AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth Care
Mushroom BodiesSmellDrosophilaDrosophila ProteinsDrosophila melanogasterOdorsOlfactory PathwaysBenzaldehydesOlfactory BulbNeuropilOlfactory PerceptionBehavior, AnimalOlfactory Receptor NeuronsMushroom PoisoningReceptors, OdorantGenes, InsectOlfaction DisordersAgaricalesAnimals, Genetically ModifiedLarvaBrainNeuronsOlfactory NerveMutationOptic Lobe, NonmammalianShiitake MushroomsFeeding BehaviorBeesInsect ProteinsAxonsPhotoreceptor Cells, InvertebrateGene Expression Regulation, DevelopmentalGanglia, InvertebrateSexual Behavior, AnimalFruiting Bodies, FungalDendritesPupaMolecular Sequence DataAppetitive BehaviorSocial BehaviorOlfactory Marker ProteinSense OrgansMemoryImmunohistochemistryHealth BehaviorEmbryo, NonmammalianBehaviorTranscription FactorsMemory, Long-TermBrain ChemistryNerve Tissue ProteinsArthropod AntennaeNeurogliaMetamorphosis, BiologicalSignal TransductionNeuropeptidesAmino Acid SequenceSexual BehaviorModels, BiologicalCell LineageGreen Fluorescent ProteinsPhenotypeWingBrain MappingPeriod Circadian ProteinsCircadian RhythmHomeodomain ProteinsAmanitaMicroscopy, ConfocalBrain InjuriesExploratory BehaviorNervous SystemCourtshipConditioning, ClassicalAssociation LearningOctopamineChild BehaviorBase SequenceTime FactorsReceptors, Biogenic AmineBrain NeoplasmsLearningAdolescent BehaviorBasidiomycotaGryllidaeConditioning (Psychology)Cell DifferentiationNervous System Physiological PhenomenaMaternal BehaviorAvoidance LearningIn Situ HybridizationChild Behavior DisordersInsect HormonesNeural Stem CellsGrasshoppersSensory Receptor CellsBehavior TherapyManducaCentral Nervous SystemMotor Activity
MelanogasterAversive olfactoryPlasticity2017Projection neuronsNeuroscience2021BulbFliesBehavioralNeuronInsectsRole in olfactoryOdorsMediateNeurons of the mushroomCircuitsAppetitiveEncodeStimuli2020AntennaePerceptionAdaptiveMutantsInsect brainAdultMammalianPathways2022DopamineHoney beesOptomotor behaviorCentersCurrent BiologyOutput neuronsMemoriesDeficitsNeural circuitInhibitionAssociativeAxonDissectionLarvalInvertebrateGermlineMechanismsMemoryCortexNeurodegenerationSynapticReceptorsEscape BehaviorAnatomicalOlfactionCircuitGlandsGenesPhysiologyVivoReceives
Melanogaster14
Aversive olfactory3
  • In Drosophila , aversive olfactory LTM is formed by repetitive training trials with rest intervals between training trial, spaced training. (sciencedaily.com)
  • Here we show that flies form short-lived aversive olfactory memories when trained with odors and sugars that are contaminated with the common insect repellent DEET. (ox.ac.uk)
  • Moreover, differential conditioning with DEET versus shock suggests that formation of these distinct aversive olfactory memories relies on a common negatively reinforcing dopaminergic mechanism. (ox.ac.uk)
Plasticity5
  • Input-timing dependent plasticity at incoming synapses of mushroom body facilitates olfactory learning in drosophila. (edu.hk)
  • Zhou M, Lei Z , Li H, Yi W, Zhang Z , Guo A . NMDA receptors-dependent plasticity in the phototaxis preference behavior induced by visual deprivation in young and adult flies. (neurotree.org)
  • Glomerulus-Selective Regulation of a Critical Period for Interneuron Plasticity in the Drosophila Antennal Lobe. (tcd.ie)
  • Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila. (tcd.ie)
  • Plasticity of recurrent inhibition in the Drosophila antennal lobe. (tcd.ie)
20171
Projection neurons4
  • Li H, Li Y, Lei Z , Wang K, Guo A . Transformation of odor selectivity from projection neurons to single mushroom body neurons mapped with dual-color calcium imaging. (neurotree.org)
  • Zhang X, Liu H , Lei Z , Wu Z, Guo A . Lobula-specific visual projection neurons are involved in perception of motion-defined second-order motion in Drosophila. (neurotree.org)
  • We characterized an olfactory-processing pathway, comprised of inhibitory projection neurons (iPNs) that target the LH exclusively, at morphological, functional and behavioral levels. (elifesciences.org)
  • In the locust, olfactory information is sent from peripheral olfactory organs to the antennal lobe (AL) and is then carried as the oscillatory output of a synchronized population of projection neurons (PNs) ( Wehr and Laurent, 1996 ) to two higher olfactory centers. (jneurosci.org)
