• Members of the src-family tyrosine kinases that are activated during the transition from G2 PHASE to M PHASE of the CELL CYCLE. (bvsalud.org)
  • Protein-tyrosine kinases play pivotal roles in cell signal transduction. (ox.ac.uk)
  • Regulation of mitogen-activated protein kinase activation by protein kinases A and C in a cell-free system. (ox.ac.uk)
  • Bosutinib (SKI-606) is a 4-anilino-3-quinoline carbonitrile, which acts as a dual inhibitor of Src and ABL kinases. (mdm2-receptor.com)
  • Bosutinib (SKI-606), 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3- (4-methyl-1-piperazinyl) propoxy]-3-quinolinecarbonitrile monohydrate, is a competitive inhibitor of both Src and ABL tyrosine kinases. (mdm2-receptor.com)
  • Bosutinib is a potent dual inhibitor of the Src and ABL tyrosine kinases (Puttini et al. (mdm2-receptor.com)
  • The tyrosine kinase Src is a member of a family of related kinases known as the Src family kinases (SFKs) that share a common structural organization and function as key regulators of signal transduction pathways triggered by a wide variety of surface receptors, including receptor tyrosine kinases, integrins, G-protein-coupled receptors, and antigen receptors (Thomas and Brugge 1997). (mdm2-receptor.com)
  • Our results suggest that a screening approach using protein crystallography is particularly useful to identify universal fragments for the conserved hydrophilic recognition sites found in target families such as SH2 domains, phosphatases, kinases, proteases, and esterases. (rcsb.org)
  • Cellular proteins encoded by the H-ras, K-ras and N-ras genes. (uchicago.edu)
  • Several of the proteins encoded by genes that are up-regulated by NF-κB are also potent NF-κB activators, thereby, forming an auto-activating loop. (biomedcentral.com)
  • Overexpression of ELF4 boosted CRC metastasis via transactivating its downstream target genes, fibroblast growth factor receptor 4 (FGFR4) and SRC proto-oncogene, non-receptor tyrosine kinase, SRC . (thno.org)
  • RESULTS: We compared MetaNovo to published results from the MetaPro-IQ pipeline on 8 human mucosal-luminal interface samples, with comparable numbers of peptide and protein identifications, many shared peptide sequences and a similar bacterial taxonomic distribution compared to that found using a matched metagenome sequence database-but simultaneously identified many more non-bacterial peptides than the previous approaches. (bvsalud.org)
  • These results indicate that SRC transcriptional regulation is much more complex than previously realized and implicates HNF-1 in both the tissue -specific regulation of the SRC gene in normal tissues and the overexpression of c-Src in certain human cancers. (xenbase.org)
  • Sequence comparisons also indicate that matk contains src homology region 2 and 3 domains but lacks the NH2-terminal myristylation signal, the negative regulatory tyrosine (Tyr-527), and the autophosphorylation site (Tyr-416) corresponding to those found in src. (ox.ac.uk)
  • Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. (expasy.org)
  • Furthermore, inhibition of endogenous PKA by the heat-stable PKA inhibitor is sufficient to stimulate MAPK activity in these extracts in the absence of protein synthesis and without dependence on a functional Ras protein. (ox.ac.uk)
  • It was originally synthesized as an inhibitor of the Src kinase family. (mdm2-receptor.com)
  • Results from a novel approach which uses protein crystallography for the screening of a low affinity inhibitor fragment library are analyzed by comparing the X-ray structures with bound fragments to the structures with the corresponding full length inhibitors. (rcsb.org)
  • Furthermore, the combination of the FGFR4 inhibitor BLU-554 and the SRC inhibitor KX2-391 dramatically suppressed ELF4-mediated CRC metastasis. (thno.org)
  • MeSH D12.776.503.280.249.500 - mannose-binding lectin MeSH D12.776.503.280.249.600 - pulmonary surfactant-associated protein a MeSH D12.776.503.280.249.625 - pulmonary surfactant-associated protein d MeSH D12.776.503.499.968.900 - wheat germ agglutinin-horseradish peroxidase conjugate See List of MeSH codes (D12.776.543). (wikipedia.org)
  • Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer. (musc.edu)
  • It is one of the most abundant proteins in the eukaryotic cells comprising 1-2% of total proteins under non-stress conditions [ 3 ]. (biomedcentral.com)
  • GAS 41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. (mpg.de)
  • Oncogene activation induces metabolic transformation resulting in insulin-independence in human breast cancer cells. (musc.edu)
  • The KDELR induces Src activation at the invadopodia and leads to phosphorylation of the Src substrates cortactin and ASAP1, which are required for basal and KDELR-stimulated ECM degradation. (oncotarget.com)
  • These results suggest that independent pp60v-src and PKC pathways converge at Ras and that PKA acts to block MAPK activation by both Ras-dependent and -independent signals. (ox.ac.uk)
  • Thus specific inhibition of individual proteins or signalling pathways holds a great potential for subversion of this genetic plasticity of cancers. (biomedcentral.com)
  • The SRC gene encodes the proto-oncogene pp60(c-)(src), a tyrosine kinase implicated in numerous signal transduction pathways. (xenbase.org)
  • This effect was found to depend on the Ca 2+ increase mediated by the phospholipase C-β (PLC-β) and protein kinase C (PKC) pathways, as well as by the reverse activity of the Na + /Ca 2+ exchanger. (molvis.org)
  • We have identified a novel pathway that directs Lyn/Src family tyrosine kinase signals to the invadopodia to regulate sarcoma cell invasion via the molecule AFAP-1-like-1 (AFAP1L1), a new member of the AFAP (actin filament-associated protein) family. (nature.com)
  • Proto-oncogene proteins that negatively regulate RECEPTOR PROTEIN-TYROSINE KINASE signaling. (nih.gov)
