CCND1Multiple Oncogenic PathwaysPathwaysCDK4MRNADifferentiationSurvivinInhibitionInhibitsProliferationKinase inhibitorPhosphorylationStrongly correlatedVEGFMiRNAsPromotesDownregulationInduceApoptosisRegulationStat3RegulatesMitoticCooperatesPathwayImmunohistochemicalTumorMutationsAmplificationExpressionTransformationGeneProteinEnhancesTissuesEGFRCellsHumanCancerActivationFunctionHighlyFound
CCND19
- Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. (wikipedia.org)
- The CCND1 gene encodes the cyclin D1 protein. (wikipedia.org)
- Amplification of the CCND1 gene is present in: non-small cell lung cancers (30-46%) head and neck squamous cell carcinomas (30-50%) pancreatic carcinomas (25%) bladder cancer (15%) pituitary adenomas (49-54%) breast carcinoma (13%) Cyclin D1 overexpression is strongly correlated to ER+ breast cancer and deregulation of cyclin D1 is associated with hormone therapy resistance in breast cancer. (wikipedia.org)
- BMP2 treatment inhibited YAP/TEAD-mediated Cyclin D1 ( ccnd1 ) expression, and knockdown of ccnd1 abrogated the BMP2-mediated inhibition of mouse NSC proliferation. (jneurosci.org)
- The cyclin D1b oncogene arises from alternative splicing of the CCND1 transcript, and harbors markedly enhanced oncogenic functions not shared by full-length cyclin D1 (cyclin D1a). (nih.gov)
- May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. (nih.gov)
- In this study, Genevestigator, Kaplan-Meier Plotter, and the Human Protein Atlas databases were used to analyze the expression of p27, cell division protein kinase 6 (CDK6), and cyclin D1 (CCND1), as well as its prognostic value in different tumor tissues and corresponding normal tissues. (omicsdi.org)
- Furthermore, HDGF could interact with c-Jun, an oncogenic transcription factor, which eventually induced the expressions of cell cycle promoters, CCND1/CDK4/CDK6. (omicsdi.org)
- This finding suggested that NAP1L1 could interact with HDGF, and the latter recruited c-Jun, a key oncogenic transcription factor, that further induced CCND1/CDK4/CDK6 expression, thereby promoting proliferation and chemoresistance in glioma cells. (omicsdi.org)
Multiple Oncogenic Pathways1
- Glycogen synthase kinase-3ß (GSK3ß) suppresses tumor progression by downregulating multiple oncogenic pathways including Wnt signaling and cyclin D1 activation. (aston.ac.uk)
Pathways4
- Increasing cyclin D1 levels during the G1 phase is induced by mitogenic growth factors primarily through Ras-mediated pathways, and hormones. (wikipedia.org)
- These Ras-mediated pathways lead to the increase in transcription of cyclin D1, and inhibit its proteolysis and export from the nucleus. (wikipedia.org)
- These diverse genetic changes lead to oncogenic signalings via MAPK, PI-3 kinase, AKT and c-Myc pathways. (biomedcentral.com)
- In addition, we discovered two degradation pathways that downregulate C/EBPδ protein levels: the pro-oncogenic SIAH2 ubiquitin ligase pathway and a pathway requiring the tumor suppressor SCF-FBXW7 ubiquitin ligase (Sarkar et al. (nih.gov)
CDK47
- This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (wikipedia.org)
- Cyclin D1 is a regulatory subunit of cyclin-dependent kinases CDK4 and CDK6. (wikipedia.org)
- The cyclin D1-CDK4 complex promotes passage through the G1 phase by inhibiting the retinoblastoma protein (pRb). (wikipedia.org)
- Cyclin D1-CDK4 inhibits pRb through phosphorylation, allowing E2F transcription factors to transcribe genes required for entry into the S phase. (wikipedia.org)
- Cyclin D1-CDK4 also enables the activation of cyclin E-CDK2 complex by sequestering Cip/Kip family CDK inhibitory proteins p21 and p27, allowing entry into the S phase. (wikipedia.org)
- Cyclin D1-CDK4 also associates with several transcription factors and transcriptional co-regulators. (wikipedia.org)
- Cells in the resulting tumors proliferated at higher rates, expressed decreased levels of p15, and expressed increased levels of cyclin D1 and cdk4, compared with control cells. (nih.gov)
MRNA2
- Initially, it was observed that SF2 associates with cyclin D1b mRNA (transcript-b) in minigene analyses and with endogenous transcript in prostate cancer (PCa) cells. (nih.gov)
- In summary, we observed that EBV LMP1 enhances the transcriptional action and mRNA amount of the cyclin D1 gene in CNE1 cells. (gp120-inhibitors.com)
Differentiation7