Neuroscience6
  • Understanding how the brain transforms sensory input into complex behavior is a fundamental question in systems neuroscience. (harvard.edu)
  • To meet these challenges, a multi-disciplinary approach employing different neuroscience research tools like molecular biology, virus-based circuit mapping, opto/chemo-genetics, in vivo/in vitro electrophysiological recording, brain imaging and novel behavioral paradigms is adopted. (edu.hk)
  • To do this, we combine neuroscience and physiology to understand how the brain and body communicate at the cellular and molecular levels. (uni-bonn.de)
  • CD BioSciences is devoted to developing the breadth and depth of Drosophila 's applications as a model organism, and advancing fundamental neuroscience research by means of interdisciplinary and cross-disciplinary approaches. (drosophilidae.com)
  • Drosophila , with its optimal balance of functional and structural complexity, is an ideal model for neuroscience research and has great potential for applications in the basic sleep biology, human health and disease. (drosophilidae.com)
  • We have built a professional Drosophila modeling platform and a team with rich neuroscience experience and cutting-edge knowledge to ensure the scientific direction of the project. (drosophilidae.com)
20213
  • She is the Gabrielle H. Reem and Herbert J. Kayden Associate Professor and Head of the Laboratory of Neurophysiology and Behavior at The Rockefeller University and, as of 2021, an Investigator of the Howard Hughes Medical Institute. (wikipedia.org)
  • Kohn, J.R., Portes, J.P., Christenson, M.P. Abbott, L.F. and Behnia R. (2021) State and Stimulus Dependence Reconcile Motion Computation and the Drosophila Connectome. (columbia.edu)
  • Nov. 24, 2021 When mice rest, individual neurons fire in seconds-long, coordinated cascades, triggering activity across the brain, according to new research. (sciencedaily.com)
Bulb5
Flies22
  • Do Flies Have Brains? (whatsthatbug.com)
  • Recent studies reveal that flies, specifically fruit flies, exhibit more advanced brain functions than previously thought. (whatsthatbug.com)
  • One such study conducted at the University of California San Diego's Kavli Institute for Brain and Mind demonstrates that fruit flies exhibit complex cognitive processes. (whatsthatbug.com)
  • So, the answer is yes, flies do have brains. (whatsthatbug.com)
  • In summary, flies do have brains with unique anatomical features that help them navigate and perceive their environment more effectively. (whatsthatbug.com)
  • Even when we restrict an odor-punishment association to a single set of synapses using optogenetics, we find that flies still show choice behavior that depends on the options it encounters. (janelia.org)
  • Roman and Zhang set about to unravel some of these mysteries by studying the brains of fruit flies (Drosophila). (uh.edu)
  • The significance of using fruit flies is that while their brain structure is much simpler with far fewer neurons, the mushroom body is analogous to the perirhinal cortex in humans, which serves the same function of sensory integration and learning. (uh.edu)
  • Thirst also permitted flies to learn olfactory cues paired with water reward. (ox.ac.uk)
  • Naive water-seeking behavior in thirsty flies did not require water taste but relied on another subset of water-responsive dopaminergic neurons that target the mushroom body β' lobe. (ox.ac.uk)
  • Our results therefore demonstrate that naive water-seeking, learned water-seeking and water learning use separable neural circuitry in the brain of thirsty flies. (ox.ac.uk)
  • Adult flies are trained en masse to differentially associate one of two visual conditioned stimuli (CS) (blue and green light as CS) with an appetitive or aversive chemical substance (unconditioned stimulus or US). (frontiersin.org)
  • In order to understand and compare the mechanisms underlying visual appetitive and aversive memories in Drosophila , we sought to establish a new behavioral paradigm for visual associative learning in adult flies. (frontiersin.org)
