Often asymptomatic carcinoid tumor. Medical search. Frequent questions

Of neoplasms in the appendix, carcinoid tumors remain the most common. (medscape.com)
Carcinoids are also the most common neoplasm of the small bowel, accounting for approximately 48% of all small bowel neoplasms. (medscape.com)
In 1907, by which time carcinoid tumors were already histologically described and had been classified as carcinoma, Oberndorfer used the term "carcinoid" (carcinoma-like) as a modifier in order to distinguish their indolent behavior from other common gastrointestinal neoplasms. (medscape.com)
Carcinoid tumors are neuroendocrine neoplasms derived from the enterochromaffin cells. (biomedcentral.com)
Carcinoid tumors of the colon are rare, comprising less than 11% of all carcinoid tumors and only 1% of colonic neoplasms. (jomi.com)
In the huge spectrum of lung neuroendocrine neoplasms, typical and atypical carcinoids should be considered as a separate biological entity from poorly differentiated forms, harboring peculiar molecular alterations. (springeropen.com)
Neuroendocrine neoplasms (NENs) include all tumors derived from the diffuse endocrine system. (springeropen.com)
sequenced the whole exome of 69 pulmonary carcinoids reporting the most frequently DNA alterations found in these neoplasms. (springeropen.com)

Intestinal carcinoid tumors are gastrointestinal neuroendocrine tumors (GI-NETs). (medscape.com)
About 66% of all carcinoid tumors develop in the gastrointestinal tract. (medifocus.com)
However, the continuous knowledge which was added by studying these tumors for nearly a century strengthen the notion that the above term was inaccurate or inadequate to describe several parameters of this heterogeneous group of gastrointestinal tumors (including the appendiceal one). (wjgnet.com)
Approximately 74% of all carcinoid tumors arise from the gastrointestinal (GI) tract and the liver is a common site for metastases [ 1 ]. (biomedcentral.com)
Reports of gastric collision tumors, comprising adenocarcinoma and gastrointestinal stromal tumor, are extremely rare. (bvsalud.org)
The tumor cells of the gastrointestinal stromal tumor were positive for H-caldesmon and CD117, weakly positive for smooth muscle actin and DOG-1, and negative for desmin, S-100 protein, CD31, and AE1/AE3. (bvsalud.org)
The tumor had grown into a mixed form of adenocarcinoma and gastrointestinal stromal tumor. (bvsalud.org)
Thus, we report the first case of a preoperatively diagnosed collision tumor in the stomach consisting of adenocarcinoma and gastrointestinal stromal tumor. (bvsalud.org)
Chapter 32 Gastrointestinal Cancers DIAGNOSIS TREATMENT DIAGNOSITC IMAGING MEDICATIONS CT scan, MRI, labeled somatostatin receptor-based diagnostic imaging ▪ Localization, TNM staging ▪ Presence of hepatic lesions SURGERY Endoscopy with biopsy ▪ Tumor visualization ▪ Histopathological analysis, grading ▪ Somatostatin analogues suppress tumor proliferation, decrease symptoms ▪ Surgical removal of tumor LAB RESULTS ▪ 5-hydroxyindoleacetic acid, chromogranin Figure 32.2 Gross pathology of carcinoid tumor of the terminal ileum. (osmosis.org)
Kaposi's Sarcoma of the Upper GI Tract Causing Severe Anemia This case demonstrates that a seemingly asymptomatic patient may have extensive involvement of Kaposi's sarcoma in the gastrointestinal tract. (medscape.com)

