Oncogenic protein. Medical search. Frequent questions

Additionally, RNA sequencing analysis of TEAD4 -overexpressing HCC cells demonstrated that TEAD4 overexpression was associated with the up-regulation of genes involved in epithelial-to-mesenchymal transition, proliferation, and protein-folding pathways. (nih.gov)
Among the most up-regulated genes following TEAD4 overexpression were the 70-kDa heat shock protein (HSP70) family members HSPA6 and HSPA1 A. Chromatin immunoprecipitation-quantitative real-time polymerase chain reaction experiments demonstrated that TEAD4 regulates HSPA6 and HSPA1A expression by directly binding to their promoter and enhancer regions. (nih.gov)
The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation. (ac.ir)
Cellular signaling pathways are networks of genes, proteins, enzymes, cytokines, and other cellular species that "communicate" in order to govern the basic functions of cells. (american.edu)
To access these locked-up genes, the cells require specific proteins that act as keys. (genengnews.com)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
Cellular proteins encoded by the c-mos genes (GENES, MOS). (bvsalud.org)
This process is mediated by a complex molecular machinery known as the spliceosome, which enables the production of multiple and functionally distinct proteins from single genes. (lu.se)

The modulation of cell cycle control mechanisms, cellular regulatory and signaling pathways by oncogenic viruses, plays an important role in viral carcinogenesis. (ac.ir)
Assistant Professor of Mathematics and Statistics Julia Chifman and her collaborators built a predictive mathematical model that connects four key cytosolic cellular signaling pathways in breast epithelial cells: the oncogenic pathway, the oxidative stress response pathway, the iron utilization pathway, and the iron homeostasis pathway. (american.edu)
Protein kinases are key regulators of signal transduction pathways that mediate cell growth, proliferation, and motility. (drexel.edu)
The work in Dr. Strochlic's lab is broadly centered on understanding certain protein kinase-mediated cell signaling pathways in the context of normal development and tumorigenesis. (drexel.edu)
Memo1, connected to many oncogenic signaling pathways, was recently suggested to bind oxidized Cu ions and promote ROS generation. (chalmers.se)
The signaling pathways activated by the oncogenic mutants are in part overlapping with those normally activated by these receptors, but there are also signal transduction pathways that are unique to the oncogenic mutants. (lu.se)
oncogenic viruses share the ability to deregulate the same cel ular pathways, In addition, ICB and ICE have performed although via different mechanisms. (who.int)
in The eTiology of head and wel -established and potential oncogenic neck cancer in europe and india viruses in deregulating pathways related In addition to functional studies, ICB (hpv-ahead) to cellular proliferation and transfor- has performed several col aborative mation as well as to the immune epidemiological studies using laboratory For four years (2010-2015), ICB response. (who.int)
In summary, we have identified, and at the molecular level characterized, signaling pathways and specific factors through which oncogenic HIF2A activity is regulated and may be targeted. (lu.se)

BRAF(V600E) is the most frequent oncogenic protein kinase mutation known. (rcsb.org)
Multiple systems of mobile level of resistance to imatinib have already been described you need to include BCR-Abl-dependent systems such as proteins overexpression or appearance of inhibitor-resistant mutations in the BCR-Abl kinase site, like the T315I gatekeeper mutation [6]. (phytid.org)
Our lab seeks to understand how the protein kinase family organises complex intracellular communication networks. (edu.au)
We employ a multidisciplinary approach including kinase biochemistry and biology, structural biology (X-ray crystallography and cryo-electron microscopy), assay development, high-throughput screening, proteomics, imaging and chemical biology to gain high-resolution insights into kinase/pseudokinase signaling proteins. (edu.au)
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)
This protein kinase is calcium-independent and phospholipid-dependent. (nih.gov)
Expression of ALK in malignant T cells is typically due to the t(2;5) translocation resulting in formation of the fusion gene which encodes a 80-kDa hybrid protein that contains portion of the nuclear protein nucleophosmin (NPM) joined to the entire cytoplasmic portion of the receptor tyrosine kinase ALK. (upenn.edu)
The NPM/ALK kinase is constitutively activated and highly oncogenic. (upenn.edu)
They function in the cell cycle to maintain MATURATION PROMOTING FACTOR in the active state and have protein-serine/threonine kinase activity. (bvsalud.org)
The expression of Wnt-5a protein co-variates with that of Syk, a tyrosine kinase that is lost in up to 30% of invasive breast carcinomas and associated with poor prognosis. (lu.se)