  • Through modeling and behavioral perturbations of the fictive olfactory environment, we demonstrate that edge-tracking represents a form of spatial navigation in which flies must continually remember the direction of the plume's boundary. (rockefeller.edu)
  • These studies highlight that instead of relying on simple sensory reflexes, flies use their sophisticated learning and navigational circuitry to track odor plumes, a feature likely to be shared between insect and mammalian brains. (rockefeller.edu)
  • In this episode we will be looking at how nervous systems can learn and form memories, and how this is studied using the brain of fruit flies, a topic investigated by André Fiala at the University of Göttingen in Germany. (researchpod.org)
  • Of course, the brains of flies and humans are quite different in size and complexity. (researchpod.org)
  • Silencing iPNs severely diminished flies' attraction behavior. (elifesciences.org)
  • addressed how attractiveness or repulsiveness of a smell, and also the strength of a smell, are processed by a part of the olfactory system called the lateral horn in fruit flies. (elifesciences.org)
  • Recent work investigating torque behavior of wild-type flies (similar to our shorter experiments here) has shown that, during extended flights, the occurrence of turning maneuvers can be described by a Le´vi distribution (Maye et al. (the-mouse-trap.com)
  • Surprisingly, as time passed after training, the behavior of DEET-sugar-trained flies reversed from conditioned odor avoidance into odor approach. (ox.ac.uk)
  • These data demonstrate that flies independently process the DEET and sugar components to form parallel aversive and appetitive olfactory memories, with distinct kinetics, that compete to guide learned behavior. (ox.ac.uk)
Behavioral8
  • Drosophila represents the Goldilocks principle of neural research, with sufficient behavioral complexity, while maintaining a huge advantage in neural simplicity," Roman said. (uh.edu)
  • The complex behaviors allow us to examine many behavioral processes like learning, attention, aggression and addiction-like behaviors, while the simplicity allows us to dissect the crucial neural activities down to single cells. (uh.edu)
  • Additionally, Drosophila has the most powerful genetic toolkit available for behavioral experimentation. (uh.edu)
  • Olfactory learning skews mushroom body output pathways to steer behavioral choice in Drosophila. (charite.de)
  • 2007). Such distributions of behavioral output, seen in foraging behavior in many animals, are characteristically long-tailed. (the-mouse-trap.com)
  • This behavioral effect correlates with altered stress and detoxification gene expression in the brain. (frontiersin.org)
  • C. Elegans Positive Olfactory Associative Memory Is a Molecularly Conserved Behavioral Paradigm. (princeton.edu)
  • The Drosophila giant fiber circuit has long served as such a model, due to large neuron size, genetic malleability, and easily visualized behavioral output: a jump in response to a threat. (eneuro.org)
Neuron2
Insects4
  • Insects have brains with neurons connected in intricate networks. (whatsthatbug.com)
  • But even these small insects, like all animals, can adjust their behavior according to experience, which is called learning. (researchpod.org)
  • Interestingly, there are very similar neuronal connections and circuits in the much smaller brains of insects. (researchpod.org)
  • Other insects, such as honey bees and hawk moths, have olfactory systems with a similar architecture and might also employ a similar spatial approach to encode information regarding the intensity and identity of odors. (elifesciences.org)
Role in olfactory2
  • Photoactivation of UpWiNs also increased the chance of returning to a location where activation was initiated, suggesting an additional role in olfactory navigation. (janelia.org)
  • Within the fly brain, Roman says, there are nerve cells that play a role in olfactory learning and memory. (uh.edu)
Odors5
Mediate2
  • The neural circuits that mediate higher cognitive functions (e.g. learning and memory, multi-tasking ability) and emotion-related behaviors (e.g. stress-induced adaptive behaviors) are not well understood. (edu.hk)
  • Using cutting-edge techniques we probed the core brain areas and circuit mechanisms that mediate these functions as well as their malfunctions in neurodegenerative diseases and neuropsychiatric conditions, to pave the way for new effective therapeutic paradigms. (edu.hk)
