Oncogenic protein retinoblastoma binding protein 1. Medical search. Frequent questions

For example, the cvclinD/CDK4 complex phosphorylates the retinoblastoma protein, which promotes progression through the G^S checkpoint. (ctsqena.com)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)

PRMT5 is a type II protein arginine methyltransferase (PRMT) that catalyzes symmetric dimethylation of arginine residues on histones and non-histone proteins. (springernature.com)
The histones and non-histone proteins of chromatin compact the DNA and govern its accessibility to enzymes during transcription, replication, repair and recombination. (biomedcentral.com)

In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
1. Disrupted systems include pro to-oncogenes, tumor suppressor genes, and regulators of apoptosis. (ctsqena.com)
These studies reveal that recurrent somatic mutations occur in only a handful of genes, with an overall mutational burden of roughly 1-2 per Mb. (springer.com)
Recent surveys along with the HDACi trichostatin A display that JAK2/STAT3 signaling was lowered by upregulation of your phrase of suppressors of cytokine signaling (SOCS) 3 and 1 genes.40 A potential strong impact in the HDAC inhibition for the phosphorylation of FLT3, STAT5 and JAK2 was not examined with this study. (immune-source.com)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
Despite the differences in their normal roles, these genes all contribute to unregulated cell division if they are present in a mutant (oncogenic) form. (cancerquest.org)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
The proliferative arrest is mediated by transcriptional repression of genes essential for cell division by the retinoblastoma protein family. (biomedcentral.com)

Although viewed as a constitutive housekeeping enzyme in the past, PP2A is a highly regulated phosphatase and is emerging as an important regulator of multiple cellular processes involving protein phosphorylation. (ac.be)
1 Reversible protein phosphorylation is an important regulatory mechanism that controls the activities of a myriad of proteins and is thus involved in virtually every major physiological process. (ac.be)
But advances in the understanding of protein phosphatases make now clear that these enzymes are precisely regulated and are as important as kinases in the regulation of cellular processes involving protein phosphorylation. (ac.be)
4 While proteins can be phosphorylated on nine amino acids, serine, threonine and tyrosine phosphorylation are by far the most predominant in eukaryotic cells. (ac.be)
Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). (nature.com)
Dawson et al.43 prove that JAK2 inhibition results in cheaper amounts of histone H3 Y41 phosphorylation about the marketer of LMO2, while increasing the binding of heterochromatin healthy proteinwith the very same site, producing decrease concept of LMO2. (immune-source.com)
10 Under normal circumstances, the p16 protein can inhibit cell cycle progression by restraining the retinoblastoma protein phosphorylation during the gap 1 and synthetic phases of the cell cycle. (rmmj.org.il)
To map the mechanisms of aggressiveness we aimed to investigate changes in protein phosphorylation across WHO grades of human meningiomas. (nature.com)

The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)
This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)
it has also been implicated in the inhibition of oncogenic transformation and along with Pur-beta in myelodysplastic syndrome progressing to acute myelogenous leukemia. (embl-heidelberg.de)
HDACi have shown to block Ras-reliant signaling and expansion transformation.41 Astonishingly, in HEL92.1.7 and MOLM-13 cells, the pracinostat IC50 on proliferation is lower compared to IC50 on inhibition of JAK2 or FLT3-ITD protein ranges, correspondingly. (immune-source.com)

DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)
Rapid growth and division of cells in tumors are correlated with intensive nucleolar metabolism as a response to oncogenic factors overexpression. (biomedcentral.com)
Overexpression of the p16INK4a protein can act as a surrogate biomarker of HPV-induced carcinomas. (rmmj.org.il)

Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins. (mcmaster.ca)
Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. (malaimare.ro)

Immunohistochemistry using CT3 shows that the antibody has high binding signals on neuroblastoma, medulloblastoma, and retinoblastoma. (wikipedia.org)
Stathmin-1 and HSP27 immunohistochemistry (IHC) were performed for each case and the results were compared to the previously available p16 IHC stains. (bvsalud.org)

Sporadic mutation (both hits are somatic) is characterized by unilateral retinoblastoma (Fig. 3,1). (ctsqena.com)
ii, Germline mutation results in familial retinoblastoma (2nd hit is somatic), characterized by bilateral retinoblastoma and osteosarcoma. (ctsqena.com)
The first mutation of RB1 in cases of retinoblastoma can be either constitutional or somatic, whereas the second mutation is always somatic. (medscape.com)
In contrast, both mutations in nonhereditary retinoblastoma are somatic. (medscape.com)

