Oncogenic receptor macrophage colony stimulating factor. Medical search. Frequent questions

TLR2, a membrane-bound receptor for bacterial lipoproteins, signals activation of inflammatory pathways, much like TLR4, the receptor for endotoxin (LPS). (campaignfornonviolentschools.org)
80%) and biological pathways (such as adipocytokine, Notch, Hedgehog and NOD-like receptor signaling) were not identified by previous gene array studies. (mdpi.com)
We further explain the pathways regulating macrophage survival proliferation differentiation and chemotaxis downstream from the CSF-1R. (techblessing.com)
An enhancer element responsive to ras and fms signaling pathways is composed of two distinct nuclear factor binding sites. (musc.edu)
Some tumor cell-inherent resistance mechanisms, such as the tumor mutational burden and aberrant expression of oncogenic pathways, restrain antitumor immunity [ 10 ]. (biomedcentral.com)
Recent studies have revealed that AXL contributes to leukaemic phenotypes through activation of oncogenic signalling pathways that lead to increased cell migration and proliferation. (cancerindex.org)

Besides the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic cells, occurs as a result of the release of endogenous and exogenous antigens (damage-associated molecular patterns, DAMPs, and pathogen-associated molecular patterns, PAMPs). (hindawi.com)
In this review, we have discussed the status and roles of various immune effector cells ( e.g ., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. (wjgnet.com)
These exosomes can interact with immune cells, such as T cells, macrophages, and dendritic cells, to modulate proinflammatory immune responses. (wphobby.com)

Rohrschneider became fascinated by the challenge of working on the normal function of the M-CSF receptor and understanding how it regulates macrophage function. (fredhutch.org)
The PtdIns 3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphoma. (musc.edu)

IL-3 and GM-CSF act on other bone marrow-derived lineages, whereas the stimulatory activity of IL-5 appears to be limited to eosinophils and thus suggests it to be the dominant factor in eosinophil proliferation. (medscape.com)
Here, we review some of the relevant literature of the role of neutrophils in different stages of the oncogenic process including tumor initiation, growth, proliferation or metastatic spreading and also focus on how neutrophil counts or the neutrophil-to-lymphocyte ratio may be used as a prognostic and predictive biomarker. (biomedcentral.com)
Thus, targeting JAK1-2 with ruxolitinib blocks a final pathway that is common to multiple pro-angiogenic factors, suppresses EC-mediated PCC proliferation, and may be useful in PDACs with a strong pro-angiogenic signature. (oncotarget.com)
Identification of the molecular mechanisms responsible for sustained cell proliferation and reduced sensitivity to antiproliferative factors in tumor cells, with particular attention to the involvement in the aforementioned biological processes of the Colony-Stimulating Factor-1 Receptor (CSF-1R) and of the Mitogen-Activated Protein Kinases (MAPK), ERK5 in particular. (unifi.it)
X-VIVO Serum-free Hematopoietic Cell Media provide nutritionally complete and balanced environments for a variety of cells including lymphokine activated killer (LAK) cells, peripheral blood lymphocytes (PBL), and tumor infiltrating lymphocytes (TIL).These media do not contain any exogenous growth factors, artificial stimulators of cellular proliferation, or undefined supplements. (lonza.com)
It also supports the proliferation of purified CD3+ cells isolated from peripheral blood and human tumors, and can be used to support the growth of human monocytes, macrophage cells and cell lines, PBL, granulocytes, and natural killer (NK) cells as well as the expansion of HUT-78 and related human lymphocytic cell lines. (lonza.com)

MST1R (RON) is a trans-membrane receptor tyrosine kinase (RTK), which is part of the c-MET proto-oncogene family. (frontiersin.org)
1987) of the CSF-1 receptor (CSF-1R) and the demonstration that it possessed intrinsic tyrosine kinase activity (Yeung et al. (techblessing.com)
1985). The c-cDNA was cloned and shown to encode a typical class III receptor tyrosine kinase (RTK) (Coussens GSI-IX et al. (techblessing.com)
Non-receptor tyrosine kinases encoded by the C-ABL GENES . (nih.gov)
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. (cancerindex.org)
AXL, a tyrosine kinase receptor, is commonly overexpressed in several solid tumours and numerous hematopoietic malignancies including acute myeloid leukaemia, acute lymphocytic leukaemia, chronic myeloid leukaemia, chronic lymphocytic leukaemia and multiple myeloma. (cancerindex.org)

Macrophages consist of closely linked bone marrow cells, blood monocytes, macrophages of tissues, and a constituent part of the mononuclear phagocyte system. (encyclopedia.pub)
These exosomes significantly increase expression of endosomal toll-like receptor 3 (TLR3), TLR7, TLR8, and TLR9 in peripheral T cells and monocytes. (wphobby.com)