Cellular iron levels and iron associated proteins are differentially expressed in many cancers, and recently, it was reported that high expression levels of iron importer and low levels of iron exporter were associated with a poor prognosis in breast cancer patients. (american.edu)
Most notably, protein kinases are frequently mutated in many human cancers and are often drivers of oncogenic signaling networks. (drexel.edu)
Persistent infection with oncogenic HPV types can cause cervical cancer in women as well as other anogenital and oropharyngeal cancers in women and men. (cdc.gov)
It is unclear why the ASPM gene is abnormally active in these cancers or what effects the extra ASPM protein may have in cancer cells. (medlineplus.gov)
A team of researchers led by Dr. Cristian Bellodi recently discovered a hardwired genetic control mechanism modulating individual spliceosomal components, known as splicing factors, in cells harboring oncogenic lesions common in human cancers. (lu.se)
This work highlighted core splicing proteins, including SF3B1, frequently mutated in various cancers. (lu.se)

Oncogenic retroviridae proteins are retroviral proteins that have the ability to transform cells. (wikipedia.org)
Oncoprotein CIP2A a Cancerous Inhibitor of PP2A forms an "oncogenic nexus" by virtue of its control on PP2A and MYC stabilization in cancer cells. (oncotarget.com)
Herein, we reviewed the recent progress in our understanding of (1) how an "oncogenic nexus" of CIP2A participates in the tumorigenic transformation of cells and (2) how we can prospect/view the clinical relevance of CIP2A in the context of cancer therapy. (oncotarget.com)
We found that O-GlcNAcylation and tyrosine phosphorylation act together to trigger pYSTAT5 levels and oncogenic transcription in neoplastic cells. (nature.com)
18 Both enzymes, OGT and OGA as well as multiple O-GlcNAcylated proteins are enriched at sites of active transcription in human cells. (nature.com)
Consistent with the high degree of selectivity, ERK phosphorylation is potently inhibited by PLX4720 in B-Raf(V600E)-bearing tumor cell lines but not in cells lacking oncogenic B-Raf. (rcsb.org)
Finally, by overexpressing TEAD4 in yes-associated protein ( YAP )/transcriptional coactivator with PDZ binding motif ( TAZ )-knockdown HCC cells, we showed that the effect of TEAD4 on cell proliferation and its regulation of HSP70 expression does not require YAP and TAZ, the main effectors of the Hippo signaling pathway. (nih.gov)
Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. (ac.ir)
The oncogenic signaling pathway includes cellular species that regulate the growth, differentiation, and survival of cells. (american.edu)
On the other hand, these proteins' expression was significantly downregulated in ARG1 silenced Huh7 cells. (hindawi.com)
Besides, the level of E-cadherin protein was upregulated in ARG1 knocked down cells. (hindawi.com)
In addition, cellular context and the intrinsic transcriptional program collaborate with genetic mutations to enable cells to form cancer-a process known as "oncogenic competence. (genengnews.com)
Of interest is the role of adenoviruses as viral vectors in vaccination and in gene therapy.For example, in viral vector vaccines against SARS-CoV2, the vector virus is used to deliver RNA encoding SARS-CoV2 spike protein into target cells. (medscape.com)
The lab uses a combination of genetic, biochemical, and cell biological approaches in both Drosophila melanogaster and mammalian cells to investigate the biology of several different protein kinases. (drexel.edu)
The quantification of protein expression for tests like PD-L1 is performed on circulating tumor cells (CTCs) and cannot be determined from circulating tumor DNA (ctDNA). (prnewswire.com)
SOX2 is the determining oncogenic switch in promoting lung squamous cell carcinoma from different cells of origin. (edu.au)
The "cargo carriers," or endosomes, of certain brain cancer cells contain overactive NHE9 proteins (blue), which pump out too many protons (orange), changing the endosomes' acidity and slowing their "shipping speed. (medicaldaily.com)
We adopted a distinct approach aimed initially at interfering with protein-protein interactions of RAS, and other so-called undruggable targets like transcription factors, using molecular biology tools called intracellular antibodies that bind to target proteins inside cells. (cancer.gov)
To avoid such reactions, Cu ions are controlled and transported by dedicated Cu transport proteins in cells. (chalmers.se)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
To activate antigen-specific CD4 T cells in vivo, the investigators utilized the nucleic acid vaccine platform, UNITE (UNiversal Intracellular Targeted Expression), which fuses a tumor-associated antigen with lysosomal-associated membrane protein 1 (LAMP1). (biospace.com)
CD154) is a transmembrane protein expressed on the surface of activated T cells, particularly on CD4 T cells, which stimulates CD40-dependent activation of antigen-presenting cells (APCs), resulting in enhancement of T cell and antibody responses. (biospace.com)
However, unlike other oncogenic retroviruses, deltaretroviruses have an additional region, tax (trans-activating region of the X gene), which has regulatory functions and is oncogenic to host cells. (cdc.gov)
Studies suggest that the ASPM protein helps maintain the orderly division of early brain cells called neural progenitor cells, which ultimately give rise to mature nerve cells (neurons). (medlineplus.gov)
By promoting the division of neural progenitor cells during early brain development, the ASPM protein helps determine the total number of neurons and the overall size of the brain. (medlineplus.gov)
A shortage of functional ASPM protein impairs cell division, especially in neural progenitor cells in the developing brain. (medlineplus.gov)
Because the ASPM protein is found in cells throughout the body, it is unclear why ASPM gene mutations affect neural progenitor cells more severely than other cell types. (medlineplus.gov)
Some researchers believe that neural progenitor cells are more sensitive than other types of cells to a shortage of the ASPM protein. (medlineplus.gov)
Other researchers have suggested that another protein may be able to compensate for the loss of the ASPM protein in cells outside the brain. (medlineplus.gov)
The ASPM gene is upregulated in several types of cancer, which means that it produces more of the ASPM protein than usual in cancer cells. (medlineplus.gov)
By a broad mass spectrometry based approach on whole cells we are in the process of identifying additional such proteins and their phosphorylation status. (lu.se)
Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)

