• Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
  • Immunogenicity of AAV vectors in humans has been linked to several limitations of the platform, including lack of efficacy due to antibody-mediated neutralization, tissue inflammation, loss of transgene expression, and in some cases, complement activation and acute toxicities. (bvsalud.org)
  • 11. Tumor-specific up-regulation of the nonclassical class I HLA-G antigen expression in renal carcinoma. (nih.gov)
  • 14. Expression of the non-classical HLA-G antigen in tumor cell lines is extremely restricted. (nih.gov)
  • Tumor antigens and danger-associated molecular patterns are also released during the lysis process which helps recruit host immune cells. (wikipedia.org)
  • The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. (thermofisher.com)
  • 6. Ocular surface epithelial cells up-regulate HLA-G when expanded in vitro on amniotic membrane substrates. (nih.gov)
  • One example of this is the targeting of CD46 on multiple myeloma cells by measles virus. (wikipedia.org)
  • Bypassing these host interactions results in increased Ad circulation times and allows for specific vector targeting to the desired cells or tissues. (medscape.com)
  • The PBMCs were reactivated with SARS-CoV-2 antigens and the production of activation-induced markers (TNF-α, IFN-γ, CD40L) was measured in CD4+ or CD8+ T-cells ex vivo. (bvsalud.org)
  • Hence, Piezo2 containing mechanosensory corneal nerves and dendritic Langerhans cells could also be regarded as central players in shaping the ocular surface neuroimmune homeostasis through the Piezo system. (bvsalud.org)
  • Genetic manipulation of capsid proteins, designed to bypass host interactions and improve target tissue infectivity, is a frequently used targeting approach for Ad5. (medscape.com)