Binding proteinMutationsRegulator of p53ProteinsWild-type p53TumorsApoptosisMutationSuppressorTarget genesSupressor genesMDM2Ovarian cancerAlterationsProto-oncogenesPathwayAssociated with tumorTP53BRCA1MalignantVariantsDeletionExpressionEGFRRegulateRegulationCancersMutantChromosomeInhibitTherapiesTranscription factorTissuesPrognosticVivoHuman genesCertain genesPolymorphismsEpidermal growth fPTENEncodes a memberGeneticBreast cancer
Binding protein2
- Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene. (wikipedia.org)
- MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M". Mol. (wikipedia.org)
Mutations15
- Mutations of p53 tumor suppressor gene increase with tumor progression in colorectal cancers. (nih.gov)
- About half of cancers sustain mutations in the TP53 gene, whereas the other half maintain a wild-type p53 (wtp53) but may compromise the p53 response because of other alterations. (aacrjournals.org)
- Database of p53 gene somatic mutations in human tumors and cell lines. (google.se)
- Different cancer types tend to depend on a limited number of 'driver' oncogene mutations. (cancerquest.org)
- ALL cancers have lots of additional changes, the so-called 'passenger' mutations, that may contribute to the cancer, but are not the main genes. (cancerquest.org)
- Apparently several cancer-causing mutations, called oncogenes, are known already. (news-medical.net)
- Genetic testing for deleterious mutations in breast cancer 1, early onset gene ( BRCA1 ) and BRCA2 can provide key information to guide clinical decision making. (jci.org)
- Women who are heterozygous carriers of mutations in either gene have a 60%-80% lifetime risk of breast cancer and a 10%-40% lifetime risk of ovarian cancer ( 1 ), reflecting a very high penetrance. (jci.org)
- Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. (cancerindex.org)
- Inactivating mutations of the retinoblastoma gene (RB) are found in a wide variety of tumour cells. (wdv.com)
- Furthermore, no activating point mutations in the K-ras oncogene nor positive immunohistochemical staining for the p53 gene were observed in a set of 48 colon tumors. (dtu.dk)
- However, there are few studies on the relationship between gene mutations in these two and the sensitization of ovarian cancer. (oncotarget.com)
- Expression of p63 is almost exclusively restricted to epithelial cells, mutations in this gene are infrequent, and its expression is increased in a variety of solid tumors, particularly those of the head and neck area 12,13 . (bvsalud.org)
- Changes in your genes are also called gene variants or mutations. (medlineplus.gov)
- The implications of gene mutations in salivary DNA for noninvasive diagnosis of head and neck cancer with a focus on oral cancer. (cdc.gov)
Regulator of p535
- Homeodomain-interacting protein kinase-2 (HIPK2) is a positive regulator of p53 oncosuppressor function. (aacrjournals.org)
- p53 E3 ubiquitin protein ligase homolog (Mdm2) is an important negative regulator of p53. (molvis.org)
- Mdm2 is a key negative regulator of p53 activity. (molvis.org)
- These results unmask KLF4 as a regulator of p53 that oncogenically transforms cells as a function of p21CIP1 status. (uu.nl)
- The MDM2 proto-oncogene (MDM2) is a primary negative regulator of p53. (bvsalud.org)
Proteins6
- Genes contain instructions for the cell on how to make proteins. (oncolink.org)
- Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
- p53 affects the transcription of many target genes and interacts with key cellular proteins. (molvis.org)
- Genetic alterations were used to propose a new molecular classification for cutaneous melanomas, based upon differentially expressed proteins and genes such as B-RAF, K-RAS, cyclin D1 e CDKN2A. (fapesp.br)
- General objective: To evaluate the cell-cycle proteins, the supressor genes and oncogenes in acral lentiginous melanomas. (fapesp.br)
- Tumor suppressor genes provide instructions for making proteins that control how fast your cells grow and divide to make new cells. (medlineplus.gov)
Wild-type p534
- Only one case with wild-type p53 gene showed normal level expression of p53 regulatory-factors (p33ING1, p14ARF, and MDM2). (nih.gov)
- A cellular phosphoprotein with an apparent molecular mass of 90 kd (p90) that forms a complex with both mutant and wild-type p53 protein has been characterized, purified, and identified. (nih.gov)
- A wild-type p53-expressing plasmid enhanced the expression of the p53-responsive element when cotransfected into cells that contain no endogenous p53. (nih.gov)
- In response to DNA-damaging agents, the wild-type p53-activated fragment 1 (WAF1 also known as p21) is an important downstream effector in the p53-specific growth arrest pathway. (lu.se)
