Oncogenic viruses. Medical search. Frequent questions

Under certain conditions the virus can cause several human cancers, that include lymphoproliferative disorders such as Burkitt and Hodgkin lymphomas and non-lymphoid malignancies such as 100% of nasopharyngeal carcinoma and 10% of gastric cancers. (inrae.fr)
Ludwik Gross (September 11, 1904 - July 19, 1999) was a Polish-American virologist who discovered two different tumor viruses-murine leukemia virus and mouse polyomavirus-capable of causing cancers in laboratory mice. (wikipedia.org)
Gross was a major proponent of the possibility that some cancers could be caused by viruses, and began a long search for viral causes of murine leukemia. (wikipedia.org)
In the course of these studies, he isolated the Gross murine leukemia virus strain, as well as the first polyomavirus (so named for its proclivity to cause cancers in multiple tissue types). (wikipedia.org)
Dr. Ludwik Gross, who influenced cancer research by showing that viruses could cause cancers in animals, died on Monday at Montefiore Medical Center in the Bronx. (wikipedia.org)
It took many decades before the seminal contributions of several virologists studying cancers were appreciated, such as Peyton Rous' 1911 discovery of the Rous sarcoma virus (which caused tumors in chickens), and discoveries of Richard Shope (rabbit fibroma) and John Bittner (mouse mammary carcinoma) in the 1930s. (cdc.gov)
PURPOSE: To test the hypothesis that exposure to poultry oncogenic viruses that widely occurs occupationally in poultry workers and in the general population, may be associated with increased risks of deaths from liver and pancreatic cancers, and to identify new risk factors. (cdc.gov)
CONCLUSIONS: This study provides preliminary evidence that exposure to poultry oncogenic viruses may possibly be associated with the occurrence of liver and pancreatic cancers. (cdc.gov)
Overall, 430 (66.8%) cancers were related to oncogenic viruses: 166/430 human papillomavirus, 232/430 herpes virus 8 and EBV and 32/430 HBV and/or HCV. (natap.org)
A significant proportion of cancers were related with oncogenic virus coinfection. (natap.org)
There is also emerging evidence that human papillomavirus (HPV) is responsible for inconsistencies in HNSCC trends, with oncogenic HPV DNA found in approximately half of oropharyngeal cancers and in a high proportion of oropharyngeal cancers in nonsmokers and nondrinkers. (cancernetwork.com)
The polyomavirus Simian Virus 40, an oncogenic DNA virus, was previously removed from polio vaccines due to concerns about a link to cancers. (theepochtimes.com)
Describe about the biology and the replicative cycle of viruses associated with cancers. (fun-mooc.fr)
About 20% of human cancers are induced by viruses, particularly in low/middle income countries, to a point that in some regions of the world, viral infection is the main etiology of human cancers. (fun-mooc.fr)
Both DNA and RNA viruses have been linked with human cancers. (fun-mooc.fr)
Epstein-Barr virus, papillomaviruses, hepatitis B virus, human herpesvirus-8 and Merkel cell polyomavirus are the five DNA viruses that are capable of causing the development of human cancers. (fun-mooc.fr)
Human T lymphotrophic virus type 1 and hepatitis C virus are the two RNA viruses that contribute to human cancers. (fun-mooc.fr)
In support of her research into the role of signaling proteins in the pathogenesis of viral associated cancers such as Kaposi's sarcoma associated herpes virus or K.S. HIV. (bwfund.org)
In the specific case of the association between the HIV virus and Kaposi sarcoma, as well as some other cancers. (bwfund.org)
The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. (educate-yourself.org)
Papilloma viruses (HPV), hepatitis B- (HBV) and C-viruses (HCV), Epstein-Barr virus (EBV), Kaposi sarcoma virus (KSHV), human T-cell-leukemia virus (HTLV) may contribute to the pathogenesis of as much as 15-20% of all human cancers. (ki.se)
Most people are familiar with human papilloma viruses for their role in genital wart infections and later cervical cancers," said Dr. Davis. (rxwiki.com)
In particular, vaccines targeting oncogenic viruses, such as the human papillomavirus and the hepatitis B virus, are exceptional examples of successful prevention of virus-associated cancers, such as cervical cancer and hepatocellular carcinoma. (jci.org)

