Onset atherosclerosis. Medical search. Frequent questions

This hypometabolism pattern implicates midlife cardiovascular risk factors and carotid atherosclerosis in Alzheimer's disease decades before the typical age of symptom onset, noted Neal Parikh, MD, of Weill Cornell Medicine in New York City, and Rebecca Gottesman, MD, PhD, of Johns Hopkins University in Baltimore, in an accompanying editorial . (medpagetoday.com)
For the first time, scientists have been able to detect signs of Alzheimer's disease 10 to 20 years before the onset of dementia. (technologyreview.com)
The mutations that cause early-onset Alzheimer's are different from those that increase the risk of developing the disease. (technologyreview.com)
For those suffering from adult-onset diabetes, atherosclerosis, Parkinson's and Alzheimer's disease, or any form of autoimmune disease such as multiple sclerosis or lupus, DHEA replacement therapy is highly recommended. (elixirnews.com)

Aims: Subclinical carotid atherosclerosis adds predictive value to traditional risk factors for cardiovascular diseases (CVDs). (lu.se)
We aim to investigate whether and how subclinical carotid atherosclerosis affects the performance of SCORE2. (lu.se)
Using SCORE2 without considering carotid atherosclerosis could under- or over-estimate the risk. (lu.se)
Lay Summaries: Subclinical carotid atherosclerosis is an important consideration in cardiovascular risk estimation by Systematic Coronary Risk Assessment 2 (SCORE2). (lu.se)
The next step will be to determine whether individuals with subclinical atherosclerosis in the carotid arteries and low brain metabolism at the age of 50 go on to experience cognitive decline 10 years later. (medpagetoday.com)
Furthermore, these data suggest that carotid atherosclerosis -- carotid atherosclerosis alone, and above and beyond comorbid cardiovascular risk factors -- may be detrimental to brain health even when it is subclinical and nonstenosing," they wrote. (medpagetoday.com)
In the younger women, there was slowing of atherosclerosis progression, as measured by carotid IMT in the estradiol arm compared with the placebo arm, and the differences were statistically significant. (medscape.com)

Intima-media thickness (IMT) is increasingly used as a surrogate end point of vascular outcomes in clinical trials aimed at determining the success of interventions that lower risk factors for atherosclerosis and associated diseases (stroke, myocardial infarction and peripheral artery diseases). (karger.com)
Atherosclerosis is the fundamental cause of a series of diseases, such as myocardial infarction, stroke and gangrene ( 2 ). (spandidos-publications.com)

Low levels of omega-3 fatty acids are associated with early-onset coronary atherosclerosis. (foundmyfitness.com)
It was observed that many of the risk factors for cardiovascular diseases begin in childhood, including high blood pressure, which can lead to coronary atherosclerosis and left ventricular hypertrophy 10 . (bvsalud.org)

Chronic inflammation plays a critical role in the progression of atherosclerosis (AS). (medsci.org)
During this process, many inflammatory factors are released, leading to aggravated progression of atherosclerosis and the formation of atherosclerotic plaques ( 7 ). (spandidos-publications.com)
Although it is biologically plausible that estrogen would reduce progression of atherosclerosis in early but not later menopause, we know that the estrogen receptors are more functional in early menopause. (medscape.com)

During atherosclerosis, the narrowing of the arterial lumen is observed through the accumulation of bio compounds and the formation of plaque within artery walls. (springer.com)
Atherosclerosis is a progressive disease, with a characteristic increase in lipid accumulation, inflammation, and plaque formation within the arterial walls [ 1 ]. (springer.com)
Therefore, we investigated the possible association of ACE gene insertion/deletion (I/D) polymorphism and the severity of atherosclerosis, estimated on the basis of the number of coronary stenoses and critical arterial occlusions observed during coronary angiography. (degruyter.com)
The exact mechanisms of pulmonary arterial remodelling that lead to the onset and progression of PH are still largely unclear. (ersjournals.com)
It is well known that endothelial dysfunction and arterial stiffness mark the onset of atherosclerosis and are associated with adverse CVD events. (acc.org)
Atherosclerosis leads to peripheral arterial disease, coronary heart disease, stroke and heart attacks. (technologynetworks.com)
Atherosclerosis is the most common form of arteriosclerosis, which is a general term for several disorders that cause thickening and loss of elasticity in the arterial wall. (msdmanuals.com)