Tumors5
- In this study, we examined the expressions of p33ING1, p14ARF, MDM2 and p21WAF1 mRNA in 25 advanced colorectal cancers by quantitative RT-PCR method, and compared the expression levels of p33ING1, p14ARF, p21WAF1 and MDM2 in relation to p53 status in the tumors. (nih.gov)
- The third, oncogene-mediated resistance, occurs when the epidermal growth factor receptor (EGFR) signals cancerous tumors to accelerate their growth, overwhelming the capacity of drugs to kill them. (naturalnews.com)
- The researchers have previously used microsatellite analysis of cervical cancer cell lines and primary tumors to localize a tumor suppressor gene to a 300kb interval of chromosome 11q13. (uclahealth.org)
- p53, mdm-2, p21, and mib-1 expression were assessed by immunohistochemical methods in primary tumors derived from 134 patients who took part in a randomized multicenter trial comparing docetaxel to sequential methotrexate and 5-fluorouracil (MF) in advanced breast cancer. (lu.se)
- Interestingly, tumors with both negative mdm-2 and p21 expression, irrespective of p53 status, had a high response rate to docetaxel but no response to MF. (lu.se)
Apoptosis11
- This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. (wikipedia.org)
- p53 participates in relevant aspects of cell biology, including apoptosis and cell cycle control and must be strictly regulated to maintain normal tissue homeostasis. (molvis.org)
- Ectopic expression of the gene in the cell lines resulted in cell growth inhibition and apoptosis in vitro and inhibition of tumor growth in vivo in nude mice. (uclahealth.org)
- Conversely, KLF4 suppresses the expression of p53 by directly acting on its promoter, thereby allowing for RASV12-mediated transformation and causing resistance to DNA-damage-induced apoptosis. (uu.nl)
- Consistently, KLF4 depletion from breast cancer cells restores p53 levels and causes p53-dependent apoptosis. (uu.nl)
- Similar to lymphomas that form in the absence of p53, lymphomas that formed in mice with low p53 levels developed rapidly (reaching terminal stage after 66 days, on average), infiltrated lung, liver, and spleen tissues, and showed little apoptosis or "programmed cell death. (sciencedaily.com)
- In contrast, lymphomas that formed in mice with intermediate p53 levels developed less rapidly (reaching terminal stage after 95 days, on average), did not infiltrate lung, liver, or spleen tissues, and showed high levels of apoptosis. (sciencedaily.com)
- In the process of apoptosis, mitochondria are a regulation object of p53 and an important participant in the energy metabolism in cells. (oncotarget.com)
- p53 is a transcription factor that participates in cell cycle checkpoint processes and apoptosis. (lu.se)
- Fosfoproteína nuclear codificada por el gen p53 (GENES P53) cuya función normal es controlar la PROLIFERACIÓN CELULAR y la APOPTOSIS. (bvsalud.org)
- Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. (bvsalud.org)
Mutation8
- T transition (nonsense mutation) at the first nucleotide of codon 298 (exon 8) in one p53-negative case, and a frame shift mutation on exon 7 in another p53-negative case. (nih.gov)
- In remaining eight p53-negative cases, there was no mutation in the entire open reading frame of p53 cDNA. (nih.gov)
- If a gene becomes damaged, this damage is called a mutation. (oncolink.org)
- Cells that are missing this gene, or have a non-functioning copy because of a mutation, may be "fixed" by adding functioning copies of p53 to the cell. (oncolink.org)
- The second, tumor-suppressor-gene-mediated resistance, results from a mutation to protein p53 that makes cancer cells enormously aggressive and resistant. (naturalnews.com)
- Sequence analysis of these genes is being used to identify BRCA1/2 mutation carriers, though these efforts are hampered by the high frequency of variants of unknown clinical significance (VUSs). (jci.org)
- Individuals carrying a mutation in the breast cancer 1, early onset gene ( BRCA1 ) are at increased risk of breast or ovarian cancer and thus are candidates for risk reduction strategies such as oophorectomy and mastectomy. (jci.org)
- 6. Identify the mutation status of genes Kras and BRAF in laser microdissected parafin embedded melanomas and epidermal melanocytes adjacent to the lesion. (fapesp.br)
Suppressor13
- however, genetic factors,such as dysfunction of some tumor suppressor genes ( p53 gene) and activation of some oncogenes may play a role in their development. (medscape.com)
- The review highlights the discovery of oncogenes and suppressor tumor genes, underlining the crucial role of these achievements in cancer diagnosis and therapies. (jcancer.org)