Polio vaccines used in the late 1950s and early 1960s were found to be contaminated with SV40 as the virus was present in monkey kidney cells that were used to grow the vaccine. (theepochtimes.com)
In addition, novel approaches such as adoptive cell therapy, oncogenic viruses, vaccines and different strategies of drug administration including sequential, or combination treatment are being tested. (nki.nl)
Simian virus 40 (SV40), a polyomavirus of rhesus macaque origin, was discovered in 1960 as a contaminant of polio vaccines that were distributed to millions of people from 1955 through early 1963. (educate-yourself.org)
The emergence of viral mutants and yet unknown viruses could push vaccines to their limits. (gesundheitsindustrie-bw.de)
Current research has focused on the determinants of infection with oncogenic HPV types, the assessment of prophylactic and therapeutic vaccines and the development of screening strategies incorporating HPV testing and other methods as adjunct to cytology. (cmaj.ca)

To date, seven viruses have been reliably connected to various forms of human cancer: Epstein Barr Virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), high-risk Human papillomavirus (HPV), Merkel Cell Polyomavirus (MCPV), Hepatitis B virus (HBV), hepatitis C virus (HCV), and Human T-cell leukemia virus type 1 (HTLV1). (physiciansweekly.com)
Lymphomagenesis are discovered in associated with EBV, HTLV-I, Human Immunodeficiency virus (HIV), Kaposi sarcoma - associated herpes virus and hepatitis c virus. (physiciansweekly.com)
Chronic infections, particularly those which are primarily characterized by an asymptomatic intracellular life cycle, e.g., latent Mycobacterium tuberculosis infection (LTBI), hepatitis B virus (HBV) infection, Chlamydia trachomatis infection, cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infections, present a unique premise to decipher the fine balance between protective host immune responses, immunopathology and full-fledged clinical disease. (frontiersin.org)
The Hepatobiliary Cancer Lab is identifying the key functions and pathways related to hepatitis B virus integration by examination of specific hepatitis B virus integration events. (mayo.edu)
These include the hepatitis B and hepatitis C viruses, which can lead to chronic infections and liver cancer and claim more than a million lives each year. (pasteur.fr)
Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6 J Virol. (usc.edu)
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission Immunity. (usc.edu)
Hepatitis C virus and autophagy Biol Chem. (usc.edu)
TNF-a Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism PLoS Pathog. (usc.edu)
Technical standards for hepatitis B virus X protein (HBx) research Hepatology. (usc.edu)
Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinoma Virol Sin. (usc.edu)
Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry J Biol Chem. (usc.edu)
Viral-load-dependent effects of liver injury and regeneration on hepatitis B virus replication in mice J Virol. (usc.edu)
Replication of hepatitis C virus RNA on autophagosomal membranes J Biol Chem. (usc.edu)
Enhancement of hepatitis B virus replication by androgen and its receptor in mice J Virol. (usc.edu)
Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling PLoS One. (usc.edu)
Hepatitis C virus translation preferentially depends on active RNA replication PLoS One. (usc.edu)
Autophagy required for hepatitis B virus replication in transgenic mice J Virol. (usc.edu)
Krüppel-like factor 15 activates hepatitis B virus gene expression and replication Hepatology. (usc.edu)
Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury PLoS One. (usc.edu)
Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes J Immunol. (usc.edu)
Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo J Virol. (usc.edu)
B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV). (cdc.gov)
The two Groups have also the estimation of the global burden of intensively col aborated to better cancer attributable to hepatitis B virus understand the natural history of HPV and hepatitis C virus infection, and infection in the oral cavity and to further that due to HIV after the introduction of define the role of the viral infection in the antiretroviral treatment. (who.int)

