LanreotideRenal or hepatic impairmentIschemia-reperfusion injuryEncephalopathySandostatinCirrhosisPortal hypertensionIndicationsImpairmentAnaloguesLesionsAnalogsGlucoseInhibitsVaricesAscitesAdipose tissueInhibitorsInsulin secretionSymptomsAcromegalySplanchnicInducesMetastasesScintigraphyInsufficiencySomatostatin receptorFibrosisMortalityLipolysisTumor growthPancreaticVaricealArteryAcuteIntrahepaticIntravenousTransjugularLipaseConcentrationsPituitaryDecreaseDiazoxideVeinsDosesReduceSignificantlyCirculationPrevalenceInfectionsFunction
Lanreotide4
- The clinically available somatostatin (SRIF) analogues, octreotide and lanreotide, are the mainstay of treatment for patients with acromegaly in whom surgery has failed to adequately control GH and IGF-I levels or where surgery is contra-indicated. (endocrine-abstracts.org)
- First-line pharmacologic treatment usually consists of one of the first generation somatostatin receptor ligands (SRLs) such as octreotide or lanreotide. (biomedcentral.com)
- Octreotide (Sandostatin, Bynfezia Pen) and lanreotide (Somatuline Depot) are given as injections under the skin. (brainandnervecenter.com)
- Telotristat (Xermelo) is a pill that is sometimes used in combination with octreotide or lanreotide to further try to improve the symptoms of carcinoid syndrome. (brainandnervecenter.com)
Renal or hepatic impairment1
- Increased risk of hypoglycemia with changes in physical activity, meal patterns, renal or hepatic impairment: monitor glucose more frequently and may need to adjust dose. (renalandurologynews.com)
Ischemia-reperfusion injury2
- 13 Furthermore, octreotide can reduce ischemia-reperfusion injury by decreasing portal pressure. (ectrx.org)
- In animal models of hepatic ischemia-reperfusion injury, use of octreotide resulted in a possible protective effect. (ectrx.org)
Encephalopathy8
- Common signs and symptoms may stem from decreased hepatic synthetic function (eg, coagulopathy), portal hypertension (eg, variceal bleeding), or decreased detoxification capabilities of the liver (eg, hepatic encephalopathy). (medscape.com)
- The symptoms of hepatic encephalopathy may range from mild to severe and may be observed in as many as 70% of patients with cirrhosis. (medscape.com)
- Findings on physical examination in hepatic encephalopathy include asterixis and fetor hepaticus. (medscape.com)
- An elevated arterial or free venous serum ammonia level is the classic laboratory abnormality reported in patients with hepatic encephalopathy. (medscape.com)
- Computed tomography (CT) scanning and MRI studies of the brain may be important in ruling out intracranial lesions when the diagnosis of hepatic encephalopathy is in question. (medscape.com)
- Bleeding into the GI tract may precipitate portal-systemic encephalopathy in patients with impaired hepatic function. (msdmanuals.com)
- Hepatic encephalopathy is another complication which develops in end stage of cirrhosis. (epainassist.com)
- The diagnosis of hepatic encephalopathy is made by expert's clinician. (epainassist.com)
Sandostatin2
- Patients not currently receiving octreotide acetate should begin therapy with Sandostatin Injection given subcutaneously in an initial dose of 50 mcg three times daily which may be titrated. (guidelinecentral.com)
- Below is the selection of side effect reports (a.k.a. adverse event reports) related to Sandostatin (Octreotide) where reactions include malaise. (druglib.com)
Cirrhosis5
- Cirrhosis is defined histologically as a diffuse hepatic process characterized by fibrosis and conversion of the normal liver architecture into structurally abnormal nodules. (medscape.com)
- In the near future, the portal hypertension market is primed to grow at a healthy clip due to the spike in liver cirrhosis, which may cause portal hypertension and other hepatic disorders. (sbwire.com)
- Hence a rising incidence of liver cirrhosis is often related to the increasing demand for effective treatment for portal hypertension. (sbwire.com)
- Цироз Cirrhosis is a late stage of hepatic fibrosis that has resulted in widespread distortion of normal hepatic architecture. (msdmanuals.com)
