QuetiapineAripiprazoleHaloperidolZiprasidoneAtypicalAntipsychoticsClozapineSchizophreniaAntipsychotic Agents0.25Commonly prescribedDoseSerumTreatmentGradualMedicationsPatientsSecond-generationDrugUsersStudyAnalysisQuetiapineAripiprazoleClozapineAntipsychoticSchizophrenia patientsTriglyceride levelsMonoamineDisturbancesSignificantlyProspectivelyRandomly assignedLithiumInpatientsGroupMedicationAverageWeeksSwitchEffectResponsePeriodCombination
Quetiapine10
- In phase 2,444 patients who had discontinued treatment were randomly reassigned to a second-generation drug: olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperdal), or ziprasidone (Geodon). (psychiatrictimes.com)
- Of those patients, 49 received open-label treatment with clozapine and 50 were assigned blindly to olanzapine, quetiapine, or risperidone. (psychiatrictimes.com)
- In the group that did not receive clozapine, patients treated with risperidone and olanzapine continued taking their medications longer than those who were treated with quetiapine or ziprasidone. (psychiatrictimes.com)
- In the group that agreed to try clozapine, patients actually receiving clozapine continued longer than patients taking olanzapine, quetiapine, or risperidone. (psychiatrictimes.com)
- In addition, the authors noted, 'at 3-month assessments, Positive and Negative Syndrome Scale total scores had decreased more in patients treated with clozapine than in patients treated with quetiapine or risperidone but not olanzapine. (psychiatrictimes.com)
- This study compared healthcare costs in patients treated with a mood stabilizer and adjunctive aripiprazole versus adjunctive olanzapine, quetiapine, risperidone or ziprasidone. (unboundmedicine.com)
- Generalized gamma regressions were used to compare the total healthcare costs of adjunctive aripiprazole treatment and treatment with adjunctive olanzapine, quetiapine, risperidone or ziprasidone. (unboundmedicine.com)
- Adjunctive aripiprazole may have economic benefits over other atypicals in terms of lower psychiatric treatment costs than adjunctive olanzapine, quetiapine, risperidone or ziprasidone, and lower total healthcare costs than adjunctive olanzapine, risperidone or ziprasidone. (unboundmedicine.com)
- With respect to individual drugs, the mean time to first improvement was 7.1 (± 4.1) days for risperidone, 6.7 (± 4.2) days for olanzapine, 6.5 (± 5.2) days for ziprasidone, 6.1 (± 4.4) days for quetiapine, 7.4 (± 3.0) days for clozapine, 5.2 (± 2.4) days for haloperidol, 5.9 (± 3.8) days for perphenazine, and 6.0 (± 3.9) days for sulpiride. (nel.edu)
- The drugs prescribed for bipolar disorder are the so-called 'atypical antipsychotics'-including Risperdal (risperidone), Zyprexa (olanzapine), Seroquel (quetiapine). (ahrp.org)
Aripiprazole5
- risperidone general medical costs were 18% higher versus aripiprazole (p=0.041). (unboundmedicine.com)
- In clinical trials involving patients with acute relapse of chronic schizophrenia, significant reductions from baseline in the mean Positive and Negative Syndrome Scale (PANSS) total score, which were comparable to those seen with haloperidol or risperidone, were observed with aripiprazole, [ 29 , 30 ] and efficacy was maintained long term. (medscape.com)
- [ 33 ] Minimal weight gain with aripiprazole compared with olanzapine has also been commented upon, as has the absence of any QTc prolongation associated with aripiprazole. (medscape.com)
- Although formal comparisons between aripiprazole and risperidone 6 mg/day [ 30 ] or haloperidol 10 mg/day [ 29 ] treatment groups were not performed in these trials, efficacy findings appeared to be comparable between treatment groups. (medscape.com)
- Researchers studied 125 kids who were prescribed Aripiprazole, Risperidone or Olanzapine for behavior problem. (cchrint.org)
Haloperidol1
- 80 patients having diagnosis of schizophrenia according to ICD-10 are assigned to treatment with olanzapine (N=20), risperidone (N=20) and haloperidol (N=40). (who.int)
Ziprasidone1
- 0.001) but not olanzapine or ziprasidone. (unboundmedicine.com)
Atypical6
- Risperidone and olanzapine are atypical antipsychotics that are now widely used in clinical practice. (nih.gov)
- All conventional and some atypical antipsychotics(e.g., risperidone) increase serum prolactin levels. (psychiatrist.com)