  • Membrane traffic is a fundamental process by which a third of the mammalian proteins are transported from their site of synthesis, the endoplasmic reticulum (ER), through a series of anatomically separated membranous compartments until they reach their cellular destinations in correctly processed forms. (oncotarget.com)
  • Cleavage of the nuclear matrix protein NuMA during apoptosis. (mpg.de)
  • Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes. (nature.com)
  • We identified a total of 213 HRPs distributed in 22 protein families named orthologous groups (OGs) with His-rich domains, including 15 newly described OGs. (bvsalud.org)
  • However it is also involved in the maturation and stabilization of a wide range of oncogenic client proteins which are crucial for oncogenesis and malignant progression. (biomedcentral.com)
  • Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells. (musc.edu)
  • It contains an intrinsic protein-tyrosine kinase activity. (rush.edu)
  • These data define a novel pathway that directs Lyn/Src family tyrosine kinase signals to sarcoma cell invadopodia through specific recruitment of Vav2 and Nck2 to phosphorylated AFAP1L1, to control cell migration and invasion. (nature.com)
  • Transforming function of the LSM1 oncogene in human breast cancers with the 8p11-12 amplicon. (musc.edu)
  • Poor correlations typically observed between RNA and protein expression datasets make it hard to accurately infer microbial protein synthesis from metagenomic data. (bvsalud.org)
  • Differential use of these promoters and their associated exons coupled with subsequent splicing to a common downstream exon results in c-Src transcripts with different 5' ends but identical coding regions. (xenbase.org)
  • Additionally, mass spectrometry-based metaproteomic analyses typically rely on focused search sequence databases based on prior knowledge for protein identification that may not represent all the proteins present in a set of samples. (bvsalud.org)
  • The pp60v-src pathway is dependent on a functional Ras signal whereas the cyclin/maturation-promoting factor pathway is not. (ox.ac.uk)
  • Functional oncogene signatures guide rationally designed combination therapies to synergistically induce breast cancer cell death. (musc.edu)
  • The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. (uchicago.edu)
  • Mutation of the HNF-1 site resulted in a dramatic reduction in SRC promoter activity. (xenbase.org)
  • BRCA1 protein level is not affected by peptide growth factors in MCF10A cell line. (musc.edu)
  • An alternative, human SRC promoter and its regulation by hepatic nuclear factor-1alpha. (xenbase.org)
  • The intermediate filament protein vimentin as differentiation marker in preimplantation porcine embryos. (mpg.de)
  • Previously pp60v-src, cyclin A, p39mos, and maturation-promoting factor (composed of Cdc2 and cyclin B) have been shown to activate mitogen-activated protein kinase (MAPK) and MAPK kinase (MEK) in cell-free extracts of Xenopus oocytes. (ox.ac.uk)
  • Here we describe the isolation of a new distal SRC promoter and associated exon, designated 1alpha, which we mapped to a position 1.0 kilobase upstream of the previously described SRC1A housekeeping promoter. (xenbase.org)
  • Local degradation of fibronectin at sites of expression of the transforming gene product pp60src. (nature.com)
  • Clinically, ELF4 expression had a positive correlation with FGF19, FGFR4 and SRC, and CRC patients who positively coexpressed FGF19/ELF4, ELF4/FGFR4, or ELF4/SRC exhibited the worst clinical outcomes. (thno.org)
  • Single-stranded DNA 'blue' T7 promoter plasmids: a versatile tandem promoter system for cloning and protein engineering. (wikidata.org)
  • 2000), An alternative, human SRC promoter and its regu. (xenbase.org)
  • Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. (musc.edu)
  • Results from the molecular dynamics simulations in water show that the trajectories of the protein complexed with ligand WA are stable over a considerably long time period of 4 ns, with the energies of the complex being lowered in comparison to the un-docked association complex, suggesting the thermodynamic stability of WA complexed Hsp90/Cdc37. (biomedcentral.com)
  • Antibodies raised against the NH2 terminus of matk immunoprecipitated a 60-kDa protein from the CMK human megakaryocyte cell line. (ox.ac.uk)
  • Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. (jefferson.edu)
  • The role of Ha-ras oncogenes in growth factor independence in rat mammary carcinoma cells. (musc.edu)
  • Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells. (musc.edu)
  • Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer. (musc.edu)
  • In addition, the SRC gene is differentially expressed, developmentally regulated, and frequently overexpressed in human neoplasia. (xenbase.org)
  • HSPs (Heat shock proteins) are highly conserved ubiquitous proteins among species which are involved in maintaining appropriate folding and conformation of other proteins and are thus referred to as molecular chaperones. (biomedcentral.com)
  • Given the central role of Src in extracellular matrix (ECM) degradation, we investigated the impact of the KDELR-Src pathway on the ability of cancer cells to degrade the ECM. (oncotarget.com)
  • Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. (nih.gov)
  • In addition, preincubation of extracts with cAMP-dependent protein kinase (PKA) blocks stimulation of MAPK by cyclin, p21V12ras, PKC, or pp60v-src, by at least 50%, but stimulation by c-Mos is unaffected. (ox.ac.uk)
  • Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes. (musc.edu)
  • Effects of expressing lamin A mutant protein causing Emery-Dreifuss muscular dystrophy and familial partial lipodystrophy in HeLa cells. (mpg.de)
  • New monoclonal antibodies recognizing phosphorylated proteins in mitotic cells. (mpg.de)
  • This graph shows the total number of publications written about "Proto-Oncogene Proteins c-mdm2" by people in this website by year, and whether "Proto-Oncogene Proteins c-mdm2" was a major or minor topic of these publications. (umassmed.edu)