Olfactory marker protein. Medical search. Frequent questions

Synapto-pHluorin selectively labeled presynaptic terminals of sensory neurons in glomeruli of the olfactory bulb. (nih.gov)
Odor sensing starts with olfactory sensory neurons in the nose, which carry the information to the olfactory bulb and subsequently to several cortical and subcortical regions. (upenn.edu)
The stem cell marker Lgr5 defines a subset of postmitotic neurons in the olfactory bulb. (upenn.edu)
Olfactory receptors are supposed to act not only as molecular sensors for odorants but also as cell recognition molecules guiding the axons of olfactory neurons to their appropriate glomerulus in the olfactory bulb. (jneurosci.org)
To scrutinize the hypothesis that olfactory receptor proteins may also be present in the axonal processes and the nerve terminals, serial sections through the olfactory bulb were probed with the antibodies. (jneurosci.org)
On serial sections through the olfactory bulb of mOR37-transgenic mouse lines, double-labeling experiments demonstrated that distinct immunoreactive glomeruli corresponded to glomeruli that were targeted by neurons expressing a particular member of the mOR37 receptor subfamily. (jneurosci.org)
their axonal projections converge onto one medial and one lateral glomerulus in the olfactory bulb. (jneurosci.org)
in the cilia recognizing odorous molecules from the environment and in the axons recognizing molecular cues in the olfactory bulb. (jneurosci.org)
The main olfactory system originates from the olfactory mucosa and projects to the main olfactory bulb (MOB), while the VNO, described by Jacobson in 1813 ( Trotier and Doving, 1998 ) projects to the accessory olfactory bulb (AOB, see Figure 2 ). (frontiersin.org)
(C) A horizontal section through the main and accessory olfactory bulb. (frontiersin.org)
The arrows indicate the projections from the MOE to the main olfactory bulb (right) and from the VNO to the AOB (left). (frontiersin.org)
1 . Short SM, Morse TM, McTavish TS, Shepherd GM, Verhagen JV (2016) Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb. (yale.edu)
Fifteen transplants were well integrated with the spared portion of the olfactory bulb (OB) as clearly demonstrated by AChE and BuChE histochemistry, while two did not integrate. (iospress.com)
It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB. (lookformedical.com)
The olfactory bulb contains several types of nerve cells including the mitral cells, on whose DENDRITES the olfactory nerve synapses, forming the olfactory glomeruli. (lookformedical.com)
The accessory olfactory bulb, which receives the projection from the VOMERONASAL ORGAN via the vomeronasal nerve, is also included here. (lookformedical.com)
Their unmyelinated AXONS synapse in the OLFACTORY BULB of the BRAIN. (lookformedical.com)
Physicians at Massachusetts Eye and Ear have, for the first time, induced a sense of smell in humans by using electrodes in the nose to stimulate nerves in the olfactory bulb, a structure in the brain where smell information from the nose is processed and sent to deeper regions of brain. (news-medical.net)
Motivated by work conducted by research colleagues at Virginia Commonwealth University's School of Medicine, Mass. Eye and Ear physicians wanted to address the question of whether electrical stimulation of the olfactory bulb could induce the sense of smell in human subjects. (news-medical.net)
Now we know that electrical impulses to the olfactory bulb can provide a sense of smell -- and that's encouraging. (news-medical.net)
Failure of robo2 expression to recover correlates with defects in the fasciculation of neurog1 mutant olfactory axonal projections and in the organisation of proto-glomeruli because projections arrive at the olfactory bulb that are reminiscent of those in robo2 mutant embryos. (silverchair.com)
Latvian researchers studied autopsy material from the olfactory bulb and tract region of the brain in controls as well as patients with HHV-6 associated encephalopathy. (hhv-6foundation.org)
The team, led by Modra Murovska from the Riga Stradins University, determined that HHV-6 viral loads in olfactory bulb tissue samples from autopsies of 20 patients with unspecified encephalopathy were significantly higher than in 17 age-matched controls or 16 younger controls. (hhv-6foundation.org)
Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb. (modeldb.science)
These results extend the characterization of our olfactory epithelium-olfactory bulb organotypic culture system and suggest that olfactory epithelium passes through an immature stage in the week following explanation and culturing. (auburn.edu)
A: Sagittal view showing the adult mouse subventricular zone (SVZ) and the migrating neuroblasts (red) reaching the olfactory bulb (OB) through the rostral migratory stream (rms). (wjgnet.com)
As only a few studies have been conducted on the impact of NPC on sensory systems, we used a mutant mouse model (NPC1-/-) to examine the effects of this disorder to morphologically distinct regions of the olfactory system, namely the olfactory epithelium (OE) and olfactory bulb (OB). (centogene.com)
The effects of these exposures on hormone concentrations, and markers of function and/or injury in the olfactory bulb, hypothalamus and testes were measured after 1, 8 and 30days exposure. (cdc.gov)
tein, and neuronal cell adhesion molecule mRNA were also increased in olfactory bulb. (cdc.gov)
right nostril occluded for a 2-day exposure, Mn accumulated only in the left olfactory bulb. (cdc.gov)

