• The GENETIC TRANSLATION product from a GENE FUSION between a sequence from the tpr protein gene on the human CHROMOSOME 1 and the gene for PROTO-ONCOGENE PROTEINS C-MET. (ouhsc.edu)
  • This graph shows the total number of publications written about "Proto-Oncogene Proteins c-abl" by people in this website by year, and whether "Proto-Oncogene Proteins c-abl" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins c-abl" by people in Profiles. (jefferson.edu)
  • The RET proto-oncogene encodes receptor-level protein tyrosine kinases that are involved in cellular proliferation pathways. (onco360.com)
  • The proto-oncogene tyrosine-protein kinase (BCR-ABL1) oncogenic breakpoint cluster region-protein with enhanced tyrosine kinase action is encoded by this fusion gene. (inter-publishing.com)
  • Association of the proto-oncogene product dbl with G protein betagamma subunits. (embl.de)
  • Rearranged during transfection (RET), kinase alterations, which include fusions and activating point mutation, lead to overactive RET signaling and uncontrolled cell growth. (medscape.com)
  • A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report. (ox.ac.uk)
  • CONCLUSIONS: In the absence of somatic copy number variations or mutations, the fully transformed phenotype of the MNTI may have arisen in infancy because of the combined effects of a germline CDKN2A mutation, tumor promoting somatic fusion genes and epigenetic deregulation. (ox.ac.uk)
  • Chimeric mutant proteins occur natually when a large-scale mutation , typically a chromosomal translocation, creates a novel coding sequence containing parts of the coding sequences from two different genes. (chemeurope.com)
  • Gag genes are part of a general architecture for retroviruses, viruses that replicate through reverse transcription, where the gag region of the genome encodes proteins that constitute the matrix, capsid and nucleocapsid of the mature virus particles. (wikipedia.org)
  • Note that since the viral oncogenes originated from a host genome, the transformation event is different from transduction, which describes the process of introducing non-native genes to a host organism via a viral infection. (wikipedia.org)
  • aRMS tissues exhibit a number of genetic changes, including loss-of-function of the p53 and Rb tumor suppressor pathways, amplification of MYCN, stabilization of telomeres, and most characteristically, reciprocal translocation of loci involving the PAX and FKHR genes, generating the PAX7-FKHR or PAX3-FKHR fusion proteins. (duke.edu)
  • Chromosome 21 likely contains 200 to 300 genes that provide instructions for making proteins. (medlineplus.gov)
  • The normal RUNX1 protein, produced from the RUNX1 gene, is part of a protein complex called core binding factor (CBF) that attaches (binds) to DNA and turns on genes involved in blood cell development. (medlineplus.gov)
  • The RUNX1-ETO fusion protein forms CBF and attaches to DNA, but instead of turning on genes that stimulate the development of blood cells, it turns those genes off. (medlineplus.gov)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • These peptides were mapped to 10,295 protein-coding genes, on average. (genomeweb.com)
  • A chromosomal translocation results in the head-to-tail fusion of the BCR and ABL1 genes. (enzolifesciences.com)
  • Multiple chromosomal translocations were identified by RNA-Seq, and fusion genes included RPLP1-C19MC, potentially deregulating the C19MC cluster, an imprinted locus containing microRNA genes reactivated by gene fusion in embryonal tumors with multilayered rosettes. (ox.ac.uk)
  • Other highly expressed genes encoded muscle proteins and modulators of the extracellular matrix. (ox.ac.uk)
  • Fusion proteins , also known as chimeric proteins , are proteins created through the joining of two or more genes which originally coded for separate proteins. (chemeurope.com)
  • Naturally occurring fusion genes are most commonly created when a chromosomal translocation replaces the terminal exons of one gene with intact exons from a second gene. (chemeurope.com)
  • Many important cancer-promoting oncogenes are fusion genes produced in this way. (chemeurope.com)
  • This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. (cancerindex.org)
  • BCR-ABL oncogene encodes a BCR-ABL tyrosine kinase (TK), which triggers different downstream targets including c-Myc, STAT5 and CrkL, which participated in the control of cell differentiation, proliferation, migration and other cellular behaviors [ 3 - 5 ]. (jcancer.org)
  • The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in cell differentiation, cell division, cell adhesion, and stress responses. (enzolifesciences.com)