The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)

Cancer has been in existence on Earth even before the appearance of man, as evidenced by paleontological findings of tumors in animals ( 1 , 2 ). (jcancer.org)
We developed a novel mouse retinoblastoma model that develops rapid bilateral tumors in both eyes. (umn.edu)
Furthermore, 5hmC is widely lost in human tumors, including retinoblastoma, although the mechanism behind its loss is unclear, as is the anti-tumor effectiveness of restoring 5hmC. (umn.edu)

Here, we show that DRAM2 may act as an oncogenic regulator in non-small cell lung cancer (NSCLC). (cancerindex.org)
The nucleolus is a subnuclear, non-membrane bound domain that is the hub of ribosome biogenesis and a critical regulator of cell homeostasis. (biomedcentral.com)
In particular, we study the retinal function of an epigenetic regulator called UHRF2, which binds to a DNA epigenetic base called 5-hydroxymethylcytosine (5hmC). (umn.edu)

In vitro mixture reports in a variety of cell phone product lines with either wt or mutant JAK2 or FLT3 also shown synergy, largely in cells that moved the mutant proteins. (immune-source.com)
The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)

The retinoblastoma-E2F pathway, which regulates the cell cycle, has been demonstrated to be upstream of EZH2, which is required for proliferative gene expression and E2F-driven proliferation. (targetedonc.com)
Association of human Pur alpha with the retinoblastoma protein, Rb,regulates binding to the single-stranded DNA Pur alpha recognitionelement. (embl-heidelberg.de)
K, p53 regulates progression of the cell cycle from Gt to S phase, 1. (ctsqena.com)

16(1): 85, 2021 Sep 20. (bvsalud.org)

Tumor suppressors such as retinoblastoma (pRB) and p53 negatively regulate RNA polymerase I and interfere with the assembly of transcriptional machinery on the rDNA promoter. (biomedcentral.com)

and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
A large part of this process is overseen by proteins of the Bcl2 family. (chop.edu)
Our laboratory has been defining the patterns of Bcl2 proteins that cause poor treatment response. (chop.edu)
1. Bcl2 normally stabilizes the mitochondrial membrane, blocking release of cytochrome c. (ctsqena.com)
240)] (14) for correlative concept of Aurora A, Aurora B, MYC and BCL2 with respect to every single (Table 1) exhibited that Aurora A and B manifestation is very related in both DLBCL and MCL. (immune-source.com)
We prove that You-2932, TMD-8, and Granta-519 tissues (Kitchen table 2) co-express Myc and Bcl2 inside an energetic BCR signaling pathway (Physique 1). (immune-source.com)

Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235. (umn.edu)

Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas. (umn.edu)

HPV types relies on the role of their major oncoproteins E6 and E7, which bind, inactivate and degrade the two major cellular tumor-suppressor gene products, p53 and the retinoblastoma tumor-suppressor protein (pRb), respectively. (srce.hr)
High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle. (malaimare.ro)
HPV is present in cervical cancer, where it expresses the oncogenic proteins E6 and E7 that inactivate the host regulatory proteins p53 and RB, respectively. (sv40.org)
The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)

By contrast, persistent cervical infection infection detected more than once in an interval of 6 months or longer with an oncogenic HPV type, especially HPV 16 and HPV 18, is the most cervical cancer hpv etiology risk factor for progression to high-grade dysplasia, a precancerous lesion that should be treated to prevent the development of invasive cancer 2. (malaimare.ro)
1 Oral squamous cell carcinoma is often preceded by potentially malignant disorders of the oral mucosa with an unpredictable course of progression. (rmmj.org.il)

The structural and functional integrity of this overhang is based on its association with a constellation of specific proteins, some of them belonging to the shelterin complex [ 10 ]. (hindawi.com)
Pur-alpha can influence viral interaction through functional associations, for example with the Tat protein and TAR RNA of HIV-1, and with large T-antigen and DNA regulatory regions of JC virus. (embl-heidelberg.de)
2014. Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress? (virosin.org)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)

2 Protein phosphatase 2A (PP2A) is a very abundant - it accounts for as much as 1% of total cellular proteins - ubiquitous and remarkably conserved enzyme. (ac.be)

