ProteinsAntisenseProteaseAmino AcidsGenomicMolecules2023AptamersBackboneConjugatesSequencesMicroarrayDegradationSyntheticBindProteinStructuralPresent inventionResiduesBiotechnologyImplicationsHigh-affinityInteractionsTherapeuticStructuresProductsResearchShortSimilarStructureProvideDeliveryActivityExpressionMethodsCell
Proteins5
- 2020. Structurally distinct telomere-binding proteins in Ustilago maydis execute non-overlapping functions in telomere replication, recombination, and protection. . (cornell.edu)
- the creation of a large number of compounds (usually proteins or peptides) through technologies such as phage display . (genomicglossaries.com)
- The Rap proteins are, in turn, inhibited by their cognate Phr peptides, which are produced as pre-Phr proteins that are exported to the extracellular milieu and cleaved to produce mature five to six amino acid Phr peptides. (nature.com)
- Of the four putative novel defence proteins (DFPs) annotated by PSI-BLAST three showed similarity to extracellular matrix proteins from vertebrates implicated in innate immunity, while the fourth was similar to, yet distinct from, the anti-microbial protein cecropin. (biomedcentral.com)
- The present invention envisions phosphorylated forms of any one of these GEF-H1 peptides, polypeptides and proteins. (justia.com)
Antisense4
- Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells. (yale.edu)
- Inactivating Gene Expression with Antisense Modified Oligonucleotides. (yale.edu)
- Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency. (yale.edu)
- Subsequent antisense oligonucleotide-knockdown transcriptomic profiling of two LEC- and two BEC-specific lncRNAs identifies LETR1 as a critical gatekeeper of the global LEC transcriptome. (nature.com)
Protease3
- Peptide nucleic acids are synthetic oligonucleotides that resist protease degradation and are used to induce repair at site specific triplex formation regions on DNA genomic sites. (wikipedia.org)
- The structure of ritonavir, a protease inhibitor based on a peptide and containing three peptide bonds, is shown on the right. (tgf-betasignal.com)
- The protease not only releases small peptides, such as the amyloid-β peptide, which drives Alzheimer's disease pathogenesis, but also intracellular domains, which can have critical functions in nuclear signaling. (cipsm.de)
Amino Acids5
- In another embodiment, serine-67 is present in a peptide of less than 30 amino acids that comprises the sequence of SEQ ID NO. 4. (justia.com)
- In another embodiment, the peptide comprising the sequence of SEQ ID NO. 4 is less than 25 amino acids in length. (justia.com)
- Preferably, this peptide is less than 20 amino acids in length. (justia.com)
- In a more preferred embodiment, the peptide comprising the sequence of SEQ ID NO. 4 is 18 amino acids long. (justia.com)
- The order of amino acids as they occur in a polypeptide chain. (lookformedical.com)
Genomic2
- Applications include separation of biotin-labeled biomolecules such as biotin- labeled antibodies, genomic DNA, RNA, PCR products, oligonucleotides (e.g. biotinylated oligo (dT) or peptides. (vectorlabs.com)
- Genomic comparison revealed high conservation of key metabolic features in sublineage II Nitrospira , including respiratory complexes I-V and the machineries for nitrite oxidation and carbon fixation via the reductive tricarboxylic acid cycle. (osti.gov)
Molecules4
- A synthetic, specially- designed oligonucleotide with the ability to recognize and bind a protein ligand molecule or molecules with high affinity and specificity. (genomicglossaries.com)
- Molecules containing both aromatic peptides and nucleic acids could in principle exploit different forces to self-assemble. (cnr.it)
- Aptamers are oligonucleotide or peptide molecules that bind to a specific target molecule. (meneldor.nl)
- Aptamer Group is a UK-based biotechnology company developing aptamers, nucleic acid molecules with affinity and selectivity for a specified target, as an alternative to antibodies. (meneldor.nl)
20231
- The global nucleic acid therapeutics CDMO market was valued at $3.88 billion in 2022 and is expected to reach $14.19 billion by 2033, growing at a CAGR of 12.55% during the forecast period 2023-2033. (gii.tw)
Aptamers1
- Aptamers are short nucleic acid sequences capable of specific, high-affinity molecular binding. (genomicglossaries.com)
Backbone2
- In peptide nucleic acid (PNA), the sugar-phosphate backbone of DNA is replaced with a protein-like backbone. (wikipedia.org)
- in case of nucleic acids, Watson-Crick pairing drives self-assembly while, in case of peptides, backbone hydrogen bonds and interactions between aromatic side chains trigger the formation of structures, such as nanotubes or ribbons. (cnr.it)
Conjugates1
- We therefore synthesized conjugates of the peptide FF to the peptide nucleic acid dimer "gc" and characterized their aggregates by different spectroscopic techniques, including NMR, CD and fluorescence. (cnr.it)
Sequences2
- Thus, in one embodiment, peptides comprising the sequences described in SEQ ID NOs. (justia.com)
- Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
Microarray1
- Analysis of syndromic DNA using an oligonucleotide microarray (Agilent 4 x 180K) demonstrated the characteristic deletion in 15q11.2-q13 (chromosome 15) found in patients with Prader-Willi syndrome. (enzolifesciences.com)
Degradation1
- To solve the problems of low siRNA transfection efficiency and degradation by nucleases, we used Lipid-polycation-nucleic acid (LPN) complex nanocarrier vectors. (docksci.com)
Synthetic1
- Dynamic and flexible nucleic acid models can provide current and future scientists with physical intuition for the structure of DNA and the ways that DNA and its synthetic mimics can be used to build self-assembling structures and advanced nanomachines. (allenpress.com)
