• There are just four branded drugs approved by the U.S. Food and Drug Administration with omega-3 fatty acids as active ingredients, and only two of those drugs (Lovaza and Vascepa) are commercially available in the U.S. Until recently, all approvals were restricted to the same niche patient population - adults with severely high triglyceride levels. (pharmamanufacturing.com)
  • Prescription omega-3 fatty acids such as omega-3-acid ethyl esters (Lovaza, Omytrg), icosapent ethyl esters (Vascepa), and omega-3-carboxylic acids (Epanova) come as a liquid filled gel capsule to take by mouth. (medlineplus.gov)
  • Through its strategic in-licensing and development strategy, Reliant has developed a portfolio of specialty medicines combating heart disease including U.S. rights to Lovaza™ (omega-3-acid ethyl esters), a treatment for adult patients with very high levels of triglycerides, reports the company. (genengnews.com)
  • The FDA has also approved Lovaza (omega-3-acid ethyl esters) as the only fish-oil supplement. (uspharmacist.com)
  • These highlights do not include all the information needed to use OMEGA-3-ACID ETHYL ESTERS CAPSULES safely and effectively. (nih.gov)
  • See full prescribing information for OMEGA-3-ACID ETHYL ESTERS CAPSULES. (nih.gov)
  • The effect of omega-3-acid ethyl esters capsules on the risk for pancreatitis has not been determined. (nih.gov)
  • The daily dose of omega-3-acid ethyl esters capsules is 4 grams per day taken as a single 4-gram dose (4 capsules) or as two 2-gram doses (2 capsules given twice daily). (nih.gov)
  • Patients should be advised to swallow omega-3-acid ethyl esters capsules whole. (nih.gov)
  • Do not break open, crush, dissolve, or chew omega-3-acid ethyl esters capsules. (nih.gov)
  • Omega-3-acid ethyl esters capsules are contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to omega-3-acid ethyl esters or any of its components. (nih.gov)
  • Omega-3-acid ethyl esters capsules are indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (greater than or equal to 500 mg/dL) hypertriglyceridemia. (nih.gov)
  • Patients should be placed on an appropriate lipid-lowering diet before receiving omega-3-acid ethyl esters capsules and should continue this diet during treatment with omega-3-acid ethyl esters capsules. (nih.gov)
  • Laboratory studies should be done to ascertain that the lipid levels are consistently abnormal before instituting therapy with omega-3-acid ethyl esters capsules. (nih.gov)
  • Apotex Omega-3-Acid Ethyl Esters Capsules 1 gram are a highly effective way to reduce bad cholesterol. (mountainside-medical.com)
  • Omega-3-Acid Ethyl Esters Capsules are a high quality product that is used to treat a variety of medical conditions. (mountainside-medical.com)
  • If you are looking for a quality product to improve your overall health, Omega-3-acid ethyl esters capsules may be the right choice for you. (mountainside-medical.com)
  • Omega-3-Acid Ethyl Esters Capsules are a potential treatment for Alzheimer's patients. (mountainside-medical.com)
  • The capsules are made of a combination of fatty acids that are known to be beneficial for the brain. (mountainside-medical.com)
  • It is a complete blend of Omega fatty acids and developed into easy-to-swallow soft-gel capsules for maximum absorption and to provide heart health benefits. (ipsnews.net)
  • You only need to take two Physio Omega capsules in the morning and maintain your health - especially heart health. (ipsnews.net)
  • ii) 1 product (omega-3-acid ethyl esters 90 soft capsules) obtained ANDA approval in the U.S. (pharmiweb.com)
  • Nonprescription omega-3 fatty acids come as gel capsules to take by mouth as directed on the package label. (medlineplus.gov)
  • or any of the ingredients in omega-3 fatty acid capsules. (medlineplus.gov)
  • There appears to be little difference in effect between dietary supplement and prescription forms of omega-3 fatty acids as to ability to lower triglycerides, but the ethyl ester products work less well when taken on an empty stomach or with a low-fat meal. (wikipedia.org)
  • Omega-3-acid ethyl esters, like other omega-3 fatty acid-based drugs, appears to reduce production of triglycerides in the liver and to enhance clearance of triglycerides from circulating very low-density lipoprotein (VLDL) particles. (wikipedia.org)