Coronary artery calcification (CAC) provides a reliable measure of atherosclerosis. (foundmyfitness.com)

We were the first group to show the role of Wnt signaling in atherosclerosis and the first to establish a genetic link between exocrine and endocrine pancreas in pathogenesis of diabetes. (yale.edu)
Vascular endothelial cells serve a key role in the pathogenesis of atherosclerosis by regulating vascular tension, platelet adhesion, inflammation and fibrinolysis ( 5 ). (spandidos-publications.com)
Therefore, the study of ox-LDL-mediated endothelial cell dysfunction can further clarify the pathogenesis of atherosclerosis and provide a more theoretical basis for the treatment and prevention of atherosclerosis. (spandidos-publications.com)
Atherosclerosis has a major impact on the pathogenesis of cardiovascular diseases. (bvsalud.org)

6 hours) versus late (6-24 hours) times from stroke onset and in the presence versus absence of large-vessel occlusion. (ajnr.org)
However, this was stronger in patients with large-vessel occlusion and longer delay from stroke onset. (ajnr.org)
Diabetes increases the risk of death from cardiovascular diseases such as stroke, coronary heart disease and atherosclerosis. (buckingham.ac.uk)
Heart Damage - A number of cardiovascular diseases have also been linked to air pollution including that of heart disease, stroke and atherosclerosis. (field.org.uk)

ObjectiveTo determine the risk of dementia after the development of late-onset epilepsy.MethodsWe used data from the Atherosclerosis Risk in Communities (ARIC) cohort study, which started in 1987 to 1989 with 15,792 mostly Black and White men and women from 4 US communities. (johnshopkins.edu)
Researchers say the results will help them test drugs that could prevent or slow the progression of the disease, not only in these groups, but also in people with the more common late-onset variety. (technologyreview.com)

Peripheral vascular disease (PVD ), or atherosclerosis of peripheral vessels, is the most common cause of symptomatic stenosis in the human vascular tree. (medscape.com)
Onset of peripheral neuropathy may be delayed several weeks after the initial toxic insult. (cdc.gov)

Coronary artery atherosclerosis, a narrowing of the heart's arteries caused by a buildup of plaque, is the single leading cause of death worldwide. (foundmyfitness.com)
Additionally, the decline in estrogen production with the onset of menopause also increases the loss of calcium from bone and calcium deposition in arteries. (knowledgeofhealth.com)
Chemicals in tobacco smoke contribute to the build-up of plaque in the arteries, increasing your risk of atherosclerosis . (epnet.com)
Cardiovascular disease arising from atherosclerosis (thickening of the arteries) kills around 17 million people worldwide each year, including 120,000 people in England and Wales, while rheumatoid arthritis affects around 400,000 people in the UK. (sciencedaily.com)
Furring of the arteries, atherosclerosis, is a leading cause of death across the world. (technologynetworks.com)
Atherosclerosis is characterized by patchy intimal plaques (atheromas) that encroach on the lumen of medium-sized and large arteries. (msdmanuals.com)
Atherosclerosis, a long-term inflammatory and immune condition affecting medium- and large-sized arteries, results in the thickening of artery walls and the accumulation of inflammatory cells and fatty streaks that establish fibrous capsules with macrophages at the site of injury. (bvsalud.org)

Matthew Meyerson relaxes during his computerized hunt for the unknown causes of diseases such as juvenile onset diabetes, rheumatoid arthritis, and different types of cancers. (harvard.edu)
These unexpected findings shed light on the very early stages in the development of inflammatory diseases such as atherosclerosis and rheumatoid arthritis," said lead author Dr Samuel Fountain of UEA's School of Biological Sciences. (sciencedaily.com)
June 13, 2019 A new study finds that antibodies that exist in the joints before the onset of rheumatoid arthritis can cause pain even in the absence of arthritis. (sciencedaily.com)

Atherosclerosis, which is believed to be the common pathophysiological basis of cardiovascular disease, is caused by inflammation, oxidative stress, and impaired lipid metabolism [ 2 , 3 ] . (medsci.org)
Inflammation and dyslipidemia together accelerate atherosclerosis [ 4 ] . (medsci.org)
However, the mechanisms underlying inflammation-mediated lipid metabolism dysregulation in accelerated atherosclerosis in ESRD are not completely understood. (medsci.org)
Inflammation and immunity are key factors for the development and complications of atherosclerosis, and therefore, the whole atherosclerotic process is a target for diagnosis and treatment. (hindawi.com)
Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis. (nih.gov)

