IntranasalAdministration, OralNasal MucosaMice, Inbred BALB CInjections, IntravenousDisease Models, AnimalLungDrug Administration RoutesTime FactorsImmunity, MucosalDrug Administration ScheduleDose-Response Relationship, DrugInjections, IntramuscularMice, Inbred C57BLUnited States Food and Drug AdministrationAdjuvants, ImmunologicRats, Sprague-DawleyImmunizationInjections, IntraperitonealNasal CavityInjections, SubcutaneousVaccinationBiological AvailabilityRats, WistarOrthomyxoviridae InfectionsAdministration, RectalNoseImmunoglobulin ANasal SpraysVaccines, AttenuatedVaccines, SyntheticAntibodies, ViralBrainImmunoglobulin GCholera ToxinDouble-Blind MethodBacterial VaccinesImmunoglobulin A, SecretoryInfluenza VaccinesLiverAntibodies, BacterialVaccines, InactivatedAdministration, TopicalRhinitis, Allergic, PerennialSpleenUnited StatesCytokinesAdministration, InhalationAerosolsTreatment OutcomeHalf-LifeArea Under CurveAdministration, CutaneousStreptococcal VaccinesOvalbuminBronchoalveolar Lavage FluidCross-Over StudiesDogsTissue DistributionMidazolamAdministration, SublingualAdministration, BuccalNasal ObstructionDrug InteractionsSneezingRecombinant ProteinsInfusions, IntravenousViral VaccinesBody WeightGenetic VectorsMice, KnockoutBehavior, AnimalAdministration, IntravenousRhinitis, Allergic, SeasonalRhinitisAllergensAnti-Allergic AgentsInjections, IntraventricularAnalysis of VarianceInfluenza A virusMucous MembranePlagueNose DiseasesInterferon-gammaAdministration, MucosalRats, Inbred StrainsPregnancyRabbitsBlood PressureEnzyme-Linked Immunosorbent AssayRandom AllocationNasal Lavage FluidDrug Delivery SystemsRNA, MessengerKidneyAbsorptionVacciniaMice, Inbred StrainsAnalgesics, OpioidNasal Decongestants
IntramuscularDeveloping intranasal vaccinesVaccinesSubcutaneous2023RouteINTRANASALLYSystemicVaccine developmentOxytocinTopicalAntigenOralNaloxoneMedication deliveryPandemicMucosal immunityInfluenza vaccinationRatsDiseaseBlueWillowFormulationsRespiratoryMechanismChallengesDosesOnsetPreclinicalAnthraxInjectionDeliveryNasal cavityResultsPrimarilyStudyOverdoseDevelopmentAutismDrugsVariabilityResearchApplicationHumanProvideMakeFood and Drug AdminSystemMarket
Intramuscular4
  • By enabling mucosal plus systemic immunity, alone or in combination with established intramuscular vaccines, intranasal vaccination offers better protection against SARS-CoV-2, along with improved patient outcomes. (ondrugdelivery.com)
  • Based on the route of administration, the intramuscular segment had the leading market share in 2022. (marketdataforecast.com)
  • Drug developers have recently created intramuscular and intranasal naloxone formulations-considered so important that their expansion is being considered for over-the-counter use. (worldwide.com)
  • The authors review current research on intranasal vaccines and make a case for their advantages over intramuscular injection, both for fighting SARS-CoV-2 infection at the source and for reducing viral shedding, which can spread the disease. (promegaconnections.com)
Developing intranasal vaccines2
  • In addition to NanoBio ® Protect, BlueWillow is currently developing intranasal vaccines that elicit both systemic and mucosal immunity for several respiratory and sexually transmitted infections, including RSV, HSV2, pandemic influenza and anthrax, as well as intranasal immunotherapy for peanut allergy and other allergic conditions. (pharmiweb.com)
  • BlueWillow is currently developing intranasal vaccines for several respiratory and sexually transmitted infections, including RSV, HSV2, pandemic influenza and anthrax, as well as vaccines for peanut allergy and other allergic conditions. (bluewillow.com)
Vaccines14
  • Nasal vaccines are intuitively logical for pathogens that enter via the nose, so it is unsurprising that the SARS-CoV-2 pandemic has reinvigorated interest in intranasal vaccine development. (ondrugdelivery.com)
  • Four intranasal vaccines have already been approved for use, 2 most recently iNCOVACC (Bharat Biotech, Hyderabad, India) and Convidecia Air™ (CanSino Biologics, Tianjin, China) - and many more are in development. (ondrugdelivery.com)
  • They are intensifying their R&D capabilities to develop neutralizing antibodies and therapeutic respiratory virus vaccines that can generate value-grab opportunities for manufacturers. (transparencymarketresearch.com)
  • BlueWillow Biologics ® is a clinical-stage, privately-held biopharmaceutical company focused on developing and commercializing topical antiseptic and anti-infective products and intranasal vaccines using its patented nanotechnology platform. (pharmiweb.com)