Neurons of the mushroom1
  • In particular, the ongoing activity of dopaminergic neurons of the mushroom body previously implicated in associative learning shapes edge-tracking behavior over multiple timescales and is necessary for continued pursuit of the plume. (rockefeller.edu)
Circuits10
  • Her lab has elucidated brain circuits that control male fly responses to female pheromones, demonstrated that the memory center of the fly brain uses compartmentalized dopamine modulation to encode behaviors, described the evolution of central neural circuits underlying courtship decisions in Drosophila and solved the structure of the invertebrate olfactory receptor co-receptor (Orco). (wikipedia.org)
  • and neuroscientist Vanessa Ruta, 45, who explores stimuli that affect neural circuits and behaviors, the foundation said. (wikipedia.org)
  • In using these tools, we are genetically identifying the molecules necessary to perform these behaviors and dissecting the logic of the neural circuits that allow for changes in behavior to occur. (uh.edu)
  • My team tackles the etiology and pathogenesis of these disorders at multiple levels, from cells to neural circuits and brain networks. (edu.hk)
  • We look not only at visible behavior, but also at neural circuits and genes that control sensations and behavior. (uni-bonn.de)
  • Abbott, L.F. and Svoboda, K., editors (2020) Brain-wide Interactions Between Neural Circuits. (columbia.edu)
  • Information about sensory stimuli - like smell - is transmitted in a hierarchical manner between circuits within different brain regions. (researchpod.org)
  • Interestingly, the transmitter substance that informs the neuronal circuits about rewarding or punishing experiences is the same in the insect brain and the mammalian brain - namely dopamine. (researchpod.org)
  • One interpretation of our results is that the mushroom body circuits defined by dunce/ rutabaga/radish expression are involved in establishing the balance between persistence and flexibility [i.e., the explore/exploit dilemma (Daw et al. (the-mouse-trap.com)
  • Two independent mushroom body output circuits retrieve the six discrete components of Drosophila aversive memory. (espci.fr)
Appetitive3
Encode3
  • We propose that exposure to cholinergic insecticides disrupts the honeybee's ability to accurately encode wide-field visual motion, resulting in impaired optomotor behaviors. (frontiersin.org)
  • Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila. (espci.fr)
  • The LH has also been proposed to encode innate olfactory preferences. (jneurosci.org)
Stimuli2
  • As a postdoctoral fellow with Richard Axel at Columbia University, Ruta switched fields to the analysis of how the brain encodes both innate and learned stimuli and discovered a sexually dimorphic circuit that drives male fly responses to a pheromone, and traced the activity of the circuit from the periphery to the motor output. (wikipedia.org)
  • The processing of odours in our brain occurs in much the same way as the processing of other sensory stimuli. (researchpod.org)
20203
  • Oct. 7, 2020 A research team has discovered that during memory consolidation, there are at least two distinct processes taking place in two different brain networks -- the excitatory and inhibitory networks. (sciencedaily.com)
  • June 5, 2020 Researchers have found that activity in adult-born neurons (ABNs) in the hippocampus, which is a brain region associated with memory, are responsible for memory consolidation during REM sleep. (sciencedaily.com)
  • Turrel O, Rabah Y, Plaçais PY, Goguel V, Preat T. (2020) Drosophila Middle-Term Memory: Amnesiac is Required for PKA Activation in the Mushroom Bodies, a Function Modulated by Neprilysin 1. (espci.fr)
Antennae1
  • Their compound eyes, antennae, and proboscis all play crucial roles in their sensory perception and feeding behaviors. (whatsthatbug.com)
Perception2
  • These results provide a basis for future investigations into the cellular and molecular mechanisms underlying visual memory and perception in Drosophila . (frontiersin.org)
  • Perception of these chemical signals may be olfactory or by contact. (lookformedical.com)