Bind2
- TFOs are short (≈15-25 nt) nucleic acid strands that bind in the major groove of double-stranded DNA to form intramolecular triplex DNA structures. (wikipedia.org)
- The Phr peptides are imported back into the cell upon reaching threshold concentrations at high cell density and bind to their cognate Rap phosphatase, inducing conformational changes that inhibit its activity 10 , 11 . (nature.com)
Protein3
- Note Each protein requires distinct dye/protein ratio, which also depends on the properties of dyes. (aatbio.com)
- 2009. Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers. . (cornell.edu)
- Chemical shift changes upon the addition of single-stranded RNAs (ssRNAs) identified a group of residues that form a positively charged patch on the protein surface as the binding site responsible for the previously reported affinity for nucleic acids. (pdfroom.com)
Structural1
- As more research labs and classrooms dive into the field of structural nucleic acid nanotechnology, students and researchers need access to interactive, dynamic, handheld models. (allenpress.com)
Present invention4
- The present invention relates to methods and systems for nucleic acid sequencing. (justia.com)
- In particular, the present invention relates to methods and systems for reducing the number of false-positives in nucleic acid sequencing. (justia.com)
- Accordingly, the technical problem underlying the present invention is the provision of means and methods to provide a reliable way of nucleic acid sequencing, in particular the identification of variations in the genome. (justia.com)
- Accordingly, the present invention envisions an isolated nucleic acid encoding the GEF-H1S polypeptide of SEQ ID NO:2, as well as an isolated nucleic acid comprising the sequence of SEQ ID NO:1. (justia.com)
Residues1
- In a preferred embodiment, a GEF-H1 polypeptide is provided that lacks the amino acid region between residues 162 and 354 of SEQ ID NO. 2. (justia.com)
Biotechnology1
- According to the National Centre for Biotechnology Information (NCBI), therapeutic nucleic acids (TNAs) are a subset of nucleic acids that are closely related compounds used to cure disease through the sequence-specific recognition of endogenous nucleic acids. (gii.tw)
Implications1
- Identification of a peptide that disrupts hADA3-E6 interaction with implications in HPV induced cancer therapy. (du.ac.in)
High-affinity1
- Their ability to fold into distinct secondary or tertiary structures gives them high affinity and specific binding toward cell-specific targets. (meneldor.nl)
Interactions2
- Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during translation of the upstream TnaC leader peptide, a process for which interactions between the TnaC nascent chain and the ribosomal exit tunnel are critical. (cipsm.de)
- Didier Trono s'est beaucoup intéressé aux interactions entre les virus et leurs hôtes, ce qui l'a conduit à étudier la biologie de pathogènes comme le VIH et le virus de l''hépatite B, et à créer des outils de transfert génétique dérivés du VIH aujourd'hui utilisés avec succès en thérapie génique. (epfl.ch)
Therapeutic1
- The therapeutic use of nucleic acids can be broadly divided into two categories, i.e. (gii.tw)
Structures1
- Peptides and nucleic acids can self-assemble to give supramolecular structures that find application in different fields, ranging from the delivery of drugs to the obtainment of materials endowed with optical properties. (cnr.it)
Products1
- According to BIS Research , the nucleic acid therapeutics CDMO market refers to the products and services provided by CDMO companies for the manufacturing of nucleic acid therapeutics. (gii.tw)
Research1
- Building on previous research, representative nucleic acid duplexes were split into logical monomer segments, and atomic coordinates were used to create solid models for 3D printing. (allenpress.com)
Short1
- A distinct group of 22q13 monosomies has been reported that result from the formation of a ring chromosome which combines loss of some long arm material with loss of part of the short arm, with no clinical consequences. (bmj.com)
Similar1
- In similar fashion, one other embodiment provides an isolated nucleic acid encoding the GEF-H1 peptide of SEQ ID NO:4. (justia.com)
Structure2
- Triple-stranded DNA (also known as H-DNA or Triplex-DNA) is a DNA structure in which three oligonucleotides wind around each other and form a triple helix. (wikipedia.org)
- There is ample evidence that distinct types of vasculature undergo tight transcriptional control to preserve their structure, identity, and functions. (nature.com)
Provide1
- NanoLINK streptavidin magnetic beads also provide an affordable alternative for automated, high throughput immobilization processes that utilize 96-well magnets to affect multiplex binding and separation of nucleic acid or immunoassay biomolecules. (vectorlabs.com)
Delivery1
- Regina Fritsche Danielson, Vice President and Head of CVRM, IMED Biotech Unit, AstraZeneca, said "Targeted kidney delivery of oligonucleotides has remained a challenging task for several years. (meneldor.nl)
Activity1
- In AST, AEG-1 causes glutamatergic excitotoxicity by downregulating the activity of the excitatory amino acid transporter 2 (EAAT2) promoter, leading to neuronal cell death in glioma-induced neurodegenerative disease ( 10 ). (spandidos-publications.com)
Expression1
- AEG‑1 is associated with glutamate excitotoxicity due to its reported function of repressing excitatory amino acid transporter 2 expression in astrocytes. (spandidos-publications.com)
Methods1
- Such methods and systems of the invention can, e.g., be employed to identify (a) variation(s) in the nucleic acid sequence of a subject. (justia.com)
Cell1
- Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)