• Nucleotide-binding oligomerization domain proteins (NODs) are modular cytoplasmic proteins implicated in the recognition of peptidoglycan-derived molecules. (hindawi.com)
  • Nucleotide-binding oligomerization domain 1 (NOD1) modulates liver ischemia reperfusion through the expression adhesion molecules. (univ-lille.fr)
  • Organic dust augments nucleotide-binding oligomerization domain expression via an NF-kB pathway to negatively regulate inflammatory responses. (cdc.gov)
  • Nucleotide-binding oligomerization domain 2 (NOD2) is involved in innate immune responses to peptidoglycan degradation products. (cdc.gov)
  • Naip contains a nucleotide binding oligomerization domain and a carboxy-terminal LEUCINE rich repeat. (bvsalud.org)
  • The crystallization conditions included approximately 25% dioxane, and subsequent experiments by circular dichroism and sedimentation velocity analytical ultracentrifugation indicated that dioxane increases the helicity and oligomerization state of the designed protein. (rcsb.org)
  • We present a biophysical characterization of the oligomerization and aggregation processes by Interferon alpha-2a (IFNα-2a), a protein drug with antiviral and immunomodulatory properties. (lu.se)
  • The nucleocapsid (N) protein of these viruses is key to the replication cycle and knowledge of the N oligomerisation state is central to understanding the viral lifecycle and for development of therapeutic strategies. (whiterose.ac.uk)
  • Changes of the protein structure and other properties due to nitration and oligomerization can alter the allergenic and inflammatory potential of a protein affecting both, the process of sensitization and the response phase of an allergy ( 9 , 10 , 25 - 31 ). (frontiersin.org)
  • We show that, while monomeric MX2 and MX1(NMX2) mutants are not anti-viral, higher order oligomerization does not appear to be required for full anti-viral activity of either protein. (kcl.ac.uk)
  • Oligomerization, fibrillization and neurotoxicity of native Aβ associated with Alzheimer's disease (AD) type has been compared with E32Q Aβ (amyloid β-protein containing residues 1-40 with the native Glu at residue 22 changed to Gln) implicated in Dutch cerebral haemorrhage disease. (uaeu.ac.ae)
  • Oligomerization in the heat shock protein (Hsp) 70 family has been extensively documented both in vitro and in vivo, although the mechanism, the identity of the specific protein regions involved and the physiological relevance of this process are still unclear. (ox.ac.uk)
  • We have found that substrate binding shifts the oligomerization equilibrium towards the accumulation of functional monomeric protein, probably by sequestering the helical lid sub-domain needed to stabilize the chaperone: substrate complex. (ox.ac.uk)
  • The H240R Protein of African Swine Fever Virus Inhibits Interleukin 1ß Production by Inhibiting NEMO Expression and NLRP3 Oligomerization. (bvsalud.org)
  • These structures are the basis of energy calculations aimed at predicting the oligomerization state directly from protein sequence. (lu.se)
  • Phosphorylation could trigger oligomerization. (lu.se)
  • Sin resolvase catalytic activity and oligomerization state are tightly coupled. (uchicago.edu)
  • Here, we performed structure-function studies to investigate the requirements for oligomerization of both MX2 and chimeric MX1(NMX2) for the inhibition of HIV-1 infection. (kcl.ac.uk)
  • We propose that lower-order oligomerization of MX2 is sufficient for effective inhibition of HIV-1. (kcl.ac.uk)
  • Inhibition of Aβ oligomerization was achieved concomitant with promotion of fibrillization, suggesting that oligomer and fibril formation are distinct and competing pathways. (utmb.edu)
  • Fluorescence-tags, commonly used to visualize the spatial distribution of proteins within cells, can influence the localization of the tagged proteins by affecting their stability, interaction with other proteins or the induction of oligomerization artifacts. (nature.com)
  • Furthermore, upon mixing the two proteins in the presence of RNA no heteromeric complexes were observed, thus revealing insights into the specificity of oligomerisation. (whiterose.ac.uk)
  • The oligomerization state of mutated proteins with amino acid substitutions at multiple putative oligomerization interfaces was assessed using a combination of covalent cross-linking, and co-immunoprecipitation. (kcl.ac.uk)
  • However, in contrast to MX1, oligomerization beyond dimer assembly does not seem to be required for the anti-viral activity of MX2 implying that fundamental differences exist between the anti-viral mechanisms employed by these closely related proteins. (kcl.ac.uk)
  • Our results show that Hsp70 oligomerization takes place through a specific interaction between the interdomain linker of one molecule and the substrate-binding domain of a different molecule, generating dimers and higher-order oligomers. (ox.ac.uk)
  • Preventing polyglutamine repeat oligomerization reverses symptoms of Huntington's chorea. (the-scientist.com)
  • PSD95-PDZ3 in the intermediate state (I) is reversibly oligomerized (RO: Reversible oligomerization). (ugr.es)
  • Here we identify small-molecule inhibitors of STOML3 oligomerization that reversibly reduce the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo. (tecan.com)
