• Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes. (musc.edu)
  • Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (bvsalud.org)
  • Cellular proteins encoded by the H-ras, K-ras and N-ras genes. (uchicago.edu)
  • Cellular- oncogenes, anti-oncogene and DNA repair genes are major types of genes that contribute to this process. (biomedcentral.com)
  • Differentially expressed genes and proteins can be screened from the level of genes and proteins, respectively. (biomedcentral.com)
  • Screening differential molecules can be accomplished in two ways: screening from protein expression data or using RNA-Seq data to detect differentially expressed genes. (biomedcentral.com)
  • Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. (avivasysbio.com)
  • It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. (avivasysbio.com)
  • To identify YpdB-regulated genes, we compared the transcriptomes of E. coli cells overproducing either YpdB or a control protein. (cipsm.de)
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
  • The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
  • The mutated or otherwise damaged versions of these genes are called oncogenes. (cancerquest.org)
  • Numerous genes have been identified as proto-oncogenes. (cancerquest.org)
  • As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
  • In contrast to sporadic cylindromas, according to one study, the fusion of MYB-NFIB genes was absent for CYLD -defective tumors in inherited disorders. (medscape.com)
  • While it is routine to detect structural viral proteins in vitro for diagnostic purposes, it previously remained impossible to directly and dynamically visualize HIV in living cells without genetic modification of the virus. (cipsm.de)
  • Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. (musc.edu)
  • ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice. (musc.edu)
  • Mechanically, miR-601 applied the operate by way of focusing on oncogene health proteins kinase tissue layer connected tyrosine/threonine A single (PKMYT1) at post-transcriptional stage. (gfap-signal.com)
  • Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. (jefferson.edu)
  • The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. (avivasysbio.com)
  • death associated protein kinase 1 [Sou. (gsea-msigdb.org)
  • In A. thaliana TTG1 acts together with R2R3-MYB and bHLH proteins (called MBW complex) to regulate different aspects of epidermal cell differentiation including the production of proanthocyanidin, anthocyanidin, seed coat mucilage, trichomes and root hairs [ 5 - 12 ]. (biomedcentral.com)
  • High trait specificity is found for the R2R3-MYB factors such that one specific R2R3-MYB gene regulates each trait [ 3 ]. (biomedcentral.com)
  • There are 139666 SANT domains in 88628 proteins in SMART's nrdb database. (embl.de)
  • Taxonomic distribution of proteins containing SANT domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with SANT domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing SANT domain in the selected taxonomic class. (embl.de)
  • Percentage points are related to the number of proteins with SANT domain which could be assigned to a KEGG orthologous group, and not all proteins containing SANT domain. (embl.de)
  • The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. (nih.gov)
  • Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF. (umassmed.edu)
  • The protein may be useful as a tumor marker. (cancerindex.org)
  • Similar to protein-coding regulators, recently mounting studies have revealed that lncRNAs are also importantly involved in tumor progression and have great potentials to be clinically applied in the treatment of cancer [ 7 ]. (aging-us.com)
  • This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. (novusbio.com)
  • A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)
  • Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer. (nih.gov)
  • The retroviral oncogene v-myb, and its cellular counterpart c-myb, encode nuclear DNA-binding proteins. (embl.de)
  • V-ets and c-ets-1, its cellular progenitor, have been shown [ 1 ] to be nuclear DNA-binding proteins. (expasy.org)
  • Since the c-myb protein is presumably the effector molecule that affects cellular functions, it is important to determine whether increased levels of this c-myb protein are produced. (aai.org)
  • ADP-ribosylation is a post-translational modification of proteins that occurs mostly in response to cellular stress and is catalysed by members of the diverse poly-ADP-ribose (PAR) polymerase (PARP/ARTD) family. (cipsm.de)
  • Progress has been made to better understand about effect of regulons (AREB/ABF, DREB, MYB, and NAC) under abiotic stresses and a number of regulons reported for stress responsive and used as a better transgenic tool of Arabidopsis and Rice. (scielo.br)
  • Progresso foi feito para entender melhor sobre o efeito dos regulons (AREB / ABF, DREB, MYB e NAC) sob estresses abióticos e uma série de regulons relatados como responsivos ao estresse e usados ​​como uma melhor ferramenta transgênica de Arabidopsis e Rice. (scielo.br)
  • In Arabidopsis thaliana ( A. thaliana ) the WD40 protein TRANSPARENT TESTA GLABRA1 (TTG1) controls five traits relevant for the adaptation of plants to environmental changes including the production of proanthocyanidin, anthocyanidin, seed coat mucilage, trichomes and root hairs. (biomedcentral.com)
  • This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. (nih.gov)
  • Additionally, miR-601 ended up being attenuated by c-Myb in transcriptional level. (gfap-signal.com)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS . (nih.gov)
  • most pertinent to the present report is an abnormally high level of c-myb proto-oncogene mRNA. (aai.org)
  • Application of unidirectional pulsatile shear stress to human umbilical vein endothelial cells (HUVECs) decreased PDCD4 protein but not mRNA level. (plos.org)
  • Specifically, the PDCD4 protein combines directly with the mRNA coding region of the target gene ( MYB/c-MYB ) to block translation [2] . (plos.org)
  • Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (bvsalud.org)
  • There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
  • His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
  • This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. (novusbio.com)
  • In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
  • The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
  • Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. (jefferson.edu)
