• Locating ribonucleoside modifications within an RNA sequence requires digestion of the RNA into oligoribonucleotides of amenable size for subsequent analysis by LC-MS (liquid chromatography-mass spectrometry). (rsc.org)
  • First, the dsRNA is degraded by a highly conserved cellular RNAse named Dicer into small oligoribonucleotides with a length of about 22 base pairs, including 2-nucleotide long 3´ overhangs. (roche.com)
  • Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). (nih.gov)