Often refractory. Medical search. Frequent questions

New treatment strategies and modalities are necessary to treat myeloma in relapse, particularly in cases of triple-refractory status defined by disease progression during or shortly after treatment with immunomodulatory agents, proteasome inhibitors, and anti-CD38 monoclonal antibody therapy. (nih.gov)
Despite the high cure rate with initial therapy, approximately 5% to 10% of patients have refractory disease, and 10% to 30% patients relapse after an initial complete response [ 2 ]. (hindawi.com)
One of the most important and widely accepted prognostic factors for patients undergoing ASCT appears to be chemosensitivity at relapse, with patients responding to second-line chemotherapy and having a much better outcome than patients with refractory disease, whose relapse rate approaches 80% in some published series [ 5 , 6 ]. (hindawi.com)
Ano ang Remission, Relapse at Refractory Lymphoma? (lymphoma.org.au)
Txawm li cas los xij, qee zaum, lymphoma tuaj yeem rov qab los tom qab lub sijhawm rov qab los (relapse) lossis refractory rau kev kho mob, txhais tau tias nws tsis teb rau kev kho mob. (lymphoma.org.au)
Remission, Relapse thiab Refractory Lymphoma yog dab tsi? (lymphoma.org.au)
Remission, Relapse ແລະ Refractory Lymphoma ແມ່ນຫຍັງ? (lymphoma.org.au)
He aha te murunga, Relapse me Refractory Lymphoma? (lymphoma.org.au)
Chii chinonzi Remission, Relapse uye Refractory Lymphoma? (lymphoma.org.au)

What Is Refractory Multiple Myeloma? (healthline.com)
Your relapsed refractory multiple myeloma healthcare team may include a hematologist, medical oncologist, registered dietitian, and other specialists. (healthline.com)
A new drug, GSK2857916, was granted a breakthrough therapy designation by the FDA to treat patients who have relapsed or refractory multiple myeloma, according to GlaxoSmithKline (GSK), the manufacturer of the agent. (curetoday.com)
GSK also noted in a press release that the European Medicines Agency (EMA) granted PRIME designation to GSK2857916 in October for the treatment of patients with relapsed and refractory multiple myeloma whose prior therapy included a proteasome inhibitor, an immunomodulatory agent and an anti-CD38 antibody. (curetoday.com)
The breakthrough designation is based on results from a phase 1 open-label, dose escalation and expansion study in patients with relapsed/refractory multiple myeloma, irrespective of BCMA expression. (curetoday.com)
On February 28, 2022 , ciltacabtagene autoleucel was approved for treatment of adults with relapsed or refractory multiple myeloma after at least four lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. (ascopost.com)
Ciltacabtagene autoleucel was approved for treatment of adults with relapsed or refractory multiple myeloma after at least four lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. (ascopost.com)

In this manuscript, we review recent promising developments in the treatment of triple-class refractory myeloma including bispecific antibodies and T cell engagers, chimeric antigen receptor cellular therapies, as well as chemotherapeutics with novel mechanisms of action. (nih.gov)
Myeloma is refractory if it doesn't respond to treatment or stops responding to treatment. (healthline.com)

This study will evaluate palbociclib in combination with chemotherapy (temozolomide and irinotecan) in children, adolescents and young adults with recurrent or refractory solid tumors. (cincinnatichildrens.org)

We identified 19 patients treated with tofacitinib and a biologic for refractory CD between 2017 and 2019. (unboundmedicine.com)

In this study, we compared transplantation outcomes of 2963 patients with primary refractory or relapsed AML given CBT, 10/10 HLA-matched UD, or 9/10 HLA-matched UD allo-HCT from 2004 to 2015 at EBMT-affiliated centers. (nature.com)
In order to challenge this hypothesis, we performed a large registry study comparing CBT with UD 10/10 or 1-antigen HLA-mismatched UD (UD 9/10) in patients with primary refractory or untreated/refractory relapsed AML. (nature.com)
Despite trends in improved survival due to better supportive care, up to 40% of patients will have primary refractory disease which has a poorly understood biology and carries a dismal prognosis. (nih.gov)