  • MX GTPases form higher-order oligomeric structures, and the oligomerization of MX1 is required for inhibitory activity against many of its viral targets. (kcl.ac.uk)
  • When 10 mol% DOPS was doped asymmetrically into the membrane's outer leaflet, oligomerization of Aβ 1-42 monomer was evident in EIS and atomic force microscopy (AFM), and confocal imaging revealed that membrane damage, resulted in extensive pyranine leakage from the pores. (rsc.org)
  • Methylene blue inhibited oligomerization when used at substoichiometric concentrations relative to that of the Aβ monomer. (utmb.edu)
  • Oligomerization of CaMKK isoforms was readily observed by treating CaMKK transfected cells with cell membrane permeable crosslinkers. (elsevierpure.com)
  • To understand the physiological significance of HS-induced RAGE oligomerization in vivo, we generated RAGE knock-in mice ( Ager AHA/AHA ) by introducing point mutations to specifically disrupt HS-RAGE interaction. (elifesciences.org)
  • This paper explores the role of heparan sulfate in the oligomerization of RAGE and the role of oligomerization in vivo function using mouse knockout models. (elifesciences.org)
  • RAGE, a druggable inflammatory receptor, is known to function as an oligomer but the exact oligomerization mechanism remains poorly understood. (elifesciences.org)
  • Taken together, these findings suggest a possible role of chaperone oligomerization as a mechanism for regulating the availability of the active monomeric form of the chaperone and for the control of substrate binding and release. (ox.ac.uk)
  • Mechanistically, pH240R interacted with NLRP3 to inhibit its oligomerization, leading to decreased IL-1 ß production . (bvsalud.org)
  • The oligomerization of light olefins to high-octane clean engine fuels is one possible way to solve increased requirements for motor fuels. (ub.ac.id)
  • This paper presents a study of catalytic oligomerization of C 2 -C 4 olefins on Ru-Fe supported pillared clay catalyst with different metallic quantity. (ub.ac.id)
  • MSN-125 interferes with correct dimer formation for Bax and Bak, thereby inhibiting further oligomerization and preventing MOMP. (cancer-research-network.com)
  • However, due to the complexity of the cell membrane, it can be challenging to address molecular level understanding of the PS-Aβ binding and oligomerization processes. (rsc.org)
  • Remarkably, Ager AHA/AHA mice phenocopied Ager −/− mice in two different pathophysiological processes, namely bone remodeling and neutrophil-mediated liver injury, which demonstrates that HS-induced RAGE oligomerization is essential for RAGE signaling. (elifesciences.org)
  • Several PRRs have been identified, among them are the TLRs (Toll-like receptors), NLRs (nucleotide-binding and oligomerization domain-like receptors), and RLR (retinoic-acid-inducible gene-1-like receptors) [ 1 ]. (hindawi.com)
  • Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain. (ox.ac.uk)
  • Membrane pore formation was visible within 30 minutes, and oligomerization, membrane-oligomer multilayer, and Aβ 1-42 fibril formation evident over 3 to 18 hours. (rsc.org)
  • Studies using microsomes have revealed that oligomerization of connexins Cx26, Cx43, and Cx32 can occur after insertion of connexins in the ER membrane (Falk et al. (reactome.org)
  • Extending this work further, the thermal oligomerization of ethylene was enhanced using high surface area supports such as silica and alumina. (purdue.edu)
  • The the minimum energy structures for each alternative oligomerization state (C2,C3,C4,D2 and C5 point group symmetry) can be downloaded here. (lu.se)
  • Higher order oligomerization is required for the anti-viral activity of MX1 against FLUAV, with current models proposing that MX1 forms ring structures that constrict around viral nucleoprotein complexes. (kcl.ac.uk)
  • We tested the method on 32 homomeric coiled-coils with different oligomerization states and known structures. (lu.se)
  • Previously we have shown that heparan sulfate (HS) plays an active role in RAGE oligomerization. (elifesciences.org)
  • Conformational changes from disordered to β-sheet occur more slowly than oligomerization, and fibrils are produced after prolonged incubation. (uaeu.ac.ae)
  • The oligomerization of CaMKKα was confirmed by the fact that GST-CaMKKα/His-CaMKKα complex from transiently expressed COS-7 cells extracts was purified to near homogeneity by the sequential chromatography using glutathione-sepharose/Ni-sepharose and was observed in a Ca 2+ /CaM-independent manner by reciprocal pulldown assay, suggesting the direct interaction between monomeric CaMKKα. (elsevierpure.com)
  • In intact cells, mutation of the Ca 2+ -binding sites in Cab45 impairs oligomerization, as well as COMP and LyzC sorting. (cipsm.de)
  • The low metal content catalysts showed higher oligomerization activity and increasing the Fe content gave selectivity to isomerization reactions. (ub.ac.id)
  • This important work highlights the connection between oligomerization via specific molecular interactions and phase separation. (sciety.org)
  • We have developed computational methods to predict the structure of homomeric coiled-coils, as well as the structure of alternative oligomerization states for the same sequence. (lu.se)
  • I really enjoyed reading about your approach to thoroughly understand the McdB-driven phase separation and oligomerization of S. elongatus carboxysomes! (sciety.org)