They are conventionally considered to originate from the serotonin-secreting enterochromaffin cells (ECs) of the intestine (also known as Kulchistky cells), but technically, intestinal carcinoid tumors include any collection of well-differentiated neuroendocrine cells within the digestive tract that are capable of secreting bioactive hormones and/or amines. (medscape.com)
Between 1952 and 1953, serotonin [5-hydroxytryptamine (5-HT)] was identified as the secretory product of enterochromaffin cells (ECs) and isolated from a carcinoid tumor of the small bowel. (medscape.com)
[ 15 ] Finally, when elevated levels of 5-hydroxyindoleacetic acid (5-HIAA), the major metabolite of 5-HT, were discovered in the urine of patients with the carcinoid syndrome, investigators realized that the carcinoid syndrome may be a humorally-mediated disorder caused by production and secretion of ectopic serotonin by carcinoid tumors. (medscape.com)
[ 16 ] The term carcinoid was also used interchangeably with APUDoma, so named by Pearse in the 1960s, who developed the concept of the amine precursor uptake and decarboxylation (APUD) system after observing the ability of the secretory granules to take up and decarboxylate amino acid precursors of biogenic amines, such as serotonin and catecholamines. (medscape.com)
However, carcinoid tumor cells are distinguished from most other types of tumors in that they secrete various hormone-like substances (e.g., serotonin, noradrenalin, histamines) which may cause symptoms throughout the body rather than symptoms localized to the organ where the tumor originates. (medifocus.com)
Carcinoid syndrome describes a combination of symptoms that result from hormones or hormone-like substances, (e.g., serotonin, gastrin, ACTH) that are produced by some carcinoid tumors. (medifocus.com)
Carcinoid tumors are neuroendocrine origin neoplasm and may produce serotonin or other functional peptide hormones. (biomedcentral.com)
The name was chosen to separate these tumors from ordinary malignancies (carcinomas), but by the 1950s, the fact that carcinoids could be malignant was obvious, thanks to Erspamer and Asero (1952), who identified serotonin production by carcinoid tumors. (medscape.com)
The pathophysiology of CHD is related to vasoactive substances secreted by the tumor, of which serotonin is most prominent in the pathophysiology of CHD. (karger.com)
Xermelo mainly targets the overproduction of serotonin hormone inside mNET cells and reduces the frequency of carcinoid syndrome diarrhea. (openpr.com)
Carcinoid syndrome, a condition of increased secretion of serotonin and other catecholamines by carcinoid tumors, may also result in pellagra due to increased utilization of dietary tryptophan for serotonin rather than niacin synthesis. (healthjade.net)

