• Lung cancer with epidermal growth factor receptor (EGFR)-activating mutations responds favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. (aacrjournals.org)
  • Here, we showed that hepatocyte growth factor (HGF), a ligand of MET oncoprotein, induces gefitinib resistance of lung adenocarcinoma cells with EGFR -activating mutations by restoring the phosphatidylinositol 3-kinase/Akt signaling pathway via phosphorylation of MET, but not EGFR or ErbB3. (aacrjournals.org)
  • De-regulation of the autocrine Wnt signaling pathway via mutations in APC and Axin have been linked to activation of various types of human cancer. (wikipedia.org)
  • In colorectal cancer, for example, mutations in APC, axin, or β-catenin promote β-catenin stabilization and transcription of genes encoding cancer-associated proteins. (wikipedia.org)
  • However, most lung adenocarcinomas either lack an identifiable driver oncogene, or harbour mutations in KRAS and are therefore still treated with conventional chemotherapy. (nature.com)
  • Many cancers originate from stem or progenitor cells hijacked by somatic mutations that drive replication, exemplified by adenomatous transformation of pulmonary alveolar epithelial type II (AT2) cells1. (stanford.edu)
  • Genomic instability, which increases the likelihood of acquiring mutations [ 3 ], is a hallmark of most cancers, including lung cancer [ 4 ], and is caused by factors such as smoking, air pollution, and radiation exposure. (biomedcentral.com)
  • The total number of somatic mutations can be quantified by tumor mutation burden (TMB) [ 5 ], associated with poor prognosis in certain cancers, including NSCLC [ 6 ]. (biomedcentral.com)
  • Comprehensive investigation of oncogenic driver mutations in Chinese non-small cell lung cancer patients. (cdc.gov)
  • We also have the ability to direct cancer-associated mutations to specific lung epithelial cell populations, which enables us to interrogate potential cells-of-origin. (edu.au)
  • The 11 genes with a high frequency of mutation differed between cancers, and mutations in many DNA DSB repair E3 ligase genes were related to a higher total mutation burden. (bmbreports.org)
  • Over 80% of oncogenic KRAS mutations happen at codon 12 the place the glycine residue is substituted by totally different amino acids, resulting in genomic heterogeneity of KRAS-mutant tumors. (bioinfor.me)
  • We propose that molecular testing for driver mutations should be considered in young patients with a light or no smoking history, even if the histological findings correspond with SqCC, and alectinib therapy represents a reasonable option in cases of ALK -rearranged lung SqCC. (biomedcentral.com)
  • Numerous oncogenic driver mutations have been identified in patients with non-small cell lung cancer. (biomedcentral.com)
  • Cancer is the result of the gradual accumulation of gene mutations that lead to an increase of cell proliferation [ 4 - 6 ] . (oaepublish.com)
  • EGFR (epidermal growth factor receptor), ALK (anaplastic lymphoma receptor tyrosine kinase), RET (ret proto-oncogene receptor tyrosine kinase), and BRAF (B-Raf proto-oncogene, serine/threonine kinase) are well-identified oncogenic driver mutations in lung cancer, and are targets for therapeutic application. (oncotarget.com)
  • Background: Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related death in Western countries. (harvard.edu)
  • Bronchioalveolar stem cells (BASCs) are a putative cancer stem cell population in mouse models of oncogenic K-ras-induced lung adenocarcinoma, an histologic subtype of NSCLC. (harvard.edu)
  • Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and is the leading cause of cancer death worldwide. (biomedcentral.com)
  • Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell lung cancer (NSCLC) accounting for about 85% of cases and lung adenocarcinoma (LUAD) being the most common subtype [ 1 ]. (biomedcentral.com)
  • The NCI-H1975 non-small cell lung cancer (NSCLC) cell line expresses the Hsp90 client EGFRL858R/T790M, a constitutively activated and erlotinib-resistant form of EGFR, and ganetespib treatment resulted in a dose-dependent decrease in EGFR expression in these cells (Fig. 2A). (medkoo.com)
  • Previous studies have demonstrated that glycolysis inhibitors reduce the proliferation of non‑small cell lung cancer (NSCLC) cells by interfering with the aerobic glycolytic pathway. (spandidos-publications.com)
  • There are primarily two types of lung cancer: Non-small cell lung cancer (NSCLC) and SCLC, and the former accounts for ~85% of all lung cancer cases ( 3 ). (spandidos-publications.com)