Submitter supplied) The activating E2F-transcription factors are best known for their dependence on the Retinoblastoma protein and their role in cellular proliferation. (nih.gov)
4.2 Adoptive T Cell Therapy Take action is a malignancy immunotherapy method in which T cells are collected from your tumor, lymph nodes, or peripheral blood of a patient and returned Vanin-1-IN-1 to the patients body after proliferation and selection of tumor-specific T cells. (azd1152.com)
Retinoblastoma tumor cell proliferation is negatively associated with an immune gene expression signature and increased immune cells. (umn.edu)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Knudson first proposed that two hits, or mutations, are required for the development of retinoblastoma. (medscape.com)

Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)

Although intracellular signal transduction is often portrayed as a protein kinase 'domino effect', the counterbalancing function of phosphatases, and thus the control of phosphatase activity, is equally relevant to proper regulation of cellular function. (ac.be)
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. (cancerindex.org)

The members of the retinoblastoma family of pocket proteins, pRb, p107 and p130, are negative regulators of the cell cycle with tumor suppressor activity and with roles in differentiation. (oncotarget.com)
We also identified binding of pRb and p130 to an enhancer with crucial regulatory activity on Sox2 expression. (oncotarget.com)

Theprotein binds preferentially to the purine-rich single strand of thiselement, PUR. (embl-heidelberg.de)

Both, E6 and E7 co-operate to induce transformation of epithelial cells by interacting with numerous host cell proteins affecting many essential cellular pathways. (srce.hr)
Generally, these receptors explain their function on the cell membrane where, after the binding with growth factors or neuregulin undergo to homo or hetero oligomerization with the activation of the intrinsic tyrosine kinase activity and the subsequent recruitment of proteins involved in the cytoplasmic signalling pathways. (biomedcentral.com)

In this context, during any sort of stress condition the alternative reading frame protein p14ARF subtracts MDM2, an E3 ubiquitin ligase, from the interaction with p53 in manner to free and stabilise p53 level in the nucleolus of the cell where it inhibits RNA polymerase I activity [ 3 ]. (biomedcentral.com)
MDM2 binds to and inhibits TP53 activity. (medscape.com)

GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. (wikipedia.org)

The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
During ribosomal RNA processing, ribosomal proteins are incorporated into the pre-ribosomal subunits to form the mature 40S and 60S subunits. (biomedcentral.com)

BACKGROUND: The aim of this study was to determine how Stathmin-1 and Heat Shock Protein 27 (HSP27) can be used as adjunctive biomarkers to differentiate high-grade dysplasia from benign/reactive lesions in cervical tissues. (bvsalud.org)

This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. (cancerindex.org)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)

In the past, most of the attention was focused primarily on protein kinases and on their regulation, mainly because phosphatases were then viewed as simple housekeeping enzymes. (ac.be)
Cyclins and cyclin-dependent kinases (CDKs) form a complex which phosphorylates proteins that drive the cell through the cell cycle. (ctsqena.com)
Homeodomain-interacting protein kinases (HIPKs) are an evolutionarily conserved kinase family comprising the members HIPK1, HIPK2, and HIPK3 in vertebrates, and, additionally, HIPK4 in mammals. (nature.com)

Ras is associated with growth factor receptors in an inactive GDP-bound state. (ctsqena.com)

HPV-induced cervical cancer ( 1 , 2 ). (cdc.gov)
Stathmin-1 and p16 were negative in all benign cervical samples. (bvsalud.org)
In many countries, vaccines against some human papillomavirus (HPV) types are now administered to girls and young women with the goal of protecting them against HPV-induced cervical cancer ( 1 , 2 ). (cdc.gov)

In this work we studied the relative contribution of the retinoblastoma family members to the regulation of Sox2 expression. (oncotarget.com)
1 “Additionally, it has been proposed that in some cancers, these enzymes repress anti-oncogenes, and treatment with EZH2/1 inhibitors might result in re-expression of these anti-oncogenes. (targetedonc.com)
The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
Stabilization of quadruplex architecture by small molecules is thus emerging as a potential anticancer approach since it is thought to interfere with oncogenic expression and telomeric maintenance in cancer cells [ 11 - 13 ]. (hindawi.com)
Western blotting confirmed the expression of DRAM2, p53, and the other involved proteins. (cancerindex.org)
Nucleolar function of EGR1 is strictly linked to the expression of nucleolar proteins such as nucleophosmin (B23) and alternative reading frame (p14ARF). (biomedcentral.com)