- Independent of CDK, cyclin D1 binds to nuclear receptors (including estrogen receptor α, thyroid hormone receptor, PPARγ and AR ) to regulate cell proliferation, growth, and differentiation. (wikipedia.org)
- Cyclin D1 also binds to histone acetylases and histone deacetylases to regulate cell proliferation and cell differentiation genes in the early to mid-G1 phase. (wikipedia.org)
- However, the role of cyclin D1b in inducing macrophage differentiation toward tumor-associated macrophage-like cells remains unknown. (bvsalud.org)
- CONCLUSION: Breast cancer cells transfected with cyclin D1b can induce the differentiation of macrophages into a tumor-associated macrophage-like phenotype, which promotes tumor metastasis in vitro and in vivo. (bvsalud.org)
- Total RNA was extracted from MDSCs at three different stages of differentiation (MDSC-P, MDSC-D1 and MDSC-D3, representing 0, 1 and 3 days after differentiation, respectively), and used to construct small RNA libraries for RNA sequencing (RNA-seq). (biomedcentral.com)
- PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. (shu.edu)
- Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. (bvsalud.org)
Survivin3
- Cell proliferation in the colonic crypts was reduced significantly by TA, coincident with increased cleaved caspase-3 and decreased Survivin, β-catenin, cyclin D1 and matrix metalloproteinase 7. (houstonmethodist.org)
- Curcumin and RL197 inhibited RKO and SW480 cancer of the colon cell development and induced apoptosis which was followed by downregulation of specificity proteins (Sp) transcription elements Sp1 Sp3 and Sp4 and Sp-regulated genes like the epidermal development aspect receptor (EGFR) hepatocyte development element receptor (c-MET) survivin bcl-2 cyclin D1 and NFκB (p65 and p50). (health-ground.com)
- Moreover, down-regulation of anti-apoptotic genes (Bcl-2, Bcl-xL and survivin) and a cell cycle regulating gene (cyclin D1) was associated with the cell growth inhibition and apoptosis. (biomedcentral.com)
Inhibition4
- In BRAF V600E mutated cells inhibition of BRAF pathway lead to a decrease in ERK1/2 phosphorylation and cyclin D1 levels and an increase in p27 Kip1 . (biomedcentral.com)
- This pathway de-represses GSK3ß inhibition of oncogenic substrates causing stabilization of cyclin D, which induces cell-cycle progression and ß-catenin, SNAIL, and SLUG, which promote epithelial to mesenchymal transition. (aston.ac.uk)
- Malignant cells expressing oncogenic B-Raf show selective inhibition of mitogen-activated protein kinase activation, proliferation, transformation, and tumorigenicity when exposed to SB-590885 , whereas other cancer cell lines and normal cells display variable sensitivities or resistance to similar treatment. (xcessbio.com)
- Our information showed that DZ1 can inhibit EBV LMP1 induced promoter exercise of cyclin D1 via EGFR or STAT3 and that DZ1 enhanced cyclin D1 promoter inhibition based on ex periments with mutants of EGFR or STAT3. (gp120-inhibitors.com)
Inhibits1
- Background Curcumin inhibits development of several cancer tumor cell lines and research in this lab in bladder and pancreatic LY-411575 cancers cells present that curcumin downregulates specificity proteins (Sp) transcription elements Sp1 Sp3 and Sp4 and pro-oncogenic Sp-regulated genes. (health-ground.com)
Proliferation3
- In colon cancer suppression of BRAF in cell lines with BRAF V600E showed significant decreased proliferation through cyclin D1 and p27 Kip1 and induces apoptosis by a significant decrease in the levels of anti-apoptotic protein Bcl-2 [ 14 ]. (biomedcentral.com)
- the chromosomal translocations including these genes are believed to exert their oncogenic activities through constitutive activation of the NF-B pathway, leading to manifestation of a number of genes important for cell survival and proliferation[21]. (californiaehealth.org)
- Uncleaved Gli travels to the nucleus and is an inducer of transcription, increasing Cyclin D1 and stimulating the cell cycle (proliferation). (shu.edu)
Kinase inhibitor2
- SB-590885 stabilizes the oncogenic B-Raf kinase domain in an active configuration, which is distinct from the previously reported mechanism of action of the multi-kinase inhibitor, BAY43-9006. (xcessbio.com)
- Unlike the multi-kinase inhibitor BAY43-9006, SB590885 stabilizes the oncogenic B-Raf kinase domain in an active configuration. (xcessbio.com)
Phosphorylation2
- Cyclin D1 is degraded by the proteasome upon phosphorylation of threonine 286 and subsequent ubiquitylation via the CRL4-AMBRA1 E3 ubiquitin ligase complex. (wikipedia.org)