Kini idariji, ifasẹyin ati Lymphoma Refractory? (lymphoma.org.au)
lymphoma refractory jẹ nigbati lymphoma rẹ ko dahun si itọju rẹ lọwọlọwọ. (lymphoma.org.au)
lymphoma Refractory ແມ່ນເວລາທີ່ lymphoma ຂອງທ່ານບໍ່ຕອບສະຫນອງຕໍ່ການປິ່ນປົວໃນປະຈຸບັນຂອງທ່ານ. (lymphoma.org.au)
Ko te lymphoma refractory te wa kaore to lymphoma e aro ki to maimoatanga o naianei. (lymphoma.org.au)
Lymphoma refractory shine lokacin da lymphoma ɗin ku bai amsa maganin ku na yanzu ba. (lymphoma.org.au)

The Food and Drug Administration (FDA) has granted accelerated approval to Lunsumio ® (mosunetuzumab-axgb) for the treatment of adults with relapsed or refractory (R/R) follicular lymphoma (FL) after 2 or more lines of systemic therapy. (empr.com)
This approval is a significant milestone for people with relapsed or refractory follicular lymphoma, who have had limited treatment options until now," said Elizabeth Budde, MD, PhD, Haematologic Oncologist and Associate Professor, City of Hope Division of Lymphoma, Department of Hematology & Hematopoietic Cell Transplantation, and Lunsumio clinical trial investigator. (empr.com)
FDA approves Roche's Lunsumio, a first-in-class bispecific antibody, to treat people with relapsed or refractory follicular lymphoma. (empr.com)

Refractory bricks are available in numerous types to suit different applications. (selfgrowth.com)
Using suitable refractory bricks for applications means a low maintenance, lucrative, and safe and sound heating system for multilateral performance. (selfgrowth.com)
The utmost temperature range refractory bricks are designed to handle varies with the meticulous unit. (selfgrowth.com)
Refractories manufacturers in India offer a variety of types of bricks through their online stores which include silicon carbide blocks, zircon blocks, acid-proof blocks, constructional high alumina blocks, low alumina blocks, industrial high alumina blocks, low alumina blocks, fly ash blocks, ceramic and tailored blocks. (selfgrowth.com)
Nowadays, fire bricks are created by refractory exporters in Kolkata using a range of advanced machinery. (selfgrowth.com)

We need large quantity following materials from Korea: 1.Torcrete concrete: product type:Alumina silica product(regular castable) Al2o3 51% Sio2 39% Cao 6.9% Fe2o3 1.1% 2.selfhardening liquid refractory mass product type:Alumina silica. (ecplaza.net)

OBJECTIVES: I. Determine the response rate of children with recurrent or refractory malignancies treated with vinorelbine. (knowcancer.com)
The findings came from a phase I/II study of JCAR014 CAR T-cell therapy in adults with relapsed/refractory B-cell malignancies. (onclive.com)

Metal Grid anchors cement or refractory linings. (thomasnet.com)
Metal Hex Grid provides surface framework to anchor and reinforce cement or refractory linings in reactor vessels, furnaces, ducts cyclones, and flue gas lines. (thomasnet.com)
Currently we are looking for refractory castables (alumina silicon based) for cement kilns, required quantity 24 tons. (ecplaza.net)

Dr. Seymour is the lead author on a paper of the results of the phase III MURANO trial, which studied venetoclax in combination with rituximab in patients with relapsed/refractory chronic lymphocytic leukemia (CLL). (cancernetwork.com)
Patients with refractory chronic lymphocytic leukemia achieved a high-response rate with CD19-targeted CAR T-cell therapy JCAR014. (onclive.com)

Sunitinib treatment for refractory malignant pheochromocytoma. (nel.edu)

The Food and Drug Administration (FDA) has approved Rezlidhia (olutasidenib) for adults with relapsed or refractory acute myeloid leukemia (AML) with a susceptible IDH1 mutation, as detected by the Abbott RealTime IDH1 Assay - a test that was approved alongside the drug. (curetoday.com)

CARY, N.C., March 12, 2021 - Biologics by McKesson , an independent specialty pharmacy specializing in oncology and rare disease areas, was selected by AVEO Oncology as a specialty pharmacy provider for FOTIVDA ® (tivozanib) for the treatment of adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) who have received two or more prior systemic therapies. (mckesson.com)

Ceramics made of pure oxides are quite often the best refractories, however, these are expensive and therefore mixtures of ceramic compounds are often used. (edu.au)
A. Yamaguchi, S. Zhang and J. Yu, "Effect of Refractory Oxides on the Oxidation of Graphite and Amorphous Carbon," Journal of the American Ceramic Society, Vol. 79, No. 9, 1996, pp. 2509-2511. (scirp.org)