Human Pur alpha, expressed as a glutathioneS-transferase fusion protein, specifically binds to the hypophosphorylatedform of Rb with an affinity as high as that of SV40 large T-antigen. (embl-heidelberg.de)
Rb binding involves a Pur alpha region with limited homologyto the Rb-binding region of SV40 large T-antigen. (embl-heidelberg.de)
Table 1: SV40 and human mesothelioma association or causation? (sv40.org)
SV40 also expresses the oncogenic protein T Ag in human mesotheliomas, which inactivates p53 and RB. (sv40.org)

The EZH2 gene encodes the protein EZH2, a histone methyltransferase and the core enzymatic subunit of polycomb repressive complex 2 (PRC2), which is involved in chromatin compaction and transcriptional silencing ( FIGURE ). (targetedonc.com)
The activity of this enzyme is under the control of two main factors, UBF and SL1 both components of the complex that stabilizes RNA Pol I on rDNA promoter [ 1 , 2 ]. (biomedcentral.com)
In budding yeast, heterochromatin is formed by the localized action of the Sir2 NAD-dependent histone deacetylase that specifically deacetylates H4-K16Ac to allow binding of the SIR silencing complex [ 8 ]. (biomedcentral.com)
The telomeres consist of repeating sequences and a set of special proteins, which interact with these repeats and spatially organize them in a specific manner, resulting in the formation of the nucleoprotein complex known as telomeric heterochromatin [ 6 , 7 ]. (actanaturae.ru)

Chimeric antigen receptor (CAR) T cells and Immunotoxins (antibody-cytotoxin fusion proteins) targeting GPC2 inhibit neuroblastoma growth in mouse models. (wikipedia.org)
Receptor binding causes GDP to be replaced with GTP, activating ras. (ctsqena.com)
107] demonstrated that IL-1 production and signaling from the IL-1 receptor are necessary components of Raf-induced transformation of NIH 3 T3 cells, which exclude other factors involvement in the vivo model [85]. (mayabouchenaki.com)

Using a multi-omic analysis with the genome-wide CRISPR screen, RNA-Seq and MSI2-HyperTRIBE, we identified the anti-apoptotic protein BCL-2, as a target of the PRMT5-MSI2 axis. (springernature.com)

Chemical carcinogenesis was brought to light with the observations of Paracelsus on cancer onset and environmental exposure to chemicals undertaken over six centuries ago ( 1 - 3 ). (jcancer.org)
These old Egyptian documents recorded cancer as a grave incurable disease and associated it to 'the curse of the gods' ( 1 ). (jcancer.org)
Thus, the control of ribosome assembly and protein synthesis is essential for the survival of cancer cells. (biomedcentral.com)
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths in the United States, with dismal overall 5-year survival rates of 6% [ 1 ]. (oncotarget.com)
The first is on the pediatric cancer retinoblastoma, which forms in the retina of children and infants. (umn.edu)
To study the correlation between the putative cancer stem cell (CSC) markers aldehyde dehydrogenase 1 (ALDH1), cluster of differentiation 44 (CD44), sex-determining region Y-box 2 (SOX2), and octamer-binding protein 4 (OCT4) and human papilloma virus (HPV) infection using p16, the surrogate marker of HPV in oral epithelial dysplasia (OED) and normal mucosa. (rmmj.org.il)
E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)
Cancer Prev Res (Phila), factor 1. (who.int)

By using a fusion of MSI2 and the RNA editing enzyme ADAR, we could quantitatively assess MSI2 binding across its targets for the first time in B-cell lymphoma cells. (springernature.com)

1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)

The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
Pur-alpha is a highly conserved, sequence-specific DNA- and RNA-binding protein involved in diverse cellular and viral functions including transcription, replication, and cell growth. (embl-heidelberg.de)
The retinoblastoma protein, Rb, is detected in extracts of monkey CV-1cells complexed with Pur alpha, a sequence-specific single-strandedDNA-binding protein implicated in control of gene transcription and DNAreplication. (embl-heidelberg.de)
1. Rb "holds" the E2F transcription factor, which is necessary for transition to the S phase. (ctsqena.com)
During embryonic development, PRMT5 is key for the maintenance of hematopoietic stem cells and B-cell development, by regulating transcription and splicing fidelity 1 . (springernature.com)