  • Triglycerides are fats consisting of 3 fatty acids covalently bonded to a glycerol molecule. (medscape.com)
  • People with high triglycerides also opt for this specially formulated Omega supplement. (ipsnews.net)
  • Omega-3 fatty acids are used together with lifestyle changes (diet, weight-loss, exercise) to reduce the amount of triglycerides (a fat-like substance) in the blood in people with very high triglycerides. (medlineplus.gov)
  • Omega-3 fatty acids may work by decreasing the amount of triglycerides and other fats made in the liver. (medlineplus.gov)
  • According to the company, oma-3 is available in both oil and powder forms of triglycerides or ethyl esters for multiple applications, while liveflax comes in 20 per cent SDG (secoisolariciresinol diglycoside, the primary lignan found in flax seed) and 40 per cent SDG. (nutraingredients.com)
  • It is the improved generation and high quality Omega-3 EPA/DHA TG concentrates with high TG (Triglycerides 80% or 90%) level, no EE (Ethyl Ester) Residue, low MG (Mono-Glycerides), low Oligomer, PAH -Benzo(a)pyrene free, high Stability and Purity. (nutraingredients.com)
  • Amarin's Vascepa is made up of one active ingredient: icosapent ethyl, which is a form of EPA. (pharmamanufacturing.com)
  • The structure and metabolism is dependent on blood plasma levels of certain essential fatty acids and their metabolites. (cochrane.org)
  • Chris Masterjohn's latest article on essential fatty acids, Precious yet Perilous , makes a compelling argument that fish oil supplementation - especially over the long-term - is not only not beneficial, but may be harmful . (chriskresser.com)
  • Mega EFA Omega-3 EPA & DHA is a premium-quality, purified fish oil supplement delivering high elemental levels of omega-3 essential fatty acids EPA and DHA. (vitacost.com)
  • Of the four FDA-approved drugs, three contain a mixture of EPA and DHA - two use the combo in ethyl ester form and the third (Epanova) contains the mixture as free fatty acids to aid bioavailability. (pharmamanufacturing.com)
  • However, a Cochrane review in 2018 did not find clear evidence that omega-3 supplementation has any impact on the prevention of vascular blockage in people with CKD. (wikipedia.org)
  • In order to receive the maximum benefits from omega-3fish oil supplementation, it is critical that these fats are provided to thebody in the same form that they are found naturally in fish. (beautybridge.com)
  • When any dose omega-3 (E-EPA or EPA) is compared with placebo, small short trials suggest that the need for neuroleptics appears to be reduced for people allocated omega-3 supplementation (n=30, 1 RCT, RR 0.73 CI 0.54 to 1.00) and mental state may improve (n=30, 1 RCT, RR not gaining 25% change in PANSS scores 0.54 CI 0.30 to 0.96, NNT 3 CI 2 to 29). (cochrane.org)
  • Enhanced increase of omega-3 index in response to long-term n-3 fatty acid supplementation from triacylglycerides versus ethyl esters. (ironmagazine.com)
  • The evidence to support this is the vast body of research studies and references that support the cardiovascular benefits of fish consumption and omega-3 supplementation. (uspharmacist.com)
  • 11 In 2007, in a major Japanese EPA Lipid Intervention Study, additional evidence supported the protective effects of omega-3 supplementation. (uspharmacist.com)
  • With all these fish-oil background studies, how do clinicians view these results versus those of recent studies such as the Alpha Omega Trial, which demonstrated no secondary prevention benefits of supplementation with an omega-3-enriched margarine spread? (uspharmacist.com)
  • In the present study we demonstrated that omega-3 PUFA supplementation in high fat diet (HFD + F) improved bone parameters, mechanical properties along with decreased BMAT in obese mice when compared to the HFD group. (bvsalud.org)
  • There is a possible association between omega-3-acid ethyl esters and more frequent recurrences of symptomatic atrial fibrillation or flutter in patients with paroxysmal or persistent atrial fibrillation, particularly within the first months of initiating therapy. (nih.gov)
  • During the October 2023 meeting, the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency, recommends an update to the product information for medicines containing omega-3-acid ethyl esters, to inform healthcare professionals and patients of the risk of atrial fibrillation. (famhp.be)