(B) A coronal section of the main olfactory epithelium, dorsal to the upper right. (frontiersin.org)
In the olfactory bulbs, afferents from the olfactory epithelium could be quantified by their expression of a genetically-encoded fluorescent marker for olfactory marker protein. (rutgers.edu)
Neurons in the OLFACTORY EPITHELIUM with proteins (RECEPTORS, ODORANT) that bind, and thus detect, odorants. (lookformedical.com)
We transplanted, as a single cell suspension, cells dissociated from the mature and immature olfactory epithelium of rats or TgR(ROSA26)26Sor mice expressing constitutively the LacZ gene into the developing brain (cerebellum, striatum, inferior colliculus, lateral ventricles) of E15 rat fetuses. (unipv.it)
Cells in large clusters generated an epithelium containing mature olfactory neurons. (unipv.it)
Our findings show that cells dissociated from the developing and adult olfactory organs when transplanted into the rat fetal brain can either completely change their fate and differentiate according to their final position or generate an olfactory epithelium if they reaggregate into large clusters. (unipv.it)
While both ompa and ompb mRNA are strongly expressed in the olfactory epithelium, ompb expression was further observable in different brain areas while ompa expression was also detected in the eyes and in other peripheral tissues. (univ-brest.fr)
Under OA ompb mRNA was down-regulated while ompa mRNA was up-regulated in the olfactory epithelium of F0 adults, suggesting a long-term intragenerational OA-induced regulation of the olfactory sensory system. (univ-brest.fr)
Contrary to the F0, the expression of ompa and ompb mRNA was not anymore significantly regulated under OA in the olfactory epithelium of juvenile F1 fish. (univ-brest.fr)
In addition to the olfactory neurons, the epithelium is composed of supporting cells, Bowman glands and ducts unique to the olfactory epithelium, and basal cells that allow for the regeneration of the epithelium, including the olfactory sensory neurons. (medscape.com)

G Protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons. (upenn.edu)
Responsiveness of G protein-coupled odorant receptors is partially attributed to the activation mechanism. (upenn.edu)
Conserved residues control activation of mammalian G Protein-coupled odorant receptors. (upenn.edu)
Set of nerve fibers conducting impulses from olfactory receptors to the cerebral cortex. (lookformedical.com)
Odorant receptors (ORs) are G protein-coupled receptors (GPCRs) that are essential for detecting and distinguishing among odorants. (bmbreports.org)
G protein-coupled receptors (GPCRs) belong to the largest class of drug targets. (mdpi.com)
A unified nomenclature for vertebrate olfactory receptors. (jax.org)
EOG recordings were made from dissected rat olfactory receptor neurons under control conditions (in the presence of extra cellular fluid -ECF) and experimental conditions (in the presence of PNC and Zn and Cu).The metal nano particles were integrated with the odorants of interest and were delivered onto the odor receptors. (auburn.edu)
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. (nih.gov)
The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. (nih.gov)
Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. (nih.gov)
It is a specialized pseudostratified neuroepithelium containing the primary olfactory receptors. (medscape.com)
To stimulate the olfactory receptors, airborne molecules must pass through the nasal cavity with relatively turbulent air currents and contact the receptors. (medscape.com)

The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. (nih.gov)

It is a highly expressed, cytoplasmic protein found in mature olfactory sensory receptor neurons of all vertebrates. (wikipedia.org)

olfactory mucosa was mostly spared. (cdc.gov)
Supporting the structural findings, electro-olfactometry of the olfactory mucosa suggests that NPC1-/- animals exhibit olfactory and trigeminal deficits. (centogene.com)

Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. (empiregenomics.com)