They found that only the fish with BRAF activated at the NC and MB stages were capable of forming tumors (what the researchers call oncogenic competence). (genengnews.com)

Furthermore, inhibitors targeting "active" protein kinases have demonstrated significant utility in the therapeutic repertoire against cancer. (rcsb.org)
Proteins kinases play essential jobs in oncogenic signaling and so are a major concentrate in the introduction of targeted tumor therapies. (phytid.org)
The manifestation and activation condition of proteins kinases (i.e., the kinome) may contribute considerably towards the mobile adaptation to medication level of resistance, and recent systems have been created to review the kinome retinoic acidity (ATRA) (Physique S7). (phytid.org)
Dr. Todd Strochlic's research interests include protein kinases, oncogenic signaling, breast cancer and Drosophila oogenesis. (drexel.edu)

namely, defects in the oncogenic pathway are noted to induce modifications in cellular iron homeostasis. (american.edu)
In the schema of our project, our team sought two central goals: to increase the biological accuracy of the model through the addition of cellular species and intra-pathway connections to the oncogenic pathway, and to conduct new simulations using the updated oncogenic pathway. (american.edu)
Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Almost all of the ASPM gene mutations responsible for MCPH reduce production of the ASPM protein. (medlineplus.gov)
Protein-truncating mutations in ASPM cause variable reduction in brain size. (medlineplus.gov)
X-linked hypophosphatemic rickets and autosomal recessive hypophosphatemic rickets are the result of mutations in PHEX (a phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and dentin matrix protein 1 ( DMP1 ), respectively. (medscape.com)

The aim of this project is to elucidate the mechanism of signal transduction of the oncogenic mutants of FLT3 and KIT and find such molecules. (lu.se)

2018). FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium. (edu.au)

A team from Memorial Sloan Kettering Cancer Center (MSKCC) in New York City report that melanoma formation depends on oncogenic competence. (genengnews.com)

The expression of a mutated hyperactive gain-of-function (GOF) STAT5 without O-GlcNAcylation resulted in decreased tyrosine phosphorylation, oligomerization and transactivation potential and complete loss of oncogenic transformation capacity. (nature.com)
Our data show that O-GlcNAcylation of STAT5 is an important process that contributes to oncogenic transcription through enhanced STAT5 tyrosine phosphorylation and oligomerization driving myeloid transformation. (nature.com)
Large-scale proteomics research have examined differential protein manifestation and phosphorylation in drug-resistant leukemia [26]C[29]. (phytid.org)

This strategy is mainly based on the tight control of the expression of its Epstein-Barr nuclear antigen-1 (EBNA1) protein, the EBV-encoded genome maintenance protein. (inrae.fr)

The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V. (lu.se)

Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
There she led a team of 6 chemists performing lead optimization on a macrocycle inhibitor of the hedgehog protein which resulted in analogs with superior potency, improved metabolic stability, excellent in vivo pharmacokinetics and no in vitro safety liabilities. (harvard.edu)
Gialeli C., Tuysuz E., Staaf J., Guleed S., Paciorek V., Mörgelin M., Papadakos K.S. and Blom A.M. (2021) Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer to chemotherapy. (lu.se)

