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  • alignment
  • SOAP (Short Oligonucleotide Analysis Package) is a suite of bioinformatics software tools enabling the assembly, alignment, and analysis of next generation DNA sequencing data. (wikipedia.org)
  • developing novel
  • PureTech Health plc, a clinical-stage biopharmaceutical company developing novel medicines focused on the Brain-Immune-Gut Axis, today announced that it has entered into a multiyear collaboration with F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc., to advance PureTech's milk-derived exosome platform technology for the oral administration of Roche's antisense oligonucleotide platform. (news-medical.net)
  • fragments
  • Oligonucleotides composed of 2'-deoxyribonucleotides (oligodeoxyribonucleotides) are fragments of DNA and are often used in the polymerase chain reaction, a procedure that can greatly amplify almost any small amount of DNA. (wikipedia.org)
  • method
  • The most common experimental method for determining T m is to measure the absorbance change of the oligonucleotide with its complement as a function of temperature ( Figure 1 ). (sigmaaldrich.com)
  • The nearest neighbors method accounts for thermodynamic as well as other factors that affect T m , including oligonucleotide and monovalent cation concentrations. (sigmaaldrich.com)
  • target
  • Bio-Synthesis's BNA gapmers chimeric antisense RNA oligonucleotide technology gives you the highest knock-down, lowest off-target effect to achieve efficient inhibition of coding and non coding long RNAs (lncRNAs). (biosyn.com)
  • The findings supported the hypothesis that PCSK9 is a potential therapeutic target for hypercholesterolemia and the researchers were able to show that BNA-based antisense oligonucleotides (AONs) induced cholesterol-lowering action in hypercholesterolemic mice. (wikipedia.org)
  • tool
  • Research done at the Welcome Trust Centre for Human Genetics shows that the Genevac EZ-2 evaporator is an ideal tool for concentrating SNP and oligonucleotides in microplates when preparing samples for microarraying and for Sequenon analysis. (pharmaceuticalonline.com)