Little is known about proneural gene function during olfactory neurogenesis in zebrafish. (silverchair.com)
The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. (empiregenomics.com)
The olfactory marker protein (omp) gene is involved in the maturation and the activity of olfactory sensory neurons in vertebrates. (univ-brest.fr)
The olfactory receptor gene family is the largest in the genome. (nih.gov)
This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. (nih.gov)
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene. (nih.gov)
The human olfactory receptor gene family. (nih.gov)
The present study uniquely combines olfactory ensheathing glia (OEG) implantation with ex vivo adenoviral (AdV) vector-based neurotrophin gene therapy in an attempt to enhance regeneration after cervical spinal cord injury. (edu.au)

A family of intracellular calcium-sensing proteins found predominately in NEURONS and PHOTORECEPTOR CELLS . (nih.gov)

To approach this critical issue, antibodies were generated against two peptides, one derived from olfactory receptor mOR256-17, one derived from the "mOR37" subfamily. (jneurosci.org)
A subfamily of MARVEL domain-containing proteins that are found in SYNAPTIC VESICLES, where they may play a role in modulating neuronal signaling. (ouhsc.edu)

In molecular biology, olfactory marker protein is a protein involved in signal transduction. (wikipedia.org)
OMP is a modulator of the olfactory signal transduction cascade. (wikipedia.org)
The study also involved with Gai-Protein Inhibition of olfactory signal transduction. (auburn.edu)
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. (childrensmercy.org)

In addition to detecting odors, olfactory sensory neurons also serve as mechanical sensors, thus the nose transmits both odor information and nasal breathing signal into the brain. (upenn.edu)
An olfactory cilia pattern in the mammalian nose ensures high sensitivity to odors. (upenn.edu)
The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS. (lookformedical.com)
While some cases of anosmia may be treated by caring for an underlying cause (often nasal obstruction, in which odors can't reach the nerves of the olfactory system due to swelling, polyps or sinus disease), other cases involving damage to the sensory nerves of the nose (i.e. head injury, viruses and aging) are much more complex. (news-medical.net)

This concept implies that olfactory receptor proteins are located in sensory cilia and in the axons. (jneurosci.org)
Proteins, usually projecting from the cilia of olfactory receptor neurons, that specifically bind odorant molecules and trigger responses in the neurons. (lookformedical.com)
Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. (childrensmercy.org)

The experiment shows that it is possible by inserting photo activated proteins into neurons photo stimulation can produce an olfactory behavior in these larvae , whereas genetically unchanged larvae generally avoid light. (sciencedaily.com)
The sense of smell is mediated through stimulation of the olfactory receptor cells by volatile chemicals. (medscape.com)

These data indicate that olfactory receptor (OR) proteins are indeed present in the axonal processes and nerve terminals of olfactory sensory neurons, thus supporting the notion that ORs may participate in the molecular processes underlying the fasciculation and targeting of olfactory axons. (jneurosci.org)
The question whether OR proteins are indeed present in the axons and nerve terminals of OSNs is thus of fundamental importance toward an understanding of the functional wiring in the olfactory system. (jneurosci.org)
Here we use optical imaging techniques to visualize odorant-evoked neurotransmitter release from the olfactory nerve into the brain's olfactory bulbs in vivo in mice. (rutgers.edu)
In this study optical imaging revealed significant reductions in odorant-evoked release from the olfactory nerve at a cadmium chloride dose two orders of magnitude less than that required to induce morphological changes in the nerve in the same animals, demonstrating that it is a more sensitive technique for assessing the consequences of intranasal neurotoxicant exposure. (rutgers.edu)
Olfactory nerve. (lookformedical.com)
The olfactory nerve conveys the sense of smell. (lookformedical.com)
Traumatic injuries to the OLFACTORY NERVE. (lookformedical.com)
Ovoid body resting on the CRIBRIFORM PLATE of the ethmoid bone where the OLFACTORY NERVE terminates. (lookformedical.com)
Diseases of the first cranial (olfactory) nerve, which usually feature anosmia or other alterations in the sense of smell and taste. (lookformedical.com)
Head anatomy with olfactory nerve. (medscape.com)
to the olfactory nerve--so, your. (cdc.gov)

This archive contains NEURON models that were run on parallel computers to explore the interactions between varying strengths of respiratory activity and olfactory sensory neuron input and the roles of periglomerular, granule, and external tufted cells in shaping mitral cell responses. (yale.edu)
In neonates, this area is a dense neural sheet, but, in children and adults, the respiratory and olfactory tissues interdigitate. (medscape.com)

Regenerated OMP positive olfactory axons originating from neuroepithelium and AChE positive fibres from OB remnant penetrated into the transplants. (iospress.com)

