• EMERYVILLE, Calif. & UBE, Japan--(BUSINESS WIRE) September 26, 2022 --Santen Inc., the U.S. subsidiary of Santen Pharmaceutical Co., Ltd. (Santen), and UBE Corporation (UBE) today announced that the U.S. Food and Drug Administration (FDA) has approved Omlonti (omidenepag isopropyl ophthalmic solution) 0.002% eye drops for the reduction of elevated intraocular pressure (IOP) in patients with primary open-angle glaucoma or ocular hypertension. (cliniexpert.com)
  • Omlonti was evaluated in three randomized and controlled clinical trials in subjects with open-angle glaucoma or ocular hypertension with average baseline IOP of 24-26 mm Hg. (cliniexpert.com)
  • Omlonti (omidenepag isopropyl ophthalmic solution) 0.002%, is a relatively selective prostaglandin E2 (EP2) receptor agonist, indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. (cliniexpert.com)
  • The program includes two separate randomized, multicentre, double-masked, parallel-group clinical studies, APOLLO and LUNAR, designed to compare the efficacy and safety of latanoprostene bunod administered once daily (QD) with timolol maleate 0.5% administered twice daily (BID) in lowering IOP in patients with open-angle glaucoma or ocular hypertension. (nicox.com)
  • Aerie Pharmaceuticals Inc (Aerie) is a pharmaceutical company that discovers, develops and commercializes therapies for the treatment of patients with open-angle glaucoma, ocular surface diseases and retinal diseases. (researchandmarkets.com)
  • The Case for Stand-alone MIGS Gets Stronger New data show meaningful reductions in IOP and medications in pseudophakic patients with open-angle-glaucoma. (medscape.com)
  • This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. (hindawi.com)
  • Transient vision loss may be related to local ocular conditions, such as ocular surface disorders (eg, dry eyes), intraocular foreign bodies or masses, central or branch retinal vein occlusion, central or branch retinal artery occlusion, arteritic anterior ischemic optic neuropathy, intermittent angle closure glaucoma, hyphema, and optic neuritis. (medscape.com)
  • Supporting patients by protecting vision across the continuum of clinical care in glaucoma is a significant aim for Santen to reduce the social and economic opportunity loss of people around the world caused by eye conditions," explains Peter Sallstig, Chief Medical Officer of Santen. (cliniexpert.com)
  • It also represents our first glaucoma offering in the U.S. We are pleased to provide doctors and patients in the U.S. with a new option to help control IOP for the more than three million Americans affected by glaucoma1 or ocular hypertension. (cliniexpert.com)
  • We have high expectations that omidenepag isopropyl will provide a new treatment option for more patients suffering from glaucoma and ocular hypertension through Santen. (cliniexpert.com)
  • Treatments that focus on IOP reduction help to slow or prevent further loss of vision for those with glaucoma or ocular hypertension. (cliniexpert.com)
  • Latanoprostene bunod, a nitric oxide-donating prostaglandin F2 alpha analog licensed by Nicox to Bausch + Lomb, is being developed for the reduction of intraocular pressure (IOP) in patients with glaucoma or ocular hypertension. (nicox.com)
  • Glaucoma is a group of eye diseases which can lead to the loss of peripheral vision and eventually total blindness. (nicox.com)
  • Ironically, these children are often under careful observation by ophthalmologists who may opt to tolerate low-grade ocular inflammation, hoping to avoid the development of corticosteroid-induced ocular adverse effects such as cataracts and glaucoma. (uveitis.org)
  • She provides a large variety of medical eye care services including low vision care, glaucoma management, anterior segment diseases, posterior segment diseases, contact lens fittings, and primary care optometry. (opmt.com)
  • After her schooling, she went through several clinical rotations, including two Veteran's Affairs outpatient clinics, where she treated ocular diseases such as glaucoma, diabetic retinopathy, macular degeneration, and more. (opmt.com)
  • Any history of penetrating ocular trauma or surgery, positive treponemal syphilis serology, or evidence of sarcoidosis needs to be excluded prior to making diagnosis of VKH. (medscape.com)
  • Ocular diseases are not only relevant social, sanitary and economic issues, but also a growing market opportunity in an increasingly ageing population. (europa.eu)
  • The present project is aimed to the clinical validation and market introduction of a device previously developed for ocular surface diseases (OSDs), named Tear Monitor and focused on diagnosis and monitoring of the Dry Eye and inflammation by measuring biomarkers in tears. (europa.eu)