  • Increases in docosahexaenoic acid (DHA) content were less marked and not dose-dependent when administered as ethyl esters. (empowerpharmacy.com)
  • DHA (DocosaHexaenoic Acid, Omega-3) is a building block for the cell membranes that manage many vital processes, such as cognitive performance, heart and blood vessel health, vision, immunity, wound healing, and all major organ functions. (drbvitamins.com)
  • DHA (DocosaHexaenoic Acid), min. (drbvitamins.com)
  • How and from where are the ingredients of Physio Omega sourced? (ipsnews.net)
  • According to GOED , suppliers produced 111,210 metric tons of EPA and DHA omega-3 ingredients in 2018. (pharmamanufacturing.com)
  • Chinese supplier Fenchem is gearing up to launch branded fatty acid ingredients oma-3, omega-3, and liveflax flax lignans for the European market. (nutraingredients.com)
  • Sourced from high quality ingredients, this Nature Made Omega 3 Fish Oil for men and women is a gluten free Omega 3 supplement (1) that has no color added, no artificial flavors, no milk and no shellfish. (kingsoopers.com)
  • But there are many types of Omega 3 supplements available on the market, and not all are as safe and as effective as they claim. (ipsnews.net)
  • Are there any side effects of using Physio Omega supplements? (ipsnews.net)
  • What makes Physio Omega special than most of the CoQ10 and fish oil supplements is that it contains EPA, DHA, and the missing type of Omega called the DPA. (ipsnews.net)
  • Unlike cheap fish oil supplements that are formulated with ethyl ester, Physio Omega is formulated in triglyceride form for maximum absorption. (ipsnews.net)
  • By taking the Physio Omega supplements, you'll also notice an increase in your energy just within the first two to three days of consumption. (ipsnews.net)
  • Most mass marketed fish oil supplements come in the ethyl ester(EE) form. (beautybridge.com)
  • Elysium says research shows free fatty acids absorb better than the ethyl ester form of the ingredient found in most dietary supplements. (nutraingredients-usa.com)
  • Two trade groups have asked a federal appeals court to dismiss an appeal filed by Amarin Pharma Inc. in a case involving certain "synthetically produced omega-3 products' being promoted as dietary supplements. (naturalproductsinsider.com)
  • Steve Mister, president and CEO of CRN, claimed in a statement that Amarin "sought to create a market monopoly over a subset of omega-3 products, which would directly hinder legitimate manufacturers from selling fish oil supplements. (naturalproductsinsider.com)
  • Sixteen percent of U.S. adults consume omega-3 fatty acid supplements, according to a recent CRN survey. (naturalproductsinsider.com)
  • Nature Made Burp Less (3) Ultra Omega-3 (1) from Fish Oil 1400 mg Softgels are dietary supplements formulated to help support a healthy heart, brain and eyes. (kingsoopers.com)
  • Offering 1400mg Omega-3 (1) concentrate from Fish Oil (EPA - 683 mg, DHA - 252 mg) per softgel, these Nature Made Ultra Fish Oil supplements support heart, brain and eye health. (kingsoopers.com)
  • Nature Made Fish Oil Omega 3 supplements are quality you can trust. (kingsoopers.com)
  • 1,2 Using a meta-analysis, other investigators also showed insufficient evidence of a secondary preventive effect of omega-3 fatty acid supplements against overall cardiovascular events among patients with a history of cardiovascular disease. (uspharmacist.com)
  • 3 Publication of these studies has caused skepticism about the cardioprotective effects of omega-3 fats and has generated controversy over fish-oil and omega-3 supplements. (uspharmacist.com)
  • In 2002 in its scientific statement on fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease, The American Heart Association announced that "randomized controlled trials have demonstrated that omega-3 fatty acid supplements can reduce cardiac death, nonfatal MI, nonfatal stroke, and atherosclerosis in coronary patients. (uspharmacist.com)
  • But, additional research is needed to confirm the health benefits of omega-3 fatty acid supplements for both primary and secondary prevention. (uspharmacist.com)
