OligonucleotidesMutagenesisMutagenesis, Site-DirectedOligonucleotides, AntisenseMolecular Sequence DataBase SequenceMutagenesis, InsertionalAmino Acid SequenceOligodeoxyribonucleotidesMutationBinding SitesEscherichia coliModels, MolecularDNAOligoribonucleotidesCloning, MolecularStructure-Activity RelationshipNucleic Acid ConformationPlasmidsPhosphorothioate OligonucleotidesKineticsOligonucleotide ProbesRecombinant ProteinsOligodeoxyribonucleotides, AntisenseSequence Homology, Amino AcidProtein BindingAmino Acid SubstitutionDNA PrimersProtein Structure, TertiaryDNA Transposable ElementsCell LineSubstrate SpecificityBacterial ProteinsThionucleotidesSequence AlignmentNucleic Acid DenaturationProtein ConformationTransfectionPoint MutationGenes, BacterialRNA, MessengerPolymerase Chain ReactionTranscription, GeneticNucleic Acid HybridizationCysteineDNA-Binding ProteinsProtein Structure, SecondaryPromoter Regions, GeneticCatalysisMutagensOligoribonucleotides, AntisenseRibonuclease HEthylnitrosoureaRestriction MappingRNADNA, BacterialDNA Mutational AnalysisAlanineDNA, Single-StrandedConserved SequenceEscherichia coli ProteinsUltraviolet RaysRecombinant Fusion ProteinsCrystallography, X-RayTranscription FactorsHistidineGuanineOrganophosphorus CompoundsSequence DeletionCatalytic DomainSOS Response (Genetics)Genetic Complementation TestCircular DichroismDNA RepairTemperatureSequence Analysis, DNASaccharomyces cerevisiaePhenotypeGenetic VectorsMolecular StructureDirected Molecular EvolutionDNA-Directed DNA PolymeraseCricetinaeElectrophoresis, Polyacrylamide GelProtein EngineeringCells, CulturedEthyl MethanesulfonateGene LibraryHeLa CellsSequence Homology, Nucleic AcidLysineGenes, SyntheticBase PairingAmino Acid MotifsGene ExpressionDNA, ComplementaryThermodynamicsGene Expression RegulationGene TargetingEnzyme Stability