  • Although valuable progress has been made in the treatment of NSCLC in previous years, the high metastasis rate, post-operative recurrence rate and resistance to chemotherapeutic drugs in lung cancer have led to unsatisfactory outcomes ( 4 , 5 ). (spandidos-publications.com)
  • In the 1920s, Otto Heinrich Warburg discovered that cancer cells, unlike normal cells, use the glycolytic pathway to obtain energy for growth even in the presence of oxygen, which is a phenomenon known as 'aerobic glycolysis' or the Warburg effect ( 9 ), and aerobic glycolysis is a common metabolic phenotype in NSCLC ( 11 ). (spandidos-publications.com)
  • In recent years, there has been a major paradigm shift in the management of non-small cell lung cancer (NSCLC). (amegroups.org)
  • In this review, we will examine the major subtypes of oncogenic drivers behind NSCLC as well as the development of targeted agents available to treat them both now and in the foreseeable future. (amegroups.org)
  • Over the last decade, molecular translational research advances have heralded major breakthroughs in the understanding, diagnosis and management of lung cancer, particularly for the more common (~80%) non-small cell lung cancer (NSCLC). (amegroups.org)
  • This distinction alone allows for a more tailored selection of cytotoxic chemotherapy in advanced NSCLC without a driver mutation, as seen with enhanced efficacy with pemetrexed in adenocarcinoma ( 14 , 15 ) or the toxicity concerns of bevacizumab in patients with squamous histology ( 16 ). (amegroups.org)
  • The traditional and now over-simplified histological distinctions within NSCLC include adenocarcinoma, SCC and large cell carcinoma ( Figure 1 ). (amegroups.org)
  • KRAS mutation is the most typical oncogenic driver in superior non-small cell lung most cancers (NSCLC), occurring in roughly 30% of lung adenocarcinomas. (bioinfor.me)
  • Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. (medscape.com)
  • Because most lung cancers cannot be cured with currently available therapeutic modalities, the appropriate application of skilled palliative care is an important part of the treatment of patients with NSCLC. (medscape.com)
  • Cigarette smoking is a strong risk factor for developing non-small cell lung cancer (NSCLC). (biomedcentral.com)
  • Chromosomal rearrangements involving the gene that encodes the RET tyrosine kinase are known oncogenic drivers in 1% to 2% of patients with non-small cell lung cancer (NSCLC). (cobioer.com)
  • ECOG1594 was the first trial comparing four different chemotherapy regimens for advanced non-small cell lung cancer (NSCLC) head to head [ 1 ]. (biomedcentral.com)
  • The majority of patients with non-small-cell lung cancer (NSCLC) present with advanced disease, with targeted therapies providing some improvement in clinical outcomes. (bmj.com)
  • Lung cancer is the most prevalent life-threatening cancer worldwide 1 with more than 80% being non-small-cell lung cancer (NSCLC). (bmj.com)
  • 3 The development of molecular targeted therapies aimed at these molecular alterations has generated great optimism for the treatment of cancers such as NSCLC, and drugs targeting the EGFR tyrosine kinase domain are now available. (bmj.com)
  • Epidermal growth factor receptor (EGFR) mutation status is regarded as a particularly important element for improving non squamous non-small cell lung cancer (NSCLC) prognosis. (biomedcentral.com)
  • Further investigation revealed that mutant EGFR could activate the oncogenic STAT3 pathway via upregulated IL-6 autocrine signaling. (wikipedia.org)
  • Detection of Novel NRG1, EGFR, and MET Fusions in Lung Adenocarcinomas in the Chinese Population. (cdc.gov)
  • EGFR downstream signaling promotes constitutive activation of TKIs domain due to the mutation in exon 19 and exon 21 (L858R point mutation), which leads to cell proliferation, invasion, metastasis, and angiogenesis, causing lung adenocarcinoma. (lidsen.com)
  • The mineral dust-induced gene, mdig, regulates angiogenesis and lymphangiogenesis in lung adenocarcinoma by modulating the expression of VEGF-A/C/D via EGFR and HIF-1α signaling. (nih.gov)
  • Research has reported that two genes in particular (human epidermal growth factor receptor [ EGFR ] and anaplastic lymphoma kinase [ ALK ]) are associated with improvements in therapeutic efficiency in non-small cell lung cancer patients receiving targeted therapies. (biomedcentral.com)
  • Despite a diagnosis of SqCC, the patient underwent ALK testing, as she was a non-smoker diagnosed with lung cancer harboring the wild-type EGFR gene. (biomedcentral.com)