This mini-review summarizes two of these viruses, EPV and HTLV-1, in terms of their general pathway of infection, the key mechanism of cancer induction, and the prominent technologies used to detect the infections. (physiciansweekly.com)
These two viruses contrast in their genetic structure, location of the infection, and latency, yet clinically, they generate similar cancer disorders. (physiciansweekly.com)
After the primary infection, the virus persists lifelong in the memory B cells of the infected individuals. (inrae.fr)
Human papilloma virus (HPV) infection is presently very frequent and contagious, it being considered a very prevalent and multi-focal STD. (scirp.org)
Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells. (harvard.edu)
During virus infection, the specific immune signals produced from infected cells are important for dictating the recruitment and activation of innate or adaptive immune cells that are required to fight virus infection. (nature.com)
For SARS-CoV-2, lung epithelial cells are the primary site of infection and therefore are responsible for initiating immune responses to virus infection. (nature.com)
In addition to direct viral sensing, cells have also evolved ways to detect the indirect effects of virus infection, such as nuclear or mitochondrial damage caused by the heavy cellular burden imposed by virus replication. (nature.com)
Moreover, cGAS is an important molecule for regulating basal expression levels of cell-intrinsic immune genes in cells and is, therefore, a central protein in immune responses to virus infection 10 . (nature.com)
Epstein-Barr virus (EBV) infection, malaria, immunodeficiency and spontaneous, somatic mutation can all contribute to the origin and maintenance of this cancer and their mechanisms are the subject of this review. (bmj.com)
Three other recent studies have identified an association between infection with SARS-CoV-2, the virus that causes COVID-19, and the development of Alzheimer's disease, thyroid dysfunction and cancer. (wsws.org)
it is posited that the effects of a SARS-CoV-2 infection may be similar to other oncogenic (cancer-causing) viruses in their impact on the RAS system. (wsws.org)

The objectives of the meeting are to discuss and to critically evaluate the epidemiology, immunology, and biology of cancer-associated viruses. (who.int)
Epidemiology, Biostatistics, Al finalizar el curso los cursantes deberán estar en condiciones de interpretar y realizar análisis crítico de la literatura científica elaborada según el método hipotético deductivo. (bvsalud.org)
The epidemiology and specificity of each type of virus and of the induced tumor will then be given in detail. (fun-mooc.fr)
• "The enemy vs. the first line of defense" with Sandie Munier, a scientist in the RNA Biology of Influenza Virus Unit, and Philippe Afonso, group leader in the Oncogenic Virus Epidemiology and Pathophysiology Unit. (pasteur.fr)

Simultaneous presence of endogenous retrovirus and herpes virus antigens has profound effect on cell-mediated immune responses: implications for multiple sclerosis. (au.dk)
Our main virus model is EBV, a lymphotropic herpes virus that is associated with lymphoid and epithelial cell malignancies including Burkitt's lymphoma (BL), nasopharyngeal carcinoma (NPC), immunoblastic lymphoma (IL) and Hodgkin's disease (HD). (ki.se)
Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1. (ki.se)

SV40 as an oncogenic virus and possible human pathogen. (elsevierpure.com)
In the 70-ies of XX century, Italian scientist Renato Dulbecco in the works for the study of polyoma virus and monkey virus SV40 has proved all of the theories formulated by L. A. Zilber. (researchbib.com)
The health regulator says Pfizer did not disclose the presence of the Simian Virus 40 (SV40) DNA sequence in its mRNA COVID-19 vaccine at the time of filing. (theepochtimes.com)
Health Canada has confirmed the presence of a Simian Virus 40 (SV40) DNA sequence in the Pfizer COVID-19 vaccine, which the manufacturer had not previously disclosed. (theepochtimes.com)
Simian virus 40 (SV40) a monkey virus found for years in the polio vaccine and is a potent cancer agent. (educate-yourself.org)
SV40 is a potent DNA tumor virus that induces tumors in rodents and transforms many types of cells in culture, including those of human origin. (educate-yourself.org)

Several cellular oncogenes confer on FeLV the ability to induce sarcomas (see also SARCOMA VIRUSES, FELINE). (harvard.edu)
Yes, I think that many of these viruses, although they're very different from each other, they use very similar mechanisms or pathways to actually induce the transformation process of the oncogenic process. (bwfund.org)
So I think that understanding how one virus can induce transformation opens a window into how other oncogenic viruses in the human population also cause cancer. (bwfund.org)
ICB's findings showed that assays established by the Group, aiming has coordinated the HPV-AHEAD several oncogenic viruses have the to characterize the natural history of consortium, which included a multi- ability to induce epigenetic changes and several viruses at different anatomical disciplinary team in Europe and deregulate cel ular gene expression. (who.int)

Our research focuses on human tumor viruses. (ki.se)

