• 14. Induction of fos and sis proto-oncogenes and genes of the extracellular matrix proteins during butyrate induced glioma differentiation. (nih.gov)
  • These rearrangements fuse the collagen type I alpha 1 ( COL1A1 ) and the PDGF-beta chain ( PDGFB , c-sis proto-oncogene) genes. (medscape.com)
  • Proteínas celulares de unión al ADN codificadas por el gen sis (GENES SIS). (bvsalud.org)
  • Cellular DNA-binding proteins encoded by the sis gene (GENES, SIS). (bvsalud.org)
  • Such findings not only validate the study of retroviral oncogenes as models for the biochemical basis of human cancer, they also invite a direct assault on an apparently limited set of cellular genes important in the creation of a canc- er cell, irrespective of external cause. (nih.gov)
  • Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. (uchicago.edu)
  • Real-time polymerase chain reaction was used to analyze the mRNA expression levels of pluripotency-associated genes and oncogenes and to detect telomerase activity in the cells. (tmu.edu.tw)
  • The expression levels of pluripotency-related genes (Janus kinase-signal transducer 2 [JAK2] and signal transducer and activator of transcription 3 [STAT3]) increased, whereas those of oncogenes (Ras, SRC, HER2, and C-sis) decreased. (tmu.edu.tw)
  • CAAT box (also CAT box) A conserved sequence found within the promoter region of the protein-encoding genes of many eukaryotic organisms. (fao.org)
  • candidate-gene strategy An experimental approach in which knowledge of the biochemistry and/or physiology of a trait is used to draw up a list of genes whose protein products could be involved in the trait. (fao.org)
  • Transcription by RNA POL II is bona fide assumed for protein coding genes but must be supported by alpha-amanitin data if the end product is an RNA. (expasy.org)
  • Genes inducing cellular senescence tend to be overexpressed with age in human tissues and are significantly overrepresented in anti-longevity and tumor-suppressor genes, while genes inhibiting cellular senescence overlap with pro-longevity and oncogenes. (biomedcentral.com)
  • Gene amplification, the increase in the copy number of a portion of the genome, is a common manifestation of genome instability in tumour cells and an important mechanism of oncogene activation as well as drug resistance, since it leads to over-expression of relevant genes. (biomedcentral.com)
  • c-sis proteins make up the B chain of PLATELET-DERIVED GROWTH FACTOR. (bvsalud.org)
  • The PDGFB gene provides instructions for making one version (isoform) of the platelet derived growth factor (PDGF) protein. (medlineplus.gov)
  • Shimizu A, O'Brien KP, Sjoblom T, Pietras K, Buchdunger E, Collins VP, Heldin CH, Dumanski JP, Ostman A. The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. (medlineplus.gov)
  • v-sis Platelet Derived Growth Factor beta polypeptide is the viral homologue of PDGFB. (medindex.am)
  • Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. (umassmed.edu)
  • Expression of the c-met proto-oncogene and its ligand, hepatocyte growth factor, in Hodgkin disease. (musc.edu)
  • It has been shown that the sis oncogene is derived from the PDGF B-chain gene. (wikipedia.org)
  • Finally, the third gene to be discussed here that may influence the absorption of lead is the hemochromatosis gene coding for the HFE protein. (nih.gov)
  • iii) DNA-mediated gene transfer into rodent cells has uncovered active oncogenes in human and other tumors. (nih.gov)
  • Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. (uams.edu)
  • Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (uchicago.edu)
  • Chronic inhalation exposure to environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs), cigarette smoke, 4‐aminobiphenyl (4‐ABP), ethylene oxide, and styrene is associated with elevations in biomarkers such as DNA adducts, protein adducts, sister chromatid exchanges (SCEs), chromosomal aberrations, gene mutation, and/or oncogene activation. (nyu.edu)
  • The PDGFB gene provides instructions for a precursor protein that must be processed to be able to perform its function. (medlineplus.gov)
  • The COL1A1-PDGFB fusion gene provides instructions for making a fusion protein. (medlineplus.gov)
  • In the translocation, the PDGFB gene loses the part of its DNA that inhibits its activity, and production of the COL1A1-PDGFB fusion protein is controlled by COL1A1 gene sequences. (medlineplus.gov)
  • As a result, the gene fusion leads to the production of large amounts of the fusion protein. (medlineplus.gov)
  • Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
  • ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. (iiab.me)
  • HER2 is colocalised and most of the time, coamplified with the gene GRB7, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. (iiab.me)
  • Identification of the v-Src protein was critical to understanding how alterations in a normal cellular gene could lead to cancer. (harvard.edu)
  • Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by the CDH1 gene . (wikidoc.org)
  • GTPase HRas also known as transforming protein p21 is an enzyme that in humans is encoded by the HRAS gene . (wikidoc.org)
  • Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes. (lookformedical.com)
  • Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
  • for example, protein kinase activation is part of the platelet activation signal pathway. (lookformedical.com)
  • HRAS acts as a molecular on/off switch, once it is turned on it recruits and activates proteins necessary for the propagation of the receptor's signal, such as c-Raf and PI 3-kinase . (wikidoc.org)
  • PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. (thermofisher.com)
  • The NHEJ pathway requires the activity of several proteins, including the DNA-PK complex, which is composed of a heterodimeric subunit with DNA end-binding activity (Ku) and a catalytic subunit, the DNA-dependent protein kinase (DNA-PKcs). (biomedcentral.com)
  • The Ku proteins bind the ends of the DSB and recruit DNA-PKcs, whose kinase activity is essential for the activation of other repair factors. (biomedcentral.com)
  • The collagen promoter drives COL1A1 and PDGFB fusion protein production. (medscape.com)
  • Before processing, the precursor PDGFB protein attaches (binds) to another PDGFB protein or a similar protein called the PDGFA precursor protein, forming a structure known as a dimer. (medlineplus.gov)
  • The COL1A1-PDGFB protein forms a dimer and is processed like the normal PDGFB precursor protein. (medlineplus.gov)
  • Simon MP, Navarro M, Roux D, Pouyssegur J. Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17;22)(q22;q13.1) in Dermatofibrosarcoma protuberans (DP). (medlineplus.gov)
  • Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumors. (uams.edu)
  • The ectodomain of this protein mediates bacterial adhesion to mammalian cells, and the cytoplasmic domain is required for internalization. (wikidoc.org)
  • moreover, the cellular oncogenes show many signs of being the targets for various mutational events that lead to eancer in animals and man. (nih.gov)
  • Our laboratory first unveiled cellular oncogenes by finding that the DNA of birds and mammals contains homologues of v-sre, the oncogene of Rous sarcoma virus. (nih.gov)
  • In the decade that followed, several developments enlarged the repertoire of cellular oncogenes and strengthened the argument that they are involved in many forms of cancer. (nih.gov)
  • ii) The study of re- troviruses lacking their own oncogenes provided the first direct evidence that known cellular oncogenes could participate in carcinogenesis, as the targets for activation by viral insertional mutations. (nih.gov)
  • Again cellular oncogenes previously identified by their homology with retroviral oncogenes have frequently been implicated, and an explicit definition of carcinogenic change at the nucleotide level has been possible for the first time. (nih.gov)
  • The size of the complete repertoire of cellular oncogenes is unknown. (nih.gov)
  • It is increasingly becoming clear that miRNAs generate a complex network with mRNAs, snoRNAs, long non-coding RNAs, and RNA binding proteins to establish cellular transcriptome ( Mattick and Makunin, 2006 ). (frontiersin.org)
  • This protein is involved in many cellular processes, including cell growth and division (proliferation), maturation (differentiation), and movement. (medlineplus.gov)
  • The active PDGF-BB or PDGF-AB protein binds to a PDGF receptor, which initiates cellular signaling. (medlineplus.gov)
  • The Hannink lab has identified several protein complexes that regulate cellular responses to oxidative stress and is interested in developing therapeutic approaches that target these protein complexes and will increase the ability of normal cells to withstand oxidative stress. (missouri.edu)
  • We also build cellular senescence protein-protein interaction and co-expression networks. (biomedcentral.com)