  • The most popular supplements among cardiologists were multivitamins, omega-3/fish oil, and vitamin C. 6 A majority of the U.S. population consumes fish-oil supplements daily, and this is due to the fact that a high percentage of health care providers recommend the daily use of these products to the public. (uspharmacist.com)
  • 9 In 1989, the Diet and Reinfarction Trial demonstrated a 30% reduction in cardiovascular mortality in patients consuming high amounts of omega-3 from fish sources or supplements. (uspharmacist.com)
  • Most of the omega-3 our bodies have are from diets and supplements. (xendurance.eu)
  • Omega-3 supplements are not made equal. (xendurance.eu)
  • Many supplements opt to use Ethyl Ester as it's the cheaper option. (xendurance.eu)
  • Other supplements like Xendurance's Omega D3 use the triglyceride form of omega-3 fatty acids. (xendurance.eu)
  • Along with EPA and DHA Omegas, Physio Omega also contains docosapentaenoic acid (DPA). (ipsnews.net)
  • The effect of fish oil, omega-3 fatty acids on the risk for pancreatitis or on cardiovascular morbidity and mortality has not been established. (empowerpharmacy.com)
  • For cardiovascular support take 3 softgels per day, or as recommended by a nutritionally-informed physician. (drbvitamins.com)
  • Pharma's "deep and extensive omega-3 pipelines," says Ismail, "reach far beyond the cardiovascular space. (pharmamanufacturing.com)
  • Accordingly, this hypothesis predicts that optimization of n-3 fatty acid status and associated cardiovascular and cerebrovascular integrity prior to onset will be an efficacious preventive strategy for both MDD and CHD. (hindawi.com)
  • While taking omega-3 helps with cardiovascular health, there's no clear evidence yet that it entirely removes the risk of heart attacks or strokes. (xendurance.eu)
  • Riesgo coronario atribuible a los factores de riesgo cardiovascular en población española. (guiasalud.es)
  • OM3CA bioavailability (area under the plasma concentration-time curve from zero to the last measurable concentration) is up to 4-fold greater than that of OM3FA ethyl esters, and unlike ethyl esters, the absorption of OM3CA is not dependent on pancreatic lipase hydrolysis. (ku.edu)
  • Adults, take one Nature Made Ultra Fish Oil 1400 mg (1000mg Omega-3) (1) softgel daily with water and a meal for optimal absorption. (kingsoopers.com)
  • Krill contain a rather unique reddish antioxidant called astaxanthin , and they're also rich in phospholipids , which help emulsify fatty acids and enhance their absorption and retention. (healthyfellow.com)
  • Other omega-3 fish oil-based prescription drugs on the market have similar uses and mechanisms of action. (wikipedia.org)
  • Fish oil, omega-3 fatty acids is administered orally. (empowerpharmacy.com)
  • Clinically significant interactions of fish oil, omega-3 fatty acids with other drugs due to inhibition or induction of CYP450 mediated metabolism are not expected. (empowerpharmacy.com)
  • Because fish oil, omega-3 fatty acids may increase LDL or total serum cholesterol, they should be used cautiously in patients with hypercholesterolemia or mixed dyslipidemias. (empowerpharmacy.com)
  • Because fish oil, omega-3 fatty acids inhibit platelet aggregation, caution is advised when fish oils are used concurrently with anticoagulant therapy, thrombolytic therapy, or anti-platelet therapy. (empowerpharmacy.com)
  • Physio Omega is a new fish oil supplement designed for improving heart health. (ipsnews.net)
  • Here, we'll share all the essential information about the product, Physio Omega fish oil reviews, and the pros and cons attached to the product to help you quickly decide if it's good for your health. (ipsnews.net)
  • Physio Omega is a triple Omega fish oil supplement developed by PhysioTru. (ipsnews.net)
  • But it is more than just a mediocre fish oil supplement because it contains a particular type of Omega, the DPA, along with EPA and DPH. (ipsnews.net)
  • Physio Omega is all-natural, and the Omegas are sourced from Menhaden fish wild-caught in clean American water. (ipsnews.net)
  • Omega-3s are a family of polyunsaturated fats (commonly referred to as "fish oils") that the human body needs but cannot manufacture on its own. (pharmamanufacturing.com)
  • Among these critical fatty acids are two sought-after acids - EPA and DHA - which can be found in a variety of sources, including fatty or oily fish, fish body or liver oils, marine crustaceans, marine microorganisms, or even genetically modified terrestrial plants. (pharmamanufacturing.com)