15 The dynamic addition and removal of O-GlcNAc has been described for multiple cytoplasmic and nuclear proteins and it affects the function of various signaling molecules and transcription factors. (nature.com)

Oncogenic fusion proteins, such as for example EWS-FLI1, are great therapeutic targets because they are just located inside the tumor. (acancerjourney.info)
Presently, a couple of no clinically obtainable targeted realtors that inhibit these exclusive tumor-specific protein. (acancerjourney.info)
These posters to be presented at the AACR Meeting focus on the investigational nucleic acid platform, UNITE™ (UNiversal Intracellular Targeted Expression) for two vaccines, ITI-3000 for Merkel cell carcinoma (targeting the large T antigen of the Merkel cell polyomavirus) and Her2/Neu-LAMP DNA vaccine, both of which fuse a tumor associated antigen with lysosomal associated membrane protein 1 (LAMP-1). (biospace.com)
This presentation reports results of preclinical mouse studies on a HER2/Neu-LAMP DNA vaccine that included a bicistronic DNA construct in which both the tumor antigen (HER2) fused with LAMP-1 (lysosomal- associated membrane protein 1) and sCD40L were expressed separately. (biospace.com)

Gene marker subsets and disease markers were validated using rtPCR and protein expression. (cdc.gov)
Purpose: Gene fusions are important oncogenic drivers and many are actionable. (researchgate.net)
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
The ASPM gene provides instructions for making a protein that is involved in cell division. (medlineplus.gov)
ICB's findings showed that assays established by the Group, aiming has coordinated the HPV-AHEAD several oncogenic viruses have the to characterize the natural history of consortium, which included a multi- ability to induce epigenetic changes and several viruses at different anatomical disciplinary team in Europe and deregulate cel ular gene expression. (who.int)

Through simulations, Chifman and her collaborators found that overexpression of Ras, a central species in the oncogenic pathway, led to a cancer phenotype in the iron homeostasis pathway. (american.edu)
Additionally, overexpression of ARG1 led to a significant increase in the expression of Vimentin, N-cadherin, and β -catenin both at protein and mRNA levels, which promotes the EMT process. (hindawi.com)

Indeed, MCPyV-encoded proteins are likely targets for cytotoxic immune responses to MCC as they are both foreign to the host and necessary to maintain the oncogenic phenotype. (bmj.com)

Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)

Treatment of MM with 4Ei-10 resulted in decreased cell proliferation, increased sensitivity to pemetrexed and altered expression of malignancy-related proteins. (umn.edu)
RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation. (uclahealth.org)

LTS220A, encoding a mutated form of MCPγV-LT that diminishes its pro-oncogenic properties, was introduced into the UNITE platform. (biospace.com)

20. Morrison JA, Raab-Traub N. Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling. (ac.ir)
Ribosomal proteins (RPs) play important roles in modulating the MDM2-p53 pathway. (elifesciences.org)

To overcome this limitation, we scanned the MCPyV oncoproteins large T and small T antigen and the virus-capsid protein VP1 for potential T-cell epitopes, and tested for major histocompatibility complex (MHC) class I affinity. (bmj.com)
Both are composed of type-specific HPV L1 protein, the major capsid protein of HPV. (cdc.gov)
The advent of immunoblotting, ≈100 times more sensitive than techniques of the 1970s ( 6 ), enabled the detection of antibodies reactive with recombinant purified BLV p24 capsid protein in serum samples from 39% of 257 self-selected human volunteers ( 7 ). (cdc.gov)

Among our notable achievements, we commercialized our liquid biopsy test for PD-L1 protein expression last June. (prnewswire.com)
Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). (cdc.gov)
We found that Wnt-5a protein expression is reduced in many invasive breast carcinomas and that reduced Wnt-5a expression in the primary tumour strongly correlates with an increased risk of metastatic disease and shorter survival. (lu.se)
Despite the co-expression, loss of Wnt-5a and Syk protein appear to be regulated at the translational and transcriptional levels, respectively. (lu.se)

This review discusses the interaction between proteins of several human oncogenic viruses with the Wnt signaling pathway. (ac.ir)
We wondered if these difficulties could be overcome by focussing on the antibody combining site (i.e. the part of antibody interacting with antigen) to guide the derivation of chemical compounds that would be surrogates of the antibody, because the combining site is the part relevant to the protein-protein interaction between antibody and antigen. (cancer.gov)
The corollary is that the specific interaction interface between the antibody fragment with target protein would be mimicked by the chemical compound surrogates. (cancer.gov)