  • Learn more about how to coadminister vaccines on CDC's Vaccine Administration Route and Site page. (aap.org)
  • The market is driven by factors such as the emerging intranasal vaccines for COVID-19, rising acceptance of self-administration of medication, and growing use of nasal sprays due to simple administration techniques. (tritonmarketresearch.com)
  • New technologies have created opportunities to develop novel vaccines, including vaccines for sexually transmitted infections, influenza, and arthropodborne viruses. (cdc.gov)
  • New approaches to trivalent inactivated vaccine include high-dose HA vaccines, synthesis of recombinant HA antigen, addition of adjuvants, and intranasal transdermal administration and tissue culture production of whole viruses. (cdc.gov)
  • Aptar Pharma has combined its intranasal Unidose Powder Nasal Spray System with TFF Pharmaceuticals' Thin Film Freezing technology platform to develop and test the administration of dry powder vaccines. (packagingeurope.com)
  • COVID-19 Intranasal Vaccines Revisited: Can They Reduce Breakthrough Infections? (promegaconnections.com)
  • The blog post proposed one possible solution to stopping the virus at the source of infection: intranasal SARS-CoV-2 vaccines. (promegaconnections.com)
  • Intranasal vaccines offer other advantages over current mRNA vaccines . (promegaconnections.com)
  • Current lipid-encapsulated mRNA vaccines are not formulated for intranasal administration (7). (promegaconnections.com)
  • Most of the intranasal SARS-CoV-2 vaccines in clinical trials at present are either adenoviral vector vaccines or live-attenuated virus vaccines. (promegaconnections.com)
Subcutaneous1
  • In studies to date with subcutaneous administration of bremelanotide variability in plasma exposure has been significantly reduced, with no statistically significant difference in mean changes in blood pressure seen in subjects receiving bremelanotide compared to placebo. (palatin.com)
20231
  • 2023. Intranasal atomization of ketamine, medetomidine and butorphanol in pet rabbits using a mucosal atomization device. (awionline.org)
Route5
  • Nasal administration, popularly known as snorting, is a route of administration in which drugs are insufflated through the nose. (wikipedia.org)
  • Large-molecule drugs can also be delivered directly to the brain by the intranasal route, the only practical means of doing so, following the olfactory and trigeminal nerves (see section below), for widespread central distribution throughout the central nervous system with little exposure to the blood. (wikipedia.org)
  • The intranasal pathway has been proposed as a non-invasive alternative route to deliver therapeutics to the brain. (iozk.de)
  • A mounting body of evidence is accumulating that the underexplored intranasal delivery route might represent a major breakthrough to combat glioblastoma. (iozk.de)
  • This method has the potential to be a non-invasive administration route and may offer additional advantages such as ease of administration, increased patient compliance, lower dose requirements, rapid onset of action, and minimized systemic exposure, which may reduce the risk of peripheral toxicity. (psychedelicfinance.com)
INTRANASALLY1
  • The current study is designed to validate our hypothesis that increases in blood pressure and gastrointestinal events seen with intranasally administered bremelanotide were primarily related to high intranasal absorption in a subset of patients. (palatin.com)
Systemic3
  • It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects. (wikipedia.org)
  • Potential advantages may include ease of administration, increased patient compliance, lower dose requirements, rapid onset of action, and minimized systemic exposure. (psychedelicfinance.com)
  • Intranasal drug delivery is a practical and accessible method for treating localized symptoms as well as achieving systemic drug absorption. (essays.se)
Vaccine development2
  • However, intranasal vaccine development does face some challenges. (promegaconnections.com)
  • Results from selected preclinical studies illustrating different approaches to intranasal vaccine development are summarized here. (promegaconnections.com)
Oxytocin5
  • Intranasal oxytocin is also being actively investigated for many psychiatric conditions including alcohol withdrawal, anorexia nervosa, PTSD, autism, anxiety disorders, pain sensation and schizophrenia. (wikipedia.org)
  • In a double blind randomized trial we examined the influence of intranasal administration of oxytocin on real, high-cost donating money to a charity with-out any expectation for reciprocation. (vu.nl)