Conclusions: We found a high prevalence of women who were carriers of oncogenic HPV in climacteric women with normal Pap smears (latent infections) in our health region. (scirp.org)
A common feature of these oncogenic viruses is their capacity to establish persistent infections that are either asymptomatic or are accompanied by benign cell proliferations. (ki.se)

Herpes simplex virus (HSV), human papillomavirus (HPV), Epstein-Barr virus (EBV), and Kaposi sarcoma-associated herpesvirus (KSHV) are associated with other premalignant and carcinogenic conditions leading to oral cancer. (bvsalud.org)

Viruses that produce tumors. (wakehealth.edu)
In 1944, when Stewart requested support to study the link between animal tumors and viruses, the directors of the NIH Laboratory of Microbiology and the National Cancer Institute (NCI) refused on the grounds that the proposal seemed dubious and that she lacked appropriate qualifications. (cdc.gov)
So in 1956, when Stewart approached Eddy for assistance growing the agent causing parotid tumors in mice, Eddy readily agreed and the 2 women rapidly worked out the characteristics of the agent that was not referred to as a virus in their publications until 1959. (cdc.gov)
Together they showed that the virus produced 20 types of mouse tumors and could cause tumors in other small mammals. (cdc.gov)
At Eddy's suggestion, the virus was dubbed polyoma, which means many tumors, and they named it the SE (Stewart-Eddy) polyomavirus. (cdc.gov)
They also demonstrated that the virus causes cell necrosis and proliferation in cell culture, that it is highly antigenic, and that it leads to formation of specific antibodies in infected animals whether or not tumors develop. (cdc.gov)
In addition to spontaneously developing neoplastic diseases, tumors have been associated with parasitism and oncogenic viruses. (merckvetmanual.com)
The MOOC offers a broad overview of the state of knowledge on viruses associated with cancer, the different mechanisms of carcinogenesis, the host immune response and progress in preventing tumors. (fun-mooc.fr)
Define the role of the immune system in controlling these viruses and the induced tumors. (fun-mooc.fr)
At the end we will report innovations in the prevention of virus induced tumors. (fun-mooc.fr)

Gross murine leukemia virus is a retrovirus whose human counterpart is T cell lymphotropic virus I, while murine polyomavirus is closely related to the human Merkel cell polyomavirus that causes most forms of Merkel cell carcinoma. (wikipedia.org)

People with HIV (human immunodeficiency virus) or AIDS (acquired immunodeficiency syndrome) have a greater risk of developing some types of NHL. (cancer.ca)
Examples of retroviruses are the human immunodeficiency viruses and the human T-cell leukemia viruses. (msdmanuals.com)

Both the viruses can immortalize lymphocytes invitro and lymphomas are common manifestation of majority oncogenic viruses. (physiciansweekly.com)

A recently-published meta-analysis [1] shows a prevalence of HPV with oncogenic risk (with normal Pap smears) of 10.4%, increasing significantly with climacteric (45 - 55 years). (scirp.org)

To understand Stewart's role in catalyzing viral oncology research, it is necessary to recognize that until the 1950s, scientists dismissed the idea that viruses could cause cancer. (cdc.gov)
Immunological recognition of commensal microbes, such as bacterial species resident in the gut or lung as well as dormant viral species, i.e., cytomegalovirus (CMV) or Epstein-Barr virus (EBV), in combination with a balanced immune regulation, is central to achieve immune-protection. (frontiersin.org)
Like all plus-strand RNA viruses, the SARS-CoV-2 replication process within cells requires de novo production of viral RNA species, including single-strand (ss)RNA and double-strand (ds)RNA that can be sensed by cytosolic pattern recognition receptors (PRRs) subsequently activating antiviral pathways 7 . (nature.com)
The virus has viral proteins that it comes with that can modulate these host signal transduction pathways and the same signal transduction pathways that are modulated by one virus may also be modulated by other oncogenic viruses. (bwfund.org)
The co-evolution of viruses with their hosts has led to the selection of a broad repertoire of viral strategies for manipulation of the cellular environment. (ki.se)
Progression to malignancy is associated with the expression of viral proteins whose primary function is to drive virus replication by regulating cell proliferation, apoptosis and the recognition of infected cells by the immune system. (ki.se)
A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. (ki.se)
(3) The virus inserts its own genetic code into an infected cell and either destroys it to release viral particles or transforms it into a cancer cell giving it viral properties such as unlimited growth. (animalresearch.info)
Some viruses have an outer envelope consisting of protein and lipid, surrounding a protein capsid complex with genomic RNA or DNA and sometimes enzymes needed for the first steps of viral replication. (msdmanuals.com)