Olfactory+marker+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL (June 2002). (wikipedia.org)
[ 3 ] A 2002 study showed that the prevalence of objective olfactory impairment in adults older than 53 years is 24.5% and grows more prevalent with age, reaching 62.5 % in those aged 80-97 years. (medscape.com)

CONCLUSIONS: We conclude that the olfactory neuronal pathway is efficient for translocating in the brain. (cdc.gov)

Intranasal exposure to cadmium has been related to olfactory dysfunction in humans and to nasal epithelial damage and altered odorant-guided behavior in rodent models. (rutgers.edu)
It may result in various olfactory dysfunction including a complete loss of smell. (lookformedical.com)

By means of immunohistochemistry and double-labeling studies using transgenic mouse lines as well as Western blot analyses, it was demonstrated that the newly generated antibodies specifically recognized the receptor proteins. (jneurosci.org)
In this study, antibodies were generated against unique epitopes of distinct OR types and used in immunohistochemical experiments to visualize the receptor proteins in whole-mount preparations and tissue sections of the olfactory system. (jneurosci.org)

Primary OEG were transduced with AdV vectors encoding rat brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or bacterial marker protein beta-galactosidase ( LacZ) and subsequently implanted into adult Fischer rats directly after unilateral transection of the dorsolateral funiculus. (edu.au)
Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)
however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)
In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)

was subsequently clearly documented by means of genetically manipulated mice that generated a bicistronic mRNA encoding the OR as well as a marker protein. (jneurosci.org)
To explore interactions between respiration, inhibition, and olfaction, experiments using light to active channel rhodopsin in sensory neurons expressing Olfactory Marker Protein were performed in mice and modeled in silico. (yale.edu)

Unmyelinated olfactory afferents of the lamina propria seem less affected than ensheathing cells. (centogene.com)

This breakthrough in human patients opens the door for a 'cochlear implant for the nose' to be developed -- though the study authors caution that the concept of an olfactory stimulator is more challenging than existing technologies. (news-medical.net)
Odorants can also be perceived by entering the nose posteriorly through the nasopharynx to reach the olfactory receptor via retronasal olfaction. (medscape.com)

The presence of OMP in these cells indicates that the olfactory system may participate in shaping the chemosensory CB function.Conclusions: The findings support the notion that the transduction mechanisms of chemoreceptive systems contain a degree of homology, irrespective of the anatomical localization and the functional role these systems fulfill. (unisalento.it)
The olfactory system is closely connected with other brain regions that are involved in cognition and emotion, which may underlie strong associations between smell deficits and neuropsychiatric disorders. (upenn.edu)
The accessory olfactory system is present in most tetrapods. (frontiersin.org)
The accessory olfactory system may complement the main olfactory system and may contribute different perceptual features to the construction of a unitary representation, which merges the different chemosensory qualities. (frontiersin.org)
The accessory olfactory system may differ in morphology even in closely related species, most probably in relation to functional specialization (for a review, see Salazar and Quinteiro, 2009 ). (frontiersin.org)
The first functional investigation of the accessory olfactory system pointed to a general chemosensation role. (frontiersin.org)
We conclude that the duration of proneural expression in EON progenitors is crucial for correct development of the zebrafish olfactory system. (silverchair.com)
Ocean acidification has been shown to potentially impair olfactory system in fish and it is therefore essential to develop biological tools contributing to better characterize such effects. (univ-brest.fr)
NPC1-/- animals present myelinlike lysosomal deposits in virtually all types of cells of the peripheral and central olfactory system. (centogene.com)
Our data demonstrate a pronounced neurodegeneration and glia activation in the olfactory system of NPC1-/-, which is accompanied by sensory deficits. (centogene.com)

The lack of correlation between the severity and duration of olfactory disturbances and serum levels of inflammatory markers seems to further suggest that the pathogenetic mechanisms underlying the loss of smell in coronavirus disease 2019 patients are related to local rather than systemic inflammatory factors. (kcl.ac.uk)
The murine family has a well developed sense of smell and is widely used in the field of olfactory research. (auburn.edu)

Strong evidence of a role for HHV-6 in unspecified encephalopathy came from the ultrastructural changes found via electron microscopy in the olfactory pathways of these patients, but not in any control tissues. (hhv-6foundation.org)
Ultrastructural changes in the olfactory pathways of HHV-6+ patients. (hhv-6foundation.org)

Odorants diffuse into the mucous and are transported to the olfactory receptor. (medscape.com)