The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase. (musc.edu)
Macrophages primarily have three major vital roles, phagocytosis, presentation of antigens, and in immunomodulation by producing different cytokinesis and growth factors [ 1 ] . (encyclopedia.pub)
Macrophages contain antigen-presenting cells, immunomodulators, and phagocytosis that play a vital role in the initiation and maintenance of inflammatory functions [ 6 ] . (encyclopedia.pub)
CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. (thermofisher.com)

The TME of solid cancers appears to be fundamentally different from that of the leukemias, in which clinical ACT trials with chimeric antigen receptor T cells have demonstrated efficacy. (wikipedia.org)
However, chimeric antigen receptor T (CAR-T) cell immunotherapy and immune checkpoint blockade (ICB), which have produced unprecedented clinical benefits in a variety of different cancers, produce promising results in only some highly selected patients with PDAC. (biomedcentral.com)

The infiltration of multiple types of tumor-promoting immune cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs) and other immune cells, mediates immune evasion and tumor progression [ 9 ]. (biomedcentral.com)
The real-time analysis in GBM-on-a-Chip showed that mesenchymal GBM niche attracted low number of allogeneic CD154+CD8+ T-cells but abundant CD163+ tumor-associated macrophages (TAMs), and expressed elevated PD-1/PD-L1 immune checkpoints and TGF-β1, IL-10, and CSF-1 cytokines compared to proneural GBM. (elifesciences.org)

In addition, the cytokine byproduct TGF-β activates macrophages to have an M2-like tumor-associated macrophage (TAM) phenotype. (nature.com)
Macrophages that infiltrate the tumor parenchyma have an M1 phenotype and M2 phenotype present in the tumor microenvironment [ 4 ] . (encyclopedia.pub)

The importance of these dynamic cellular interactions in the development of cancer has stimulated strong interest in evaluating components of the tumor microenvironment as targets for cancer therapy. (biomedcentral.com)

Multiple cytokines stimulate eosinophil production, including IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-5. (medscape.com)
Examples for such strategies include inhibition of CXCR1 and CXCR2 to decrease migration of neutrophils to tumoral areas or the inhibition of granulocyte colony stimulating factor to decrease the amount of neutrophils which has shown efficacy in preclinical models. (biomedcentral.com)
Maturation depends on different stimulating factors including the granulocyte-macrophage-colony stimulating factor (GM-CSF) and the granulocyte-colony stimulating factor (G-CSF), two of the most relevant growth factors that control such maturation process. (biomedcentral.com)
Macrophages are components of innate immunity derived from the myeloid progenitor cell namely known as the granulocyte-macrophage colony forming unit (GM-CFU) inside bone marrow. (encyclopedia.pub)

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy. (swissbiotech.org)

We hypothesized that GR1SN contains factors secreted by probiotic Rabbit Polyclonal to NBPF1/9/10/12/14/15/16/20 which inhibit pro-inflammatory cytokine expression in the myometrium. (campaignfornonviolentschools.org)
A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)

Around this time, Dr. Chuck Sherr at St. Jude's and Dr. Richard Stanley at Albert Einstein identified the normal cellular Fms protein as the cell surface receptor for a growth factor known as the macrophage colony-stimulating factor or M-CSF. (fredhutch.org)
The only ligand recognized to bind MST1R (RON) is Macrophage Stimulating 1 (MST1), also known as Macrophage Stimulating Protein (MSP) or Hepatocyte Growth Factor-Like Protein (HGFL). (frontiersin.org)
1988). Another oncogenic derivative is the product of a t(3;5)(p21;q33) translocation RBM6-CSF-1R a constitutively activated CSF-1R fusion protein comprised of the amino-terminal 36 amino acids of RNA-binding motif 6 (RBM6) joined to the carboxy-terminal 399 amino acids of the CSF-1R which leads to an acute megakaryoblastic leukemia (Fig. 1A). (techblessing.com)
Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. (musc.edu)
ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice. (musc.edu)
The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF). (musc.edu)
The carboxy-terminal catalytic domain of the GTPase-activating protein inhibits nuclear signal transduction and morphological transformation mediated by the CSF-1 receptor. (musc.edu)
Main scientific achievements deal with the elucidation of mechanisms of signaling by the Colony-Stimulating Factor 1 Receptor as well as the role of Mitogen-Activated Protein Kinases, ERK5 in particular, in normal and neoplastic cells. (unifi.it)
They function in the cell cycle to maintain MATURATION PROMOTING FACTOR in the active state and have protein-serine/threonine kinase activity. (bvsalud.org)

Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. (mdpi.com)
Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time. (bvsalud.org)
Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation. (nih.gov)
Inflammatory Factors Involved in Cancer Transformation" Encyclopedia , https://encyclopedia.pub/entry/46606 (accessed December 11, 2023). (encyclopedia.pub)

Basilea Pharmaceutica Ltd. (SIX: BSLN) announced today that it has initiated the phase 1/2 FIDES-02 study ( F ibroblast growth factor I nhibition with DE razantinib in S olid tumors) with the pan-fibroblast growth factor receptor (FGFR) kinase inhibitor derazantinib. (swissbiotech.org)
Derazantinib also inhibits the colony-stimulating-factor-1-receptor kinase (CSF1R). (swissbiotech.org)

Hypoxia also causes the upregulation of hypoxia-inducible factor 1 alpha (HIF1-α), which induces angiogenesis and is associated with poorer prognosis and the activation of genes associated with metastasis, leading, for instance, to increased cell migration and also ECM remodeling. (wikipedia.org)
Recent evidence suggests that plakoglobin may suppress tumorigenesis and metastasis by multiple mechanisms, including the suppression of oncogenic signaling, interactions with various proteins involved in tumorigenesis and metastasis, and the regulation of the expression of genes involved in these processes. (oncotarget.com)
An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. (musc.edu)

In this context, β-catenin has a well-documented oncogenic potential as a component of the Wnt signaling pathway. (oncotarget.com)

Inhibition of the type I TGF-β receptor with SB505124 does not alter endothelial activation in vitro , but decreases pro-angiogenic gene expression and suppresses angiogenesis in vivo . (oncotarget.com)

The ETS family of oncogenic transcription factors in solid tumours. (musc.edu)

The glycoprotein colony-stimulating factor-1 (CSF-1) also known as macrophage-CSF (M-CSF) was the first of the CSFs to be purified (Stanley and Heard 1977) and was shown to stimulate the formation of colonies of macrophages (Stanley et al. (techblessing.com)
Viral infection primarily reflects binding between its membrane glycoprotein spike and the angiotensin-converting enzyme 2 (ACE2) receptor on select host human cell surfaces 15 . (wphobby.com)

4 Pre-clinical data has shown that tumor macrophage depletion through CSF1R blockade renders tumors more responsive to T-cell checkpoint immunotherapy, including approaches targeting PD-L1/PD-1. (swissbiotech.org)
Exosome depletion abolished these stimulated responses. (wphobby.com)

Mamasheva E, O'Donnell C, Bandekar A, Sofou S: Heterogeneous liposome membranes with pH-triggered permeability enhance the in vitro antitumor activity of folate-receptor targeted liposomal doxorubicin. (trpv-antagonist.com)

While high-risk markers of poor prognosis have been identified, factors predicting regional control or survival remain uncertain. (unav.edu)

This approach has been successful and agents against oncogenic alterations like those targeting HER2 overexpression in breast and gastric cancer, or BRAF in melanoma, have shown clinical benefit [ 1 ]. (biomedcentral.com)
Triple-negative breast cancer (TNBC), which lacks the expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), accounts for 10-15% of breast cancers [ 2 ]. (nature.com)

Fip1-like1-platelet-derived growth factor receptor alpha chain ( FIP1L1-PDGFRA ) mutation has been described in adult patients with hypereosinophilic syndrome. (medscape.com)
[ 5 ] Specifically, a novel oncogenic mutation ( FIP1L1-PDGFRA ), which results in a constitutively activated platelet-derived growth factor receptor-alpha ( PDGFRA ), has been invariably associated with a primary eosinophilic disorder and results in clonal lines of pathologic cells. (medscape.com)

Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1. (musc.edu)
Here, we report that plasma exosomes of COVID-19 patients contain SARS-CoV-2 double stranded RNA (dsRNA) and stimulate robust production of interleukin-6 (IL-6), IL-8, tumor necrosis factor-α (TNF-α), and other inflammatory cytokines and chemokines by human peripheral mononuclear cells. (wphobby.com)

Uveal melanomas differ significantly from cutaneous melanoma in incidence, prognostic factors, molecular characteristics, and treatment. (cancer.gov)
The first wave had the highest number of registered cases and COVID-19 mortality.Conclusion Tumor stage or melanoma treatments are non-significant prognostic factors for COVID-19 mortality. (unav.edu)

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. (cancerindex.org)

Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes. (musc.edu)
To identify the TJP1-dependent factors important in the development of LMS, genes with altered expression were selected in SK-LMS-1 cells such as cyclinD1, CSF1 and so on. (molcells.org)

