• Onchocerciasis, caused by the parasitic nematode, Onchocerca volvulus afflicts some 37 million people worldwide, and is the second leading infectious cause of blindness globally. (biomedcentral.com)
  • Onchocerciasis drug discovery studies have so far been based on in vivo models using Onchocerca species which are not the closest to O. volvulus, and which may therefore, not adequately mimic the natural infection in humans. (biomedcentral.com)
  • Therefore, this study was carried out to develop a better drug screening model for onchocerciasis, based on the use of cow-derived O. ochengi , the closest known relative of O. volvulus . (biomedcentral.com)
  • This study reveals the Syrian hamster as an appropriate small animal model for screening of novel compounds against O. ochengi , the closest known relative of O. volvulus . (biomedcentral.com)
  • Onchocerciasis is a neglected tropical disease caused by the filarial nematode, Onchocerca volvulus . (biomedcentral.com)
  • The intensity of natural transmission of Onchocerca ochengi and Onchocerca volvulus by anthropo-boophilic Simulium damnosum s.l. was studied longitudinally in two cattle watering sites of a cattle ranch within a predominantly cattle populated area of the Guinea savanna of Cameroon and related to cattle O. ochengi skin microfilaria abundance. (vetres.org)
  • During the 12 months study period, a total of 4 696 flies was individually dissected to examine the monthly transmission potential (MTP) of O. ochengi and O. volvulus . (vetres.org)
  • L'intensité de la transmission naturelle de Onchocerca ochengi et Onchocerca volvulus par l'anthropo-boophile Simulium damnosum s.I. a été étudiée longitudinalement à deux points d'eau d'un élevage de bovins, situé dans une région de savane guinéenne du Cameroun comportant une population principalement bovine, et a été corrélée à l'abondance en microfilaires de O. ochengi dans la peau des bovins. (vetres.org)
  • Au cours des 12 mois de l'étude, un total de 4 696 mouches a été disséqué individuellement, afin d'examiner le potentiel de transmission mensuel (PTM) de O. ochengi et O. volvulus . (vetres.org)
  • Subcutaneous nodule on hip caused by encysted Onchocerca volvulus. (medscape.com)
  • One specimen of S. vorax was positive for Onchocerca volvulus in the body, and out of 155 S. dentulosum, 30% and 11% were infected and infective (respectively). (bvsalud.org)
  • BACKGROUND: High ongoing Onchocerca volvulus transmission was recently documented in Maridi County, South Sudan. (bvsalud.org)
  • I have been working on onchocerciasis for 18 years, focusing on the Onchocerca ochengi bovine system as an analogue of the human disease. (gnatwork.ac.uk)
  • The population dynamics of cattle microfilariae therefore plays an important role in the regulation of O. ochengi transmission. (vetres.org)
  • Onchocerca fasciata is a prevalent filarial species in camelids of Asia and Africa forming nodules in the skin of dromedary and Bactrian camels. (biomedcentral.com)
  • The annual transmission potentials (ATP) of O. ochengi were calculated to be 7 732 and 1 669 at the riverbank and the lake, respectively. (vetres.org)
  • Dynamique de la transmission de Onchocerca ochengi et corrélation entre la densité de leurs microfilaires chez les bovins et le potentiel de transmission. (vetres.org)
  • Les potentiels de transmission annuels (PTA) de O. ochengi ont été de 7 732 et 1 669 au niveau de la rivière et du lac, respectivement. (vetres.org)
  • 17. Phytochemical analysis and in vitro anthelmintic activity of Lophira lanceolata (Ochnaceae) on the bovine parasite Onchocerca ochengi and on drug resistant strains of the free-living nematode Caenorhabditis elegans. (nih.gov)
  • Under the applied experimental conditions in a cell proliferation test, O. ochengi galectin failed to significantly stimulate peripheral blood mononuclear cells (PBMCs) from O. ochengi -infected cattle, regardless of their parasite load. (biomedcentral.com)
  • Dynamique de la transmission de Onchocerca ochengi et corrélation entre la densité de leurs microfilaires chez les bovins et le potentiel de transmission. (vetres.org)
  • In southern California, ocular infections caused by Onchocerca lupi were diagnosed in 3 dogs (1 in 2006, 2 in 2012). (nih.gov)
  • Right eye of a dog with Onchocerca lupi infection, southern California, USA, 2004. (nih.gov)
  • A) Multiple sequence alignment of ITS sequences from the 3 dogs and sequences from various Onchocerca parasites. (cdc.gov)
  • 5. In vitro activity of Cameroonian and Ghanaian medicinal plants on parasitic (Onchocerca ochengi) and free-living (Caenorhabditis elegans) nematodes. (nih.gov)
  • IgG from Onchocerca -infected humans and cattle showed similar cross-reaction with both respective galectins. (biomedcentral.com)
  • The population dynamics of cattle microfilariae therefore plays an important role in the regulation of O. ochengi transmission. (vetres.org)
  • Molecular approaches to the population biology of Onchocerca ocheng i in cattle (Prof. R. Post, British Mus. (uni-tuebingen.de)
  • Ultimately, enucleation was performed, and histology revealed Onchocerca adult worms. (nih.gov)
  • Development of the bovine Onchocerca ochengi model for studies on the biology. (uni-tuebingen.de)