GenesSubunitHomologRELATumorHomology domainProto-oncogenesELISA KitP105KinaseAvianNuclearSequencesReceptorMutationsCyclin D1NfkbMeSHTumorigenesisOncogenicEncoded by the REL geneVitroKappaSerineBindTranscriptionalEncodesIsoformCell cycle progressionHeat shock pTissue homogenatesSuppressorsLymphomaRegulateActivationP100GTPaseActivatorLocusPhosphorylationSignalsFamilyMotifTransactivationComplexesProgression
Genes15
- The bcl-3 protein does not inhibit either the DNA-binding activity of the Rel protein or its ability to trans-activate genes linked to the kappa B site. (duke.edu)
- Proteínas celulares de unión al ADN codificadas por el gen rel (GENES REL). (bvsalud.org)
- Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (bvsalud.org)
- Maternal genes involved in dorsoventral (D/V) patterning of the Drosophila embryo interact to establish a stable nuclear concentration gradient of the Dorsal protein which acts as the morphogen along this axis. (silverchair.com)
- To direct signals to specific target genes, Ets proteins interact with (other) transcription factors that promote the binding of Ets proteins to composite Ras-responsive elements. (embl.de)
- Cellular proteins encoded by the H-ras, K-ras and N-ras genes. (uchicago.edu)
- In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
- This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
- Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
- Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
- Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
- The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
- The mutated or otherwise damaged versions of these genes are called oncogenes. (cancerquest.org)
- Numerous genes have been identified as proto-oncogenes. (cancerquest.org)
- As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
Subunit2
- This protein is the full-length p52 subunit and partial p100 subunit. (abcam.com)
- His research integrates issues of Cancer cell, Protein subunit and Carcinogenesis in his study of Cancer research. (research.com)
Homolog2
- NF-kB P65 is also known as RelA (v-rel avian reticuloendotheliosis viral oncogene homolog A) and belongs to the Rel family of proteins. (thermofisher.com)
- Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NF kB (p50 and p65) and the Drosophila maternal morphogen, dorsal. (sabbiotech.cn)
RELA5
- NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. (nih.gov)
- Rel se combina frecuentemente con otras proteínas relacionadas (FN-KAPPA B, I-kappa B, relA) para formar heterodímeros que regulan la transcripción. (bvsalud.org)
- Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (bvsalud.org)
- NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. (hmdb.ca)
- Mammalian nuclear factor κB (NFκB) consists of five members, including RelA/p65, c-Rel, RelB, NFκB1(p50) and NFκB2(p52). (oncotarget.com)
Tumor15
- Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF. (umassmed.edu)
- We have recently shown that tumor necrosis factor (TNF) α induces caspase-dependent and -independent JNK activation and ROS accumulation in cellular FLICE-inhibitory protein (c-Flip) −/− murine embryonic fibroblasts (MEFs). (nature.com)
- The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors. (nature.com)
- Although the precursor protein of NFκB2 (p100) is thought to act as a tumor suppressor in mammalian cells, the molecular mechanism of its anti-tumor activity is far from clear. (oncotarget.com)
- Although the diverse tumor-promoting roles of NFκB in cancer cell proliferation, anti-apoptosis, angiogenesis, invasion and metastasis, are well established [ 3 - 9 ], much less is known about how p100, a precursor protein of NFκB2, acts as a tumor suppressor in many mammalian cells [ 10 ]. (oncotarget.com)
- Description: Quantitativesandwich ELISA kit for measuring Human p53/tumor protein, p53/TP53 in samples from serum, cell culture supernates, urine, cerebrospinalfluid (CSF), tissue homogenates, cell lysates. (ksiazkiwnauce.pl)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Wilms Tumor Protein (WT1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Wilms Tumor Protein (WT1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
- Description: A sandwich ELISA kit for detection of Wilms Tumor Protein from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (kits-elisa.com)
- Description: Quantitative sandwich ELISA for measuring Human Wilms tumor protein (WT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (kits-elisa.com)
- [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
- A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)
- In a number of studies, it has been shown that while only a select number of cells are actually infected with the virus, numerous viral proteins are released into the cancer and stromal cells in the microenvironment and these viral proteins are known to affect tumor behavior and aggressiveness. (surgicalneurologyint.com)
- Oncomodulatory viruses, such as human cytomegaloviruses (HCMV), are known to release over 200 proteins, many of which can alter tumor behavior [ Table 1 ]. (surgicalneurologyint.com)
- Rather, only a few cells need to be infected, with the release of viral proteins from the viruses, which occupy most if not all of the tumor cells, including stromal cells. (surgicalneurologyint.com)
Homology domain2
- The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. (wikipedia.org)
- As part of one scientific family, Guido Franzoso deals mainly with the area of NFKB1, narrowing it down to issues related to the Molecular biology, and often Transactivation, Rel homology domain, Function and Proto-Oncogene Proteins c-rel. (research.com)
Proto-oncogenes3