Shortly thereafter, in 1954, Thorson and colleagues were the first to report an association between carcinoid tumors and the carcinoid syndrome symptoms (ie, flushing, diarrhea, bronchoconstriction, and cardiac disease). (medscape.com)
Invasive tumors can produce compression effects such as superior vena cava syndrome. (wikipedia.org)
Over the years it became clear that carcinoid tumors can be quite aggressive, can metastasize, and can cause carcinoid syndrome . (medifocus.com)
Symptoms are often associated with the site of tumor origin and reflect the tumor obstructing organs involved in normal body function but may be less specific if related to carcinoid syndrome. (medifocus.com)
Findings range from no tumor-related symptoms (most carcinoid tumors) to full symptoms of carcinoid syndrome (primarily in adults). (medscape.com)
Multiple endocrine neoplasia, type 1 (MEN 1) is an autosomal dominant syndrome characterized by hyperplasia or adenomas of the parathyroid glands, pancreatic islet cell tumors (also known as pancreatic neuroendocrine tumors), and/or pituitary gland tumors. (msdmanuals.com)
Malignant carcinoid syndrome occurs in fewer than 10% of patients with a carcinoid tumor. (medscape.com)
Carcinoids do not produce the malignant carcinoid syndrome until they are no longer confined to the small bowel or mesentery, perhaps because the liver breaks down the secretory products of tumors restricted to those locations. (medscape.com)
If a patient is thought to have carcinoid syndrome, blood and urine tests must be performed to determine levels of bioactive substances secreted by carcinoid tumors. (medscape.com)
The presence of two or more of MEN1 associated tumors is diagnostic of the syndrome. (endocrine-abstracts.org)
Most patients are asymptomatic and according to the disease extension they may present with cough, dyspnea, chest pain, and superior cava vein syndrome. (cmp.org.pe)
Up to 25% of these tumors arise in the setting of MEN type I as well as Cushing's syndrome. (surgpath4u.com)
Carcinoid syndrome develops in about 50% of the population with neuroendocrine tumors ( 1 ). (snmjournals.org)
Carcinoid heart disease manifests in many patients with carcinoid syndrome ( 2 ), but the prevalence dropped to approximately 20% after the introduction of newer therapies such as somatostatin analogs and 177 Lu-DOTATATE, along with everolimus, sunitinib, and the combination of capecitabine and temozolomide ( 3 ). (snmjournals.org)
The patient was thus considered for PRRT as a potential way to control the functioning carcinoid syndrome. (snmjournals.org)
Treatment focuses on control of the underlying carcinoid syndrome, targeting subsequent valvular heart disease and managing consequent heart failure. (karger.com)
According to the National Organization for Rare Disorders (NORD), 2017, each year, only 27 individuals per million population are estimated to be diagnosed with carcinoid tumors in the U.S., amongst whom, only 10% individuals develop carcinoid syndrome. (openpr.com)
Increasing prevalence of the disease is in turn, increasing demand for carcinoid syndrome diarrhea treatment devices. (openpr.com)
This in turn is expected to fuel growth of the carcinoid syndrome diarrhea treatment market. (openpr.com)
Carcinoid syndrome is caused by secretion of certain harmful chemicals by carcinoid tumors. (openpr.com)
Carcinoid syndrome may occur due to infection or other related diseases, and medical or surgical treatments such as anesthesia, chemotherapy, embolization, and tumor debulking. (openpr.com)
Carcinoid syndrome being a rare condition, there are very few if any treatment options available. (openpr.com)
In February 2017, Lexicon Pharmaceutical Inc., announced that the U.S. Food and Drug Administration (FDA) approved Xermelo (Telotristat etiprate) as the first and only orally administered therapy for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog therapy (SSA) for adults. (openpr.com)
Furthermore, in 2017, Ipsen Biopharmaceutical, announced the U.S. Food and Drug Administration (FDA) approval for a supplemental indication of Somatuline Depot (lanreotide) Injection 120 mg for the treatment of carcinoid syndrome, to reduce the frequency of short-acting somatostatin analogue rescue therapy. (openpr.com)
Development of first-of-its-kind therapeutic approach to treat carcinoid syndrome diarrhea creates highly lucrative growth opportunities for market players. (openpr.com)
However, low awareness and certain side effects associated with this therapy are expected to hinder growth of the carcinoid syndrome diarrhea treatment market. (openpr.com)

Duodenal gastrinomas, carcinoid tumors of the foregut, benign adrenal adenomas, and lipomas also occur. (msdmanuals.com)
MEN1 also includes a predisposition to gastrinomas in the duodenum, bronchopulmonary and thymic neuroendocrine tumors, gastric carcinoids, adrenal adenomas (occasionally carcinomas), angiofibromas, lipomas, and other tumors ( table 2 and figure 1 ). (medilib.ir)

Masses in the anterior portion of the mediastinum can include thymoma, lymphoma, pheochromocytoma, germ cell tumors including teratoma, thyroid tissue, and parathyroid lesions. (wikipedia.org)
Ovarian teratoma is a benign or malignant tumor belonging to a group of germ cell tumors . (cancerwall.com)

Signs and symptoms of carcinoid tumors vary greatly and depend on the tumor location and size as well as on the presence of metastases. (medscape.com)
Central nervous system involvement is rare and has been reported either as metastases to the brain and spine or primary tumors involving the sacrococcygeal spine. (biomedcentral.com)
and asthma attacks-caused by vasoactive hormones secreted by metastases from carcinoid tumors. (medscape.com)
Imaging studies also must be performed to detect the sites of either primary tumors or metastases. (medscape.com)