Adaptive4
  • Behavior is therefore extremely adaptive and flexible. (uni-bonn.de)
  • In addition, the neural networks for adaptive behavior are the target of common neurological diseases. (uni-bonn.de)
  • Attaining the right balance between persistence and flexibility is a crucial feature of adaptive behavior, because it reflects the balance between exploration and exploitation of natural resources. (the-mouse-trap.com)
  • This review summarizes the neuronal functions of the PIWI-piRNA pathway in multiple animal species, including their involvement in axon regeneration, behavior, memory formation, and transgenerational epigenetic inheritance of adaptive memory. (molcells.org)
Mutants3
  • It is increasingly apparent that many classical Drosophila learning and memory mutants are also defective in short-term processes relevant to selective attention. (the-mouse-trap.com)
  • The Drosophila mutants dunce1, rutabaga2080, and radish1 share olfactory memory defects but differ conspicuously for short-term processes relevant to visual attention. (the-mouse-trap.com)
  • We also used an antibody (which we verified against mutants and our tagged lines to be highly specific) and found no expression in mushroom bodies. (brembs.net)
Insect brain8
  • The insect brain is typically divided into three major regions, each responsible for various functions. (whatsthatbug.com)
  • Some key components within the insect brain have evolved to perform specific tasks. (whatsthatbug.com)
  • As seen, the insect brain may be smaller and simpler than a mammalian brain, but it still exhibits complex functions like learning, memory, and decision-making. (whatsthatbug.com)
  • Additionally, the connectome of an insect brain was mapped, revealing intricate networks of interconnected neurons in the Drosophila larva. (whatsthatbug.com)
  • A recent achievement by scientists includes the completion of the first map of an insect brain for the fruit fly larva. (whatsthatbug.com)
  • Decades of research have revealed that in the insect brain, odours evoke activity in small groups of Kenyon cells of the mushroom body. (researchpod.org)
  • An insect brain organizes numbers on a left-to-right mental number line. (cbi-toulouse.fr)
  • How the humble insect brain became a powerful experimental model system. (unibas.ch)
Adult4
  • Expression of iron transporters and pathological hallmarks of parkinson's and alzheimer's diseases in the brain of young, adult, and aged rats. (edu.hk)
  • This one isoform is expressed throughout the adult brain of the fly, but not in the mushroom bodies, where a few previous reports had detected it, using a technique which can sometimes lead to incorrect expression patterns. (brembs.net)
  • Amnesiac is required in the adult mushroom body for memory formation. (espci.fr)
  • Drosophila adult muscle development and regeneration. (unibas.ch)
Mammalian2
  • This principle is very similar to how odours are encoded in parts of the cortex of the mammalian brain, but at a much smaller size. (researchpod.org)
  • The firing process of R5 neurons in the ellipsoid body is in a manner similar to the firing of neurons during slow-wave sleep in the mammalian neocortex. (drosophilidae.com)
Pathways1
  • Whereas the more persistent optomotor behavior of dunce1 and rutabaga2080, both affecting the cAMP-associated pathways (Davis et al. (the-mouse-trap.com)
20221
  • Silva B, Mantha OL, Schor J,Pascual A, Plaçais PY, Pavlowsky A* , Preat T* (2022) Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. (espci.fr)
Dopamine2
Honey bees1
Optomotor behavior1
  • Here, we show that sublethal exposure to two commonly used insecticides, imidacloprid (a neonicotinoid) and sulfoxaflor, results in impaired optomotor behavior in the honeybee. (frontiersin.org)
Centers3
  • Using calcium imaging and optogenetic perturbations of specific neuronal populations, we reveal that edge-tracking relies on the mushroom body and central complex, two highly interconnected brain centers implicated in olfactory learning and spatial navigation. (rockefeller.edu)
  • I have no idea how long you have been working with Drosophila, but it is a rookie mistake to ever assume anything but the worst about fly strains you obtain from others (including from stock centers). (brembs.net)