- The proto-oncogenes would be in control of the movement of a car (the gas pedal in the animation below). (cancerquest.org)
- Some proto-oncogenes work to regulate cell death. (cancerquest.org)
- The proto-oncogenes that have been identified so far have many different functions in the cell. (cancerquest.org)
ELISA Kit2
- Description: Quantitativesandwich ELISA kit for measuring Human protein disulfide isomerase, PDI in samples from serum, plasma, tissue homogenates. (knoblauchpublishing.com)
- Description: Quantitativesandwich ELISA kit for measuring Human Protein jagged-1 (JAG1) in samples from serum, plasma, tissue homogenates. (kits-elisa.com)
P1053
- 1992). "Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B.". Oncogene. (wikipedia.org)
- NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. (hmdb.ca)
- cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. (sabbiotech.cn)
Kinase3
- Furthermore, TNF α and Fas induced the cleavage of mitogen-activated protein kinase/ERK kinase kinase (MEKK)1, resulting in generation of a constitutive active form of MEKK1 leading to JNK activation in c-FLIP knockdown cells. (nature.com)
- Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. (jefferson.edu)
- A-kinase anchoring protein 13 [Sourc. (gsea-msigdb.org)
Avian1
- The v-ets oncogene was originally discovered as part of a fusion protein expressed by a transforming retrovirus (avian E26), and later shown to be transduced from a cellular gene. (embl.de)
Nuclear7
- As targets of the Ras-MAPK signaling pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling cascades. (embl.de)
- Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified. (nih.gov)
- Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
- In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
- This graph shows the total number of publications written about "Nuclear Factor 90 Proteins" by people in this website by year, and whether "Nuclear Factor 90 Proteins" was a major or minor topic of these publications. (ouhsc.edu)
- Below are the most recent publications written about "Nuclear Factor 90 Proteins" by people in Profiles. (ouhsc.edu)
- For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
Sequences3
- Removal of the amino-terminal sequences of the bcl-3 protein generates a protein that inhibits the DNA binding of the p50-p65 heterodimer but, like the 37-kD (I kappa B alpha) protein, is no longer able to inhibit the binding of the p50 and p49 homodimers with kappa B DNA. (duke.edu)
- The Ets domains and the flanking amino acid sequences of the proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificities. (embl.de)
- Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp kB sequence in the immunoglobulin k light chain enhancer. (sabbiotech.cn)
Receptor2
- et al, Lack of bombesin receptor-activated protein attenuates bleomycin-induced pulmonary fibrosis in mice. (sabbiotech.cn)
- A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS . (nih.gov)
Mutations1
- Different cancer types tend to depend on a limited number of 'driver' oncogene mutations. (cancerquest.org)
Cyclin D12
- The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2. (musc.edu)
- Mechanistically, p100 inhibited Cyclin D1 protein translation by activating the transcription of LARP7 and its hosted miR-302d, which could directly bind to 3′-UTR of cyclin d1 mRNA and inhibited its protein translation. (oncotarget.com)
Nfkb1
- Dexamethasone also inhibited GM-CSF-induced NFkB activation by preventing a significant decrease on the IkB-a protein levels, thus blocking NF-kB migration to the nucleus.Conclusions : The corticosteroid dexamethasone inhibits GM-CSF-induced NF-kB activation, iNOS protein expression and NO production. (pdffox.com)
MeSH4
- Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- Factor For Inversion Stimulation Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Tumorigenesis2
- Rearrangement or overexpression of c-rel can cause tumorigenesis. (bvsalud.org)
- Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. (umassmed.edu)
Oncogenic1
- NCMV proteins and their oncogenic effects on cell mechanisms. (surgicalneurologyint.com)
Encoded by the REL gene1
- The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. (wikipedia.org)
Vitro3
- Furthermore, bcl-3 antisera immunoprecipitates an in vitro-radiolabeled 37-kD (I kappa B alpha) protein. (duke.edu)
- Comparison of tryptic peptide maps of the bcl-3 protein synthesized in vitro, and p56 and p38 from HeLa cells, shows that they are all structurally related. (duke.edu)
- It codes for a 'b-HLH' DNA-bind-ing protein which can dimerize and bind to DNA in vitro and to polytene chromosomes in vivo. (silverchair.com)
Kappa8
- Scholars@Duke publication: The proto-oncogene bcl-3 encodes an I kappa B protein. (duke.edu)
- The bcl-3 protein is able to inhibit the DNA binding and trans-activation of authentic NF-kappa B heterodimers p50-p65 and p49-p65, as well as p50 and p49 homodimers. (duke.edu)
- A human 37-kD protein (I kappa B alpha), identified previously as a member of the I kappa B family, is also unable to inhibit DNA-binding activity of the Rel protein. (duke.edu)
- However, unlike bcl-3, the 37-kD (I kappa B alpha) protein has no effect on the DNA-binding activity of p50 or p49 homodimers. (duke.edu)
- Two dimensional phosphotryptic peptide maps of the human bcl-3 and the human 37-kD (I kappa B alpha) proteins reveal that the phosphopeptides from the 37-kD (I kappa B alpha) protein are nested within the bcl-3 protein. (duke.edu)
- We propose that the bcl-3 and 37-kD (I kappa B alpha) proteins are related and are members of the I kappa B family. (duke.edu)