  • Notably, inhibition of GPR171 synergistically enhanced the tumoricidal activity of an epidermal growth factor receptor (EGFR) inhibitor in lung cancer cells. (oncotarget.com)
  • The epidermal growth factor receptor (EGFR) mutation status assessment has become increasingly important given the significant impact of tyrosine kinase inhibitors in lung cancer management. (biomedcentral.com)
  • EGFR mutation status was assessed for lung adenocarcinoma samples (formalin fixed- paraffin embedded samples) using qPCR, SNaPshot and NGS (Ion Torrent™) techniques. (biomedcentral.com)
  • Lung adenocarcinoma samples addressed for routine EGFR testing to the local molecular diagnostic laboratory between October 2013 and June 2015 were considered. (biomedcentral.com)
  • KRAS(G12D) drives lepidic adenocarcinoma through stem-cell reprogramming. (stanford.edu)
  • In so doing, we also uncover a capacity for oncogenic KRAS to reprogram a differentiated and quiescent cell back into its parent stem cell en route to adenomatous transformation. (stanford.edu)
  • 2019). Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma. (edu.au)
  • Leading experts Estelamari Rodriguez, MD, MPH, from the University of Miami Sylvester Comprehensive Cancer Center, Jason Porter, MD, from West Cancer Center & Research Institute, and Terri Conneran, founder of KRAS Kickers, discuss the latest in lung cancer treatments and ongoing clinical trials. (thepatientstory.com)
  • Their focus is on any KRAS oncogene or cancer type with the mission of connecting people to the latest research resources and community. (thepatientstory.com)
  • I wanted to connect with other people so that we can all learn what this means and how we can make it better to live with KRAS cancers. (thepatientstory.com)
  • Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical Ras effectors is still very limited. (tum.de)
  • We show that cell-autonomous phosphoinositide 3-kinase (PI3K) and 3-phosphoinositide-dependent protein kinase 1 (PDK1), but not Craf, are key effectors of oncogenic Kras in the pancreas, mediating cell plasticity, acinar-to-ductal metaplasia (ADM), and pancreatic ductal adenocarcinoma (PDAC) formation. (tum.de)
  • This contrasts with Kras-driven non-small cell lung cancer, where signaling via Craf, but not PDFK1, is an essential tumor-initiating event. (tum.de)
  • These in vivo genetic studies together with pharmacologic treatment studies in models of human ADM and PDAC demostrate tissue-specific differences of oncogenic Kras signaling and define PI3K/PDK1as a suitable target for therapeutic intervention specifically in PDAC. (tum.de)
  • Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer-related death worldwide, with more than 780,000 new cases and around 745,000 deaths each year [ 1 ]. (oncotarget.com)
  • It has been reported that lung cancer cells exhibit upregulated expression of all key glycolytic enzymes [hexokinase 2 (HK2), phosphofructokinase and pyruvate kinase (PK)] ( 13 ), suggesting that the essential enzymes of the aerobic glycolytic pathway have a critical role in the development of lung carcinoma. (spandidos-publications.com)
  • Lung carcinoma is the leading cause of cancer-related death in men and women worldwide. (msdmanuals.com)
  • Dr. Hsu has confirmed the clinical relevance of the MCT-1 activation in different types of aggressive breast cancers and lung carcinoma. (nhri.org.tw)
  • Immunostaining of clinical samples indicated that GPR171 was overexpressed in 46.8% of lung carcinoma tissues. (oncotarget.com)
  • Depletion of GPR171 with an anti-GPR171 antibody decreased proliferation of lung carcinoma cells and attenuated tumor progression in a mouse xenograft model. (oncotarget.com)
  • and large cell carcinoma (5-15% of all lung cancers) [ 4 , 5 ]. (oncotarget.com)
  • For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
  • Moreover, it was shown that tumor progression selects for cells that are VEGF-dependent, challenging the belief that VEGF's role in cancer is limited to angiogenesis. (wikipedia.org)
  • Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)
  • The Notch signaling network exerts oncogenic and tumor‑suppressive effects in a cancer stage‑ or (sub)type‑dependent manner. (spandidos-publications.com)
  • Oncogenic K-ras-induced BASC accumulation and tumor growth were blocked by treatment with a small molecule PI3K inhibitor and enhanced by inactivation of phosphatase and tensin homologue deleted from chromosome 10, a negative regulator of PI3K. (harvard.edu)
  • Comprehensive analysis of tumor mutation burden and immune microenvironment in prostate cancer. (cdc.gov)
  • However, the mitochondrial oxidative phosphorylation (OXPHOS) pathway in tumor cells has also been implicated in lung cancer metabolism. (spandidos-publications.com)