The most common symptom associated with carcinoid tumors is vague abdominal pain, with diagnosis occurring either incidentally or late in the course of disease, when the lesion may manifest as a complication of mechanical effects or as a result of significant hormone production. (medscape.com)
The age at diagnosis varies somewhat among specific tumor locations but typically, most people diagnosed with a carcinoid tumor are in their 50s. (medifocus.com)
Due to their vague and intermittent symptoms, diagnosis of carcinoid tumors may be delayed, especially in children, in whom the tumor is rare and the diagnosis is unexpected. (medscape.com)
Laboratory diagnosis of carcinoid tumors depends on the identification of the characteristic biomarkers of the disease. (medscape.com)
Primary cervical carcinoid tumor is extremely rare, but should be included in the differential diagnosis of enhancing expansile extradural masses compressing the spinal cord and nerves. (biomedcentral.com)
Challenges in Diagnosing Biliary Stricture Diagnosis and staging of biliary tumors is difficult despite advances in imaging modalities. (medscape.com)
See "Multiple endocrine neoplasia type 1: Clinical manifestations and diagnosis", section on 'Monitoring for MEN1-associated tumors' and "Multiple endocrine neoplasia type 1: Management" . (medilib.ir)
If such an MEN1 variant cannot be identified, the definition of MEN1 allows the diagnosis to be made clinically: as the occurrence of two or more primary MEN1 tumor types (parathyroid, enteropancreatic endocrine, and pituitary tumors), or in family members of a patient with a clinical diagnosis of MEN1, the occurrence of one of the MEN1-associated tumors. (medilib.ir)
It is asymptomatic with a benign course and occurs most often in young adults, with a median age at diagnosis in the 3rd or 4th decade(3).HHV-8-associated Castleman disease is more aggressive, occurs predominantly in immunosuppressed / human immunodeficiency virus (HIV)-positive patients and manifests commonly with generalized lymphadenopathy, constitutional symptoms, and hematologic and/or immunologic abnormalities. (iriakerala.org)
The diagnosis is often made based on clinical signs and symptoms of acute appendicitis or coincidentally via imaging methods when it is asymptomatic. (acquaintpublications.com)
The current TNM staging system is used for non-small cell lung cancer (NSCLC) and more recently neuroendocrine tumors including small cell lung cancer (SCLC), and provides a framework for the assessment of prognosis and the assignment of therapy for patients with a new diagnosis of lung cancer using the histopathologic evaluation of the primary tumor (T), lymph nodes (N), and metastatic disease (M). (sts.org)

low mitotic rate TYPES ▪ Embryonic origin of GI tract (e.g. foregut, midgut, hindgut) Foregut tumors (e.g. stomach) ▪ Type I ▫ Most common ▫ Originates from enterochromafﬁn-like (ECL) cells ▫ In association with high gastrin levels secondary to chronic atrophic gastritis ▫ Small, usually benign ▪ Type II ▫ Originates from ECL cells ▫ In association with high gastrin levels induced by gastrinomas (e.g. (osmosis.org)

Neuroendocrine tumor of the rectum is a rare epithelial tumor of rectum arising from enterochromaffin cells, most often in the mid-rectum. (orpha.net)
In 1914, Gosset and Masson demonstrated that carcinoid tumors might arise from enterochromaffin cells (Kulchitsky cell) within glands of Lieberkühn using silver impregnation techniques. (medscape.com)

Загальні відомості про ендокринні пухлини підшлункової залози Pancreatic endocrine tumors arise from islet and gastrin-producing cells and often produce many hormones. (msdmanuals.com)

Duodenal carcinoid tumor in a 77 year old man: Oblique CT images show. (myesr.org)
A lack of treatment guidelines for duodenal carcinoids, owing to inconsistent data, makes managing these cases challenging. (medscape.com)

Therapy in stage I tumors consists of surgical resection with good prognosis. (wikipedia.org)
The prognosis (outlook or chance of recovery) for patients with carcinoid tumors is based primarily on size of the tumor and the degree to which it has spread and invaded other tissues in the body. (medifocus.com)
Therapeutic options in patients with progressive and disseminated metastatic neuroendocrine gastroenteropancreatic (GEP) tumors are often limited, and prognosis is often poor ( 1 , 2 ). (snmjournals.org)

It is probable that more people may actually have carcinoid tumors but because carcinoids are often asymptomatic, an individual may never know that a carcinoid has developed. (medifocus.com)