- En el CITOPLASMA, las proteínas B I-kappa se unen al factor de transcripción NF-KAPPA B. La estimulación celular causa su disociación y traslocación del NF-kappa B activo al núcleo. (bvsalud.org)
- In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)
Serine1
- A-Raf proto-oncogene, serine/threoni. (gsea-msigdb.org)
Bind1
- A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. (bvsalud.org)
Transcriptional3
- This protein belongs to the rel proto-oncogene and NF-KB transcriptional factor family and acts by controlling zygotic gene expression. (silverchair.com)
- A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
- Deleterious, protein-altering variants in the transcriptional coregulator ZMYM3 in 27 individuals with a neurodevelopmental delay phenotype. (uams.edu)
Encodes1
- This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)
Isoform2
- Expression of the inducible isoform of nitric oxide synthase (iNOS) protein was evaluated by western blot analysis and immunofluorescence microscopy. (pdffox.com)
- PREDICTED: proto-oncogene c-Rel isoform 2 [Papio anubis]. (bioinformatics.org)
Cell cycle progression3
- Cyclin E and Bcl-xL cooperatively induce cell cycle progression in c-Rel-/- B cells. (musc.edu)
- Knockdown of p100 in cultured human bladder cancer cells promoted anchorage-independent growth accompanied with elevating abundance of cell-cycle-related proteins and accelerated cell-cycle progression. (oncotarget.com)
- The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
Heat shock p1
- DnaJ heat shock protein family (Hsp4. (gsea-msigdb.org)
Tissue homogenates7
- Description: A sandwich quantitative ELISA assay kit for detection of Human Protein Disulfide Isomerase (PDI) in samples from serum, plasma, tissue homogenates or other biological fluids. (knoblauchpublishing.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Protein Disulfide Isomerase (PDI) in serum, plasma, tissue homogenates and other biological fluids. (knoblauchpublishing.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Protein Disulfide Isomerase (PDI) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (knoblauchpublishing.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Fatty Acid Binding Protein 6, Ileal (FABP6) in samples from serum, plasma, tissue homogenates or other biological fluids. (elisastrip.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Fatty Acid Binding Protein 6, Ileal (FABP6) in serum, plasma, tissue homogenates and other biological fluids. (elisastrip.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Mouse Jagged 1 Protein (JAG1) in samples from tissue homogenates or other biological fluids. (kits-elisa.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Rat Angiopoietin Like Protein 4 (ANGPTL4) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. (ksiazkiwnauce.pl)
Suppressors1
- Both oncoproteins exert pleiotropic functions on their host cells, such as inactivation of the major tumour suppressors, p53 and retinoblastoma protein (pRB), respectively [ 10 ]. (biomedcentral.com)
Lymphoma1
- The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma. (wikipedia.org)
Regulate2
- Additionally, METTL3 was proved to regulate the expression and methylation level of circ -0,000,953 through YTHDF2 (YTH N6-methyladenosine RNA binding protein 2). (bvsalud.org)
- The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
Activation2
- Our previous studies showed that the expression of the monocyte-chemoattractant protein (MCP)-1, a chemokine, which triggers the infiltration and activation of cells of the monocyte-macrophage lineage, is abrogated in human papillomavirus (HPV)-positive premalignant and malignant cells. (biomedcentral.com)
- The protein plays a role in regulating DNA topology and activation of RIBOSOMAL RNA transcription. (childrensmercy.org)
P1002
- Here, we are, for the first time, to report that p100 protein expression was dramatically decreased in bladder cancers of N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-treated mice and human patients. (oncotarget.com)
- Furthermore, p100 suppressed the expression of PHLPP2 (PH domain and leucine-rich repeat protein phosphatases 2), thus promoting CREB phosphorylation at Ser133 and subsequently leading to miR-302d transcription. (oncotarget.com)
GTPase1
- The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. (uchicago.edu)
Activator1
Locus1
- The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
Phosphorylation2
- A human myeloid cell line, Mo7, and a daughter cell line expressing the bcr/abl oncogene, Mo7-P210, were used in a comparative study analyzing the effects of p210(BCR/ABL) expression on tyrosine phosphorylation, specific DNA binding and expression of the proto-oncoprotein c-Rel. (elsevierpure.com)
- Tyrosine phosphorylation and DNA binding of c-Rel were slightly elevated in Mo7-P210 cells. (elsevierpure.com)
Signals1
- In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)
Family3
- Different members of the Ets family proteins display distinct DNA binding specificities. (embl.de)
- A family of double-stranded RNA-binding proteins that are related to NFATC TRANSCRIPTION FACTORS. (ouhsc.edu)
- The interleukin 2 CD28-responsive complex contains at least three members of the NF-κB family: c-Rel, p50, and p65. (google.com.tw)
Motif1
Transactivation1
- His Molecular biology research integrates issues from NFKB1, Ankyrin, DNA-binding protein, Transactivation and Ankyrin repeat. (research.com)
Complexes1
- The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
Progression1
- Although it is believed that deregulated viral oncogene expression is the first event towards anogenital cancer, the immunological defense mechanisms still have to be evaded so that progression towards cervical cancer can take place [ 11 ]. (biomedcentral.com)