  • The omega-3 fatty acids in this product are derived fromfish oils in their natural triglyceride (TG) form -the same way they naturallyoccur in fish. (beautybridge.com)
  • The supplement, called Matter, pairs a high dose suite of B vitamins with specially formulated omega-3s from fish oil. (nutraingredients-usa.com)
  • The new supplement includes the B vitamins and folate, a bilberry extract as well as a specially formulated 'omega-3 lysine complex' which is a powdered from of fish-oil derived omega-3s in a free fatty acid form. (nutraingredients-usa.com)
  • Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) are abundantly found in fish oil, and are both highly lipolytic (i.e. they burn fat) as well as highly anabolic (i.e. they build muscle). (ironmagazine.com)
  • For those who don't consume fish regularly, a Fish Oil for women and men like this Nature Made Ultra Omega 3 fish oil supplement (1) can help provide Omega-3s. (kingsoopers.com)
  • 3)Coated to reduce fish burps. (kingsoopers.com)
  • Omega 3 950 mg is Solgar's highest concentration of the natural Omega 3 polyunsaturates EPA and DHA from cold-water fish. (giftespot.com)
  • Scientists noted the decreased prevalence of CVD in Eskimos who consumed large quantities of omega-3-rich fish and sea mammals. (uspharmacist.com)
  • Omega-3 is usually found in fish, where humans can mainly get this fat. (xendurance.eu)
  • However, if you need a supplement for it, you can take fish oil to get the recommended amount of omega-3 fatty acids that your body needs. (xendurance.eu)
  • This type of omega-3 is derived from natural fish oil, but it's been bonded with ethyl to make a synthetic version. (xendurance.eu)
  • Among the pipeline treatments is an orphan drug being jointly developed by KD Biopharma and SLA Pharma, currently in phase 3 trials for a rare hereditary condition that leads to colorectal cancer. (pharmamanufacturing.com)
  • Prescription omega-3 products are more concentrated, requiring fewer softgels for the same daily dose. (wikipedia.org)
  • Omega-3 fatty acids reduce the hepatic production of triglyceride (TG)-rich very-low-density lipoproteins and may increase the removal rate of TG-rich lipoproteins by increasing lipoprotein lipase activity. (empowerpharmacy.com)
  • Also, Physio Omega helps reduce harmful triglyceride levels, which leads to decreased risk of heart attacks and strokes. (ipsnews.net)
  • If it had gone on for longer than that, it's likely the oxidative damage caused by omega-3 fats would have been even worse. (chriskresser.com)
  • Patients taking omega-3-acid ethyl esters and an anticoagulant or other drug affecting coagulation (e.g., anti-platelet agents) should be monitored periodically. (nih.gov)
  • Comment: Patients taking omega-3-fatty acids and an anticoagulant or other drug affecting coagulation should be monitored periodically due to potential increased risk of bleeding. (medscape.com)
  • 3 Because of the high prevalence of CAM use among patients with mental illness, and especially among persons with major depressive disorder, it is important to examine the efficacy and safety evidence of CAM modalities used as either monotherapies or in combination with conventional pharmacological agents to treat depressed mood. (psychiatrictimes.com)
  • In a small randomized placebo-controlled trial , depressed patients treated with a combination of folic acid (0.5 mg) plus fluoxetine experienced significantly greater improvements in mood than the fluoxetine-only group. (psychiatrictimes.com)
  • Here evidence implicating omega-3 (n-3) fatty acid deficiency in the pathoaetiology of CHD and MDD is reviewed, and the hypothesis that n-3 fatty acid deficiency is a preventable risk factor for CHD comorbidity in MDD patients is evaluated. (hindawi.com)
  • This body of evidence provides strong support for future studies to evaluate the effects of increasing dietary n-3 fatty acid status on CHD comorbidity and mortality in MDD patients. (hindawi.com)
  • Omega-3-acid ethyl ester medicines were approved for medical use in the European Union in 2000 and in the United States in 2004. (wikipedia.org)
  • Thus, our study highlights the beneficial effects of omega-3 PUFA-enriched diet on bone and cellular metabolism and its potential use in the treatment of metabolic bone diseases. (bvsalud.org)