Patients are usually asymptomatic but can present with myasthenia gravis-related symptoms, substernal pain, dyspnea, or cough. (wikipedia.org)
Particularly noteworthy was a remarkable improvement in the symptomatic scale, with the patient being asymptomatic for dyspnea at that point (from New York Heart Association grade III at baseline to grade I after 6 cycles) and with a substantial reduction of urinary 5-hydroxyindole acetic acid (5-HIAA) to nearly one sixth the baseline level. (snmjournals.org)
Extrinsic bronchial compression by a large central tumor or malignant mediastinal adenopathy can cause dyspnea, which is common with patients with small cell lung cancer (SCLC). (sts.org)
As with dyspnea, obstruction or compression of the bronchus by the tumor itself or by enlarged lymph nodes can cause wheezing if peripheral bronchi are affected or stridor if the trachea or main bronchi are involved. (sts.org)

New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma. (wjgnet.com)
In 1907, Oberndorfer[ 1 ] first introduced the term "carcinoid" to describe "little carcinomas" of the small intestine which were thought (by him at that time) to be probably benign. (wjgnet.com)
Some authors prefer carcinoid , atypical carcinoid, small cell and large cell neuroendocrine carcinomas whereas others prefer well, moderately and poorly differentiated neuroendocrine carcinoma. (surgpath4u.com)
Moran CA, Suster S. Neuroendocrine carcinomas (carcinoid tumor) of the thymus. (surgpath4u.com)

Typically, 90% of carcinoid tumors originate from the distal ileum or appendix (the embryologic midgut. (medscape.com)

This is especially true for carcinoids, even because there is a small core of well differentiated NENs with a relatively high proliferative index showing the ability to metastasize as poorly differentiated forms [ 5 ]. (springeropen.com)
Solid, poorly differentiated tumors. (cancerwall.com)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)

Hindgut Carcinoid Tumors - These tumors originate in the large intestines, specifically in the transverse colon, descending colon, and rectum. (medifocus.com)
however, tumors can originate from any cell of the amine precursor uptake and decarboxylation system and, therefore, produce several intestinal hormones. (medscape.com)

If feasible, the treatment of choice for carcinoid tumors is surgical excision. (medscape.com)
The surgical technique may vary according to the type or location of the tumor. (medscape.com)
Complete surgical removal of all tumor tissues, when feasible, is the best treatment. (medscape.com)

The present case is a 39-year-old man diagnosed with an asymptomatic gastric submucosal tumor. (bvsalud.org)

The atypical carcinoid (AC) of thymus is the most aggressive and uncommon neoplasm in the anterior mediastinum, that belongs to the neuroendocrine primary tumors of thymus. (cmp.org.pe)
Typical carcinoids have a mitotic count of less than 2 MF per 10 HPF whereas atypical carcinoid have between 2-10 MF per 10 HPF (Fletcher). (surgpath4u.com)

A section (on the right) of an intestinal carcinoid mass arising from the mucosa (150 X). Image courtesy of Professor Pantaleo Bufo, University of Foggia, Italy. (medscape.com)

Later in the course, the tumor may present with rectal bleeding, abdominal or rectal pain, tenesmus, changes in bowel habits, or weight loss. (orpha.net)