- In the last mentioned, both isoforms play an anti-proliferative function by marketing APC-dependent phosphorylation of -catenin - a transcription aspect favorably regulating Myc and cyclin D1 appearance C therefore concentrating on it to proteasome-mediated degradation [7]. (greatlakeshighereducationnow.com)
Strongly correlated1
- Finally, the relevance of SF2 function was established, as SF2 strongly correlated with cyclin D1b (but not cyclin D1a) in human PCa. (nih.gov)
VEGF2
- Cyclin D1 overexpression has been shown to correlate with early cancer onset and tumor progression and it can lead to oncogenesis by increasing anchorage-independent growth and angiogenesis via VEGF production. (wikipedia.org)
- Other studies in colon cancer cells report similar responses and also show downregulation of cyclin D1 bcl-2 VEGF and p65 (NFκB) and other pro-oncogenic factors [15-19]. (health-ground.com)
MiRNAs5
- 16. Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs. (nih.gov)
- MiRNAs upregulation or deregulation was found to have oncogenic potential. (jcancer.org)
- Recently, accumulating preclinical studies have illustrated the feasibility of slowing tumor progression by either overexpressing tumor suppressive miRNAs, or by neutralizing the activities of oncogenic miRNAs in cell- and animal-based models of cancer. (biomedcentral.com)
- There were 9 up-expressed, 165 down-expressed, and 15 up-expressed, 145 down-expressed in MDSC-D1 and MDSC-D3, respectively, compared to those in MDSC-P. Also, 17 up-expressed, 55 down-expressed miRNAs were observed in MDSC-D3 compared to those in MDSC-D1. (biomedcentral.com)
- Regarding the 53 novel miRNAs, there were 7 up-expressed, 31 down-expressed, and 8 up-expressed, 26 down-expressed in MDSC-D1 and MDSC-D3, respectively, compared to those in MDSC-P. The expression levels of 12 selected miRNA genes detected by RT-qPCR were consistent with those generated by deep sequencing. (biomedcentral.com)
Promotes1
- This finding was significant, as the A870 allele promotes cyclin D1b in benign prostate tissue, but in primary PCa, cyclin D1b production is independent of A870 status. (nih.gov)
Downregulation1
- This results in preferential downregulation of oncogenic proteins leading to cell cycle arrest in the G1 phase and to increased expression of translationally regulated pro-apoptotic proteins. (nih.gov)
Induce4
- Cyclin D1 was originally cloned as a breakpoint rearrangement in parathyroid adenoma and was shown to be required for progression through the G1 phase of the cell cycle to induce cell migration, angiogenesis and to induce the Warburg effect. (wikipedia.org)
- Neither inactivation of Tgfbr2 nor expression of oncogenic Kras alone was sufficient to induce formation of intestinal neoplasms. (nih.gov)
- Human herpesviruses are known to induce a broad spectrum of diseases, ranging from common cold sores to cancer, and infections with some types of these viruses, known as human oncogenic herpesviruses (HOHVs), can cause cancer. (encyclopedia.pub)
- Furthermore, in the experimental systems where GSK3B has an oncogenic function its targeting continues to be demonstrated useful, either by itself on in conjunction with chemotherapy, to induce or boost tumor cells loss of life [13], [14]. (greatlakeshighereducationnow.com)
Apoptosis1
- Cyclin D1 overexpression can also down-regulate Fas expression, leading to increased chemotherapeutic resistance and protection from apoptosis. (wikipedia.org)
Regulation2
- Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression. (rochester.edu)
- This underlying mech anism for cyclin D1 regulation requires regulated binding of EGFR and STAT3 while in the cyclin D1 professional moter area likewise as rising the promoter activ ity with the cyclin D1 gene. (gp120-inhibitors.com)
Stat31
- It remains unclear whether oncogenic Stat3 signaling pathway is involved in the oncogenesis of bladder cancer. (biomedcentral.com)
Mitotic1
- Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (wikipedia.org)
Cooperates1
Pathway2
- It mediates beta-catenin dephosphorylation at adhesion junctions and acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. (shu.edu)
- Our contributions to elucidate the tumor suppressor-like functions of C/EBPδ in mammary epithelial cells include the findings that C/EBPδ augments cyclin D1 protein degradation by the APC/Ccdc27 pathway (Pawar et al. (nih.gov)
