• This study investigates whether or not an interrelationship exists between the expression of resistance-related proteins (P-glycoprotein, glutathione S-transferase, topoisomerase II) and proto-oncogene products (c-fos, c-myc, c-K-ras, epidermal growth factor receptor [EGF-R], and c-neu proteins. (curehunter.com)
  • Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. (springer.com)
  • The cells transcribed all the PDGF-related genes and translated the PDGF-A and PDGF-B mRNAs into protein, as demonstrated by immunocytochemistry and immunoprecipitation. (elsevier.com)
  • UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. (uniprot.org)
  • The Bacillus thuringiensis (Bt) toxin genes currently employed in commercial crops are all members of a class of toxin proteins that accumulate, as crystals, in stationary stage bacteria (bacteria that have completed their growth cycle) these genes are designated Cry followed by numbers and letters that indicate there origin and specificity. (i-sis.org.uk)
  • Another kind of Bt toxin, the VIP (vegetative insecticidal protein) group of toxins are produced in vegetative cells, the genes are designated VIP followed by numbers and letters related to their origin and specificity. (i-sis.org.uk)
  • When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). (uniprot.org)
  • Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). (uniprot.org)
  • When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). (uniprot.org)
  • Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. (uniprot.org)
  • The formation of complexes between growth factor receptors and members of a family of G-protein-coupled receptors whose natural ligands are S1P (sphingosine 1-phosphate) and LPA (lysophosphatidic acid) represents a new signalling entity. (strath.ac.uk)
  • Some of the protein members containing death domain motifs include receptors known to be associated with apoptotic processes, such as the Fas receptor and the tumour necrosis factor (TNF) in mammalian cells (references provided in the patent). (i-sis.org.uk)
  • Disturbances in one or some of these so-called oncogenes (Gk ónco(s) bulk, mass) can lead to transformation of a normal cell into a tumor cell and result in cancer. (nobelprize.org)
  • Bishop's and Varmus' discovery of the cellular origin of retroviral oncogenes has had an extensive influence on the development of our knowledge about mechanisms for tumor development. (nobelprize.org)
  • This receptor complex allows for integrated signalling in response to growth factor and/or S1P/LPA and provides a mechanism for more efficient activation (due to integrated close-proximity signalling from both receptor classes) of the p42/p44 MAPK (mitogen-activated protein kinase) pathway. (strath.ac.uk)
  • They often have protein kinase activity. (curehunter.com)
  • Reddy EP, Reynolds RK, Santos E, Barbacid M. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. (springer.com)
  • Monocarboxylate transporters (MCTs) are transmembrane proteins that control the lactate metabolism and associated with poor prognosis in solid tumors including breast cancer (BC). (bioportfolio.com)
  • By use of these viruses they managed to construct a nucleic acid probe which selectively identified the oncogene. (nobelprize.org)
  • They also work to develop 3D-printed osteoregenerative scaffolds, with a goal to create products that elicit high rates of spine fusion without the need for exogenous growth factors, such as bone morphogenetic protein-2. (northwestern.edu)
  • To clarify the inhibition mechanism of PDGF-B/c-sis mRNA translation, effects of three SORFs in the 5'-UTR on the translational regulation were investigated in transient expression assays. (elsevier.com)
  • Although this is a relatively common mechanism of oncogenesis in animals, very few oncogene-carrying viruses have been identified in man. (encyclopedia.com)
  • Expression of PDGF-B/c-SIS is regulated at the translational level, in addition to at the transcriptional level. (elsevier.com)
  • Breast cancer pathobiology is known to be influenced by the differential expression of a group of proteins called the kinesin superfamily (KIFs), which is instrumental in the intracellular transport of chromosomes along microtubules during mitosis. (bioportfolio.com)
  • However, their misregulation may contribute to uncontrolled cell growth owing to premature sister chromatid separation, highlighting their importance in cancer. (bioportfolio.com)
  • The term oncogene was introduced in the middle of the 1960s to denote special parts of the genetic material of certain viruses. (nobelprize.org)
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • These data suggest that DMF downregulates cytokine secretion not only by inhibiting NF-κB but a wider range of NF-κB-linked signaling proteins, which may explain its potential beneficial effect in asthma. (edu.au)
  • Dickson C, Peters G. Potential oncogene product related to growth factors. (springer.com)