Our work on intracellular antibody fragments as tools for analysis of protein complexes argued that these macromolecules could also be employed for target validation in diseases and then as guides for target-specific surrogate compounds as inhibitors. (cancer.gov)

Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time. (bvsalud.org)

Kaposi's sarcoma-associated herpesvirus G-protein coupled receptor activates the canonical Wnt/beta-catenin signaling pathway. (ac.ir)

The Epstein-Barr virus (EBV) is the first oncogenic virus described in human. (inrae.fr)

The detection of high-oncogenic HPV genotypes in patients with breast cancer supports the hypothesis of an etiologic role for the virus in breast cancer development. (who.int)
Whereas the oncogenic Wnt-1 is the main Wnt protein investigated in breast cancer, very little work has been focused on Wnt-5a, a protein supposedly antagonizing the oncogenic effects of Wnt-1. (lu.se)

Using the novel CRISPR/Cas9-based enChIP technology in combination with SILAC-MS, we have isolated and identified potential regulatory proteins bound to the HIF2A promoter at normoxia and hypoxia. (lu.se)

Most of the oncogenic viruses modulate the canonical Wnt signaling pathway. (ac.ir)
icB iS mainly focuSed on The characTerizaTion of The Biological properTieS of well-eSTaBliShed and novel poTenTial oncogenic viruSeS. (who.int)
In the 2014-2015 biennium, ICB has vaccination and HPV-based screening performed several functional studies in Bhutan and Rwanda, the first two low- on wel -known and potential oncogenic income countries to successful y adopt viruses, such as Epstein-Barr virus HPV vaccination practices. (who.int)

CUC-1 knock-out worms have more developmental defects, implying that Atox1-like proteins contribute to cell migration during development. (chalmers.se)

Activated cap-dependent translation promotes cancer by stimulating translation of mRNAs encoding malignancy-promoting proteins. (umn.edu)

Via the addition of a phosphate group, these enzymes control the activity, localization, and/or function of substrate proteins. (drexel.edu)

The ZEBRA (Z EBV replication activator) protein is the major transcription factor of EBV, expressed upon EBV lytic cycle activation. (mdpi.com)

7-Cl-Ph-Ethyl-GMP is an analog of cap and inhibits protein translation by binding and sequestering eIF4E thus blocking eIF4E from binding to the mRNA cap. (umn.edu)
In turn, the CFTR protein level depends, at least in part, on the level of CFTR mRNA. (bvsalud.org)
At the ribosome, the processed mRNA is translated to produce proteins from amino acid units. (cdc.gov)

OGT transfers O-GlcNAc moieties from UDP-GlcNAc to serine and threonine residues of proteins and O-GlcNAcase (OGA) catalyzes the opposite reaction to remove O-GlcNAc. (nature.com)

Unlike concentrating on an enzyme on the ATP binding site, advancement of a healing target for the transcription aspect requires very particular disruption of the DNA-protein or protein-protein connections [4]. (acancerjourney.info)
EWS-FLI1 needs disorder for maximal transactivation of transcription [10] as well as the disordered character from the transcription aspect facilitates the protein-protein complexes that result in oncogenesis [11]. (acancerjourney.info)

Latent Membrane Protein 1 (LMP1) and LMP2A Collaborate To Promote Epstein-Barr Virus-Induced B Cell Lymphomas in a Cord Blood-Humanized Mouse Model but Are Not Essential. (ac.ir)

Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer. (ac.ir)

Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). (novusbio.com)

proteins could carry out their biological functions. (lu.se)

Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)

His research has led to the identification of several non-coding RNA species and RNA-binding proteins that are important in acute leukemia. (uclahealth.org)
RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia. (uclahealth.org)

Anatomy4

Diseases3

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes13

Information Science3

Genes10

Pathways9

Kinase10

Cancers6

Cells32

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Kinases4

Cellular4

Mutations4

Signal transduction1

20181

Melanoma1

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Genome1

Tyrosine1

Inhibitor3

Signaling molecules1

Tumor4

Gene6

Overexpression2

Phenotype1

Adaptor protein1

Proliferation2

Diminishes1

Roles2

Capsid protein3

Expression4

Interaction3

Macromolecules1

Transformation1

Activates1

Human1

Breast Cancer2

Regulatory1

Viruses3

Defects1

Promotes1

Enzymes1

Activation1

MRNA3

Serine1

Transcription2

Membrane protein1

Cause of can1

Intracellular1

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Molecular1

Leukemia2