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  • exon
  • Antisense PMO found in dystrophic dog model was effective in cells from exon 7-deleted DMD patient," PLoS ONE , vol. 5, no. 8, Article ID e12239, 2010. (hindawi.com)
  • Functional analysis of 114 exon-internal AONs for targeted DMD exon skipping: indication for steric hindrance of SR protein binding sites," Oligonucleotides , vol. 15, no. 4, pp. 284-297, 2005. (hindawi.com)
  • Antisense-induced exon skipping restores dystrophin expression in DMD patient derived muscle cells," Human Molecular Genetics , vol. 10, no. 15, pp. 1547-1554, 2001. (hindawi.com)
  • Abstract
  • The published abstract entitled, "Phase I Study of LErafAON-ETU, an Easy-To-Use Formulation of Liposome Entrapped c-raf Antisense Oligonucleotide, in Advanced Cancer Patients," highlights the successful initial clinical dosing of this novel drug formulation. (rxpgnews.com)
  • vivo
  • Moreover, the current approaches and applications of mass spectrometry for quantitative analysis of antisense oligonucleotides and their metabolites as well as their impurities during in vitro and in vivo studies were discussed. (bioportfolio.com)
  • Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system. (bioportfolio.com)
  • These results suggest that CD40 antisense ODNs effectively interfere with CD154/CD40 interactions in vivo and, therefore, may provide a novel approach to the treatment of patients with chronic IBD. (bmj.com)
  • malignant
  • Becker D, Meier CB, Herlyn M (1989) Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor. (springer.com)
  • Effectiveness
  • A duplex formed by an antisense molecule and its DNA or RNA target is significantly stabilized by free intercalating agents, thereby enhancing the effectiveness of the antisense molecule. (google.com)
  • effectively
  • We give an overview of the generalized fibrotic process, concentrating on key players and highlight where antisense oligonucleotides have been used effectively in cellular and animal models of different fibrotic conditions. (mdpi.com)