  • In 2008, the National Defense Authorization Act authorized the Secretary of Defense to "establish a Center of Excellence to address the full scope of vision care including prevention, diagnosis, mitigation, treatment, research and rehabilitation of military eye injuries and diseases. (health.mil)
  • That year, the Vision Center of Excellence was established to address the full scope of vision care, including prevention, diagnosis, mitigation, treatment, research, and rehabilitation of military eye injuries and diseases including visual dysfunctions related to traumatic brain injury. (health.mil)
  • Preschool vision screening could allow detection and treatment of vision abnormalities during a critical developmental stage, preserving function and quality of life. (uspreventiveservicestaskforce.org)
  • [2] In addition, up to 45% of astronauts flying missions greater than 30 days demonstrate ocular abnormalities through fundus examination and orbital and brain imaging [7] with or without the presence of subjective symptoms. (aao.org)
  • Although such a surgical replacement of the natural lens with an artificial lens is significantly effective in restoring vision to most patients, this procedure is not free of complications. (molvis.org)
  • The evolution of contact lenses is also associated with advancements in technology, manufacturing processes, chemical and physical properties, and reduction in microbial contamination and ocular complications. (news-medical.net)
  • However, Candell, Chalom and colleagues recently reported that, in a retrospective study, although the prevalence of uveitis was lower in ANA-negative patients compared with ANA-positive patients, ocular complications were more common in children with uveitis who were ANA negative. (uveitis.org)
  • No statistically significant difference was found between group 1 and group 2 when comparing the change of mean best corrected distance visual acuity (BCVA) between month 12 and inclusion (p = 0.6) and the rate of ocular complications. (bvsalud.org)
  • Postoperative endophthalmitis, although very rare, is one of the most serious, sight-threatening complications of ocular surgery. (medscape.com)
  • Optometry and Vision Science. (wikipedia.org)
  • Published in September's Optometry and Vision Science , a small-scale study of 21 vapers and 21 healthy nonsmokers found moderate-to-severe symptomatic dry eye and poorer tear film quality among the former as opposed to the latter. (aoa.org)
  • This action relieves the redness of the eye caused by minor ocular irritants. (wikipedia.org)
  • Blurred vision (42.4%), headache (23.0%) and redness (23.0%) were the most experienced symptoms. (dovepress.com)
  • About three-fourths of computer-using bank workers suffered from CVS with the most experienced symptoms being blurred vision, headache and redness of eyes. (dovepress.com)
  • Low-dose brimonidine reduced ocular redness in such subjects with efficacy maintained over 1 month and negligible rebound redness. (amplifyeye.care)
  • The aim of this study was to evaluate the safety and efficacy of brimonidine tartrate ophthalmic solution 0.025% for the treatment of ocular redness. (amplifyeye.care)
  • Brimonidine 0.025% appeared safe and effective for reduction of ocular redness, with an 8-hour duration of action, no evidence of tachyphylaxis, and negligible rebound redness. (amplifyeye.care)
  • Ocular symptoms are correlated to systemic disease activity and can present as an initial manifestation of SLE. (bmj.com)
  • 2 Ocular involvement may correlate with systemic disease activity and precede other systemic symptoms stressing the important role the ophthalmologist may play. (bmj.com)
  • Children with transient vision loss are less likely to have an ischemic cause for their symptoms and are more likely to have a benign disorder. (medscape.com)
  • Post-Concussive Syndrome- If you have ever experienced a concussion, there are a number of symptoms that relate to the connection between vision function and These symptoms can include: blurred vision (especially when reading), headaches associated with reading, double vision, eye pain, poor reading comprehension, light sensitivity and frequent loss of place when reading. (opmt.com)
  • Symptoms include conjunctival injection, ocular burning, photophobia, visual disturbances and tend to eb and flow depending on associated factors (ie: seasonal allergies, increased screen time, contact lens) (Shtein, 2021). (npace.org)
  • 1 Similar to other inflammatory maculopathies, some patients suffer from an antecedent febrile illness before the ocular signs and symptoms develop. (aao.org)