Tumorigenesis and diagnostic practice applied in two oncogenic viruses: Epstein Barr virus and T-cell lymphotropic virus-1-Mini review. (physiciansweekly.com)

The results of their collaboration were picked up by a 1959 Time Magazine cover story, citing John Heller, then the NCI director, "the hottest thing in cancer research is research on viruses as possible causes of cancer. (cdc.gov)
Eight viruses, one bacterium and three parasites have been classified as group 1 carcinogens (known to be carcinogenic to humans) by the International Agency for Research on Cancer, a division of the World Health Organization. (pasteur.fr)
New Research on Oncogenic Viruses. (au.dk)

Classification of viruses is principally according to their genome sequence taking into consideration nature and structure of their genome and their method of replication, but not according to the diseases they cause (see International Committee on Taxonomy of Viruses (ICTV), 2021 release ). (msdmanuals.com)
Certain single-strand, (+) sense RNA viruses termed retroviruses use a very different method of replication. (msdmanuals.com)

During this MOOC, we will review the different mechanisms of virus induced carcinogenesis, from direct integration of the virus in the genome to non-specific inflammation and immune disorders. (fun-mooc.fr)
Positive-sense RNA viruses possess a single-stranded RNA genome that can serve as messenger RNA (mRNA) that can be directly translated to produce an amino acid sequence. (msdmanuals.com)
Negative-sense RNA viruses possess a single-stranded negative-sense genome that first must synthesize a complementary positive-sense antigenome, which is then used to make genomic negative-sense RNA. (msdmanuals.com)
the genome of RNA viruses ranges from 3.5 kilobases (some retroviruses) to 27 kilobases (some reoviruses), and the genome of DNA viruses ranges from 5 kilobases (some parvoviruses) to 280 kilobases (some poxviruses). (msdmanuals.com)
This manageable size together with the current advances in nucleotide sequencing technology means that partial and whole virus genome sequencing will become an essential component in epidemiologic investigations of disease outbreaks. (msdmanuals.com)

Since the discovery of oncogenic viruses, the world scientific community has long been working on studying the mechanisms of their action. (researchbib.com)
Because RNA transcription does not involve the same error-checking mechanisms as DNA transcription, RNA viruses, particularly retroviruses, are particularly prone to mutation. (msdmanuals.com)
oncogenic viruses share the ability to deregulate the same cel ular pathways, In addition, ICB and ICE have performed although via different mechanisms. (who.int)
The clinicopathologic spectrum, role of oncogenic viruses, treatment outcomes, and underlying disease mechanisms of these LPDs are incompletely understood. (medscape.com)

The success of the first five Emerging Oncogenic Viruses meetings (held in 2010, 2012, 2014, 2016, and 2018), together with the enthusiastic support of our colleagues in the oncogenic virus field, has encouraged us to repeat the event in 2022. (who.int)

in The eTiology of head and wel -established and potential oncogenic neck cancer in europe and india viruses in deregulating pathways related In addition to functional studies, ICB (hpv-ahead) to cellular proliferation and transfor- has performed several col aborative mation as well as to the immune epidemiological studies using laboratory For four years (2010-2015), ICB response. (who.int)

The World Socialist Web Site recently reported on a groundbreaking study which points to a mechanism of the virus that could potentially cause the irreversible fusion of brain cells. (wsws.org)
Currently, there are six viruses recognised as potentially oncogenic in humans. (animalresearch.info)

It was the first virus to be officially identified for its role in the onset of human cancer. (pasteur.fr)
Yes, I think it's been pretty underappreciated by the general public on the role of viruses in cancer. (bwfund.org)
Emergent human pathogen simian virus 40 and its role in cancer. (educate-yourself.org)

The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION. (bvsalud.org)

This MOOC is open to anyone interested in cancer-associated viruses, with a good scientific background. (fun-mooc.fr)

Explain the mechanism of tumorigenesis induced by these viruses. (fun-mooc.fr)
Treatment and prevention strategies critically depend on the double understanding of the mechanism of cell tumorigenesis and the way they are influenced by viruses. (fun-mooc.fr)