- For example, p53 is a gene called a "tumor suppressor gene. (oncolink.org)
- This is in contrast with tumor suppressor genes which must BOTH be defective to lead to abnormal cell division. (cancerquest.org)
- Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
- Researchers have now identified a tumor suppressor gene, cystatin E/M, which may be involved in the control of cervical cancer development. (uclahealth.org)
- Researchers have now obtained evidence confirming cystatin E/M as the cervical cancer suppressor gene. (uclahealth.org)
- Thus, his results clearly demonstrated that cystain E/M is a cervical cancer suppressor gene and controls cell growth through the inhibition of cathepsin L. His laboratory used lentiviral tetracycline inducible system for the exogenous expression of cystatin E/M and have shown growth suppression in xenograft tumor mice model pointing to suppressor function of cystatin E/M protein. (uclahealth.org)
- Using the inducible and HPV 16 E6 or E7 or E6 and E7 gene transformed human epidermal keratinocyte system the laboratory has shown non-cell autonomous growth inhibition of the tumor cell lines pointing to the utility of developing this suppressor protein for clinical studies. (uclahealth.org)
- This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)
- The study, published in the February issue of Nature Genetics, focussed on the role of a tumor suppressor gene called p53 in a mouse model of lymphoma. (sciencedaily.com)
- Isoforms of Wilms' tumor suppressor gene (WT1) have distinct effects on mammary epithelial cells. (famri.org)
- TP53 is a type of gene called a "tumor suppressor. (medlineplus.gov)
Target genes4
- Our data show that the stable knockdown of HIPK2 led to wtp53 misfolding, as detected by p53 immunoprecipitation with conformation-specific antibodies, and that p53 protein misfolding impaired p53 DNA binding and transcription of target genes. (aacrjournals.org)
- We present evidence that zinc supplementation to HIPK2i cells increased p53 reactivity to conformation-sensitive PAb1620 (wild-type conformation) antibody and restored p53 sequence-specific DNA binding in vivo and transcription of target genes in response to Adriamycin treatment. (aacrjournals.org)
- Products of myc oncogenes are transcription factors that bind to the DNA sequence, CACGTG, and regulate the expression of multiple target genes. (bdbiosciences.com)
- Here we examined 145 SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)
Supressor genes1
- DNA from both transformed and tumor cells derived from transformed cells were subjected to differential PCR to detect changes in gene copy number and gene expression of five proto-oncogenes (K-ras, c-fos, c-jun, sis, erb-B2) and two tumor supressor genes (p53, p16). (cdc.gov)
MDM212
- Interestingly, in eight cases with p53 wild-type gene, 6 cases (75%) showed a marked down-regulation of p14ARF mRNA, and three cases (37.5%) over-expressed MDM2 mRNA. (nih.gov)
- The purpose of this study was to determine if Mdm2 regulates p53 in vivo in the adult lens. (molvis.org)
- We analyzed mice expressing human p53 transgene (Tg p53 ) selectively in the lens in the presence or absence of Mdm2 . (molvis.org)
- Mice with the required genotypes were obtained by crossing transgenic, mdm2 +/− , and p53 −/− mice. (molvis.org)
- In a wild-type genetic background ( mdm2 +/+ ), lens damage and microphthalmia were observed only in mice homozygous for Tg p53 ( t/t ). (molvis.org)
- However, in an mdm2 null background, just one allele of Tg p53 ( mdm2 −/− /Tg p53 t/0 mice) was sufficient to cause lens damage and microphthalmia. (molvis.org)
- Furthermore, Mdm2 in only one allele was sufficient to rescue these deleterious effects, since the mdm2 +/− /Tg p53 t/0 mice had eye size and lens morphology similar to the control mice. (molvis.org)
- Mdm2 regulates p53 in the adult lens in vivo. (molvis.org)
- This information may have relevance for analyzing normal and pathological conditions of the lens, and designing cancer therapies targeting Mdm2-p53 interaction. (molvis.org)
- Mdm2 binds directly to the transcriptional activation domain of p53 and blocks p53-dependent transcription. (molvis.org)
- The lethality of mdm2 −/− mice before implantation makes it impossible to analyze Mdm2 interaction with p53 in vivo at specific times of development, at postnatal/adult stages, or in specific cell types. (molvis.org)
- In the present study, we aimed to validate gene amplification, protein expression, and the putative tumor biological function of MDM2 in a well-characterized Western GC cohort. (bvsalud.org)