The GPC2 gene is at locus 7q22.1 and encodes for a 579 amino acid protein. (wikipedia.org)
This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)

Here, Neuregulin 1 mediated proliferative stimuli, promotes ErbB3 relocalization from the nucleolus to the cytoplasm and increases pre-rRNA synthesis. (biomedcentral.com)

We show that the SNF2-like HELLS interacts with E2F3 in vivo and cooperates with its oncogenic functions. (nih.gov)

CT3 does not bind human normal tissues except the testis. (wikipedia.org)
The other project involves the study of a single nucleotide polymorphism (SNP) in the human p53 gene that results in either arginine (R) or proline (P) at position 72 of the p53 protein. (mdanderson.org)
Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
Sequence of cDNA comprising the human pur gene and sequence-specificsingle-stranded-DNA-binding properties of the encoded protein. (embl-heidelberg.de)
The human Pur factor binds strongly to a sequence element repeated withinzones of initiation of DNA replication in several eukaryotic cells. (embl-heidelberg.de)

It is unknown whether any EZH2 targets are essential for EZH2-mediated transformation across all cell types or whether oncogenic changes are cell type-specific. (targetedonc.com)

Protein Phosphatase 2A (PP2A) is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C) subunit and a structural (A) subunit, in association with a third variable regulatory (B) subunit. (ac.be)
The purine-rich element binding (Pur) protein family protein consists PURalpha/beta/gamma in humans. (embl-heidelberg.de)
The DYRK family has been characterized in organisms from yeast to humans and can be divided into five subfamilies, class I DYRKs, class II DYRKs, YAKs, HIPKs, and PRP4s 1 . (nature.com)

MSI2 RNA-IP assays demonstrated that MSI2 binds c-MYC mRNA and this interaction is disrupted by the drug combination. (springernature.com)

1-5 On fundus examination, these lesions often appear elevated, pigmented (usually grey, white or brown, but may be orange, yellow or green) and are frequently associated with overlying glial tissue that may produce retinal distortion, wrinkling and/or striae. (reviewofoptometry.com)

IL-1 and IL-6 stimulate IL-17 producing cells. (mayabouchenaki.com)

Post-translational modifications of histones represent an important mechanism modulating the accessibility of chromatin and contributing to the recruitment of other proteins to chromatin [ 2 ]. (biomedcentral.com)

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria. (embl-heidelberg.de)

Inthe absence of DNA, glutathione S-transferase-Pur alpha binds to p56RB, anNH2-terminal-truncated Rb protein purified from Escherichia coli,containing the T-antigen binding domain, to form multimeric complexes. (embl-heidelberg.de)

Burkitt lymphoma (BL) can be classified into three forms which differ in geographic distribution and Epstein-Barr virus (EBV) association: endemic (eBL), sporadic (sBL) and HIV-associated BL ( table 1 ). (bmj.com)
There is a low background incidence of BL worldwide (sBL), which is rarely associated with EBV and accounts for 1-2% of adult lymphoma in Western Europe and America, but eBL is associated with (EBV) in over 95% of cases and is predominant in the equatorial belt of Africa and other parts of the world where malaria is hyperendemic. (bmj.com)

Anatomy2

Diseases6

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

Health Care2

Geographicals1

Phosphorylates the retinoblastoma protein2

Histones and non-histone proteins2

Genes10

Phosphorylation8

Inhibition4

Overexpression3

Apoptosis2

Immunohistochemistry2

Somatic4

CDK41

Tumors3

Regulator3

Mutant proteins2

Regulates3

20211

Negatively regulate1

Bcl26

Pathway1

Bilateral1

Inactivate4

Progression2

Functional4

Cellular proteins1

Proliferation3

Mutations2

Regulate1

Signal transduction2

P1302

Preferentially1

Pathways2

MDM22

Tumorigenesis1

Subunits2

Biomarkers1

Chromosome2

Kinases3

Inactive GDP-bound1

Cervical3

Expression6

SV404

Complex4

Receptor3

Apoptotic1

Cancer8

Enzyme1

Tumour1

Transcription5

Encodes2

Promotes1

Vivo1

Human5

Transformation1

Family3

Assays1

Lesions1

Stimulate1

Mechanism1

Repeats1

Absence1

Lymphoma2