The optimal management of patients with carcinoid tumors involves a multidisciplinary team of health care providers including an oncologist, gastroenterologist, surgeon, radiologist and nuclear medicine specialist. (medifocus.com)
PHCT should be one of the differential diagnoses in patients with small hepatic tumor, even in regions with high prevalence of HBV infection and HCC. (biomedcentral.com)
The majority of patients diagnosed with carcinoid tumors have no symptoms, and their tumors are found incidentally during endoscopy. (jomi.com)
This type of tumor affects younger patients (until the age of 20 years). (cancerwall.com)
Therapeutic options in patients with advanced-stage gastroenteropancreatic (GEP) neuroendocrine tumors are limited. (snmjournals.org)
The intent was to treat all patients because of uncontrolled tumor disease ( n = 21), contraindication to chemotherapy or surgery ( n = 7), or uncontrolled and badly tolerated clinical symptoms ( n = 4). (snmjournals.org)
Because 111 In emits short-range electrons that can have significant biologic effects at a cellular level ( 17 - 19 ), radionuclide therapy with a high activity of 111 In-pentetreotide has been used in a few patients with GEP tumors ( 5 , 20 - 30 ). (snmjournals.org)
We report the results of radionuclide therapy with either 111 In-pentetreotide or 131 I-MIBG in a population of patients with advanced-stage GEP tumors. (snmjournals.org)
Considering the significantly shortened overall survival of patients with carcinoid heart disease, the relative paucity of available treatment options, and the risk of complications during corrective surgery on poorly controlled functioning disease, 177 Lu-DOTATATE can emerge as a potent option in this group of patients. (snmjournals.org)
When Brunner Glands Are Not So Innocent Two cases of Brunner gland tumors are reported in which both patients present with melena and anemia, but one case is benign and the other is malignant. (medscape.com)
Multiple parathyroid tumors causing primary hyperparathyroidism are the most common component of MEN1, occurring in the large majority of patients by age 50 years, and is the initial manifestation of the disorder in most patients. (medilib.ir)
Most patients are asymptomatic or minimally symptomatic, and hypercalcemia is detected by biochemical screening. (medilib.ir)
Patients developed symptoms after a median of 16 days (range 2-120 days) and were asymptomatic after 68 days (mean, range 27-93 years). (medscape.com)
Perhaps with lung cancer screening strategies, more asymptomatic patients with lung cancer will be detected in the future. (sts.org)

Although these tumors develop most often in the pancreas, they may appear in other organs. (msdmanuals.com)
It is characterized by tumors envolving the parathyroid glands, the endocrine pancreas and the pituitary. (endocrine-abstracts.org)
Tumors or cancer of the PANCREAS. (lookformedical.com)

The tumors are slow growing, in early stages majority are asymptomatic and are diagnosed incidentally. (orpha.net)
This patient underwent a laparoscopic right colectomy with ileocolic anastomosis as a curative procedure that removed both an unresectable polyp that was found in his ascending colon as well as a carcinoid tumor that was incidentally found at his ileocecal valve. (jomi.com)
Incidentally, on further work-up, the patient was found to have a carcinoid tumor at the ileocecal valve. (jomi.com)

However, the tumor biopsy revealed a malignant neoplasm that originating from neuroendocrine cells. (biomedcentral.com)

1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)

Disease association - MEN1 is characterized by predisposition to tumors of the parathyroid glands, anterior pituitary, and pancreatic islet cells. (medilib.ir)

Thus, the term "carcinoid" was replaced by the term "gastroenteropancreatic neuroendocrine tumors, GEP-NETs"[ 2 ]. (wjgnet.com)
In 1980, the World Health Organization (WHO) applied the term carcinoid to all tumors of the diffuse endocrine system (synonymous with amine precursor uptake and decarboxylation [APUD] and neuroendocrine cell system). (medscape.com)

The tumor does not respond well to chemotherapy or radiation, thus, 5 year survival is about 30-60% (Fletcher). (surgpath4u.com)
To overcome the carcinoid crisis, treatment options may considered such as surgery, chemotherapy, targeted radionuclide therapy, radiofrequency ablation, and chemoembolization on the basis of patient-by-patient. (openpr.com)

The World Health Organization (WHO) and the European Neuroendocrine Tumor Society (ENETS) both incorporate mitotic count and Ki-67 proliferation for the classification of gastroenteropancreatic NETs (GEP-NETs). (medscape.com)
The first group includes typical carcinoids (TCs) and atypical carcinoids (ACs), characterized by a low mitotic count with absence of necrosis. (springeropen.com)

There are many types of tumors that arise from the neuroendocrine system of which carcinoid tumors are the most common. (medifocus.com)
Carcinoid tumors arise from neuroendocrine cells, which are widespread in the human body, especially in the organs derived from the primitive intestine. (medscape.com)