  • Participants in the current study were 57 female undergraduate students, aged 18-30 years, who received a nasal spray containing either 24 IU of oxytocin or a placebo, and were then given the opportunity to make a charita-ble donation. (vu.nl)
  • In contrast, oxytocin administration was ineffective in enhancing donating behavior in individuals who experienced high levels of parental love-withdrawal. (vu.nl)
  • We conclude that the positive effect of oxytocin administration on prosocial behavior may be limited to individuals with supportive backgrounds. (vu.nl)
Topical2
  • However, multiple aspects of topical sinonasal drug delivery for CRS need to be addressed explicitly by future research, which may lead to novel therapeutic interventions with potential opportunities for personalized medicine. (pfmjournal.org)
  • b) Inhaled, intranasal, or topical corticosteroids are permitted. (moffitt.org)
Antigen2
  • The vaccine combines BlueWillow's novel intranasal NanoVax system with recombinant protective antigen (rPA) for anthrax from PBL. (bluewillow.com)
  • Any intranasal vaccine must overcome the barrier posed by nasal mucus, in order for the antigen to be effectively delivered to nasal epithelial cells. (promegaconnections.com)
Oral5
  • Nasal administration can therefore be used as an alternative to oral administration, by crushing or grinding tablets or capsules and snorting or sniffing the resulting powder, providing a rapid onset of effects. (wikipedia.org)
  • However, the variability in the amount absorbed after nasal administration should be comparable to that after oral administration. (wikipedia.org)
  • are also currently administered by nasal administration because a fast effect is desired and oral administration can be prohibited by nausea. (wikipedia.org)
  • Peptide drugs (hormone treatments) are also available as nasal sprays, in this case to avoid drug degradation after oral administration. (wikipedia.org)
  • The peptide analogue desmopressin is, for example, available for both nasal and oral administration, for the treatment of diabetes insipidus. (wikipedia.org)
Naloxone5
  • Naloxone administration is an important component of resuscitation attempts by emergency medical services (EMS) for opioid drug overdoses. (cdc.gov)
  • We reviewed medical examiner files on all individuals who died of an opioid-related drug overdose in Rhode Island from January 1, 2012 through March 31, 2014, underwent attempted resuscitation by EMS providers, and had records available to assess for naloxone administration. (cdc.gov)
  • Naloxone is an opioid antagonist whose administration during resuscitation efforts serves as an important component in EMS response to opioid overdoses. (cdc.gov)
  • However, appropriate administration of naloxone depends first on recognition of the possibility of opioid overdose in an EMS encounter. (cdc.gov)
  • In this study, records of physical exam findings were not sufficiently available to fully assess EMS clinical decision making around naloxone administration. (cdc.gov)
Medication delivery2
  • The area of intranasal medication delivery provides a huge opportunity for research - both for specifically developed pharmaceutical drugs designed for intranasal treatment, as well as for investigating off label uses of commonly available generic medications. (wikipedia.org)
  • For instance, in July 2021, InnarisBio created intranasal medication delivery technology to improve treatment for mental health conditions. (tritonmarketresearch.com)
Pandemic2
  • Ross Woodburn, managing director at BUBL Packaging explores how manufacturers that adapted faster by using core skills and exploiting knowledge of specific sectors created opportunities for growth during the pandemic. (packagingeurope.com)
  • Changing consumer habits during the pandemic have led to a plethora of new behavioural trends, which equate to a host of opportunities for brands hoping to capture new market share in the beverage sector. (packagingeurope.com)
Mucosal immunity1
Influenza vaccination1
  • Every visit is an opportunity to administer and/or promote influenza vaccination, and to strengthen relationships with patients and families to encourage vaccine confidence. (aap.org)
Rats2
  • Validated intranasal administration method in rats should be in place. (scanbalt.org)
  • Experiment 2: A separate group of rats will receive intranasal CBD administration. (mystateline.com)
Disease4
  • Intranasal Calcitonin, calcitonin-salmon is used to treat Hypercalcaemia arising out of malignancy, Paget's disease of bone, post menopausal and steroid induced osteoporosis, Phantom limb pain and other metabolic bone abnormalities, available as Rockbone, Fortical and Miacalcin Nasal Spray. (wikipedia.org)
  • Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM? (iozk.de)
  • Fihurka O, Aradi S, Sava V, Sanchez-Ramos J. Key Features in the Design and Function of Nanocarriers for Intranasal Administration of Gene Therapy in Huntington Disease. (scientificarchives.com)
  • HD is an autosomal dominant neurodegenerative disease for which several clinical trials have demonstrated gene-lowering effects following intrathecal administration. (scientificarchives.com)
BlueWillow2
  • ANN ARBOR, Mich., (October 23, 2019) - BlueWillow Biologics ® , a clinical-stage biopharmaceutical company, today announced the U.S. Food and Drug Administration (FDA) has cleared its investigational new drug (IND) application for BW-1010, the company's next-generation anthrax vaccine candidate. (bluewillow.com)
  • ANN ARBOR, Mich., (July 23, 2019) - BlueWillow Biologics ® today announced the issuance of U.S. patent number 10,206,996 to BlueWillow for the development of an intranasal NanoVax ® herpes simplex virus (HSV) vaccine. (bluewillow.com)
Formulations1
  • Opportunities to minimise cold-chain requirements with powder-based formulations. (ondrugdelivery.com)
Respiratory1
  • 1 More generally, the attractions of intranasal vaccination point to potential for other indications, such as respiratory syncytial virus. (ondrugdelivery.com)
Mechanism1
  • Exploring the mechanism of drug delivery is an opportunity for us to further enhance the treatment experience," said Florian Brand, Co-Founder, and CEO of atai Life Sciences. (psychedelicfinance.com)
Challenges1
  • Julie Suman and Nektaria Karavas discuss the challenges and opportunities of intranasal vaccination - showcasing current understanding for both liquid and powder products. (ondrugdelivery.com)
Doses2
  • Through 2025, Valneva has the opportunity to purchase up to 90 million extra doses. (medgadget.com)
  • Experiment 3: Building upon the outcomes of Experiment 1, the study will assess intranasal CBD doses that yield significant brain exposure in rat models of anxiety and chronic pain. (mystateline.com)
Onset1
  • Other potential drug candidates for nasal administration include anaesthetics, antihistamines (Azelastine), antiemetics (particularly metoclopramide and ondansetron) and sedatives that all benefit from a fast onset of effect. (wikipedia.org)
Preclinical1
  • A preclinical efficacy service provide with proven track record of intranasal delivery is needed to support the program. (scanbalt.org)
Anthrax1
  • Development of an intranasal anthrax vaccine is ongoing through BlueWillow's partnership with Porton Biopharma Limited (PBL) under contract #HHSN272201600045C from NIAID for the development of a next-generation NanoVax ® anthrax vaccine. (bluewillow.com)
Injection2
  • Currently, nucleic acid therapies may be delivered via intermittent administration intrathecally or via intracerebroventricular injection or may be introduced by intraparenchymal injection of viral vectors encoding these therapies. (scientificarchives.com)
  • Any licensed influenza vaccine (injection and intranasal) appropriate by age and health status can be used for vaccination. (aap.org)
Delivery8
  • The recent developments in intranasal drug delivery systems are prodigious. (wikipedia.org)
  • Local administration methods of therapeutic agents, such as convection enhanced delivery and intracerebral injections, are often associated with adverse events. (iozk.de)
  • This article explores the rationale for intranasal drug delivery and the key intranasal drug product formulation design and optimization considerations that can help ensure safe and effective product performance and manufacturability. (catalent.com)
  • atai has initiated a Phase 1 proof-of-concept clinical trial to demonstrate the safety, tolerability, and direct-to-brain delivery of intranasal INB-01, a sol-gel based drug-delivery technology. (psychedelicfinance.com)
  • NEW YORK and BERLIN, Oct. 18, 2022 (GLOBE NEWSWIRE) -- atai Life Sciences ("atai" or the "Company") (NASDAQ: ATAI), a clinical-stage biopharmaceutical company aiming to transform the treatment of mental health disorders today announced the initiation of the Phase 1 proof-of-concept (PoC) clinical trial of intranasal INB-01, a sol-gel based, excipient (drug-delivery) technology. (psychedelicfinance.com)
  • These results are a promising predictor for the use of INB-01 in human subjects for intranasal direct-to-brain drug delivery. (psychedelicfinance.com)
  • A non-invasive method of drug delivery, intranasal atomization, has shown positive results in human medicine and in some animal species. (awionline.org)