Women with premature ovarian insufficiency (POI) have a higher risk of premature atherosclerosis and unfavorable lipid profiles. (menopause.org.au)
Premature atherosclerosis is also associated with mutations in the ABCC6 gene. (wikidoc.org)
Premature atherosclerosis is also associated with mutations in the ABCC6 gene, even in those without PXE. (wikidoc.org)

Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. (hindawi.com)
At the onset of atherosclerosis, LDL is deposited on vascular endothelial cells to be oxidized to form ox-LDL, which is then absorbed by macrophages to form foam cells. (spandidos-publications.com)
Annibale Puca, Head of the laboratory at the IRCCS MultiMedica and Professor at the University of Salerno, added: "Gene therapy with the healthy gene in mouse models of disease has already been shown to prevent the onset of atherosclerosis, vascular aging, and diabetic complications, and to rejuvenate the immune system. (sflorg.com)

The drastic decline in DHEA that occurs in maturing adults coincides with the onset of a host of age-related diseases. (lifeextension.com)
As most members know, DHEA is abundantly produced in healthy young adults, but its levels decline dramatically with advancing age, 1,2 coinciding with the onset of numerous diseases of aging. (lifeextension.com)
Background: Early-onset atherosclerosis is a marker of future cardiovascular diseases. (bvsalud.org)
They also affirmed that this can lead to the earlier onset of diabetes mellitus type 2 and atherosclerotic diseases 9 . (bvsalud.org)

There is now robust and compelling data suggesting that, apart from quality-of-life issues, prevention of coronary disease, reduction in osteoporosis and fracture risk, reduction in new-onset diabetes mellitus and all-cause mortality occur6. (menopause.org.au)

Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
While DHEA's demonstrated anti-aging benefits have made it a popular supplement, powerful new evidence supports DHEA's critical role in alleviating depression, 8,9 enhancing endothelial function, 10-12 preventing atherosclerosis, 13-15 increasing bone mass, 16-18 slowing osteoporosis, 16-18 improving insulin resistance, 19,20 and even hastening wound healing. (lifeextension.com)
Oxidized low-density lipoprotein (ox-LDL) is widely recognized to participate in the occurrence and development of atherosclerosis through inducing oxidative chain reaction and endothelial dysfunction ( 6 ). (spandidos-publications.com)

The drugs giant has been marketing the intravenous form of the drug, as Brinavess, in the European Union and Latin America for the rapid conversion of recent onset atrial fibrillation and was looking to launch the product in 30 additional countries this year. (pharmatimes.com)

A new study suggests that low levels of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with increased risk of early-onset coronary artery atherosclerosis. (foundmyfitness.com)
Of these, low blood levels of EPA and DHA were positively associated with early onset of coronary artery atherosclerosis, suggesting a protective role for omega-3 fatty acids in cardiovascular disease. (foundmyfitness.com)
Fortunately, the natural history of CAD is characterized by early onset and a long dormant phase. (medscape.com)
By recruiting more than thousand kindreds with early onset CAD and multiple metabolic risk factors for genetics and metabolic studies we have been able to map, identify and characterize a dozen of human disease genes for CAD and MetS, which have been reported in leading journals such as Nat Genet, Science, NEJM, Cell Metab, JCI, PNAS, AJHG, etc. (yale.edu)
The aim of this study was to comprehensively identify proteins that are enriched in amyloid plaques using unbiased proteomics in two subtypes of early onset AD: sporadic early onset AD (EOAD) and Down Syndrome (DS) with AD. (researchsquare.com)
We focused our study on early onset AD as the drivers of the more aggressive pathology development in these cases is unknown and it is unclear whether amyloid-plaque enriched proteins differ between subtypes of early onset AD. (researchsquare.com)
Familial hypercholesterolemia is a well-known genetic disease caused by a mutation in the LDL receptor which causes early onset atherosclerosis. (technologynetworks.com)
The study used data from the PESA (Progression of Early Sub-clinical Atherosclerosis) study of white employees, ages 40 to 54, of a Madrid bank with no clinically apparent cardiovascular disease. (medpagetoday.com)
MATR3 haploinsufficiency and early-onset neurodegeneration. (nih.gov)
The onset of tobacco use occurs primarily in early adolescence, a developmental stage that is several decades removed from the death and disability that are associated with smoking and smokeless tobacco use in adulthood. (cdc.gov)
[ 1 ] The trial included 643 women, about half of whom were in early menopause (within 6 years of onset) with a mean age of 55 years. (medscape.com)