  • Spaceflight associated Neuro-Ocular Syndrome (SANS)-formerly called visual impairment and intracranial pressure (VIIP) syndrome [1] -is a constellation of findings and symptoms that have been found in astronauts who have undergone long duration space flight (LDSF) missions in microgravity environments (e.g. (aao.org)
  • It may well be that high computer usage raises the number of dry eye sufferers and/or increases the severity of symptoms, but studies have not produced any direct comparison of groups that would allow us to conclude that computer use bears a long- term causal relation to ocular surface disease. (universityhealthcenter.in)
  • Common symptoms of a retinal detachment include flashes of light, severe loss of vision and/or spots floating in your vision. (shoptometry.com)
  • Symptoms of acute angle closure are severe ocular pain. (msdmanuals.com)
  • Banish Using tobacco from your Picture: Using tobacco is undoubtedly an unrelenting adversary to ocular overall health, igniting numerous eyes problems which includes macular degeneration and cataracts. (newbigblog.com)
  • In 2021, RestoringVision provided 311,483 adults living in poverty with protective sunglasses to safeguard their vision against harmful UV rays and 47,565 children with sunglasses to protect their young eyes. (restoringvision.org)
  • Dry eye disease (DED) is a condition of the ocular surface characterized by tear film instability due to reduction of tear production and/or increased evaporative loss from any dysfunction of the lacrimal functional unit (Shtein, 2021). (npace.org)
  • If treatment failure occurs, adding or switching to higher viscosity gel/ointment preparation can be more effective, but do cause temporary blurry vision (Shtein, 2021). (npace.org)
  • Ocular disorders: BALVERSA can cause central serous retinopathy/retinal pigment epithelial detachment (CSR/RPED). (nih.gov)
  • Ocular manifestations of SLE are common and may lead to permanent blindness from the underlying disease or therapeutic side effects. (bmj.com)
  • This medical device can restore vision in people with specific types of blindness. (news-medical.net)
  • Further reduction in the occurrence of irreversible blindness secondary to uveitis in patients with JIA depends on early diagnosis of iridocyclitis, facilitated by mandatory vision screening programs in day care centers and schools, and on the use of therapeutic algorithms that include methotrexate and other immunomodulators to eradicate intraocular inflammation. (uveitis.org)
  • Our hope is that cooperation among physicians of all specialties caring for patients with JIA will reduce the ocular morbidity and blindness secondary to JIA-associated iridocyclitis. (uveitis.org)
  • In 1999, the global initiative "VISION 2020: the Right to Sight" was established as a partnership between WHO and the International Agency for the Prevention of Blindness with the aim of eliminating avoidable blindness. (who.int)
  • In order to introduce this strategy in countries, the Health Assembly, in resolution WHA56.26, urged Member States to establish national VISION 2020 committees on eye health and prevention of blindness. (who.int)
  • The Secretariat and the regional coordinating offices of the International Agency for the Prevention of Blindness supported Member States in implementing and periodically monitoring and assessing their national and subnational VISION 2020 plans for eye health and prevention of blindness. (who.int)
  • 2020 committee on eye health and prevention of blindness and 104 Member States had reported having a national VISION 2020 plan, as urged in resolutions WHA56.26 and WHA59.25. (who.int)
  • In some patients geographic atrophy, pigmentary changes, and a subfoveal neovascular net develops with macular scarring, vitreous hemorrhage, and severe reduction of vision. (arizona.edu)
  • This severe ocular infection, caused by Gnathostoma spinigerum nematodes, led to vision loss in the patient's left eye. (cdc.gov)
  • Some patients have had ocular examinations during the transient vision loss event that demonstrate the visible vasospasm on clinical exam, fundus photography, or fluorescein angiography. (medscape.com)
  • Patients with JIA-associated uveitis should be promptly referred to colleagues experienced with such therapy before permanent ocular damage develops. (uveitis.org)
  • 1 By restoring vision, and even treating preexisting refractive errors, cataract surgery produces an amazing improvement in the lives of our patients. (crstoday.com)
  • Probable VKH disease: Patients with probable VKH disease include those with isolated ocular disease. (medscape.com)
  • It is the number one cause of vision loss in diabetic patients. (shoptometry.com)