- Association between serum testosterone levels, body mass index (BMI) and insulin in male patients with schizophrenia treated with atypical antipsychotics--olanzapine or risperidone. (nel.edu)
- Konarzewska B, Galińska-Skok B, Waszkiewicz N, Łazarczyk-Kirejczyk J, Malus A, Simonienko K, Szulc A. Association between serum testosterone levels, body mass index (BMI) and insulin in male patients with schizophrenia treated with atypical antipsychotics--olanzapine or risperidone. (nel.edu)
- 2. Hypersensitivity to olanzapine, or history of dyskinesia or extrapyramidal syndrome on atypical neuroleptic. (knowcancer.com)
- Aims: To study the effects on glucose and lipid metabolism with the use of atypical and typical antipsychotics in the treatment of schizophrenia Methods: The present study is a 12 weeks open label prospective study of antipsychotic drugs olanzapine, risperidone and haloperidol in patients with schizophrenia. (who.int)
Antipsychotics3
- While the results of phase 1 suggested a superiority of olanzapine in length of time to drug discontinuation, 'the hope that other new antipsychotics with fewer metabolic side effects might offer a similar effect was not fulfilled,' according to Carol A. Tamminga, MD, who wrote an editorial that accompanied 2 articles reporting phase 2 results in the April 2006 issue of American Journal of Psychiatry . (psychiatrictimes.com)
- In the study, researchers demonstrated that influencing genes prevented weight gain in rodent models being administered the antipsychotics risperidone and olanzapine. (psychcentral.com)
- As extrapyramidal side effects have occurred over the past two years, the first generation antipsychotics were replaced with olanzapine. (srce.hr)
Clozapine3
- Forty-four percent of the clozapine patients continued to take the medication for the duration of the 18-month study, as did 29% of the patients receiving olanzapine. (psychiatrictimes.com)
- 4. History of clozapine-induced agranulocytosis because patients will be at increased risk for neutropenia with Olanzapine. (knowcancer.com)
- Clozapine [odds ratio (OR) 3.67, 95% confidence interval (CI) 1.94-6.94] confers the highest risk of SCD followed by risperidone (OR 3.04, 95% CI 2.39-3.86) then olanzapine (OR 2.04, 95% CI 1.52-2.74). (medscape.com)
Schizophrenia3
- Olanzapine is approved for the treatment of schizophrenia and bipolar disorder. (knowcancer.com)
- The FDA has approved Olanzapine for mental health diseases (schizophrenia, acute mania, and bipolar disorder). (knowcancer.com)
- Improvement in social functioning in outpatients with schizophrenia with prominent negative symptoms treated with olanzapine or risperidone in a 1 year randomized, open-label trial. (bvsalud.org)
Antipsychotic Agents1
- Risperidone belongs to the group of medications known as antipsychotic agents . (medbroadcast.com)
0.252
- To this end we tested the effect of 1.25 and 2.5 mg/kg olanzapine and 0.25 and 0.4 mg/kg risperidone using female and male Wistar rats in the CAR test. (lu.se)
- Each yellowish-orange, film-coated, oblong, biconvex tablet debossed with '0.25' on one side and 'R' on the other contains 0.25 mg of risperidone. (medbroadcast.com)
Commonly prescribed1
- In this study, we investigated whether sex-specific differences could be observed in response to the commonly prescribed APDs olanzapine and risperidone using the conditioned avoidance response (CAR) test. (lu.se)
Dose4
- Whereas there were no significant differences between the female and male rats in response to either dose of olanzapine administration, an injection of 0.4 mg/kg risperidone significantly suppressed avoidance more in female rats than in male rats. (lu.se)
- The dose of risperidone varies according to needs and the condition being treated. (medbroadcast.com)
- The safety of risperidone has not been established beyond a maximum dose of 16 mg per day (8 mg given twice daily). (medbroadcast.com)
- If you are found to be eligible to take part in this study and before you receive your first dose of Olanzapine, you will have routine blood tests (about 2 teaspoons). (knowcancer.com)
Serum2
- In olanzapine group there is a mean increase of 6.3 mg/dl in FBS and 3.7 mg/dl in PPBS and mean increase of 7.8 mg/dl in serum cholesterol. (who.int)
- In risperidone group, there is mean increase of 2.3 mg/dl in FBS and 2.8 mg/dl in PPBS and mean increase of 0.98 mg/dl in serum cholesterol. (who.int)