  • In the case of the murine leukemia viruses, a species of viruses capable of causing cancer in murines (mice), the viral life cycle can also be responsible for oncogenesis through a Gag-v-Onc fusion protein called "Mo-MuLV(src)", which is a Gag-v-Src protein capable of inducing oncogenesis in living mice. (wikipedia.org)
  • Protein tyrosine kinase Abl promotes hepatitis C virus particle assembly via interaction with viral substrate activator NS5A.Miyamoto D, et al. (inter-publishing.com)
  • In other words, the linear portion of a polypeptide which corresponds to a given domain, such as a tyrosine kinase domain, may be removed from the rest of the protein without destroying its intrinsic enzymatic capability. (chemeurope.com)
  • The chimeric fusion gene BCR-ABL is responsible for production of the oncoprotein bcr-abl tyrosine kinase. (msdmanuals.com)
  • The fusion protein produced from the t(8;21) translocation, called RUNX1-ETO, retains some functions of the two individual proteins. (medlineplus.gov)
  • The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. (nature.com)
  • During this translocation, a piece of chromosome 9 containing the oncogene ABL is translocated to chromosome 22 and fused to the BCR gene. (msdmanuals.com)
  • Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. (jefferson.edu)
  • The Gag-v-Onc fusion protein from the Rous sarcoma virus illustrates the dual role that the fusion protein plays in the viral and host cellular life cycle. (wikipedia.org)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
  • The Bone Morphogenetic Protein Receptor ( BMPR ) family includes transmembrane receptors that play vital roles in tissue development and cellular signaling. (news-medical.net)
  • Point mutations in RET or chromosomal rearrangements involving gene fusions of RET with various partners result in oncogenesis via abnormally overactive cellular proliferation. (onco360.com)
  • The v-ets oncogene was originally discovered as part of a fusion protein expressed by a transforming retrovirus (avian E26), and later shown to be transduced from a cellular gene. (embl.de)
  • The vast majority of cellular proteins, many of which are the most interesting and important molecules for regulating normal and neoplastic growth, lie within the cell, hidden from monoclonal antibody (mAb) therapeutics by the barriers of the plasma membrane. (oncotarget.com)
  • MAb have reached intra-cellular targets, but usually after the cell has lysed, releasing histones as an example, or tumor-associated vesicular cargo into the extracellular milieu such as in melanosomal granules, or exposing intracellular proteins by permeabilized membranes. (oncotarget.com)
  • The Rho family of GTP-binding proteins has been implicated in the regulation of various cellular functions including actin cytoskeleton-dependent morphological change. (embl.de)
  • Kask L., Hillarp A., Ramesh B., Dahlbäck B., and Blom A. M. (2002) Structural requirements for the intra-cellular subunit polymerization of the complement inhibitor C4b-binding protein. (lu.se)
  • Autophagy functions in tumor suppression by, for example, preserving protein and organelle homeostasis. (hindawi.com)
  • ARA-C reduced EWS/FLI protein abundance and accordingly diminished cell viability and transformation and abrogated tumor growth in a xenograft model. (broadinstitute.org)
  • A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia. (harvard.edu)
  • 2018). FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium. (edu.au)
  • The bcr-abl fusion protein is a well-known example of an oncogenic fusion protein, and is considered to be the primary oncogenic driver of chronic myelogenous leukemia. (chemeurope.com)
  • As targets of the Ras-MAPK signaling pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling cascades. (embl.de)
  • it still remains to be determined if there are more proteins that can regulate the RPs-MDM2-p53 pathway. (elifesciences.org)
  • analyzed the impact of RN1 (a natural product extracted from Panax notoginseng ) on bone morphogenetic protein receptors (BMPR1A and BMPR2). (news-medical.net)
  • Its activity is directed by intracellular signals mediated by various types of receptors such as G protein-coupled receptors. (embl.de)
  • Malignant transformation is usually the result of chromosomal translocations that activate proto-oncogenes or create a chimeric fusion protein. (oncolink.org)
  • Like in HIV's replication cycle, these proteins are needed for viral budding from the host cell's plasma membrane, where the fully formed virions leave the cell to infect other cells. (wikipedia.org)
  • The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. (embl-heidelberg.de)
  • Proteomic and phosphoproteomic data illuminated biology downstream of copy number aberrations, somatic mutations, and fusions and identified therapeutic vulnerabilities associated with driver events involving KRAS, EGFR, and ALK. (cngb.org)
  • Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. (jcancer.org)
  • Chronic myeloid leukemia (CML) is a clonal expansion of the progenitor hematopoietic stem cells arising from the existence of the fusion BCR-ABL oncogene, that represents 15%-20% of the newly diagnosed cases of leukemia patients [ 1 - 2 ]. (jcancer.org)
  • The human eight twenty-one (ETO, MTG8 or CBFA2T1) and related myeloid transforming gene products MTGR1 and MTG16 as well as the Nervy protein contain the NHR1-4 domains. (embl-heidelberg.de)
  • Indolizine: In-Silico Identification of Inhibitors against Mutated BCR-ABL Protein of Chronic Myeloid Leukemia. (inter-publishing.com)
  • Acute Myeloid Leukemia (AML) with MLL gene rearrangements demonstrate unique gene expression profiles driven by MLL-fusion proteins. (ox.ac.uk)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Different members of the Ets family proteins display distinct DNA binding specificities. (embl.de)
  • It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. (embl.de)
  • The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and thus is believed to be involved in receptor-mediated regulation of the proteins. (embl.de)
  • Oncogene Proteins, Fusion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • Rous sarcoma virus Fusion protein Fusion gene Fusion transcript Chimeric gene Bcr-abl fusion protein Oncovirus Retrovirus Retrotransposon Retroposon Integrase gag-onc+Fusion+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) http://www.ijbs.com/v06p0730.htm#headingA7 Lewin, Benjamin (1999). (wikipedia.org)
  • Recombinant human protein Gal-3, EGFR, BMPR1A, and BMPR2 were obtained from Sino Biological. (news-medical.net)
  • RET fusions occur in 1-2% of metastatic NSCLC patients. (onco360.com)
  • The TAF homology (TAFH) or Nervy homology region 1 (NHR1) domain is a domain of 95-100 amino acids present in eukaryotic proteins of the MTG/ETO family and whereof the core ~75-80 residues occur in TAF proteins. (embl-heidelberg.de)
  • ONCOGENE FUSION includes an ONCOGENE as at least one of the fusion partners and such gene fusions are often detected in neoplastic cells and are transcribed into ONCOGENE FUSION PROTEINS. (edu.au)
  • We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
  • Blom A. M . , Berggård K., Webb J. H., Villoutreix B., Lindahl G. and Dahlbäck B. (2000) Human C4b-binding protein has overlapping but not identical binding sites for C4b and streptococcal M-proteins. (lu.se)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • Maloney K, McGavran L, Murphy J, Odom L, Stork L, Wei Q, Hunger S. TEL-AML1 fusion identifies a subset of children with standard risk acute lymphoblastic leukemia who have an excellent prognosis when treated with therapy that includes a single delayed intensification. (ucdenver.edu)
  • Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia. (ox.ac.uk)
  • Especially in the case where the linkers enable protein purification , linkers in protein or peptide fusions are sometimes engineered with cleavage sites for proteases or chemical agents which enable the liberation of the two separate proteins. (chemeurope.com)
  • The Ets domains and the flanking amino acid sequences of the proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificities. (embl.de)
  • Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia. (ucdenver.edu)
  • Pre- and post-treatment blood-based genomic landscape of patients with ROS1 or NTRK fusion-positive solid tumours treated with entrectinib. (ucdenver.edu)
  • Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)
  • BMPR family of proteins is a valuable tool for studying ligand-receptor interactions, downstream signaling events, and determining therapeutic targets. (news-medical.net)
  • This technique is often used for identification and purification of proteins, by fusing a GST protein , FLAG peptide, or a hexa-his peptide (aka: a 6xhis-tag) which can be isolated using nickel or cobalt resins ( affinity chromatography ). (chemeurope.com)
  • In this context, one alternative approach is to select intracellular antigenic targets that are exposed on the cell surface as part of the normal process of protein catabolism and presentation on MHC molecules. (oncotarget.com)
  • Intracellular proteins are usually degraded by the proteasome or endo/lysosomes, and the resulting specific peptide fragments bind to MHC class molecules. (oncotarget.com)
  • The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. (uams.edu)
  • They also further defined subtype 1 as representing cell proliferation-related processes (cell cycle and DNA replication RNA processing, translation, and protein degradation). (genomeweb.com)
  • Translation of this fusion gene results in a single polypeptide with function properties derived from each of the original proteins. (chemeurope.com)