We also discuss normal synthesis of tachykinins and their receptors, yet focus on their regulation by microRNA, messenger RNA stabilizing proteins, and transcription factors like Restrictive Element-1 Silencing Factor (REST). (brainimmune.com)

In addition, chemokines are shown to stimulate recruitment of maternal peripheral leukocytes into uterine tissues, simultaneously amplifying the inflammatory signals. (campaignfornonviolentschools.org)
Tumor-associated macrophages (TAM) are created by cancerous and stroma cells in the tumor and are enlisted by tumor growth factors and chemokines [ 4 ] . (encyclopedia.pub)

CSF1/CSF1R Blockade reprograms tumor-infiltrating macrophages and improves response to T cell checkpoint immunotherapy in pancreatic cancer models. (swissbiotech.org)

Herein, we demonstrate that myostatin propeptide expands primitive CML and normal BM cells, as shown by increased colony-forming capacity. (haematologica.org)
ebv reactivation in latently infected b cells is essential for persistent infection whereby b cell receptor (bcr) activation is a physiologically relevant stimulus. (liverpool.ac.uk)

Macrophages help in maintaining and initiating inflammation [ 2 ] . (encyclopedia.pub)
AXL also plays an important role in inflammation and macrophage ontogeny. (cancerindex.org)

The CSF-1 receptor (CSF-1R) is activated with the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). (techblessing.com)
Interleukin 10 helps in the deactivation of activated macrophages [ 1 ] . (encyclopedia.pub)
M2 macrophages are characterized by their anti-inflammatory and wound-healing endotype, and they are further divided into different subtypes: the M2a macrophages subtype, which responds to Interleukin-4 and Interleukin-13 during fungal and helminth infections [ 7 ] . (encyclopedia.pub)

of CSF-1 IL-34 and the CSF-1R and the mechanism of ligand binding to and activation from the receptor. (techblessing.com)

Further investigation indicated that G-CSF induction by GR1SN in the absence of TNF- is due to activation of a toll-like receptor (TLR)2-dependent pathway13. (campaignfornonviolentschools.org)
Transcriptional activation of a conserved sequence element by ras requires a nuclear factor distinct from c-fos or c-jun. (musc.edu)

He also went proto-oncogene hunting, cloning out the normal cell version of the Fms oncogene and identifying the mutations that make it oncogenic. (fredhutch.org)
This was one of the initial discoveries that mutations in a cell surface receptor could initiate oncogenesis, just one year after the avian erythroblastosis virus oncogene was found to be a mutant EGF receptor. (fredhutch.org)

and (v) the role of hypoxia-inducible factor-1 in lung development. (stanford.edu)
Finally, we discuss the possible role of tumour-associated macrophages in future treatment options. (touchoncology.com)

He and wife, Jean, and young children, Reuben and Monica, spent an enjoyable sabbatical year in Melbourne, Australia, working with Dr. Don Metcalf at the Walter and Eliza Hall Institute, the world center for research into hematopoietic regulatory factors. (fredhutch.org)

The strategy of converting M2- into M1-like macrophages has shown promising results in cancer treatment. (nature.com)

5 CSF1R-mediated signaling is important for the maintenance of tumor-promoting macrophages and therefore has been identified as a potential target for anti-cancer drugs. (swissbiotech.org)
For more information about risk factors, see Skin Cancer Prevention and Genetics of Skin Cancer . (cancer.gov)

FGFR gene aberrations occur in about 15 to 20 percent of advanced urothelial cancers and have been established as oncogenic drivers. (swissbiotech.org)

The majority of the factors we assessed were significantly associated with OS or PFS. (bvsalud.org)

They express a high level of mannose receptor (CD206) and are the largest secretor of pro-fibrotic factors, such as TGF-β and GF (growth factors), etc. (encyclopedia.pub)

Anatomy15

Organisms4

Diseases1

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes9

Pathways6

Dendritic cells3

Regulates2

Proliferation6

Tyrosine6

Monocytes2

Phagocytosis4

Chimeric antigen receptor2

TAMs2

Phenotype2

Microenvironment1

Granulocyte4

Inhibitors1

Cytokine2

Protein9

Transformation4

Kinase2

Metastasis3

Signaling pathway1

Inhibition1

Solid tumours1

Glycoprotein2

Depletion2

Antitumor1

Survival1

HER22

Mutation2

Mononuclear2

Prognostic factors2

Subunit1

Genes2

Transcription factors1

Chemokines2

Blockade1

Cells2

Inflammation2

Interleukin3

Ligand1

Activation2

Oncogene2

Role2

Regulatory1

Shown1

Cancer2

Cancers1

Significantly1

Growth factors1