Treatment2
- A MEDLINE search (1966-1999) showed that, following the introduction of these agents in recent years, 26 cases of induced hypomanic and manic syndromes have been reported during standard olanzapine (N = 10) or risperidone (N = 16) treatment. (nih.gov)
- Risperidone - approved for treatment of bipolar disorder. (slideshare.net)
Gradual1
- Olanzapine was reduced and risperidone introduced by gradual titration (4 mg daily). (srce.hr)
Medications1
- Medications like risperidone are thought to work by correcting the function of nerve pathways in certain areas of the brain. (medbroadcast.com)
Patients1
- We found that most patients were taking risperidone (N = 96), followed by olanzapine (64 patients). (nel.edu)
Second-generation1
- Risperidone was the most used second-generation antipsychotic, followed by olanzapine. (bvsalud.org)
Drug1
- Drug interactions are reported among 61 people who take Allegra and Olanzapine. (ehealthme.com)
Users1
- Currently, eHealthMe is studying from 63,439 Olanzapine users. (ehealthme.com)
Study2
- The phase IV clinical study analyzes what interactions people who take Allegra and Olanzapine have. (ehealthme.com)
- The study doctor will decide if you should continue receiving Olanzapine after 4 months. (knowcancer.com)
Analysis1
- A critical analysis of these case reports reveals that the effects on mood were sometimes insufficiently documented and that in about half of them (N = 16) evidence is highly suggestive of a causative role of risperidone or olanzapine in the induction of (hypo)manic symptomatology. (nih.gov)
Quetiapine7
- Most children received either aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel) or risperidone (Risperdal) for about 11 weeks. (nih.gov)
- Those taking olanzapine or quetiapine had significant adverse changes in total cholesterol, triglyceride, non-HDL (bad) cholesterol levels and the ratio of triglycerides to HDL cholesterol. (nih.gov)
- 2007). In our context, the most commonly prescribed antipsychotics in this population are risperidone, quetiapine, and olanzapine (Castro-Fornieles et al. (sciencedaily.com)
- 2008). In the first study comparing 3 different second-generation antipsychotics (SGAs) in 110 patients with early onset psychosis (mean age 15.5), no significant differences were found in the reduction on any symptomatology scale in patients treated with risperidone, quetiapine, or olanzapine for six months (Castro-Fornieles et al. (sciencedaily.com)
- 17. Nocturnal enuresis in patients taking clozapine, risperidone, olanzapine and quetiapine: comparative cohort study. (nih.gov)
- Regulation of phospho-Ser-GSK3 was a shared effect among several atypical antipsychotics, including olanzapine, clozapine, quetiapine, and ziprasidone. (researchgate.net)
- Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population. (cdc.gov)
Aripiprazole2
- Olanzapine, haloperidol and aripiprazole were the most frequently used drugs (46.3%, 15.6% and 10%, respectively). (who.int)
- Analysis of covariance was performed to compare the triglyceride levels among the three antipsychotic groups: olanzapine, risperidone or aripiprazole. (go.jp)
Clozapine1
- Newer medications such as olanzapine, risperidone, and clozapine may be effective with fewer side effects. (health.am)
Antipsychotic3
- These results suggest that there are potential differences in antipsychotic-associated hepatic enzyme alterations between risperidone and olanzapine treatment. (nih.gov)
- This medication combines fluoxetine and the antipsychotic olanzapine . (healthline.com)
- Risperidone was the most used second-generation antipsychotic, followed by olanzapine. (bvsalud.org)
Schizophrenia patients2
- This study was conducted to prospectively examine the effect of switching from risperidone to olanzapine on female schizophrenia patients who experienced menstrual disturbances, galactorrhea, and/or sexual dysfunction. (nih.gov)
- Combined study of genetic and epigenetic biomarker risperidone treatment efficacy in Chinese Han schizophrenia patients. (cdc.gov)
Triglyceride levels2
- With risperidone, only triglyceride levels rose significantly. (nih.gov)
- In the post-hoc analysis, inpatient triglyceride levels were significantly higher in the olanzapine group (106.5 ± 61.8 mg/dL) than the risperidone group (97.1 ± 50.4 mg/dL). (go.jp)
Monoamine1