  • Certain metabolic alterations, also referred to as metabolic reprogramming, are commonly observed in tumor cells and are proposed to be hallmarks of cancer ( 8 ). (spandidos-publications.com)
  • Implementation of this model as an autochthonous lung cancer model showed that transduction-mediated activation of Myc led to accelerated tumor progression and significantly reduced overall survival relative to nontargeted tumor controls. (figshare.com)
  • DNA DSB repair E3 ligase genes are involved in tumor suppressive or oncogenic functions, such as RNF168 and FBXW7, by assisting the functionality of these genomic alterations. (bmbreports.org)
  • The TNM (tumor-node-metastasis) staging system from the American Joint Committee for Cancer Staging and End Results Reporting is used for all lung carcinomas except small-cell lung cancer. (medscape.com)
  • Indeed, the so-called "Vogelgram", the most important model of cancer development, has been proposed in this tumor type. (oaepublish.com)
  • Dr. Hsu's research interest is to investigating the oncogenic mechanisms that induce DNA damage, chromosomal instability, mitotic catastrophe, neoplastic multinucleation, tumor progression, metastasis and microenvironment. (nhri.org.tw)
  • Her laboratory has identified the oncogenic kinase pathways involving the microRNA biogenesis, EMT signaling activation and tumor progression/metastasis. (nhri.org.tw)
  • Aberrant activation of MCT-1 in cancer cells induces generation of intracellular ROS, tumor-promoted cytokines and the miRNAs which potentially activate the differentiation of immune cells, endothelial cells and fibroblasts. (nhri.org.tw)
  • Here, we show that an increase in the levels of GPR171 is crucial for lung cancer tumor progression in vitro and in vivo . (oncotarget.com)
  • The surgical approach in gastric cancer depends on the location, size, and locally invasive characteristics of the tumor. (medscape.com)
  • Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)
  • Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2019 8 14 (11): 2003-2008. (cdc.gov)
  • My laboratory generates preclinical models of lung cancer and employs diverse disciplines such as molecular biology, clinical oncology, immunology and metabolomics to prioritise clinically relevant questions. (edu.au)
  • We hypothesized that Wnt activation in pulmonary microvascular endothelial cells (PMVECs) is required for pulmonary angiogenesis, and its loss contributes to PAH.METHODS: Lung tissue and PMVECs from healthy and PAH patients were screened for Wnt production. (stanford.edu)
  • Dr. Tushar Desai specializes clinically in the treatment of general pulmonary and Interstitial Lung Diseases like Idiopathic Pulmonary Fibrosis (IPF). (stanford.edu)
  • Dr. Desai conducts basic and translational research on lung stem cells that repair and regenerate the lung after injury, and their role in diseases like IPF, Chronic Obstructive Pulmonary Disease (COPD), and lung adenocarcinoma. (stanford.edu)
  • My lab is focused on understanding the causes of and working towards specific molecular and cell-based treatments for lung diseases like cancer, pulmonary fibrosis, COPD. (stanford.edu)
  • We are focused on Wnt signaling because this appears to be a key signal that confers stem cell potency in both mouse and human lung, and is overactive in diseases like lung adenocarcinoma and Idiopathic Pulmonary Fibrosis (IPF). (stanford.edu)
  • Frequent NRG1 fusions in Caucasian pulmonary mucinous adenocarcinoma predicted by Phospho-ErbB3 expression. (cdc.gov)
  • Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes. (cdc.gov)
  • Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic interstitial lung disease. (lungdiseasesjournal.com)
  • slideshow for more information on benign and malignant etiologies of solitary pulmonary nodules and the Cutaneous Clues to Diagnosing Metastatic Cancer slideshow to help identify various skin lesions that are cause for concern. (medscape.com)
  • Clinical cancer research : an official journal of the American Association for Cancer Research 2021 5 27 (14): 4066-4076. (cdc.gov)
  • Journal of the National Cancer Institute 2021 3 113 (9): 1194-1202. (cdc.gov)
  • According to the latest statistical report from the American Cancer Center from 2021, lung cancer has the second-highest incidence and the highest mortality rate among all malignancies ( 2 ). (spandidos-publications.com)
  • Similarly, HER2 overexpression occurs in approximately a quarter of breast cancers and correlates with poor prognosis. (wikipedia.org)
