Loading...
  • leukemia
  • Another example of an oncogene is the Bcr-Abl gene found on the Philadelphia chromosome , a piece of genetic material seen in Chronic Myelogenous Leukemia caused by the translocation of pieces from chromosomes 9 and 22. (wikipedia.org)
  • Examples include imatinib, which targets the bcr-abl oncogene in chronic myeloid leukemia and also targets the c-kit oncogene in gastrointestinal stromal tumors, and gefitinib and erlotinib, which target the epidermal growth factor receptor (EGFR) in non-small cell lung carcinoma (NSCLC), pancreatic cancer, and glioblastoma. (aacrjournals.org)
  • murine
  • Dependence on the continued expression of other oncogenes for the maintenance of the neoplastic state has also been seen in other tissues in murine models ( Table 1 ). (aacrjournals.org)
  • tumors
  • Example of three colon tumors (up) whose growth was inhibited (down) a molecule of RNA (ribonucleic acid) which acts as identified anti-oncogene. (innovations-report.com)
  • We believe this discovery will be the starting point to find many other oncogenes and anti-oncogenes that coexist in regions of our genome, that when their life together deteriorates, contribute to the development of human tumors," said Dr. Esteller. (innovations-report.com)
  • mechanism
  • Although this is a relatively common mechanism of oncogenesis in animals, very few oncogene-carrying viruses have been identified in man. (encyclopedia.com)
  • protein products
  • Blood samples were obtained from all workers and analyzed for PAH-DNA adducts and protein products encoded by nine specific oncogenes. (cdc.gov)
  • The cases in which oncogene encoded protein products were identified came from one individual with high exposure and another with a medium level of exposure. (cdc.gov)
  • The authors speculate that the two workers who tested positive for oncogene protein products and had high levels of PAH-DNA adducts have a high probability of developing malignant disease. (cdc.gov)
  • genetic
  • Numerous studies using human cancer cell lines indicate that although these cells are aneuploid and carry several genetic and epigenetic abnormalities, they can also be highly dependent on the activity of a single oncogene for continued cell proliferation and survival ( Table 1 ). (aacrjournals.org)
  • efficacy
  • The efficacy of this strategy requires novel methods, including integrative genomics and systems biology, to identify the state of oncogene addiction (i.e., the "Achilles heel") in specific cancers. (aacrjournals.org)
  • The most convincing evidence for the concept of oncogene addiction comes from the increasing number of examples of the therapeutic efficacy of antibodies or drugs that target specific oncogenes in human cancers ( Table 1 ). (aacrjournals.org)
  • oncogenic
  • used an integrative genomic approach to identify potential oncogenes by determining which signaling pathways downstream of oncogenic Ras contribute to cell transformation. (sciencemag.org)
  • proliferation
  • If a cell that usually does not produce growth factors suddenly starts to do so (because it developed an oncogene), it will thereby induce its own uncontrolled proliferation ( autocrine loop ), as well as the proliferation of neighboring cells. (wikidoc.org)
  • known
  • A known oncogene previously associated with carcinomas of the breast, liver, ovaries, and colon appears to suppress the growth of melanoma cells, a team of researchers reported recently in Cell Reports. (modernmedicine.com)
  • Genetics
  • A study coordinated by Manel Esteller, Director of the program of epigenetics and cancer biology at the Bellvitge Institute for Biomedical Research (IDIBELL), Professor of genetics at the University of Barcelona and ICREA researcher, has discovered the existence of an antitumor molecule that originates within an oncogene. (innovations-report.com)
  • Oncogene is a peer-reviewed scientific journal published by the Nature Publishing Group addressing cancer cell genetics and the structure and function of oncogenes. (wikipedia.org)
  • site
  • Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Oncogene . (nature.com)