Crosstalk between the main and accessory olfactory systems occurs at different levels of central processing, in brain areas where the inputs from the two systems converge. (frontiersin.org)
Hyperphosphorylation of the microtubule-associated protein tau is hypothesized to lead to the development of neurofibrillary tangles in select brain regions during normal aging and in Alzheimer disease (AD). (bvsalud.org)
Roalf and his laboratory also plan to investigate whether protein markers of Alzheimer's, which are present in the olfactory region of the brain before dementia occurs, can be detected in nasal fluid to provide an even earlier warning of the disease process. (neurosciencenews.com)
F: Confocal images showing immunostaining in the DG for the astrocyte marker GFAP in green, for the progenitor precursor marker T-box brain protein 2 (TBR2) in red and for the neuronal precursor marker Doublecortin (DCX) in red. (wjgnet.com)
A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been implicated in a variety of human diseases. (nih.gov)
So from there, we got brain imaging using MRIs as well as blood markers and cerebrospinal fluid markers. (cdc.gov)

Rodents primarily use olfactory cues to guide their behaviors, e.g., locating food, communicating with conspecifics, and avoiding danger. (upenn.edu)

For histochemistry and western blotting, we used antibodies against a series of neuronal and glia marker proteins, as well as macrophage markers. (centogene.com)
Especially supporting cells of the OE and central glia cells are affected, resulting in pronounced astrocytosis and microgliosis in the OB and other olfactory cortices. (centogene.com)

Here, we show that the zebrafish Atonal genes neurogenin1 ( neurog1 ) and neurod4 are redundantly required for development of both early-born olfactory neurons (EONs) and later-born olfactory sensory neurons (OSNs). (silverchair.com)

Three highly conserved regions have been identified as possible protein-protein interaction sites in OMP, indicating a possible role for OMP in modulating such interactions, thereby acting as a molecular switch. (wikipedia.org)
This was demonstrated by anatomical methods and selective amplification of cDNA encoding for neuronal specific transcripts (microtubule-associated protein 2 and middle-molecular-mass neurofilament protein) expressed by the engrafted cells. (unipv.it)
We report differential protein levels based on the stage of AD, anatomic specific tau species, as well as differences in TH and NF-H. In addition, exploratory findings were made of the high molecular weight tau species big tau that is unique to peripheral tissues. (bvsalud.org)

Here, we have targeted expression of synapto-pHluorin, a pH-sensitive protein that reports synaptic vesicle fusion, to olfactory sensory neurons in mouse. (nih.gov)
FEAST: A flow cytometry-based toolkit for interrogating microglial engulfment of synaptic and myelin proteins. (harvard.edu)

abstract = "Objective To analyse the correlations between olfactory psychophysical scores and the serum levels of D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin and neutrophil-to-lymphocyte ratio in coronavirus disease 2019 patients. (kcl.ac.uk)

Myelin Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)

Complex interactions are now emerging between the main and accessory olfactory systems, both at anatomical and at functional level. (frontiersin.org)

The misfolding and self-assembly of proteins into amyloid fibrils that occurs in several debilitating and age-related diseases is affected by common components of amyloid deposits, notably lipids and lipid complexes. (edu.au)

Lineage specification of olfactory neural precursor cells depends on continuous cell interactions. (unipv.it)

When IgG or antiolfactory marker protein antibody was substituted for G-protein antibodies, the odorantinduced currents were not significantly changed. (auburn.edu)

The olfactory neuroepithelium is located at the upper area of each nasal chamber adjacent to the cribriform plate, superior nasal septum, and superior-lateral nasal wall. (medscape.com)

Although sample sizes were small, these findings are, to our knowledge, the first comparison of these specific protein changes in these tissues. (bvsalud.org)

S100 proteins are markers for inflammatory disease and cancer. (hhv-6foundation.org)

Anatomy5

Chemicals and Drugs3

Phenomena and Processes1

Health Care1

Bulb30

Epithelium10

Receptors13

Assigned to the olfactory receptor1

Cytoplasmic protein found in mature1

Mucosa2

Mature olfactory recepto1

Gene8

Intracellular calcium-1

Subfamily2

Signal transduction4

Odors4

Cilia3

Stimulation2

Nerve11

Respiratory2

Axons1

20022

PATHWAY1

Dysfunction2

Receptor proteins2

Rats4

Mice2

Afferents1

Nose2

System10

Smell2

Pathways2

Odorants1

Brain6

Cues1

Glia2

OSNs1

Molecular3

Synaptic2

Abstract1

MeSH1

Functional1

Occurs1

Neural1

Antibodies1

Neuroepithelium1

Tissues1

S1001