Ovarian cancer3
- Some of the best known are the BRCA1 and BRCA2 breast cancer genes, also implicated in some cases of ovarian cancer, the p53 gene involved in many different tumours, and the EGFR gene targeted by AstraZeneca's Iressa and Genentech and OSI Pharmaceutical's Tarceva, which have remarkable effects against a small percentage of patients with lung cancer. (news-medical.net)
- This study aims to investigate the association of p53 and D-loop gene with drug resistance and sensitization induced by metformin in ovarian cancer. (oncotarget.com)
- This study was designed to investigate the association of gene polymorphisms in the p53 gene and mitochondrial genome D-loop region with metformin-induced sensitization and prognosis of ovarian cancer. (oncotarget.com)
Alterations4
- The study also looked at the impact of paternally expressed genes: IGF2, PEG1, PEG3, DLK1, and DIO3 for transcriptomic and epigenomic alterations of the imprinted genes in fetal tissues. (genengnews.com)
- A recurring problem in the clinic is that many detectable changes within the BRCA1 gene produce subtle alterations to the protein that are not easily recognized as either harmful (loss-of-function) alleles or harmless and thus inconsequential polymorphisms. (jci.org)
- Alterations in p53 Influence hTERT, VEGF and MMPs Expression in Oral Cancer Patients. (cdc.gov)
- OncoKB currently contains 4472 alterations for 595 genes of 38 tumor types. (lu.se)
Proto-oncogenes6
- Proto-oncogenes are genes that normally help cells grow and divide to make new cells, or to help cells stay alive. (cancer.org)
- The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
- The proto-oncogenes would be in control of the movement of a car (the gas pedal in the animation below). (cancerquest.org)
- Numerous genes have been identified as proto-oncogenes. (cancerquest.org)
- Some proto-oncogenes work to regulate cell death. (cancerquest.org)
- The proto-oncogenes that have been identified so far have many different functions in the cell. (cancerquest.org)
Pathway1
- Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. (nature.com)
Associated with tumor1
- The p63 protein, a homologue of p53, may be associated with tumor formation in the epithelial tissue, acting as an oncogene 11,12 . (bvsalud.org)
TP538
- A TP53 genetic test usually uses a sample of your blood to look for changes in the tumor protein 53 gene, or TP53 for short. (medlineplus.gov)
- Changes in the TP53 gene are linked to many different types of cancer . (medlineplus.gov)
- If you have certain changes in a TP53 gene, the gene or the protein it makes may not work well or may stop working completely. (medlineplus.gov)
- Changes in your TP53 gene can be acquired or inherited. (medlineplus.gov)
- Most changes in TP53 genes are acquired changes. (medlineplus.gov)
- Inherited changes in the TP53 gene cause a rare genetic condition called Li-Fraumeni syndrome (LFS). (medlineplus.gov)
- A TP53 genetic test is used to look for changes in your TP53 genes. (medlineplus.gov)
- The test can check whether an acquired change in your TP53 gene is causing your cancer. (medlineplus.gov)
BRCA13
- To date, inheritance of a mutant BRCA1 or BRCA2 gene is the best-established indicator of an increased risk of developing breast cancer. (jci.org)
- In a candidate gene study aiming at identifying genetic determinants of breast cancer susceptibility, we undertook the full sequencing of the NBN gene in our cohort of 97 high-risk non- BRCA1 and - BRCA2 breast cancer families, along with 74 healthy unrelated controls, also from the French Canadian population. (biomedcentral.com)
- As the number and characteristics of such alleles are undetermined, a focussed candidate gene approach based on genes closely interacting with the known susceptibility genes such as BRCA1 and BRCA2 , the two major susceptibility genes identified yet, constitutes a study design of choice to identify rare-moderate-penetrance susceptibility alleles. (biomedcentral.com)
Malignant1
- Adusumilli PS, Chan MK, Hezel M, Yu Z, Stiles BM, Chou TC, Rusch VW, Fong Y. Radiation-induced cellular DNA damage repair response enhances viral gene therapy efficacy in the treatment of malignant pleural mesothelioma. (famri.org)
Variants1
- Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. (cancerindex.org)
Deletion2
- 3. Evaluate the genes p16INK4A, CCDN1 e PTEN for amplification or deletion, through FISH. (fapesp.br)
- 5. Correlate immunohistochemical expression, mRNA e gene amplification or deletion of genes p16, CCDN1 e PTEN. (fapesp.br)
Expression23
- MicroRNAs (miRNAs) are endogenous noncoding RNAs that act as post-transcriptional regulators of gene expression by binding to the 3′-untranslated region (UTR) of target mRNAs. (nature.com)
- Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
- In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)
- The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
- Scientists armed with whole genome sequence data can now ask questions about genome structure and organization that impact gene expression. (genengnews.com)
- Improved access to bioinformatics tools enables scientists to process, manage, and store raw data, annotate sequences to define genes, and quantitate RNA sequence data to get insight into gene expression patterns. (genengnews.com)
- Amy Radunz, a nutritionist from the department of animal sciences at the University of Wisconsin in River Falls, has partnered with molecular biologist Hasan Khatib, an associate professor at University of Wisconsin-Madison, to ask how differences in maternal diet during pregnancy induce gene expression and DNA methylation changes in fetal tissues in sheep. (genengnews.com)
- Exogenous expression of PACS-1 into miRNA 34a or 449a transfected cervical cancer cell lines leads to reversal of the DNA damage response (DDR), p53 activation and cell death induced by the two miRNAs. (uclahealth.org)
- The data has further shown activation of DDR and p53 with the loss of PACS-1 expression confirming a nuclear role for PACS-1 in DNA replication. (uclahealth.org)
- While none of the transformed cells showed changes in gene amplification, increases in the expression of c-jun and p16 were observed and sis was under expressed. (cdc.gov)
- Tumor cells showed increased copy number of the K-ras gene and increased expression of c-fos, erbB2 and K-ras, while c-myc and sis were under expressed. (cdc.gov)
- Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
- The results were validated both by gene expression analysis and immunohistochemistry study in an independent 55 clinical samples from Fudan University Shanghai Cancer Center. (cancerindex.org)
- In the mouse model, forced expression of the Myc oncogene in B-cells causes the mice to develop B-cell lymphomas by 4 to 6 months of age. (sciencedaily.com)
- Along with a recent study by Hannon and his colleagues that demonstrated germline transmission of RNAi, the current study establishes RNAi as a convenient alternative to traditional, laborious, and less flexible homologous recombination-based gene knockout strategies for studying the effects of reduced gene expression in a wide variety of settings. (sciencedaily.com)
- Gene expression profiling in pulmonary hypertension. (famri.org)
- Luciferase reporter gene assay of the promoter construct bearing this variant did not suggest a variation of expression in the MCF-7 breast cancer cell line, but indicated a reduction of luciferase expression in both the HEK293 and LNCaP cell lines. (biomedcentral.com)
- How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
- Gene amplification and protein expression were correlated with diverse clinicopathological patient characteristics including patient outcome. (bvsalud.org)
- In breast cancer patients, it is unclear whether measuring p53, mdm-2, or p21 expression provides information on how patients will respond to chemotherapy. (lu.se)
- p53, mdm-2, p21, and mib-1 expression were not significantly associated with response to chemotherapy, time to progression, or overall survival in the whole patient population or in the docetaxel group. (lu.se)
- MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)
- MicroRNAs (miRNAs) are small, noncoding RNAs that bind to the 3' UTR of target mRNAs, and silence gene expression by inducing degradation of target mRNAs or inhibition of protein translation [ 10 ]. (cdc.gov)
EGFR1
- However, since H-Ras is hardly mutated in human gliomas, this oncogene only serves as a surrogate for EGFR, which is overexpressed in gliomas (EGFR amplification leads to Ras activation, hence Ras is a good surrogate for EGFR). (genengnews.com)
Regulate2
- Our research focuses on the molecular mechanisms by which cancer-relevant genes regulate the networks in which they are embedded. (cuanschutz.edu)
- Because miRNAs may regulate approximately 60% of human genes [ 11 ], the relationship between miRNAs and human diseases has been extensively explored in the last decade. (cdc.gov)
Regulation2
- Schuldiner O, Eden A, Ben-Yosef T, Yanuka O, Simchen G, Benvenisty N. ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast. (bdbiosciences.com)
- The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. (lu.se)
Cancers3
- Fifteen of 25 colorectal cancers (60%) showed abnormal accumulation of p53 protein in the nucleus, and the remaining 10 colorectal cancers (40%) were negative for p53 immunostaining. (nih.gov)