  • Comprehensive analysis of the clinicopathological features, targetable profile, and prognosis of mucinous adenocarcinoma of the lung. (cdc.gov)
  • This study aimed to find new biomarkers to facilitate the prognosis and diagnosis of ovarian cancer. (bvsalud.org)
  • The shift towards targeted therapies in cancer treatment, which began with the development of tamoxifen and accelerated following the success of such drugs as rituximab and imatinib (Gleevec), has altered our perceptions of cancer treatment and cancer prognosis. (drugtargetreview.com)
  • MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer. (nih.gov)
  • Specific lipids in cancer tissues have been reported as potential biomarkers reflecting patient prognosis and the risk of postoperative recurrence. (biomedcentral.com)
  • Instead, this research suggests that VEGF receptor-targeted therapeutics may impair cancer survival and invasion as well as angiogenesis. (wikipedia.org)
  • Global and endothelial-specific Wnt7a-/- mice were generated and exposed to chronic hypoxia and Sugen-hypoxia (SuHx).RESULTS: Healthy PMVECs demonstrated >6-fold Wnt7a expression during angiogenesis that was absent in PAH PMVECs and lungs. (stanford.edu)
  • Furthermore, in human breast cancer, interference with the de-regulated Wnt signaling pathway reduces proliferation and survival of cancer. (wikipedia.org)
  • Both mouse and human in vivo models of HER2-overexpressing breast cancers relied critically on this HER2-IL-6-STAT3 signaling pathway. (wikipedia.org)
  • Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. (nature.com)
  • These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis. (nature.com)
  • His lab also studies the molecular signals that regulate lung stem cell activity, and how the signals can be manipulated to restore their activity. (stanford.edu)
  • We focus our attention on lung stem cells and the molecular signals that regulate their activity to repair and regenerate lung tissue after injury. (stanford.edu)
  • Its molecular interactions were determined through KEGG analysis, and real-time PCR-based expression analysis was performed to assess its co-expression with another oncogenic cellular pathway (miR-223, KLF9, and PKCε) proteins in ovarian cancer. (bvsalud.org)
  • In 2005, the first-ever trial combining small molecular targeted agent known as bevacizumab, an anti-vascular endothelial growth factor (VEGF) monoclonal antibody, with doublet chemotherapy, had shown superiority of overall survival with this treatment modality in advanced non-squamous non-small cell lung cancer patients without brain metastasis [ 2 ]. (biomedcentral.com)
  • 2 The pathogenesis of lung cancer involves the accumulation of several molecular abnormalities over time. (bmj.com)
  • Moreover, the LINC00852 target S100A9 had a positive regulatory role in the progression, migration, invasion, and metastasis of lung adenocarcinoma cells, both in vitro and in vivo. (madiclab.com)
  • ADCs and CAR‑Ts could alter the therapeutic framework for refractory cancers, especially diffuse‑type gastric cancer, ovarian cancer and pancreatic cancer with peritoneal dissemination. (spandidos-publications.com)
  • CONCLUSION: Through further in vitro and in vivo validation, these variants can be used at the clinical level as novel prognostic markers and therapeutic targets against cervical cancer. (bvsalud.org)
  • This study provides a broad list of candidate genes as potential biomarkers for genomic instability and novel therapeutic targets in cancer. (bmbreports.org)
  • Her laboratory also establishes a unique ex vivo three dimensional dissection of tumorigenic microenvironment to analyze the therapeutic effect and utilizes an in vivo animal work to demonstrate the tumorigenic outcomes upon gain or loss of the oncogenic activity. (nhri.org.tw)
  • Therefore, suppressing the MCT-1 oncogenic mechanism may strengthen the cancer therapeutic outcomes. (nhri.org.tw)
  • G protein-coupled receptors (GPCRs) are among the most significant therapeutic targets and some of them promote the growth and metastasis of cancer. (oncotarget.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • The analysis revealed PKCε variants promoted aberrant interactions with Smad3 that might lead to the activation of oncogenic pathways. (bvsalud.org)
  • The RAS gene family, responsible for signal transduction within the mitogen activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K) pathways, is frequently involved in carcinogenesis, and alterations in its member genes can be detected, with variable frequency, in a wide variety of solid and hematological cancers. (oaepublish.com)