  • At The Eye Shop Optometry, we are committed to helping our patients enjoy exceptional vision throughout their lifetime. (shoptometry.com)
  • At 20/20 Eyecare of London, we are committed to helping our patients enjoy exceptional vision throughout their lifetime. (2020eyecareoflondon.com)
  • RÉSUMÉ Nous avons évalué les causes des déficiences visuelles et de la cécité chez 694 patients diabétiques ayant consulté dans notre centre des soins oculaires à Sanaa (Yémen) entre 2001 et 2005 en examinant leur dossier médical. (who.int)
  • The phase 2b study met its primary efficacy endpoint which was the reduction in mean diurnal intraocular pressure (IOP) on day 28 and showed positive results on a number of secondary endpoints. (nicox.com)
  • Causes of ischemic transient vision loss include giant cell arteritis, cerebrovascular ischemia, and retinal arteriolar emboli. (medscape.com)
  • Ocular trauma or ocular surgery in one eye can lead to loss of vision in the healthy eye. (medscape.com)
  • At this point, the diagnosis was not clear, given her vision of 20/20 and the normal fundus appearance. (aao.org)
  • The early recognition of disease and treatment provides reduction of visual morbidity and mortality. (bmj.com)
  • She had no history of ocular problems or allergic reactions. (cdc.gov)
  • However, vision loss may result from involvement of the retina, choroid and optic nerve. (bmj.com)
  • Vogt-Koyanagi-Harada (VKH) disease is a multisystem autoimmune inflammatory disorder with ocular, auditory, skin, and neurologic involvement. (medscape.com)
  • The vision-robbing consequences of low-grade uveitis occur extremely slowly, typically over a period of 4 to 8 years, and the end result is clear: even low-grade uveitis may lead eventually to ocular damage, including band keratopathy, maculopathy (macular edema, macular cysts, epiretinal membrane), glaucomatous optic neuropathy, and cataract formation from chronic inflammation and corticosteroid therapy. (uveitis.org)
  • Although no RCT data compares efficacy, avoiding preservatives, especially benzalkonium chloride, is recommended to avoid ocular inflammatory response (Messmer, 2015). (npace.org)
  • Its aetiology is diverse due to the contributions of the different neuro-ophthalmic structures (eye, optic nerve, and brain) to image formation and perception, but may be categorised into ocular causes (corneal, lenticular, vitreoretinal and macular) or optic neuropathies. (medicalcriteria.com)
  • [ 1 ] Transient vision loss may be unilateral or bilateral and may last from seconds to hours. (medscape.com)
  • Causes of bilateral vision loss in children include migraine and, less commonly, epileptic seizure. (medscape.com)
  • Early detection of eye disease is vital to preserving your vision. (opmt.com)
  • Even mild disease can affect vision and make daily tasks, like driving or reading, more difficult, affecting quality of life. (npace.org)
  • There needs to be more prospective studies to elucidate direct relationship between ocular surface disease (e.g. (universityhealthcenter.in)
  • In Yemen, diabetes mellitus is a com- Vincent targets of reduction of blind- directions, pupillary reflexes and Gold- mon disease among adult Yemenis with ness due to diabetic retinopathy [9]. (who.int)
  • Some authors refer to ischemic transient vision loss as amaurosis fugax syndrome, so transient vision loss can be a symptom of a serious vision or life-threatening condition, requiring urgent investigation and treatment, or it may have a more benign origin (eg, migraine, dry eye). (medscape.com)
  • A 27-year-old male presented one week after surgical repair of his fractured left zygomatic arch, 5 weeks post-assault, complaining of persistent blurred vision in the left eye and worsening migraine headaches. (openaccesspub.org)
  • We report an uncommon case of delayed onset blurred vision and migraine headache post-surgical repair of an assault-induced left zygomatic arch fracture in a patient with an ipsilateral ACPP. (openaccesspub.org)
  • A 27-year-old male with a past medical history of diabetes mellitus was referred to the ophthalmology clinic complaining of persistent blurry vision in the left eye and worsening migraine headaches. (openaccesspub.org)
  • Dr David Stager , a venerated body in ophthalmology, imparts very helpful information into encouraging healthy eyesight and raising total vision health. (newbigblog.com)
  • Arteritic anterior ischemic optic neuropathy (AAION) also may present with transient vision loss, but in general, transient vision loss does not occur prior to nonarteritic AAION. (medscape.com)
  • Local ocular therapies are options with promising efficacy. (bmj.com)