  • Supportive but not conclusive research shows that consumption of EPA and DHA Omega-3 fatty acids may reduce the risk of coronary heart disease. (kingsoopers.com)
  • Other large randomized trials have documented the beneficial effects of omega-3 fatty acid in primary and especially in secondary prevention of coronary heart disease (CHD). (uspharmacist.com)
  • While use in pregnancy has not been well studied, some omega-3 fatty acids appear beneficial. (wikipedia.org)
  • The DPA is a specific type of Omega that researchers found to be most beneficial for heart health. (ipsnews.net)
  • Researchers found DPA is a special type of Omega-3 that is most beneficial for improving lipid metabolism, heart health, and also brain health. (ipsnews.net)
  • Bone parameters (bone microstructure, bone marrow adiposity, bone strength) were examined by µCT and 3-point bending test. (bvsalud.org)
  • Full-spectrum Omega-3 blend developed into pill form for oral consumption. (ipsnews.net)
  • Salivary seromucous glands are regulated predominantly by parasympathetic activation of muscarinic receptors, resulting in exocrine secretion of mucins and macroglobulin responsible by lubrication and protection of oral mucosa 3-4 . (bvsalud.org)
  • This class of LDL-lowering drugs, also known as bile acid sequestrants or bile acid-binding drugs, works in the intestines by promoting increased disposal of cholesterol. (drhendesi.com)
  • Your body uses cholesterol to make bile, an acid used in the digestive process. (drhendesi.com)
  • Lipoproteins have an outer core of cholesterol, phospholipids, and apoproteins and an inner core composed of TG and cholesterol ester (CE). (medscape.com)
  • Preclinical evidence suggests that n-3 fatty acids EPA and DHA (Omega-3) supplemented as phospholipids (PLs) may be more effective than triacylglycerols (TAGs) in reducing hepatic steatosis. (bvsalud.org)
  • Krill oil proponents claim that it is essentially a superior form of omega-3s. (healthyfellow.com)
  • Adam Ismail, who has spent over 20 years working in the omega-3 space, and is now serving as chief strategy officer for KD Pharma Group, recently identified 88 drugs in pharma's preclinical and clinical pipeline that use EPA, DHA or derivatives. (pharmamanufacturing.com)
  • As pharma continues to test the waters, the clinical and financial significance of omega-3 treatments is becoming too compelling to ignore. (pharmamanufacturing.com)
  • TAS-102 (Taiho Pharma USA, Inc.) is an anti-cancer drug under development and in stage 3 clinical trials for the treatment of colorectal cancer. (drugbank.com)
  • A study by Mata et al demonstrated that oxidative damage increases as intake of omega-3 fat increases . (chriskresser.com)
  • Doctor's Best Calamari DHA Omega-3 is produced from sustainably harvested squid, and molecularly distilled to ensure purity. (drbvitamins.com)
  • That same medicine, along with a handful of other omega-3 drugs, is also being explored as a COVID-19 treatment. (pharmamanufacturing.com)
  • Additional trials evaluating omega-3 drugs as treatments and preventatives for mental health and depression, gastrointestinal diseases, eye diseases and rare genetic disorders are underway. (pharmamanufacturing.com)
  • Omega-3-acid ethyl esters may increase levels of low-density lipoprotein (LDL). (nih.gov)
  • The original study, called VITACOG and published in 2010 in the journal Plos One ​, ​ ​ used as a study material a vitamin complex consisting of 0.8 mg folic acid, 0.5 mg cyanocobalamin (Vitamin B12) and 20 mg pyridoxine HCl (Vitamin B6). (nutraingredients-usa.com)
  • Homocysteine is an amino acid associated with cognitive decline, part of which is caused by the natural loss of brain tissue as people age. (nutraingredients-usa.com)
  • Once acted on by LPL, which is attached to the luminal side of the capillary endothelium adjacent to muscle and adipose tissue, chylomicrons release TGs as monoglycerides and free fatty acids. (medscape.com)
  • Adipose tissue uses free fatty acids and monoglycerides to resynthesize TGs that are stored for future energy needs. (medscape.com)
  • However, the impact of omega-3 PUFAs on bone marrow adipose tissue (BMAT) and bone marrow stromal cell (BMSC) metabolism has not been intensively studied yet. (bvsalud.org)