[ 1 ] The prevention and treatment of atherosclerosis requires control of the known modifiable risk factors for this disease. (medscape.com)
In addition, addressing risk factors with lifestyle changes is an integral part of atherosclerosis prevention. (medscape.com)
Systematic Coronary Risk Assessment 2 (SCORE2), an algorithm composed of traditional risk factors, is a state-of-the-art to estimate the 10-year risk of first-onset CVDs. (lu.se)
Given the variations in age of onset and severity it is likely that other unknown risk factors (genetic and dietary) may be involved. (wikidoc.org)
This video presents following topics about Atherosclerosis: Definition Epidemiology Risk factors Clinical aspects. (drbeen.com)
The careful targeting of these risk factors -- on a communitywide basis -- has proven successful in preventing the onset and development of tobacco use among young people. (cdc.gov)

We leverage modern techniques of functional genomics, epigenetics, transcriptomics, proteomics, gene editing and model-driven experimentation to understand the underlying causes of atherosclerosis and metabolic syndrome and discover therapeutic targets. (yale.edu)
One of our groundbreaking discoveries was the identification of founder mutations in the DYRK1B gene, underlying atherosclerosis, metabolic syndrome, and fatty liver disease. (yale.edu)

Age of onset and clinical manifestations may vary widely among patients with a given lysosomal storage disease, and significant phenotypic heterogeneity between family members carrying identical mutations has been reported. (medscape.com)

In addition to atherosclerosis, there can be plaque rupture and thrombotic occlusion of the blood vessel. (medscape.com)

Why do women experience a steep increase in heart attacks with the onset of menopause? (knowledgeofhealth.com)
Some experts are now recommending that HRT should be considered as part of a general prevention strategy for women at the onset of the menopause [2]. (menopause.org.au)
Half of the women were in later menopause (at least a decade since onset) and had a mean age of 63 years. (medscape.com)

The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated with the severity of atherosclerosis" Clinical Chemistry and Laboratory Medicine , vol. 46, no. 4, 2008, pp. 446-452. (degruyter.com)
Dr Ellen Keeley continued, "This biomarker test, which only requires a blood sample, could be further developed to predict the risk of silent atherosclerosis in clinical practice. (technologynetworks.com)

Liu QJ, Yuan W, Yang P, Shao C. Role of glycolysis in diabetic atherosclerosis. (wjgnet.com)

New research shows that DHEA protects against atherosclerosis, improves insulin sensitivity, increases bone mass, and promotes well-being. (lifeextension.com)

Niemiec, P., Zak, I. and Wita, K. (2008) The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated with the severity of atherosclerosis. (degruyter.com)

We cannot say definitively that estradiol was preventing heart attacks in these women, but there was evidence for slowing of atherosclerosis in the younger women. (medscape.com)

Nevertheless, prevention of cardiac events is likely to have the largest impact on decreasing the burden of atherosclerosis. (medscape.com)
These findings strongly suggest that the largest impact on decreasing the global burden of atherosclerosis will come from prevention of events. (medscape.com)
Therefore, S/V might be utilized as a promising therapeutic strategy for the prevention and treatment of atherosclerosis. (spandidos-publications.com)

The median time to dementia ascertainment after the onset of LOE was 3.66 years (quartile 1-3, 1.28-8.28 years).InterpretationThe risk of incident dementia is substantially elevated in individuals with LOE. (johnshopkins.edu)

Systemic juvenile idiopathic arthritis (sJIA), adult-onset Still's disease (AOSD), gout, and pseudogout: rheumatologist. (aetna.com)

Molecular imaging with radionuclide-based approaches may potentially provide a novel noninvasive assessment of biologic processes in PVD, such as angiogenesis and atherosclerosis. (medscape.com)