  • Transient hypoxia of any part of the visual system can result in a temporary disturbance of vision. (medscape.com)
  • Vasospasm may cause a temporary reduction in blood flow to the visual system and transient vision loss. (medscape.com)
  • Other changes in visual function and ocular anatomy, such as CST. (globenewswire.com)
  • Ophthalmology is a health care area where the availability of easy to use point of care (PoC) medical devices based on biomarkers is fundamental for improving patient vision care, reducing number and frequency of sick leave and disability due to visual problems and for getting a significant reduction of overcrowding of ophthalmology units at health systems. (europa.eu)
  • Indirect evidence supports the utility of multiple screening tests for identifying preschool children at higher risk for vision problems and the effectiveness of some treatments for improving visual acuity outcomes. (uspreventiveservicestaskforce.org)
  • The most common causes of vision problems in children are amblyopia (a neurodevelopmental disorder that arises from abnormal processing of visual images that leads to a functional reduction of visual acuity) and its associated risk factors ( Table 1 ), nonamblyopic strabismus and nonamblyopic refractive error. (uspreventiveservicestaskforce.org)
  • Visual loss describes temporary or permanent reduction in visual acuity and/or field. (medicalcriteria.com)
  • A larger reduction of myopia and less early posttreatment subjective ocular discomfort can be seen with a smaller treatment zone, but likely at the expense of a transient decrease in low-contrast visual acuity. (bvsalud.org)
  • Visual and ocular changes associated with exposure to two tertiary amines. (cdc.gov)
  • In the following days, the development of conjunctivitis and reduction in visual acuity prompted her to visit the general practitioner. (cdc.gov)
  • A follow-up study of vision disturbances among workers at a printing company. (cdc.gov)
  • Sunglasses with UV protection are not only essential to preserve the health of the eyes, but these are also important to prevent and reduce the risks of suffering from other vision problems that result from exposure to solar radiation such as cataracts, pterygium, photo conjunctivitis, and photokeratitis. (restoringvision.org)
  • Sunglasses effectively protect the eyes from harmful UVA/UVB rays that can cause cataracts and thus serve as an effective tool for maintaining healthy, clear vision. (restoringvision.org)
  • The 3.5 mm protocol rendered less subjective ocular discomfort posttreatment and a larger improvement than the 4.0 mm protocol in UDVA: -0.52 (-0.72, -0.32) logMAR (medians and interquartile ranges, IQR) and -0.38 (-0.50, -0.22), p = 0.003 and MRSE: +1.25 D (0.75, 1.50) and +1.0 (0.75, 1.0), p = 0.037. (bvsalud.org)
  • Many individuals experience eye discomfort and vision problems when viewing digital screens. (universityhealthcenter.in)
  • Increased Screen Time During COVID-19 May Accelerate Myopia Boom A new review article wrestles with the pandemic's possible ocular implications for children, who are home in front of their screens at levels like never before. (medscape.com)
  • Her professional specialties include emergency ocular care, primary care, and geriatric ocular care. (opmt.com)
  • and now, evidence suggests there could be ocular health considerations, too. (aoa.org)
  • Through the work of prevention and promoting awareness of the damage caused by solar radiation, we will reduce the expenses of health care by preventing ocular health issues created by the highest UV index," Dr. Medina said. (restoringvision.org)
  • And by implementing this program we will contribute to the public health improvement through a risk reduction in ocular health. (restoringvision.org)
  • An emerging, but not (yet) FDA approved, eye drop showed efficacy in using eye-platelet rich plasma and growth factors to address surface evaporation and promote ocular surface health. (npace.org)
  • However, their usage, even for 3 hours/day, has led to a health risk of developing computer vision syndrome (CVS), low-back pain, tension headaches and psychosocial stress. (dovepress.com)
  • Prioritize Twelve-monthly Eye Exams: Anchoring your vision overall health program with the twelve-monthly eye exam is vital. (newbigblog.com)
  • Although the Bethesda, Maryland-based center is not a treatment facility, it works to improve vision health, optimize readiness, and enhance quality of life for service members and veterans by promoting collaboration, facilitating integration, and serving as an advocate for vision across the departments of Defense's and Veterans Affairs' health care systems. (health.mil)