  • Communication from Learned to Innate Olfactory Processing Centers Is Required for Memory Retrieval in Drosophila. (espci.fr)
Current Biology1
  • Gregg Roman, an associate professor of biology and biochemistry at UH, and Shixing Zhang, his postdoctoral associate, describe their findings in a paper titled "Presynaptic Inhibition of Gamma Lobe Neurons Is Required for Olfactory Learning in Drosophila," appearing Nov. 27 in Current Biology, a scientific bimonthly journal published by Cell Press. (uh.edu)
Output neurons1
  • Using a photoactivation screen of a new collection of split-GAL4 drivers and EM connectomics, we identified a cluster of neurons postsynaptic to the mushroom body output neurons (MBONs) that can trigger robust upwind steering. (janelia.org)
Memories1
  • How memories are used by the brain to guide future action is poorly understood. (janelia.org)
Deficits2
  • They weer aqble to show that despite overt similar olfactory memory deficits, the attention-like processes worked in opposite ways in the two mutant models. (the-mouse-trap.com)
  • Drosophila neprilysin 1 rescues memory deficits caused by amyloid-β peptide. (espci.fr)
Neural circuit3
  • In this endeavour she also investigates the neural circuit mechanisms underlying cognitive functions and the emergence of emotions-related behaviors that could be impaired in different brain disorders including neurodegenerative diseases. (edu.hk)
  • Neural circuit basis of cognitive functions and emotions-related behaviors. (edu.hk)
  • Lei Z , Henderson K, Keleman K . A neural circuit linking learning and sleep in Drosophila long-term memory. (neurotree.org)
Inhibition1
Associative1
  • In olfactory associative learning in Drosophila, multiple compartments of the mushroom body act in parallel to assign valence to a stimulus. (janelia.org)
Axon1
  • This study investigated the role of miR-34 in two other types of large-scale axon degeneration in Drosophila: axotomy-induced axon degeneration in olfactory sensory neurons (OSNs) and developmentally related axon pruning in mushroom body (MB) neurons. (sdbonline.org)
Dissection1
  • Identification of this large population of electrically coupled neurons in this classic model, and the ability to genetically manipulate these electrically synapsed neurons, expands the GF system capabilities for the nuanced, sophisticated circuit dissection necessary for deeper investigations into brain formation. (eneuro.org)
Larval1
  • For example, the complete wiring map of a larval fruit fly brain can provide valuable data for studies involving network architecture and machine learning. (whatsthatbug.com)
Invertebrate1
  • Thus, our results provide insight into how learned abstract valences are gradually transformed into concrete memory-driven actions through divergent and convergent networks, a neuronal architecture that is commonly found in the vertebrate and invertebrate brains. (janelia.org)
Germline1
Mechanisms4
  • We have been leveraging the concise architecture of the Drosophila olfactory and navigational circuitry to elucidate the neural mechanisms underlying odor navigation. (rockefeller.edu)
  • Such behavior has been found to be ecologically advantageous, but mechanisms driving such alternation tendencies have not been documented in the Drosophila brain. (the-mouse-trap.com)
  • Our purpose is to discover the relationship among sleep behavior, the nervous system and genetics accurately and rapidly, promoting the study and application of sleep disease mechanisms. (drosophilidae.com)
  • Uncovering the functions of ABPs in olfactory recognition of the diamondback moth, Plutella xylostella (L.), is fundamental to revealing the molecular mechanisms of olfaction of the moth. (insect.org.cn)
Memory10
  • In work that bridged her postdoc and the establishment of her own independent group her at Rockefeller University, Ruta demonstrated that the mushroom body encodes information using a rewriteable random access memory architecture. (wikipedia.org)
  • How can a single memory support optimal behavior across different sets of choice options? (janelia.org)