- In addition, combination treatment of mice with risperidone and a monoamine reuptake inhibitor antidepressant imipramine or fluoxetine elicited larger increases in brain phospho-Ser-GSK3 than each agent alone. (researchgate.net)
Disturbances1
- Twenty female patients with DSM-IV schizophrenia who were taking risperidone and were suffering from menstrual disturbances, galactorrhea, and/or sexual dysfunction were enrolled. (nih.gov)
Significantly1
- The study found that remaining on olanzapine for 1 year or more significantly lowered violence risk compared to first switch period, but no significant change in violence risk was found for subjects remaining on risperidone for 1 year or more. (psychiatrist.com)
Prospectively1
- This study prospectively examined the effectiveness of treatment with olanzapine versus risperidone in reducing violent behavior among patients with schizophrenia under "usual care" conditions in the community. (psychiatrist.com)
Randomly assigned1
- In this open-label, 28-week, randomized controlled trial, stable patients with schizophrenia treated with risperidone or olanzapine were randomly assigned to the reduction group (dose reduced by 50% in 4 weeks and then maintained) or maintenance group (dose kept constant). (qxmd.com)
Lithium1
- This 52-week double-blind placebo-controlled trial recruited patients with bipolar I disorder (n=159) who recently remitted from a manic episode during treatment with risperidone or olanzapine adjunctive therapy to lithium or valproate. (umn.edu)
Inpatients1
- The charts were reviewed for six hundred and sixty-seven (667) inpatients with psychotic disorders who were treated with either risperidone (n=289) or olanzapine (n=145) alone at a university-affiliated hospital between 1998 and 2002. (nih.gov)
Group4
- Frequencies of elevation greater than the reference level in any enzyme among aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphotase (ALP) were higher in the olanzapine-treated group (26.9%) than in the risperidone-treated group (14.2%) [odds ratio (OR)=2.225, 95% confidence interval (CI)=1.362-3.638, P=0.002]. (nih.gov)
- Frequencies of elevation greater than the reference level in ALT were higher in the olanzapine-treated group than in the risperidone-treated group (OR=2.182, P=0.004), as were frequencies with two-fold (OR=3.064, P=0.017) and three-fold (OR=2.883, P=0.039) elevation. (nih.gov)
- Recovery time was longer in the olanzapine-treated group than in the risperidone-treated group (P=0.0059), as was latency time (P=0.0044). (nih.gov)
- Patients were randomized to one of three conditions: discontinuation of risperidone or olanzapine and substitution with placebo at (i) entry ('0-weeks' group) or (ii) at 24 weeks after entry ('24-weeks' group) or (iii) continuation of risperidone or olanzapine for the full duration of the study ('52-weeks' group). (umn.edu)
Medication1
- Specifically, adherence with prescribed medication was found to mediate the association between olanzapine treatment and reduced violent behavior. (psychiatrist.com)
Average1
- Weight rose highest in patients taking olanzapine, with an average increase of nearly 19 pounds. (nih.gov)
Weeks2
- Patients were switched from risperidone to olanzapine over a 2-week period, then treated with olanzapine for 8 additional weeks. (nih.gov)
- These findings suggest that risperidone or olanzapine adjunctive therapy for 24 weeks is beneficial but continuation of risperidone beyond this period does not reduce the risk of relapse. (umn.edu)
Switch1
- 01) following the switch from risperidone to olanzapine. (nih.gov)
Effect1
- Effect of risperidone metabolism and P-glycoprotein gene polymorphism on QT interval in patients with schizophrenia. (cdc.gov)
Response1
- Given high rates of treatment failure for initial therapy of schizophrenia , is combining risperidone and olanzapine an appropriate approach to improve clinical response while also limiting potential adverse effects? (medscape.com)
Period1
- Whether continuation of olanzapine beyond this period reduces relapse risk remains unclear but the potential benefit needs to be weighed against an increased risk of weight gain. (umn.edu)
Combination1
- [ 6 ] This article reviews the available evidence to determine whether risperidone and olanzapine can be safely and effectively used in combination for the treatment of refractory schizophrenia. (medscape.com)