It is described as "iron-refractory" because the condition is totally resistant (refractory) to treatment with iron given orally and partially resistant to iron given in other ways, such as intravenously (by IV). (medlineplus.gov)
Even with first dose of IVIG up to 10% - 20% of patients develop refractory Kawasaki Disease, i.e., remain unresponsive to initial IVIG treatment. (scirp.org)
Second dose of IVIG is recommended treatment for refractory Kawasaki Disease but other alternative treatments are also being considered to lower the risk of complications. (scirp.org)
We will review general treatment approach in refractory Kawasaki disease. (scirp.org)
This review focuses on the treatment options currently available for relapsed and refractory disease after autotransplant. (hindawi.com)
Macroscopic observation of endobronchial Microascus cirrosus lesion in patient in France with refractory microascus bronchopulmonary infection before (A) and after (B) olorofim treatment. (cdc.gov)
Trichomonal vaginitis refractory to conventional treatment. (bmj.com)
This phase I trial studies the side effects and best dose of palbociclib when given alone and in combination with sorafenib, decitabine, or dexamethasone in treating patients with leukemia that has come back (recurrent) or that does not respond to previous treatment (refractory). (mdanderson.org)
Combination tofacitinib and a biologic was effective in achieving clinical and endoscopic improvement in some patients with severe, refractory CD, although a larger sample size is needed to further assess the efficacy and long-term safety of this treatment strategy. (unboundmedicine.com)
Eight of 11 patients with ibrutinib-refractory disease and PET avidity at baseline also responded to treatment, including 7 complete responses. (onclive.com)
A recent national practice guideline recommends the use of opioids for the treatment of refractory dyspnea in patients with advanced chronic obstructive pulmonary disease (COPD). (cmaj.ca)
Bridging this gap will require initiatives to improve the uptake of practice guidelines and to increase confidence in prescribing opioids for dyspnea refractory to conventional treatment. (cmaj.ca)
Novel transplant approaches for patients with treatment-refractory severe aplastic anemia / Richard W. Childs. (nih.gov)
Proper characterization and tailored treatment for refractory AML could improve patient outcomes and should be studied prospectively in clinical trials. (nih.gov)

Although iron deficiency anemia is relatively common, the prevalence of the iron-refractory form of the disease is unknown. (medlineplus.gov)
Were they the average types of patients with relapsed/refractory disease or was there something distinct about the particular patient cohort on this trial? (cancernetwork.com)
Analysis of bone marrow by flow cytometry showed 1 of the 3 patients who received nonstandard lymphodepletion had no evidence of disease in marrow, as did 15 of 17 patients who received cyclophosphamide/fludarabine lymphodepletion and 11 of the 16 patients with ibrutinib-refractory disease. (onclive.com)
We are so pleased to distribute this meaningful therapy to patients whose disease has relapsed or become refractory to multiple lines of therapy. (mckesson.com)

5% in bone marrow) are not included in this group of disorders (see Refractory Anemia with Excess Blasts ). (medscape.com)

See Pathology of Refractory Anemia with Excess Blasts , Chronic Anemia , Chronic Pediatric Anemia , and Emergent Management of Acute Anemia for complete information on these topics. (medscape.com)
The total study population comprised 48 patients with acute lymphoblastic leukemia and 64 with non-Hodgkin's lymphoma, as well as 24 patients with ibrutinib (Imbruvica)-refractory CLL, who were the focus of Dr. Turtle's presentation. (onclive.com)

Refractory ceramics are insulating materials and are designed to withstand high stresses and temperatures and must also resist the effects of molten metals, abrasive particles and hot gases. (edu.au)

However, in many other parts of the world, chemoimmunotherapy remains the standard in the relapsed/refractory setting, particularly with bendamustine and rituximab, given that ibrutinib is not universally available or reimbursed for that indication. (cancernetwork.com)
There were 19 patients who were ibrutinib-refractory and 6 venetoclax (Venclexta)-refractory. (onclive.com)
Of 16 ibrutinib-refractory patients evaluable for responses, 11 achieved objective responses, including the 4 patients who had complete responses. (onclive.com)

In this interview, we discuss the results of the phase III MURANO trial, which tested the combination of venetoclax with rituximab in relapsed/refractory CLL. (cancernetwork.com)