  • Significantly, LTM is encoded in these mushroom body neurons, and blocking outputs from these neurons suppress recall of LTM whereas activating these neurons produces memory-associated behaviors. (sciencedaily.com)
  • Drosophila can formed Long-term memory (LTM) by repetitive training trials with rest intervals. (sciencedaily.com)
  • Dunce phosphodiesterase acts as a checkpoint for drosophila long-term memory in a pair of serotonergic neurons. (espci.fr)
  • Ingestion of artificial sweeteners leads to caloric frustration memory in Drosophila. (espci.fr)
  • Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory. (espci.fr)
  • Drosophila neprilysins are involved in middle-term and long-term memory. (espci.fr)
  • The Full-Length Form of the Drosophila Amyloid Precursor Protein Is Involved in Memory Formation. (espci.fr)
  • Learning and memory: Clashing engrams in the fly brain. (tcd.ie)
Cortex2
  • From there, the information is directed via mitral cells to higher brain regions such as parts of the cerebral cortex. (researchpod.org)
  • Set of nerve fibers conducting impulses from olfactory receptors to the cerebral cortex. (lookformedical.com)
Neurodegeneration1
  • A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. (tcd.ie)
Synaptic2
  • Liu H , Zhou B, Yan W, Lei Z , Zhao X , Zhang K, Guo A . Astrocyte-like glial cells physiologically regulate olfactory processing through the modification of ORN-PN synaptic strength in Drosophila. (neurotree.org)
  • Choudhury SD, Mushtaq Z, Reddy-Alla S, Balakrishnan SS, Thakur RS, Krishnan KS, Raghu P, Ramaswami M, Kumar V. σ2-Adaptin Facilitates Basal Synaptic Transmission and Is Required for Regenerating Endo-Exo Cycling Pool Under High-Frequency Nerve Stimulation in Drosophila. (tcd.ie)
Receptors2
  • First, an RNAi screen was carried out involving 19 hormone receptors, individually and specifically, in a male reproductive tissue (accessory gland) for their requirement in Drosophila male fertility. (sdbonline.org)
  • Neurons in the OLFACTORY EPITHELIUM with proteins ( RECEPTORS, ODORANT ) that bind, and thus detect, odorants. (lookformedical.com)
Escape Behavior1
  • The GF circuit targets two large muscle sets used for rapid escape behavior, the tergotrochanteral muscle (TTM), which controls the legs for jumping, and the dorsal longitudinal muscle (DLM), which controls the wings ( Tanouye and Wyman, 1980 ). (eneuro.org)
Anatomical1
  • Scientists have long been fascinated by how anatomical structures in the brain can generate the diversity of behaviors apparent in the animal kingdom. (harvard.edu)
Olfaction2
  • Oct. 5 - Barry Ache , University of Florida - "What the Nose Tells the Brain: Ligand-induced Selective Signaling in Olfaction. (ufl.edu)
  • Mechanosensation provides animals with important sensory information in addition to olfaction and gustation during feeding behavior. (biologists.com)
Circuit3
  • We illustrate how animals integrate these learning principles using the fruit fly olfactory learning circuit, one of nature's best-characterized and highly optimized schemes for learning. (jneurosci.org)
  • Here, we report design and results of a neuronal inactivation screen aimed at discovering brain regions and circuit components controlling gap-crossing behaviour. (nature.com)
  • A Drosophila Circuit for Habituation Override. (tcd.ie)
Glands3
  • Subsequently, by using independent RNAi/ dominant negative forms, it was shown that Ecdysone Receptor (EcR) is essential for male fertility due to its requirement in the normal development of accessory glands in Drosophila: EcR depleted glands fail to make seminal proteins and have dying cells. (sdbonline.org)
  • Further, the data point to a novel ecdysone receptor that does not include Ultraspiracle but is probably comprised of EcR isoforms in Drosophila male accessory glands. (sdbonline.org)
  • and the associated olfactory glands. (lookformedical.com)
Genes2
Physiology1
  • Male accessory gland is the major source of proteinaceous secretions, collectively called as seminal proteins (or accessory gland proteins), which upon transfer, manipulate the physiology and behavior of mated females. (sdbonline.org)
Vivo1
Receives1
  • The central complex, which includes the fan and ellipsoid bodies, receives and processes signals that regulate sleep duration and balance. (drosophilidae.com)