  • We analysed tumour and matched normal material from 230 previously untreated lung adenocarcinoma patients who provided informed consent ( Supplementary Table 1 ). (nature.com)
  • Like human lepidic adenocarcinoma, the tumour cells slowly spread along alveolar walls in a non-destructive manner and have low ERK activity. (stanford.edu)
  • Currently available cancer model systems for targeted drug screening are typically derived from either commonly used tumour cell lines or from established cell lines that have been modified to overexpress specific targets. (drugtargetreview.com)
  • Even when well-characterised cancer lines are used as screening models, the screening of therapies that target a specific oncogenic mechanism is confounded by the complex web of mechanisms that promote tumour growth. (drugtargetreview.com)
  • We are also interested in tumour heterogeneity and how this heterogeneity influences metastatic dissemination in lung cancer. (edu.au)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • Furthermore, TPD52 and miR-223 expression were upregulated in the early stages of cancer and non-metastatic cancers. (bvsalud.org)
  • Overall, this work demonstrates how CRISPRa can be used for rapid functional validation of putative oncogenes and may allow for the identification and evaluation of potential metastatic and oncogenic drivers through competitive screening. (figshare.com)
  • See the Critical Images slideshow Cutaneous Clues to Diagnosing Metastatic Cancer to help identify various skin lesions that are cause for concern. (medscape.com)
  • Metastatic ALK -rearranged lung adenocarcinoma patients treated with ALK inhibitors demonstrate higher response rates, improved progression-free survival, and reduced toxicity relative to those treated with conventional chemotherapy regimens. (biomedcentral.com)
  • Schiza A, Fredriksson I, Sund M, Valachis A. De novo metastatic breast cancer in men vs women: a Swedish population-based cohort study. (cancercentrum.se)
  • Methodology/Principal Findings: We used genetic and pharmacologic approaches to modulate the activity of phosphatidylinositol 3-kinase (PI3K), a key mediator of oncogenic K-ras, in two genetic mouse models of lung adenocarcinoma. (harvard.edu)
  • Lung stem cells can also be exploited to treat monogenic diseases, by using CRISPR to correct the genetic mutation then transplanting them back into the patient. (stanford.edu)
  • RESULTS: This study revealed that genetic variants rs1553369874 and rs1345511001 were associated with cervical cancer. (bvsalud.org)
  • With these two technologies combined, we can now better understand cancer genomes and create disease models driven by genetic abnormality. (drugtargetreview.com)
  • 8 When used together with the unedited parental cell line, engineered cancer cells come with a built-in isogenic control with an identical genetic background. (drugtargetreview.com)
  • Engineered cancer models can then be assembled into isogenic cancer panels by introducing sets of genetic variants in parallel. (drugtargetreview.com)
  • Genetic alterations found in human lung cancer patients can be replicated in our models using Cre-LoxP recombination and CRISPR/Cas9 technology. (edu.au)
  • Lung cancer is the most common cause of global cancer-related mortality, leading to over a million deaths each year and adenocarcinoma is its most common histological type. (nature.com)
  • Our experimental approaches involve mouse genetics, single cell genomics, organoid culture, lung slice culture, and we perform histological analysis of lung tissue using advanced fluorescence microscopy technologies. (stanford.edu)
  • My lab also studies the role of TERT in lung stem cell biology and repair of acute lung injury, which is a culprit gene mutation in IPF. (stanford.edu)
  • A case of multiple primary lung adenocarcinoma with a CD74-NRG1 fusion protein and HER2 mutation benefit from combined target therapy. (cdc.gov)
  • DNA damage response-related E3 ligases, such as RNF168, FBXW7, and HERC2, were generated with more than 10% mutation in several cancer cells. (bmbreports.org)
  • Current evidence indicates that RNAs play important roles in oncogenesis and cancer pathogenesis. (biomedcentral.com)
  • This review focuses on an up-to-date understanding of the functions of E3 ligases in cancers and debates the perspectives of cancer cells that rely on inhibition or activation of ubiquitylation of target proteins. (bmbreports.org)
  • Tyrosine kinase inhibitors and immunotherapy for lung cancer are the two major areas undergoing rapid development. (biomedcentral.com)