Ovipositioning Behaviour of Aedes aegypti in Different Concentrations of Latex of Calotropis Procera: Studies on Refractory Behaviour and its Sustenance across Gonotrophic Cycles. (who.int)

The approval was based off findings from the phase 1/2 trial, Study 2102-HEM-101, which included 147 patients with relapsed or refractory AML that harbored an IDH1 mutation, as determined by the Abbott RealTime IDH1 Assay. (curetoday.com)
X. Li, M. Rigaud and S. Palco, "Oxidation Kinects Graphite of Phase in Magnesia-Carbon Refractories," Journal of the American Ceramic Society, Vol. 78, No. 4, 1995, pp. 965-971. (scirp.org)

The basics of heat transfer will then be covered, from molten steel through layers of refractories to the steel ladle shell, followed by insulation choices, how they affect ladle shell temperatures, and refractory expansion dynamics. (aist.org)

Extracorporeal cardiopulmonary resuscitation (ECPR) in patients with prolonged or refractory out‐of‐hospital cardiac arrest (OHCA) is likely to be beneficial when used as part of a well developed emergency service system. (mja.com.au)

About half of all patients undergoing ASCT are rescued and definitely cured by such an approach, but the outcome of patients relapsing or refractory to second-line chemotherapy and ASCT is dismal, with a median survival of less than three years [ 4 ]. (hindawi.com)
For patients who do not promptly achieve return of spontaneous circulation (ROSC) with these measures and in whom cardiac arrest becomes refractory, brain and end‐organ dysfunction progresses and survival with good neurological outcomes becomes extremely uncommon. (mja.com.au)

Audit and review clinical outcomes of all patients having ESWT for refractory plantar fasciitis (see section 3.1). (nice.org.uk)

Chronic inhalation and biopersistence of refractory ceramic fiber in rats and hamsters. (nih.gov)

Because of their high heat resistance, ceramic materials are used as refractories. (edu.au)

The seminar will start by discussing the raw materials used in the manufacture of refractories, why they are used, their availability and expected characteristics. (aist.org)

Unlike some other relapsed/refractory studies in which the patients could have had an unlimited number of prior treatments, this one was capped at three, although, they did need to have at least one prior chemotherapy-containing regimen. (cancernetwork.com)

Therapy selection in the relapsed/refractory setting may impact the risk estimates obtained in the model. (medscape.com)
GSK2857916, a B-cell maturation antigen (BCMA) antibody-drug conjugate, is indicated for patients who have failed at least three prior lines of therapy, including an anti-CD38 antibody, and who are also refractory to a proteasome inhibitor and an immunomodulatory agent. (curetoday.com)

Mortex is a trusted refractory manufacturer in India with classy features. (selfgrowth.com)

Despite the new technologies and process, the use of magnesia carbon refractory remains constant. (scirp.org)
Namely the magnesia carbon refractory is widely used due low-priced cost, high refractivity, excellent corrosion resistance, thermal shock resistance, low thermal expansion, high slag penetration resistance and low wettability. (scirp.org)
The main disadvantages of use magnesia carbon refractories are the high carbon oxidation susceptibility and the formation CO and CO 2 gases. (scirp.org)
The use of open cell carbon-foam magnesia composite for refractory application can offer a substitute for the traditional refractory material since the high carbon content can be minored and the low mechanical strength and poor oxidation resistance of these materials can be improved. (scirp.org)
W. Silveira and G. Falk, "Production of MgO-X Refractory Material with Cellular Matrix by Colloidal Processing," Low Carbon Economy , Vol. 3 No. 3A, 2012, pp. 83-91. (scirp.org)
M. Rigaud, "New Additives in Carbon-Bonded Refractories. (scirp.org)

The manufacturer claims that refractory linings that incorporate the hex grids have improved heat and abrasion resistance thus, a longer effective service life. (thomasnet.com)
S. Zhang and W. E. Lee, "Influence of Additives on Corrosion Resistance Corrosion Resistance and Corroded Microstructures of MgO-C Refractories," Journal of the European Ceramic Society, Vol. 21, No. 13, 2001, pp. 2393-2405. (scirp.org)

We conducted two qualitative studies to explore the experiences of patients and family caregivers with opioids for refractory COPD-related dyspnea and the perspectives and attitudes of physicians toward opioids in this context. (cmaj.ca)
Discrepancies between the positive experiences of patients and family caregivers with opioids and the reluctance of physicians to prescribe opioids for refractory dyspnea constitute an important gap in care. (cmaj.ca)