  • One of the approaches that led to finding the first oncoprotein involved attempts to develop antibodies to the v-Src protein by generating tumors in a variety of animals. (harvard.edu)
  • Once activated, receptors stimulate signal transduction events in the cytoplasm , a process by which proteins and second messengers relay signals from outside the cell to the cell nucleus and instructs the cell to grow or divide. (wikidoc.org)
  • Excess PDGF-BB protein abnormally stimulates cells to proliferate and differentiate, leading to the tumor formation seen in dermatofibrosarcoma protuberans. (medlineplus.gov)
  • One important question is whether the membrane protein needs links to cytoskeletal proteins to function as a motor as the model predicts. (nih.gov)
  • Our experimental results show that elevation of rigidity and invasiveness of TGFβ-stimulated NSCLC cells correlates with upregulation of several cytoskeletal and motor proteins including vimentin, a canonical marker of EMT, and less-known unconventional myosins. (nature.com)
  • Our experimental results provide insights into TGFβ-induced cytoskeletal remodeling of NSCLC cells and suggest that mediators of elevated cell stiffness and migratory activity such as unconventional cytoskeletal and motor proteins may represent promising pharmaceutical targets for restraining invasive spread of lung cancer. (nature.com)
  • PDGF is the major serum polypeptide mitogen for cells of mesenchymal origin and has two dissimilar subunits, A and B. The B chain has homology to SIS and is alone sufficient for mitogenesis. (medindex.am)
  • Substitution of a valine for a glutamic acid in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (iiab.me)
  • The fusion protein is then processed into functional PDGF-B and subsequently interacts with the PDGF receptor on the cell surface of DFSP tumor cells. (medscape.com)
  • The molecular hallmark of DSCRT is the EWS-WT1 fusion protein. (sarcomahelp.org)
  • The authors conclude that the occurrence of only two cases of oncogene activation suggests that the workers have minimized their exposures to hazardous wastes by wearing protective clothing and equipment and observing appropriate work practices. (cdc.gov)
  • Activation of the ras oncogene in the two workers may be a reflection of their cigarette smoking. (cdc.gov)
  • What are the biochemical conse- quences of oncogene activation and how do those consequences lead to the loss of growth control and the other changes that typify a cancer cell? (nih.gov)
  • It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation. (jefferson.edu)
  • Rho GTPase activating protein 18. (gsea-msigdb.org)
  • Rho GTPase activating protein 35. (gsea-msigdb.org)
  • The HRAS protein is a GTPase and is an early player in many signal transduction pathways and is usually associated with cell membranes due to the presence of an isoprenyl group on its C-terminus . (wikidoc.org)
  • The rate of conversion is usually slow but can be sped up dramatically by an accessory protein of the GTPase activating protein (GAP) class, for example RasGAP . (wikidoc.org)
  • Once the dimer is formed, the precursor proteins are processed by being cut at specific locations, which forms the functional (active) PDGF proteins, called PDGF-BB and PDGF-AB. (medlineplus.gov)
  • Processing removes the COL1A1 portion, which forms a protein that researchers believe functions like the active PDGF-BB protein. (medlineplus.gov)
  • The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail . (wikidoc.org)
  • Transformation of cells by v-sis is related to its interaction with the PDGF receptor and also its ability to alter other transcription factors. (nih.gov)
  • I found that the same common mutations are associated with WGD in human lung adenocarcinomas and demonstrated that these oncogenes can cause WGD in primary human airway cells. (hopkinsmedicine.org)
  • Instead of triggering cell growth in response to particular signals from outside the cell, the overactive protein directs cells to grow and divide constantly. (wikidoc.org)
  • When mutated, proto-oncogenes have the potential to cause normal cells to become cancerous . (wikidoc.org)
  • These mutations lead to an HRAS protein that is always active and can direct cells to grow and divide without control. (wikidoc.org)
  • The high frequency of isochromosome formation in cells deficient for RAD54 suggests that homologous recombination proteins might play a role in preventing rearrangements at the centromeres. (biomedcentral.com)