  • Reporting to the Research and Development Directorate of the Defense Health Agency and the Office of Patient Care Services within the VA, VCE integrates DOD and VA-funded research related to vision health with a strong focus on ocular blast injury and traumatic brain injury (TBI) to improve operational readiness. (health.mil)
  • Tetryzoline eye drops may cause blurred vision, eye irritation and dilated pupils. (wikipedia.org)
  • Extensive use of computers will result in computer vision syndrome (CVS), and the prevalence is increased dramatically. (dovepress.com)
  • Computer vision syndrome (CVS), also referred to as digital eye strain, describes eye and vision-related problems that result from prolonged computer, tablet, e-reader and cell phone use. (universityhealthcenter.in)
  • Treatments target evaporation of the tear film on the surface of the eye and optimization of meibomian gland production to promote underlying ocular moisture (Messmer, 2015). (npace.org)
  • Environmental strategies such as avoidance of heating and air conditioning or room humidification reduce evaporation from the ocular surface. (npace.org)
  • One study shows higher degree of meibomian gland dysfunction (MGD) in symptomatic computer users than in computer users who have lesser degrees of ocular surface complaints. (universityhealthcenter.in)
  • 3 Ocular complaints of computer users have been grouped together and collectively termed as CVS. (dovepress.com)
  • In adults, transient vision loss (TVL) is a frequently encountered complaint that, in most cases, has an identifiable cause. (medscape.com)
  • Transient vision loss in children is less common than in adults and is more likely to have a benign origin. (medscape.com)
  • Transient vision loss is a symptom rather than a diagnosis. (medscape.com)
  • Embolic occlusions of the arteries supplying the eye are a common cause of transient vision loss in adults. (medscape.com)
  • Gaze-evoked amaurosis (compression) is transient vision loss occurring when looking in a particular direction. (medscape.com)
  • The transient reduction in LCVA was larger with the 3.5 mm protocol (p (bvsalud.org)
  • Several additional large, international retrospective clinical studies found a significant reduction in endophthalmitis rates with intracameral antibiotic prophylaxis. (medscape.com)
  • Similarly, when a cataract surgery complication occurs, whether due to poor-quality ocular tissue or an iatrogenic cause, we need to recognize the issue, react appropriately, and recover. (crstoday.com)
  • The SCL is a wearable ophthalmic device associated with functions beyond vision correction. (news-medical.net)
  • No adverse events, and no reductions in ECC or BSCVA were noted. (bvsalud.org)
  • In the three studies, IOP reductions were observed for all treatment arms. (cliniexpert.com)
  • No vision threatening pathologies were identified and surgical treatment was not recommended. (openaccesspub.org)
  • Management of your diabetes under the care of a medical professional - with a treatment plan that includes regular visits to the eye doctor - is the best way to prevent loss of vision. (shoptometry.com)
  • However, vision-related problems associated with TBI are often overlooked during initial treatment of a brain injury, said Dr. Michael Pattison, VCE's program manager of readiness and operations optometry. (health.mil)
  • Acute macular neuroretinopathy (AMN) was first described by Drs. Bos and Deutman after a series of 4 women presented with acute decline in vision and were found to have paracentral scotomata corresponding to wedge-shaped lesions of the macula. (aao.org)
  • Despite the seemingly constant reduction in the relative value given to cataract surgery by insurance companies, it is not an easy procedure. (crstoday.com)
  • We report a case of delayed vision loss and headache post zygomatic fracture repair surgery in patient with a confirmed ipsilateral ACP pneumatization. (openaccesspub.org)
  • objective and stipulated indicators to 1 randomly selected village for each se- Information about other ocular surgery review the progress [2]. (who.int)
  • Vision early is normal and a slow loss of vision occurs sometime after the drusen appear in most individuals. (arizona.edu)
  • Additionally, researchers noticed significant reductions of noninvasive tear breakup time, fluorescein breakup time and tear meniscus height among vapers while vaping at higher voltages. (aoa.org)
  • The American Optometric Association defines CVS as a complex of eye and vision problems related to the activities that stress the near vision and that are experienced in relation to, or during, the use of the computer. (dovepress.com)