Sanajan kitu, dina sababaraha kasus, lymphoma bisa datang deui sanggeus waktu remisi (kambuh) atawa jadi refractory kana perlakuan, hartina teu ngabales perlakuan. (lymphoma.org.au)
Sanajan éta bisa ngarasa disheartening pikeun manggihan yén anjeun geus relapsed, atawa nu lymphoma anjeun refractory kana perlakuan, loba jalma masih bisa ngabales ogé kana jenis salajengna perlakuan. (lymphoma.org.au)
Paunenge uine kudzoka zvakare kana refractory lymphoma iwe ungangoda kutanga rudzi rwakasiyana rwekurapa. (lymphoma.org.au)

This presentation will provide information on how to select refractory materials, their testing methods and the impact of properties on performance. (aist.org)
M. N. Khezrabadi, J. Javadpour, H. R. Rezaie and R. Naghizadeh, "The Effect of Additives on the Properties and Microstructures of Al2O3-C Refractories," Journal of Materials Science, Vol. 41, No. 10, 2006, pp. 3027-3032. (scirp.org)
I'm Messi Mei who responsible to the series of refractory materials marketing. (top500.de)

Systems measuring slag from tap, ladle refractory at tap, ladle metallurgy furnace argon surface plum and rate of meniscus rise in vacuum tank degasser-supporting ladles. (aist.org)

Locate Refractory Mortar Suppliers near you in Alabama. (macraesbluebook.com)

Iron-refractory iron deficiency anemia results from an inadequate amount (deficiency) of iron in the bloodstream. (medlineplus.gov)
The symptoms of iron-refractory iron deficiency anemia can include tiredness (fatigue), weakness, pale skin, and other complications. (medlineplus.gov)
Researchers suspect that iron-refractory iron deficiency anemia is underdiagnosed because affected individuals with very mild symptoms may never come to medical attention. (medlineplus.gov)
Mutations in the TMPRSS6 gene cause iron-refractory iron deficiency anemia. (medlineplus.gov)
The epidemiologic features of refractory anemia with ring sideroblasts (RARS) are similar to those of most other types of myelodysplastic syndrome (MDS). (medscape.com)
Despite the presence of such characteristic signs and symptoms as hemorrhagic gastroenteritis, hemolytic anemia, and refractory hypotension, the diagnosis of copper sulfate ingestion was delayed for several days after ingestion, when the family first volunteered that the patient had vomited blue-green material the day before his admission to the hospital. (nih.gov)

PURPOSE: This is a 2-part study of pembrolizumab (MK-3475) in pediatric participants who have either advanced melanoma or a programmed cell death ligand 1 (PD-L1)-positive advanced, relapsed or refractory solid tumor or lymphoma. (cincinnatichildrens.org)
T. R. Lipinski, R. Fichtner and T. Benecke, "Study of the Oxidation Protection of MgO-C Refractories by Means of Boron Carbide," Steel Research, Vol. 63, No. 11, 1992, pp. 493-495. (scirp.org)
This case study is consistent with previous reports indicating that appropriate doses of sunitinib can induce a partial antitumor response in patients with refractory pheochromocytoma. (nel.edu)

The use of refractory products is mandatory for all closed fireplaces, where the products are exposed to harsh thermal conditions: a temperature above 1000°C and often continuous fire. (terreal.com)

Anatomy7

Organisms1

Diseases76

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment70

Psychiatry and Psychology3

Phenomena and Processes15

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science2

Health Care16

Relapse9

Multiple Myeloma7

Myeloma2

Recurrent or refractory solid1

20171

Primary refractory3

Lymphoma refractory5

Follicular lymphoma3

Bricks5

Castable1

Malignancies2

Cement3

Chronic lymphocy2

Malignant1

Adults1

Specialty1

Oxides2

Treatment14

Disease4

Disorders1

Acute2

Metals1

Ibrutinib3

Venetoclax1

Behaviour1

Phase2

Insulation1

Extracorporeal1

Survival2

Outcomes1

Ceramic fiber1

Heat resistance1

Characteristics1

Chemotherapy1

Therapy2

India1

Carbon6

Resistance2

Patients and Family2

Kana3

Materials3

Furnace1

Suppliers1

Anemia6

Study3

Temperature1