  • Herein, we summarize emerging agents including tyrosine kinase inhibitors, checkpoint inhibitors, and other potential immunotherapy such as chimeric antigen receptor T cell for non-small cell lung cancer attempting to provide insights and perspectives of the future in anticancer treatment. (biomedcentral.com)
  • We are interested in understanding mechanisms of immunosurveillance with the aim of exploiting this knowledge to harness the immune system to treat lung cancer. (edu.au)
  • 2 Discovery and development of new therapies for current and emerging cancer targets relies heavily on high-throughput screening and iterative refinement of lead compounds and biologics. (drugtargetreview.com)
  • Furthermore, S100A9 strongly activated the P38 and REK1/2 kinases, and slightly activated the phosphorylation of the JNK kinase in the MAPK pathway in A549 and SPCA-1 cells.Conclusion: LINC00852 targets S100A9 to promote progression and oncogenic ability in lung adenocarcinoma SM through activation of the MAPK pathway. (madiclab.com)
  • Therefore, considerable effort has been focused on the identification of effective drug targets for lung cancer. (oncotarget.com)
  • By contrast, models derived from cell lines modified to overexpress a particular cancer biomarker have a clear oncogenic mechanism. (drugtargetreview.com)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • 2018). Synergy between the KEAP1/NRF2 and PI3K pathway drives non-small cell lung cancer with an altered immune microenvironment. (edu.au)
  • We evaluated the diagnostic and prognostic value, and origin of whole blood NEAT1 in colorectal cancer. (biomedcentral.com)
  • The diagnostic value of whole blood NEAT1 expression was evaluated in test ( n = 60) and validation ( n = 200) cohorts of colorectal cancer patients and normal controls (NCs). (biomedcentral.com)
  • Whole blood NEAT1 expression was significantly higher in colorectal cancer patients than in NCs. (biomedcentral.com)
  • NEAT1_v1 and NEAT1_v2 expression were highly accurate in distinguishing colorectal cancer patients from NCs (area under the curve: 0.787 and 0.871, respectively). (biomedcentral.com)
  • Whole blood NEAT1 expression is a novel diagnostic and prognostic biomarker of overall survival in colorectal cancer. (biomedcentral.com)
  • In the present study, we determined the diagnostic and prognostic significance and of whole blood NEAT1 in patients with colorectal cancer. (biomedcentral.com)
  • The evolution from benign to malignant lesions and their acquisition over time has been extensively studied, especially in colorectal cancer (CRC) [ 7 ] . (oaepublish.com)
  • Thoracic cancer 2022 9 13 (21): 3063-3067. (cdc.gov)
  • Autocrine signaling plays critical roles in cancer activation and also in providing self-sustaining growth signals to tumors. (wikipedia.org)
  • Another group found that high serum levels of IL-6 correlated with poor outcome in breast cancer tumors. (wikipedia.org)
  • Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
  • Thereby, the studies identify the information for understanding the stepwise progression of tumors under the oncogenic stress. (nhri.org.tw)
  • Several studies have outlined the importance of autocrine IL-6 signaling in lung and breast cancers. (wikipedia.org)
  • Vashishth A, Shuaib M, Bansal T, Kumar S. Mycobacterium Tubercular Mediated Inflammation and Lung Carcinogenesis: Connecting Links. (lidsen.com)
  • Mycobacterium tuberculosis (MTB) induced tuberculosis has been known as one of the risk factors for lung carcinogenesis. (lidsen.com)
  • This review article has tried to draw a relationship between chronic tuberculosis and lung carcinogenesis. (lidsen.com)
  • The stage at which ovarian cancer is diagnosed mainly determines the survival outcomes of patients. (bvsalud.org)
  • In the present study, the aim was to find the association of its variants rs1553369874 and rs1345511001 with cervical cancer and to determine the influence of these variants on the protein-protein interactions of PKCε, which can lead towards cancer development and poor survival rates. (bvsalud.org)
  • Moreover, improvement in survival over the past several decades is lower for lung cancer than all other cancers [ 2 ]. (oncotarget.com)
  • R, Flisberg P, Hedlund L, Östlund I, Bergkvist L. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane. (cancercentrum.se)
  • Through flow cytometric studies we have developed methods to interrogate the immune microenvironment of lung cancer. (edu.au)
  • These engineered models have the potential to dramatically accelerate the development of targeted cancer therapeutics. (drugtargetreview.com)
  • By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