Immunohistochemical1
- Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma. (wikipedia.org)
Tumor4
- For example, ZNF322A and c-Jun cooperatively bind to AP-1 elements on the cyclin D1 and alpha-adducin promoters to transcriptionally upregulate their expression to enhance tumor growth and tumor metastasis [ 2 ]. (nature.com)
- however, the underlying mechanism(s) that control tumor-specific cyclin D1b induction remain unsolved. (nih.gov)
- Ewing sarcoma (EWS), a highly aggressive pediatric tumor, is driven by EWS- FLI1 , an oncogenic transcription factor that remodels the tumor genetic landscape. (aabioetica.org)
- This offers significant advantages for studying tumor pathogenesis and molecular mechanisms of oncogenesis caused by a single initiating oncogenic event introduced through the mouse germ line. (molvis.org)
Mutations1
- Thyroid carcinomas show a high prevalence of mutations in the oncogene BRAF which are inversely associated with RAS or RET/PTC oncogenic activation. (biomedcentral.com)
Amplification1
- Increased levels of cyclin D1 resulting from genomic amplification mediate SB590885 resistance in B-Raf V600E-mutated melanomas. (xcessbio.com)
Expression3
- 5. DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1. (nih.gov)
- Our hypothesis is that consumption of diets rich in marine n-3 PUFAs exerts anti-prostate cancer activity because they reduce the expression of translationally regulated oncogenic proteins and increase expression of translationally regulated pro-apoptotic proteins. (nih.gov)
- As secondary endpoint in all studies we will correlate both clinical parameters of prostate cancer with the expression of translationally regulated oncogenic proteins such as Ras, c-myc and cyclin D1, and of pro-apoptotic proteins such as CHOP. (nih.gov)
Transformation2
- The inter action of oncoproteins E6 and E7 of higher oncogenic risk with intracellular variables is usually a critical stage for induction of malignant transformation. (gp120-inhibitors.com)
- Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time. (nih.gov)
Gene1
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. (wikipedia.org)
Protein2
- Cyclin D1 is a protein required for progression through the G1 phase of the cell cycle. (wikipedia.org)
- Here, we identify the RNA-binding protein ASF/SF2 as a critical, allele-specific, disease-relevant effector of cyclin D1b production. (nih.gov)
Enhances1
- We previously reported that cyclin D1b enhances the invasiveness of breast cancer cells by inducing EMT. (bvsalud.org)
Tissues1
- Cyclin D1 is expressed in all adult human tissues with the exception of cells derived from bone marrow stem cell lines (both lymphoid and myeloid). (wikipedia.org)
EGFR1
- RET fusions as primary oncogenic drivers and secondary acquired resistance to EGFR tyrosine kinase inhibitors in patients with non-small-cell lung cancer. (cdc.gov)
Cells4
- This study aimed to explore the relationship between breast cancer cells overexpressing cyclin D1b and TAMs. (bvsalud.org)
- METHODS: Mouse breast cancer 4T1 cells were transfected with cyclin D1b variant and co-cultured with macrophage cells in a Transwell coculture system. (bvsalud.org)
- RESULTS: After co-culture with breast cancer cells overexpressing cyclin D1b, RAW264.7 macrophages were differentiated into an M2 phenotype. (bvsalud.org)
- Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. (nih.gov)
Human2
- We analyzed intestinal tumors that arose in mice that express an oncogenic (active) form of Kras and that have Tgfbr2 inactivations-2 common molecular events observed in human colorectal tumors. (nih.gov)
- Some types of herpesvirus that can lead to cancer are recognized to be oncogenic, such as Epstein-Barr virus (EBV, also known as human herpesvirus 4) and Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8) [ 3 ] [ 4 ] . (encyclopedia.pub)
Cancer1
- Cyclin D1 overexpression is correlated with shorter cancer patient survival and increased metastasis. (wikipedia.org)
Activation1
- It is regarded as that A20-mediated oncogenic activities in MALT lymphoma depend within the NF-B activation induced by TNF or additional unidentified molecules[13]. (californiaehealth.org)
Function1
- Cyclins function as regulators of CDKs (cyclin-dependent kinase). (wikipedia.org)
Highly1
- Cyclin D1b is a highly oncogenic splice variant of cyclin D1. (bvsalud.org)
Found1
- Cyclin D1 has been found to be overexpressed in breast carcinoma. (wikipedia.org)