  • In addition, intranasal delivery results in broader protection due to the presence of nasal-associated lymphoid tissue (NALT). (tritonmarketresearch.com)
Nasal cavity2
Results1
  • The results from this study in the male demographic we are targeting for commercialization, combined with results from our study reported last August, are intended to further address concerns raised by the Food and Drug Administration," said Trevor Hallam , Ph.D., Executive Vice President of Research and Development of Palatin. (palatin.com)
Primarily2
  • The overall objective of this review is to discuss the key features in the design of nanocarriers for intranasal administration of gene-therapy for HD, focusing primarily on our series of published work on the use of nanocarriers for gene therapy. (scientificarchives.com)
  • 2 However, the roots of opioid crisis lay much closer to the contemporary era, primarily in the 1990s when drug companies falsified data in order to convince both the Drug Enforcement Administration (DEA) and prescribers that opioids were safe and effective by citing the high number of patients with undertreated pain. (pharmacytimes.com)
Study2
  • Data from this study will be submitted to the Food and Drug Administration. (palatin.com)
  • The objective of this study was to evaluate the effects of intranasal atomization, compared to. (awionline.org)
Overdose1
  • Intranasal administration has been available in the overdose tool kits since 2016. (ottawa.edu)
Development2
  • The challenge is sponsored by BARDA DRIVe, and includes partnerships with two National Institutes of Health institutes ( National Center for Advancing Translational Sciences (NCATS) and National Institute of Child Health and Human Development (NICHD)), and the Health Resources & Services Administration (HRSA) Maternal & Child Health Bureau (MCHB). (uelmn.org)
  • The development of animal models provide opportunities for more accurate risk assessment data. (cdc.gov)
Autism1
  • By advancing our knowledge, we can promote acceptance, inclusion, and meaningful opportunities for individuals with autism and their families. (supportivecareaba.com)
Drugs1
  • Drugs for continuous and frequent administration may be less suitable because of the risk of harmful long-term effects on the nasal epithelium. (wikipedia.org)
Variability1
  • Nasal administration has also been associated with a high variability in the amount of drug absorbed. (wikipedia.org)
Research2
  • Uncover major shifts and emerging opportunities with our exclusive PRO research. (trendhunter.com)
  • This Funding Opportunity Announcement (FOA) encourages grant applications for Countermeasures Against Chemical Threats (CounterACT) Cooperative Research Projects (U01s). (nih.gov)
Application1
  • Objective 2: Demonstrating the pharmacological relevance of brain CBD concentrations following intranasal application (Experiment 3). (mystateline.com)
Human1
  • Daily administration of m-chlorophenylpiperazine to healthy human volu. (erowid.org)
Provide1
  • Case Studies provide an opportunity for students to apply the foundational knowledge presented in the chapter and strengthen their critical-thinking skills. (paramedicshop.com.au)
Make1
  • We have an opportunity to make a difference right now, to help protect our communities, and to set the stage for a dramatically improved approach to prevention as the country continues to fight against the spread of infection and takes steps to embrace a return to normalcy. (pharmiweb.com)
Food and Drug Admin3
  • Government agencies are attempting to stop this devastating public health crisis, regulatory bodies are facing criticism over opioid approvals, and lawmakers are putting public pressure on the U.S. Food and Drug Administration (FDA) to take action. (worldwide.com)
  • Alcon, Inc. has announced that the U.S. Food and Drug Administration (FDA) has approved PATANASE(R) (olopatadine hydrochloride) nasal spray for the relief of the symptoms of seasonal allergic rhinitis in patients 12 years of age and older. (news-medical.net)
  • FDA U.S. Food and Drug Administration. (cdc.gov)
System1
  • Figure 1 highlights the nasal-pharyngeal-associated lymphoid tissue (NALT) that constitutes the nasal immune system and is consequently the primary target for intranasal vaccination. (ondrugdelivery.com)
Market2
  • The commercial opportunity for bremelanotide is significant with an estimated market of $500 million to $600 million per year. (palatin.com)
  • Which region is expected to create the most profitable market opportunities? (dailyhover.com)