And what the virus does is that it modulates or changes or manipulates those pathways so that the virus is able to either stick latent and hidden from the host immune system or replicate itself and disseminate throughout the host's body, or, in fact, a new individual. (bwfund.org)

As obligatory intracellular parasites, viruses encode proteins that reprogram host cellular signaling pathways that control proliferation, differentiation, cell death, genomic integrity, and recognition by the immune system. (fun-mooc.fr)

These viruses cause cancer by "altering tumor suppressing pathways by means of its nonstructural proteins, and triggering inflammatory cascades by enhancing cytokine production in the form of a 'cytokine storm' paving the way for the emergence of cancer stem cells in target organs. (wsws.org)
Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints. (ki.se)

Here again we would always be confronted with the potential danger of picking up other contaminating viruses or other microbic agents infectious for man. (ronpaulforums.com)
But under conditions of immunosuppression, such as people infected with HIV or people taking immunosuppressive therapies in order to get a transplant, for example, it's under those types of circumstances that these viruses can manifest themselves and have oncogenic potential. (bwfund.org)
In the 2014-2015 biennium, ICB has vaccination and HPV-based screening performed several functional studies in Bhutan and Rwanda, the first two low- on wel -known and potential oncogenic income countries to successful y adopt viruses, such as Epstein-Barr virus HPV vaccination practices. (who.int)

Insertional polymorphisms of endogenous feline leukemia viruses. (harvard.edu)
Genomically intact endogenous feline leukemia viruses of recent origin. (harvard.edu)

In 1954, Eddy had been sidelined for whistleblowing about the presence of live virus in Jonas Salk's inactivated polio vaccine (the infamous Cutter incident). (cdc.gov)
12] As early as 1953, Dr. Herald R. Cox, a scientist working at Lederle Laboratories, one of the polio vaccine manufacturers, published an article in a peer reviewed scientific journal in which he stated, [P]oliomyelitis virus has so far been cultivated only in the tissues of certain susceptible species namely, monkey or human tissues. (ronpaulforums.com)

It was demonstrated in the early 1970s that the "Epstein-Barr" virus was indeed responsible for Burkitt's lymphoma. (pasteur.fr)

Thus, Gross identified two critical animal viruses that serve as models for viruses causing cancer in humans. (wikipedia.org)

Epstein-Barr virus promotes genomic instability in Burkitt's lymphoma. (ki.se)

Virus control goes epigenetic PLoS Pathog. (usc.edu)

The main provision of this theory was the assumption that tumor modification of cells occurs as a result of association its genetic material with new genetic information of oncogenic viruses. (researchbib.com)
either DNA or RNA viruses may have single or double strands of genetic material. (msdmanuals.com)

For this, we set out to find out the results of applying the molecular biology techniques for the determination and typification of the human papilloma virus (HPV), together with colposcopic (with 5% acetic acid) and cytologic (conventional exfoliative Pap smear) studies, by means of a sample that is representative of our reference menopause consult for the central district of Malaga, Western Costa del Sol and Guadalhorce Valley. (scirp.org)

In 1956, Dr. Sabin took this virus and passaged it through seven cultures of African Green Monkey kidney cells. (ronpaulforums.com)
11] When the poliovirus was passaged through the monkeys or grown on the monkey kidney cells for production, extraneous viruses became part of the final poliovirus vaccine. (ronpaulforums.com)
13] In fact, in 1958, a scientific journal reported that the rate of isolation of new simian viruses (from monkey kidney cells) has continued unabated. (ronpaulforums.com)

Oncogenic viruses and cancer Virol Sin. (usc.edu)

And these viruses usually establish lifelong latency in the human population and normally don't cause much of a problem. (bwfund.org)

Only after Stewart fulfilled Koch's postulates in 1957, with the assistance of Dr. Bernice Eddy, did oncologists pay heed to viruses. (cdc.gov)

The reason why it took so much time to confirm that viruses can cause cancer is essentially because viruses are necessary but not sufficient to cause cervical cancer. (animalresearch.info)

Later the undefined mechanism behind the induction of cancer by these viruses was unveiled gradually along with the responsible cofactors and mimicry mechanism. (physiciansweekly.com)
The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress. (ki.se)

Anatomy1

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