  • Early-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes. (cdc.gov)
  • However, despite encouraging progress in this area, there remain significant challenges regarding relevant cancer biomarker identification and testing, low clinical trial success rates for new therapies and rapid development of resistance to certain targeted therapies. (drugtargetreview.com)
  • Moreover, CRISPR/Cas9-engineered cancer models can be designed to mimic specific cancer genotypes found in clinical patient samples. (drugtargetreview.com)
  • Lung Cancer Treatments: Is a Clinical Trial Right for Me? (thepatientstory.com)
  • We cover cancers across the board, including lung cancer, with a focus on biomarkers and clinical trials . (thepatientstory.com)
  • See Clinical Presentations of Lung Cancer: Slideshow , a Critical Images slideshow, to help efficiently distinguish lung carcinomas from other lung lesions, as well as how to stage and treat them. (medscape.com)
  • I connected with other lung cancer groups and heard about biomarkers. (thepatientstory.com)
  • Consequently, novel objective biomarkers that reflect postoperative risk in lung cancer patients who smoke must be identified. (biomedcentral.com)
  • From our data, we propose three PC isomers, PC (14:0_18:2), PC (16:1_16:1), and PC (16:0_16:2), and a lipid peak of m/z 736.5276 as novel candidate biomarkers for postoperative recurrence risk in lung ADC and SQCC patients who are smokers. (biomedcentral.com)
  • With the recent advancements in mass spectrometry technology, lipidomics has been utilized as a new field for exploring cancer biomarkers [ 12 ]. (biomedcentral.com)
  • Understand the different lung cancer types and the significance of biomarker testing through this live conversation. (thepatientstory.com)
  • One major interest is the development of novel preclinical models that closely resemble human lung cancer. (edu.au)
  • Pathological and Prognostic Indications of the mdig Gene in Human Lung Cancer. (nih.gov)
  • Because cigarette smoking and oncogenesis alter lipid metabolism in lung tissue, we hypothesized that the lipid profiles in lung cancer tissues are influenced by cigarette smoking and can reflect the postoperative recurrence risk in smoking lung cancer patients. (biomedcentral.com)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • Notch signaling is aberrantly activated in breast cancer, non‑small‑cell lung cancer and hematological malignancies, such as T‑cell acute lymphoblastic leukemia and diffuse large B‑cell lymphoma. (spandidos-publications.com)
  • Ovarian cancer ranks sixth in terms of incidence rates while seventh in terms of mortality rates. (bvsalud.org)
  • Further study revealed that TPD52 mRNA and miRNA-223 expression was elevated, while the expression of KLF 9 and PKCε was reduced in the blood of ovarian cancer patients. (bvsalud.org)
  • Smoking is the major cause of lung adenocarcinoma but, as smoking rates decrease, proportionally more cases occur in never-smokers (defined as less than 100 cigarettes in a lifetime). (nature.com)
  • Approximately 80% of all patients with lung cancer are considered for systemic therapy at some point during the course of their illness. (medscape.com)
  • Several other studies have shown that human monocyte cells infected by MTB enhance the invasion and cause induction of epithelial-mesenchymal transition (EMT) characteristics in lung cancer cell co-culture. (lidsen.com)
  • Metastasis is a major cause of cancer deaths, and strategies to prevent or halt invasion are lacking. (wikipedia.org)
  • Lung cancer remains by far the single most common cause of cancer-related mortality with nearly 1.6 million deaths worldwide in 2012 or nearly 20% of cancer mortality as a whole ( 1 ). (amegroups.org)
  • Lung and bronchus cancers account for the greatest proportion of cancer deaths worldwide [ 1 , 2 ]. (oncotarget.com)
  • Defects in DNA double-strand break (DSB) repair signaling permit cancer cells to accumulate genomic alterations that confer their aggressive phenotype. (bmbreports.org)
  • In 2014, an official announcement from Pfizer indicated the trial failure of dacomitinib in patients with refractory advanced non-small cell lung cancer. (biomedcentral.com)
  • Our efforts focused on comprehensive, multiplatform analysis of lung adenocarcinoma, with attention towards pathobiology and clinically actionable events. (nature.com)
  • It has been proposed that tuberculosis causes chronic inflammation, which increases the risk of lung cancer by creating a favorable environment. (lidsen.com)
  • Chronic inflammation increases the risk of many cancers, including lung cancer. (msdmanuals.com)