Cell AgingCyclin-Dependent Kinase Inhibitor p16TelomereFibroblastsTumor Suppressor Protein p53OncogenesAging, PrematureCyclin-Dependent Kinase Inhibitor p21Telomere ShorteningTelomerasebeta-GalactosidaseCell Transformation, NeoplasticAgingDNA DamageCell ProliferationCells, CulturedCell Line, TumorGenes, rasCell LineRetinoblastoma ProteinCell CycleSignal TransductionCell Cycle CheckpointsOncogene ProteinsOxidative StressTumor Suppressor ProteinsTumor Suppressor Protein p14ARFNuclear ProteinsNeoplasmsSirtuin 1RNA, Small InterferingGene Expression RegulationPhenotypeProgeriaApoptosisLongevityOncogene Proteins, ViralTelomeric Repeat Binding Protein 2DNA-Binding Proteinsras ProteinsGenes, p16Cell DivisionReactive Oxygen SpeciesRNA InterferenceDiploidyDown-RegulationProto-Oncogene Proteins c-mycGene Expression Regulation, NeoplasticModels, BiologicalTranscription FactorsMutationGene Knockdown TechniquesCell Line, TransformedHeterochromatinRepressor ProteinsOncogene Protein p21(ras)Hydrogen PeroxideProto-Oncogene Proteins p21(ras)Werner SyndromeProto-Oncogene ProteinsTransfectionUp-RegulationBase SequenceBlotting, WesternMolecular Sequence DataGene SilencingRNA, MessengerCell Cycle ProteinsPlant LeavesTranscription, GeneticMice, KnockoutPromoter Regions, GeneticOxidantsReverse Transcriptase Polymerase Chain ReactionHCT116 CellsPolycomb Repressive Complex 1TOR Serine-Threonine KinasesForeskinGenes, p53Nevus, PigmentedHistonesCyclin-Dependent Kinase Inhibitor p15MicroRNAsProtein-Serine-Threonine KinasesGene ExpressionNeoplasm ProteinsProto-Oncogene Proteins c-mdm2Papillomavirus E7 ProteinsInhibitor of Differentiation Protein 1PhosphorylationMice, Inbred C57BLGenomic InstabilityMice, TransgenicEmbryo, MammalianEpithelial CellsOncogene Protein p55(v-myc)Jumonji Domain-Containing Histone DemethylasesOncogene Proteins, FusionCyclin-Dependent Kinase Inhibitor p27DNA