The current study aimed to evaluate how adding Oridonin to a diet impacts the onset of atherosclerosis. (bvsalud.org)

The study's high proportion of males, racial homogeneity, and inclusion only of people with atherosclerosis also limited generalizability. (medpagetoday.com)
In a pilot study, 30 rural Iowan males ages 44-73 at the study onset, about half farm ers, were evaluated. (cdc.gov)

The treatment goals for patients with coronary artery atherosclerosis are to relieve symptoms of coronary artery disease (CAD) and to prevent future cardiac events, such as unstable angina, AMI, and death. (medscape.com)
Large, multicenter randomized trials of various pharmacologic modalities have recently achieved great success in the treatment of patients with coronary artery atherosclerosis. (medscape.com)
Oxidation of low-density lipoprotein (LDL) cholesterol is crucial in the development of atherosclerosis, and low LDL levels reduce the risk of major events in patients with CVD [ 6 ]. (hindawi.com)

Atherosclerosis (AS) is one of the most common complications of diabetes. (wjgnet.com)

Managing blood glucose levels can reduce the risk or delay onset of CAD for people with diabetes. (epnet.com)
However, atherosclerosis is a sneaky killer - most people do not realize they have it until they have cardiovascular disease (CV). (technologynetworks.com)
People with two copies of the mutated LDL receptor (homozygous) have an even higher risk of atherosclerosis than those with one mutated and one normal copy (heterozygous). (technologynetworks.com)
Of 946 participants with evidence of asymptomatic atherosclerosis, the researchers evaluated 547 people with full brain 18 F-fluorodeoxyglucose (FDG) PET to assess cerebral hypometabolism. (medpagetoday.com)
Atherosclerosis is rapidly increasing in prevalence in low and middle income countries, and as people live longer, incidence will increase. (msdmanuals.com)
Cardiovascular disease onset in old people with severe hypercholesterolemia. (cdc.gov)
This report examines the past few decades' extensive scientific literature on the factors that influence the onset of use among young people and on strategies to prevent this onset. (cdc.gov)

Low PON1 activity levels have been associated with increased risk for atherosclerosis and other disorders. (cdc.gov)

Pancreas Damage - Air pollution has been linked to the onset of Type 2 Diabetes. (field.org.uk)

Under normal conditions, a thrombus is confined to the immediate area of injury and does not obstruct flow to critical areas, unless the blood vessel lumen is already diminished, as it is in atherosclerosis . (medscape.com)

Oxidation of low-density lipoprotein (LDL) cholesterol is one of the key factors for the development of atherosclerosis. (hindawi.com)

Researchers found that family members who carried the disease gene showed an increase amyloid beta protein in the blood and CSF about 30 years prior to the expected onset of the disease compared to noncarrier family members. (technologyreview.com)

Atherosclerosis has become a common disease, which increasingly threatens human health. (spandidos-publications.com)
Within 10 to 15 years of the expected onset, that high level dropped to lower than noncarriers, while levels of tau, another protein associated with the disease, increased. (technologyreview.com)
Examining changes in the newly identified markers will help them assess whether a particular treatment is working without having to wait 20 years for the outward onset of disease. (technologyreview.com)

The therapeutic effect of sacubitril/valsartan (S/V) on heart failure has been confirmed, while its role in atherosclerosis remains largely unexplored. (spandidos-publications.com)

Anatomy31

Organisms7

Diseases51

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Psychiatry and Psychology1

Phenomena and Processes42

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science2

Named Groups6

Health Care28

Geographicals6

Alzheimer's4

Carotid7

Myocardial infarction2

Coronary atherosclerosis2

Progression of atherosclerosis3

Arterial7

Calcification1

Pathogenesis4

Stroke4

Late-onset2

Peripheral2

Arteries7

Rheumatoid arthritis3

Inflammation6

Premature3

Vascular3

Diseases4

Diabetes mellitus1

Endothelial3

Atrial fibrillation1

Early11

Risk factors6

Metabolic2

Mutations1

Plaque1

Menopause3

Clinical2

Diabetic1

Improves1

Severity1

Heart attacks1

Prevention3

Dementia1

Systemic1

Biologic1

Study aimed1

Males2

Patients3

Complications1

People7

Disorders1

Damage1

Lumen1

Development1

Researchers1

Disease3

Largely1