  • This graph shows the total number of publications written about "Fusion Proteins, bcr-abl" by people in this website by year, and whether "Fusion Proteins, bcr-abl" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "Fusion Proteins, bcr-abl" by people in Profiles. (jefferson.edu)
  • Multiple alternatively spliced transcript variants have been found for this protein. (cancerindex.org)
  • Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified. (nih.gov)
  • Using lysate-based single-molecule motility assays and live-cell imaging in primary neurons, we show that JNK-interacting proteins 3 (JIP3) and 4 (JIP4) are activating adaptors for dynein that are regulated on autophagosomes and lysosomes by the small GTPases ARF6 and RAB10. (bvsalud.org)
  • The protein expressions of epithelial marker, E-cadherin and mesenchymal marker, N-cadherin were evaluated using western blot. (aging-us.com)
  • Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Different cancer types tend to depend on a limited number of 'driver' oncogene mutations. (cancerquest.org)
  • The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF). (musc.edu)
  • Non-nuclear oncogenes and the regulation of gene expression in transformed cells. (musc.edu)
  • Analysis of the v-myb structural components important for transactivation of gene expression. (musc.edu)
  • Dies lässt vermuten, dass LIN-9 und B-MYB gemeinsam die Expression der G2/M-Gene kontrollieren. (uni-wuerzburg.de)
  • Molecular basis of elevated c-myb expression in the abnormal L3T4-, Lyt-2- T lymphocytes of autoimmune mice. (aai.org)
  • This suggests that a regulatory mechanism, rather than the structural alteration of the gene, is responsible for elevated expression of c-myb in these L3T4-, Lyt-2- cells. (aai.org)
  • A highly abundant DNA binding protein whose expression is strongly correlated with the growth phase of bacteria. (childrensmercy.org)
  • Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. (sigmaaldrich.com)
  • Cytoskeletal motor proteins are essential molecular machines that hydrolyze ATP to generate force and motion along cytoskeletal filaments. (bvsalud.org)
  • Dies und die Tatsache, dass LIN-9 mit pRB in der Aktivierung differenzierungspezifischer Gene kooperiert, ließ vermuten, dass humanes LIN-9 einen bedeutenden Einfluss auf die transkriptionelle Regulation Das humane LIN-9 wurde zuerst als pRB-interagierendes Protein beschrieben und spielt eine Rolle als Tumorsuppressor im Kontext des pRB-Signalweges. (uni-wuerzburg.de)
  • In D. melanogaster und in C. elegans sind die Homologe von LIN-9 und B-MYB zusammen, als Bestandteile hoch konservierter RB/E2F-Komplexe, an der Regulation von Genen entscheidend beteiligt. (uni-wuerzburg.de)
  • This gene encodes a protein with protease activity and is expressed in the placenta. (cancerindex.org)
  • Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. (sigmaaldrich.com)
  • Adenovirus E1A enhancer-binding protein (E1A-F) (ETV4) (PEA3). (expasy.org)
  • Detailed analysis showed that the c-myb protein is primarily expressed by an abnormal T lymphocyte population that does not express the mature T cell markers, L3T4 and Lyt-2. (aai.org)
  • Sequences of the Myc oncogene have been highly conserved throughout evolution, from Drosophila to vertebrates. (sigmaaldrich.com)
  • With the use of immunoprecipitation with an anti-v-myb reagent, we found high levels of c-myb protein in the lymph nodes of lpr mice. (aai.org)
  • This graph shows the total number of publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin J Recombination Signal Sequence-Binding Protein" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Profiles. (harvard.edu)
  • PU.1 (also known as Spi-1), a protein that binds to a purine-rich sequence, the PU-box, that can act as a lymphoid-specific enhancer. (expasy.org)
  • Below are the most recent publications written about "Leucine-Responsive Regulatory Protein" by people in Profiles. (rush.edu)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse EGF Like Domain Protein, Multiple 7 (EGFL7) in serum, plasma, tissue homogenates and other biological fluids. (gkts.net)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse EGF Like Domain Protein, Multiple 7 (EGFL7) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (gkts.net)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human EGF Like Domain Protein, Multiple 7 (EGFL7) in samples from serum, plasma, tissue homogenates or other biological fluids. (gkts.net)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Dickkopf Related Protein 4 (DKK4) in serum, plasma and other biological fluids. (gkts.net)
  • transport is driven by the microtubule motor protein cytoplasmic dynein, with motor activity regulated by a sequential series of adaptors. (bvsalud.org)
  • Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. (umassmed.edu)
  • Wnt-1 signaling can also induce the phosphorylation and subsequent degradation of c-Myb. (thermofisher.com)
  • Drosophila protein pointed (pnt) which is required for glial-neuronal cell interactions. (expasy.org)
  • Drosophila protein elg-1. (expasy.org)
  • Drosophila protein pokkuri (pok) (also known as yan), which is a negative regulator of photoreceptor development. (expasy.org)
  • Drosophila ecdysone induced protein 74E. (expasy.org)
  • Description: A sandwich ELISA kit for detection of Dickkopf Related Protein 4 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (gkts.net)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Dickkopf Related Protein 4 (DKK4) in samples from serum, plasma or other biological fluids. (gkts.net)
  • GA binding protein (GAPB) α subunit. (expasy.org)
  • MORF4L1 may also participate in the formation of NuA4 related complexes which lack the HTATIP/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. (novusbio.com)
  • The ets portion of this oncogene is required for the induction of erythroblastosis. (expasy.org)
  • Based on the phylogenetic tree of the MYB proteins, Serna and Martin suggested that the additional role of the MBW complex in trichome formation has been adopted after the Asterid-Rosid division [ 5 ]. (biomedcentral.com)
  • Mammalian ELK-1, ELK-3 (also known as Net or SAP-2) and ELK-4 (also known as SRF accessory protein 1 (SAP-1)), which all form a ternary complex with the serum response factor (SRF). (expasy.org)
  • The NuA4 complex interacts with MYC and the adenovirus E1A protein. (novusbio.com)
  • A LEUCINE and DNA-binding protein that is found primarily in BACTERIA and ARCHAEA. (rush.edu)