Mature cystic teratoma is usually asymptomatic. (cancerwall.com)

Based on the imaging features, differential diagnostic possibilities of lymph nodal mass/paraganglioma / hemangiopericytoma / solitary fibrous tumor were considered. (iriakerala.org)

In some cases it may present with carcinoid symptoms of flushing and increased gut motility. (orpha.net)

We report the gratifying response of functioning metastatic neuroendocrine tumor with carcinoid heart disease (uncontrolled by long-acting octreotide) to treatment with 177 Lu-DOTATATE. (snmjournals.org)

Primary hepatic carcinoid tumor (PHCT) is very rare and difficult to diagnose before biopsy or operation. (biomedcentral.com)
When a tumour is localised, a tissue biopsy is performed to determine the presence of cancer cells, staging the cancer, and guide the patient's treatment. (theranostics.sg)

Carcinoid tumors have high potential for metastasis. (medscape.com)
A section of a rare lymph node metastasis from adenocarcinoid tumor (250 X). Image courtesy of Professor Pantaleo Bufo, University of Foggia, Italy. (medscape.com)
Encapsulated tumors can be excised, although in many cases, the tumor is invasive with local metastasis to the lymph nodes. (surgpath4u.com)

however, tumors in these locations frequently metastasize and spread through the mesenteric lymph nodes (see image below) and portal vein. (medscape.com)
Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions and must be differentiated from primary lesions. (allenpress.com)
Direct invasion of chest wall or mediastinal structures by either the tumor or enlarged lymph nodes may lead to diagnostic symptoms. (sts.org)

Overall, clinical manifestations will vary depending on the primary tumor location, particularly with respect to the non-hormonal manifestations (see Presentation ). (medscape.com)
most commonly, however, the primary tumor is in the small bowel. (medscape.com)
Most common primary anterior mediastinal tumor (20%) in adults but rarely seen in children. (wikipedia.org)
We report the first case of a primary carcinoid tumor of the cervical spine. (biomedcentral.com)
We report the first case, to the best of our knowledge, of a primary carcinoid tumor in the cervical spine. (biomedcentral.com)
These lesions are accessible through endoscopic/endobronchial ultrasound-guided or computed tomography-guided fine-needle aspiration cytology and represent a wide range of primary and metastatic tumors. (allenpress.com)

There was no tumor embolus in the vessels and the resection line was free from tumor invasion. (biomedcentral.com)
A C7 corpectomy, en bloc resection of the tumor, and anterior C6-T1 fusion were performed to decompress the spinal cord and nerves and provide stability. (biomedcentral.com)
Considering the malignancy of the tumor, we selected non-exposed endoscopic wall-inversion surgery as the resection method and successfully performed local resection. (bvsalud.org)
Carcinoid tumors larger than 2 cm require formal oncologic resection. (jomi.com)
In this case, the patient required surgery because the mass in his ascending colon was too large to be resected by endoscopic means, and carcinoid tumors of the ileocecal valve are also not suitable for endoscopic resection. (jomi.com)
The elective cases included one bariatric surgery for morbid obesity, one hiatal hernia repair, two cholecystectomies, and one small bowel resection for a carcinoid tumor. (ima.org.il)

Carcinoid tumors of the thymus are rare. (surgpath4u.com)

We undertook a more thorough investigation to rule out the possibility that the liver tumor was a metastatic carcinoid. (biomedcentral.com)
The resected liver tissue contained a 1.6 × 1.6 × 1.5 cm circumscribed tumor (Fig. 3 ). (biomedcentral.com)
Most of these tumors produce 5-hydroxytryptamine, which, in physiologic conditions, is taken up and stored in the platelets while the excesses are inactivated in the liver and lung and transformed into 5-hydroxyindoleacetic acid (5-HIAA). (medscape.com)
A 30-y-old man who had been diagnosed with a grade II jejunal neuroendocrine tumor metastatic to the liver and abdomen was found clinically and on 2-dimensional (2D) echocardiography to have the complication of carcinoid heart disease. (snmjournals.org)
Tumors or cancer of the LIVER. (lookformedical.com)
Experimentally induced tumors of the LIVER. (lookformedical.com)

