- They are also known as olfactory Schwann cells, because they ensheath the non-myelinated axons of olfactory neurons in a similar way to which Schwann cells ensheath non-myelinated peripheral neurons. (wikipedia.org)
- Olfactory glia that express the antimicrobial enzyme lysozyme (LYZ) are thought to play an important role in immunoprotection in the mucosa, where neurons are directly exposed to the external environment. (wikipedia.org)
- During development, primitive olfactory neurons extend their axons from the olfactory placode, through the mesenchyme, towards the telencephalic vesicle. (wikipedia.org)
- The mammalian olfactory system is unusual in that it has the ability to continuously regenerate its neurons during adulthood. (wikipedia.org)
- New olfactory receptor neurons must project their axons through the central nervous system to an olfactory bulb in order to be functional. (wikipedia.org)
- Olfactory receptor neurons have an average lifespan of 6-8 weeks and therefore must be replaced by cells differentiated from the stem cells that are within a layer at the nearby epithelium's base. (wikipedia.org)
- OECs are thought to be in part responsible for the neurogenesis of primary olfactory neurons through the processes of fasciculation, cell sorting, and axonal targeting. (wikipedia.org)
- The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS. (lookformedical.com)
- A ubiquitous, cytoplasmic protein found in mature OLFACTORY RECEPTOR NEURONS of all VERTEBRATES. (lookformedical.com)
- Proteins, usually projecting from the cilia of olfactory receptor neurons, that specifically bind odorant molecules and trigger responses in the neurons. (lookformedical.com)
- In many turtle species, the UCE contains ciliated olfactory receptor cells (ORCs) and the LCE contains microvillous ORCs. (bvsalud.org)
- Olfactory ensheathing cells (OECs), also known as olfactory ensheathing glia or olfactory ensheathing glial cells, are a type of macroglia (radial glia) found in the nervous system. (wikipedia.org)
- Studies dating back to the 1990s have begun researching the olfactory system of mammals, rats in particular, to gain a greater understanding of axonal regeneration and neurogenesis, and the possible implementation of these cells at the site of the spinal cord injury. (wikipedia.org)
- These results imply that the roles of the transcription factors Fezf1, Fezf2, and Bcl11b in olfactory organ development are conserved among mammals and turtles. (bvsalud.org)
- OECs are distinct from other glia in their developmental origin for they are present in the peripheral nervous system as well as the central nervous system. (wikipedia.org)
- OECs are also known to support and guide olfactory axons, grow through glial scars, and secrete many neurotrophic factors. (wikipedia.org)
- The growth and regeneration of olfactory axons can be attributable to OECs, as they form the fascicles through which axons grow from the peripheral nervous system into the central nervous system. (wikipedia.org)
- Within the olfactory system they phagocytose axonal debris and dead cells. (wikipedia.org)
- In this study, we examined the expression of Fezf1, Fezf2, and Bcl11b in the olfactory organs of embryos in three turtle species, Pelodiscus sinensis, Trachemys scripta elegans, and Centrochelys sulcata, to evaluate their involvement in the development of reptile olfactory organs. (bvsalud.org)
- This ability is associated with olfactory ensheathing glia. (wikipedia.org)
- OECs and astrocytes interact with each other to form a new glia limitans. (wikipedia.org)
- Genetic expression profile of olfactory ensheathing cells is distinct from that of Schwann cells and astrocytes. (ox.ac.uk)
- In this study, we compared the transcriptional profile of cultured OECs with that of Schwann cells (SCs) and astrocytes (ACs), two glial cell types to which OECs have similarities. (ox.ac.uk)
- Olfactory ensheathing cells (OECs), also known as olfactory ensheathing glia or olfactory ensheathing glial cells, are a type of macroglia (radial glia) found in the nervous system. (wikipedia.org)
- OECs are also known to support and guide olfactory axons, grow through glial scars, and secrete many neurotrophic factors. (wikipedia.org)
- OECs express glial markers such as glial fibrillary acidic protein, s100, and p75, and radial glial markers such as nestin and vimentin, which may further assist researchers with understanding the labeling characteristics of these specialized glia. (wikipedia.org)
- OECs have been tested successfully in experimental axonal regeneration in adult rats with traumatic spinal cord damage, and clinical trials are currently being conducted to obtain more information on spinal cord injuries and other neurodegenerative diseases. (wikipedia.org)
- Studies dating back to the 1990s have begun researching the olfactory system of mammals, rats in particular, to gain a greater understanding of axonal regeneration and neurogenesis, and the possible implementation of these cells at the site of the spinal cord injury. (wikipedia.org)
- In the peripheral nervous system OECs are dispersed within the olfactory epithelium and the olfactory nerve. (wikipedia.org)
- Multiple studies have shown that OECs may assist in treating spinal cord injury (SCI) due to their regenerate properties in the peripheral nervous system and their presence in the central nervous system. (wikipedia.org)
- The growth and regeneration of olfactory axons can be attributable to OECs, as they form the fascicles through which axons grow from the peripheral nervous system into the central nervous system. (wikipedia.org)
- OECs have shown widely varying efficacy in repairing the injured nervous system. (ox.ac.uk)