- A diagram showing the major cancer genes for some cancers. (cancerquest.org)
- More than half of all adult cancers involve a change in this gene. (medlineplus.gov)
Mutant1
- Despite the differences in their normal roles, these genes all contribute to unregulated cell division if they are present in a mutant (oncogenic) form. (cancerquest.org)
Chromosome1
- Chromosome 11q13 genomic mapping studies have also identified PACS-1 (phosphofurin acidic cluster sorter protein-1) gene as an oncogene. (uclahealth.org)
Inhibit2
Therapies3
- Insert genes into cancer cells so that chemotherapy , radiation therapy , or hormone therapies can attack the cancer cells more easily. (oncolink.org)
- Our data demonstrate that HSV-TK/GCV suicide gene therapy system is effective for treating experimental human pancreatic cancer, which is largely resistant to the common therapies, so the suicide gene therapy system may be a potential treatment approach for pancreatic cancer. (wjgnet.com)
- p53 is the most commonly mutated gene in human cancer and our research may enable effective cancer therapies. (cuanschutz.edu)
Transcription factor2
- The mdm-2 gene enhances the tumorigenic potential of cells when it is overexpressed and encodes a putative transcription factor. (nih.gov)
- p53 is a transcription factor that plays an important role in preventing cancer development. (molvis.org)
Tissues2
- The methylation specific polymerase chain reaction in conjunction with sequencing verification was used to establish the methylation patterns of the 14 genes in the liver tissues of four healthy liver donors, as well as tumor and the paired non-cancerous tissues of 30 HCC patients. (wjgnet.com)
- Both glutathione S-transferase pi ( GSTpi ) (80%, 24/30 in tumor and 56.7%, 17/30 in the paired non-cancerous tissues) and cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) ( CFTR ) (77%, 23/30 in tumor and 50%, 15/30 in the paired non-cancerous tissues) genes were prevalently hypermethylated in HCC as well as their neighboring non-cancerous tissues. (wjgnet.com)
Prognostic3
- Cox regression analysis identifies independent prognostic factors for these patients, and enrichment analysis of prognosis-related genes was also performed. (biomedcentral.com)
- We constructed a 13-gene prognostic model for LUAD patients. (biomedcentral.com)
- Within this context, we constructed a prognostic model of ERS-related genes, combining the risk scores in the model with clinical characteristics (age, sex, staging, etc.) to establish a nomogram, and found its performance in estimating patient survival was excellent. (biomedcentral.com)
Vivo1
- The new study indicates that stable suppression of deleterious genes by RNAi--in which adult stem cells are isolated, modified ex vivo, and then re-introduced into the affected individual--might be an effective strategy for treating human disease. (sciencedaily.com)
Human genes1
- The myc recognition binding site of ECA39 is located 3' to the start site of transcription in the mouse and human genes, but this element is absent in the nematode and yeast. (bdbiosciences.com)
Certain genes2
- Cell growth is normally controlled by the actions of certain genes inside each cell. (cancer.org)
- These events are dependent on the proper levels of transcription and translation of certain genes. (cancerquest.org)
Polymorphisms2
- Characterization of genetic polymorphisms in oral cancer-related genes pertaining to oxidative stress, carcinogen detoxifying, and DNA repair: A case-control study. (cdc.gov)
- Combined impacts of histamine receptor H1 gene polymorphisms and an environmental carcinogen on the susceptibility to and progression of oral squamous cell carcinoma. (cdc.gov)
Epidermal growth f1
- HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)
PTEN1
- Imbalance of genes B-RAF, K-RAS, e PTEN were evaluated. (fapesp.br)
Encodes a member1
- This gene encodes a member of the KH domain protein subfamily. (wikipedia.org)
Genetic2
- The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. (nih.gov)
- Once the gene has reached the cell, it must go to the cell's nucleus (where the DNA, or genetic code is) and combine with the human genetic material. (oncolink.org)
Breast cancer2
- Of the 11 genes mapped to this 300kb interval, cystatin E/M, a cysteine protease inhibitor, seemed to be a potential candidate due to reports of its involvement in breast cancer. (uclahealth.org)
- We found a number of SNPs in miRNAs and processing genes in association with breast cancer overall or stratified by estrogen receptor (ER) status. (cdc.gov)