  • Although the Myc oncogene has long been known to play a role in many human cancers, the mechanisms that mediate its effects in both normal cells and cancer cells are not fully understood. (silverchair.com)
  • Mutations in the c-met proto-oncogene are associated with papillary renal carcinoma and other neoplasia. (umassmed.edu)
  • Each of these mutations changes an amino acid in a critical region of the HRAS protein. (wikidoc.org)
  • The mutations responsible for Costello syndrome lead to the production of an HRAS protein that is permanently active. (wikidoc.org)
  • DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. (nih.gov)
  • Overexpression of c-sis causes tumorigenesis. (bvsalud.org)
  • The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. (uchicago.edu)
  • small integral membrane protein 1. (gsea-msigdb.org)
  • Another approach was based on a new technology that used antibodies and an immunoabsorbent molecule that could bind to a protein and separate it from thousands of other proteins. (harvard.edu)
  • In turn HRAS can bind to proteins of the Guanine Nucleotide Exchange Factor (GEF) class, for example SOS1 , which forces the release of bound nucleotide. (wikidoc.org)
  • A DNA-binding protein and AAA ATPase that consists of 5 polypeptides and plays an essential role in DNA REPLICATION in eukaryotes. (ucdenver.edu)
  • Innate Conformational Dynamics Drive Binding Specificity in Anti-Apoptotic Proteins Mcl-1 and Bcl-2. (uchicago.edu)
  • 2. Enhanced expression of the proto-oncogenes fos and raf in the rhabdomyosarcoma cell line BA-HAN-1C after differentiation induction with retinoic acid and N-methylformamide. (nih.gov)
  • 5. Increase in proto-oncogene raf expression precedes differentiation induction in different clonal rhabdomyosarcoma subpopulations. (nih.gov)
  • Viral oncogene expression in the stem/progenitor cell compartment of the mouse intestine induces adenomatous polyps. (musc.edu)
  • Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer . (iiab.me)
  • Complete loss of E-cadherin protein expression in 84% of lobular breast carcinomas. (wikidoc.org)
  • SCZD hiPSC neurons showed diminished neuronal connectivity in conjunction with decreased neurite number, PSD95-protein levels and glutamate receptor expression. (bioseek.eu)
  • These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR , where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA . (nih.gov)
  • Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner. (musc.edu)
  • These proteins all are regulated in the same manner and appear to differ largely in their sites of action within the cell. (wikidoc.org)
  • Sepased, an enzyme for resolving the cohesion of Chromatide Sister, is an oncogene and overexpressed in many human cancer. (separase.com)
  • Below are the most recent publications written about "Proto-Oncogene Proteins c-met" by people in Profiles. (umassmed.edu)
  • This graph shows the total number of publications written about "Oncogene Protein p21(ras)" by people in UAMS Profiles by year, and whether "Oncogene Protein p21(ras)" was a major or minor topic of these publications. (uams.edu)
  • Below are the most recent publications written about "Oncogene Protein p21(ras)" by people in Profiles over the past ten years. (uams.edu)
  • this mutation substitutes one protein building block (amino acid) for another amino acid in the HRAS protein. (wikidoc.org)
  • [3] HRas is a small G protein in the Ras subfamily of the Ras superfamily of small GTPases . (wikidoc.org)
  • Studies of mutant variants of Rous Sarcoma virus that caused reversible, temperature-sensitive transformation, by Steve Martin at U.C. Berkeley and later, Hidesaburo Hanafusa at the Rockefeller University, strongly supported the existence of a protein product of the ' src ' region of the genome. (harvard.edu)
  • The zinc finger CCCTC-binding protein (CTCF) carries out many functions in the cell. (elifesciences.org)
  • How can a single protein carry out so many different functions in the cell? (elifesciences.org)
  • If candidates for the motor protein can be selectively expressed in a host cell, the electrophysiological techniques that we have developed can then be used to identify the role of individual elements in the motility. (nih.gov)
  • The altered HRAS protein is permanently activated within the cell. (wikidoc.org)
  • This overactive protein directs the cell to grow and divide in the absence of outside signals, leading to uncontrolled cell division and the formation of a tumor. (wikidoc.org)