How Do You Treat a Carcinoid in the Duodenum? (medscape.com)

[ 9 ] ) Carcinoid tumors represent 90% of appendiceal tumors. (medscape.com)
Saad B, Abdelhamid B, Moulay El Mehdi TH, Abdellah B, Kouach J (2020) Appendiceal Mucocele Simulating an Ovarian Tumor. (acquaintpublications.com)

[ 4 ] but Oberndorfer called a group of small, benign-appearing tumors karzinoide tumoren (carcinoid) for the first time in 1907. (medscape.com)

Carcinoids follow a more benign clinical course than most other malignancies. (medscape.com)
[ 6 ] In its 2015 consensus statement on best practices for pulmonary neuroendocrine tumors, the ENETS noted that tumor grading based on a combination of KI-67, mitotic rate, and necrosis may be of clinical importance but lacks validation. (medscape.com)
Most carcinoid tumors are now known to be slow growing malignant tumors that have their own specific biological and clinical characteristics. (medifocus.com)
According to the American Society of Clinical Oncology (ASCO), approximately 11,500 people in the United States are diagnosed each year with a carcinoid tumor. (medifocus.com)
Pejorative events were defined as side effects due to therapy, relapse in clinical symptoms, tumor progression, tumor laboratory marker increase, and death. (snmjournals.org)
For instance, in 2009, a study by Journal of Clinical Oncology, showed 4 to 5 out of every 100,000 people are diagnosed with a neuroendocrine tumor and over 100,000 people suffering from neuroendocrine tumor in the U.S., also most individual suffering from carcinoid are asymptomatic until the tumor is fully developed. (openpr.com)

A mediastinal tumor is a tumor in the mediastinum, the cavity that separates the lungs from the rest of the chest. (wikipedia.org)
The most common mediastinal masses are neurogenic tumors (20% of mediastinal tumors), usually found in the posterior mediastinum, followed by thymoma (15-20%) located in the anterior mediastinum. (wikipedia.org)
Many signs and symptoms of a mediastinal tumor do not distinguish between these two principal classes of mediastinal tumor. (wikipedia.org)
Mediastinal tumors/lesions are frequently encountered in daily cytopathology practice. (allenpress.com)
To provide an updated review on the fine-needle aspiration cytology of mediastinal tumors/lesions, with an emphasis on diagnostic challenges. (allenpress.com)
Data were gathered from a PubMed search of peer-reviewed literature on mediastinal tumors. (allenpress.com)

Carcinoid tumors were initially identified in 1888 and were thought to clinically and histologically (cellular appearance under a microscope) resemble carcinoma cells (highly malignant cancer cells) but behave in a more benign fashion than true cancer cells. (medifocus.com)

Anatomy6

Organisms1

Diseases37

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Disciplines and Occupations1

Health Care2

Neoplasms8

Gastrointestinal10

Serotonin11

Syndrome26

Adrenal adenomas2

Germ cell t2

Metastases4

Diagnosis11

Foregut1

Enterochromaffin cells2

Endocrine tumors1

Duodenal2

Prognosis3

Often asymptomatic1

Dyspnea4

Carcinomas4

Midgut1

Poorly differentiated3

Originate2

Surgical3

Gastric1

Atypical carcinoid2

Intestinal carcinoid1

Abdominal1

Patients14

Pancreas3

Incidentally3

Originating from neuroendocrine1

Thymic tumors1

Parathyroid1

Term carcinoid2

Chemotherapy2

Mitotic count2

Arise2

Usually asymptomatic1

Solitary fibrous tumor1

Present with carcinoid1

Metastatic neuroendocrine1

Biopsy2

Metastasis3

Lymph nodes3

Primary6

Resection6

Thymus1

Liver6

Duodenum1

Appendiceal2

Oberndorfer1

Clinical6

Mediastinal6

Carcinoma1