- Octreotide is a somatostatin analog and an effective therapy for variceal bleeding and hepatorenal syndrome in patients with cirrhosis. (ectrx.org)
Portal hypertension7
- Portal hypertension results in increase of blood pressure within the portal venous system. (sbwire.com)
- Portal hypertension is a clinical condition in which blood pressure within the portal venous system increases. (sbwire.com)
- In acute conditions vasoconstrictors such as octreotide and somastostatin are administered, which explains their high demand in the global portal hypertension market. (sbwire.com)
- The major cause of portal hypertension is due to increased intrahepatic resistance to blood flow. (epainassist.com)
- The second cause of portal hypertension is due to increase in splanchnic blood flow. (epainassist.com)
- Ascites and portal hypertension should be dealt in early stages else chance of variceal bleeding and peritonitis increases. (epainassist.com)
- Portal hypertension (PHT) is a common clinical syndrome, characterized by a pathological increase in portal pressure and hemodynamic changes. (dergisi.org)
Indications3
- hSNF2b itself is normally maintained, patients usually do not improvement to build up hepatic insufficiency, and something of the principal indications of treatment would be to achieve indicator control and improve QoL therefore. (scapca.org)
- Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
- Intra-hepatic microspheres for metastases from esophageal cancer, gallbladder cancer, uveal melanom a, liver metastases of pancreatic adenocarcinoma, and other indications not listed above. (aetna.com)
Impairment1
- Moderate-to-severe hepatic impairment. (renalandurologynews.com)
Analogues2
- Furthermore, the research that evaluated the influence of somatostatin analogues on QoL included sufferers with concomitant polycystic kidney disease as part of ADPKD syndrome, and their outcomes demonstrated a decrease in both hepatic and renal volumes. (scapca.org)
- Proton pump inhibitor (PPI) for those with suspected Non-variceal UGIB (NVUGIB), somatostatin analogues such as octreotide and antibiotics in suspected cases of variceal UGIB (VUGIB) and in those with clinical suspicion of liver disease, timely blood transfusion and early use of endoscopy may not occur in these settings due to lack of appropriate specialists, lack of resources or supply chain issues. (researchsquare.com)
Lesions2
- During initial treatment with chemotherapy, skin lesions and joint pain improved with the declining lipase levels. (hss.edu)
- The association between the cutaneous and hepatic lesions is not understood but is speculated to involve hypoaminoacidemia or abnormal zinc metabolism. (msdvetmanual.com)
Analogs2
- Insulin and its analogs lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. (globalrph.com)
- Beta-blockers (propranolol), somatostatin and analogs of longacting somastatin (octreotide) that all have an effect on the portal blood flow may be used for treatment. (dergisi.org)
Glucose9
- Approximately 2 years before our evaluation, the patient noted a relatively abrupt increase in her blood glucose levels, as determined by fingerstick glucose monitoring and as corroborated by an increasing A1C into the 9-10% range. (silverchair.com)
- The patient had had no recent hypoglycemia, although occasionally she noted improved glucose control for 1-2 days that was unexplained. (silverchair.com)
- Direct oral absorption results in rapid increase of blood glucose concentrations. (medscape.com)
- Concentrated dextrose infusions provide higher amounts of glucose and increased caloric intake with minimum fluid volume. (medscape.com)
- Glucose-elevating agents can act in the pancreas or the peripheral tissues to increase blood glucose levels. (medscape.com)
- Glucagon also increases hydrolysis of glycogen to glucose (glycogenolysis) in the liver. (medscape.com)
- Agents that inhibit insulin secretion increase glucose levels by reducing peripheral glucose metabolism. (medscape.com)
- This agent increases hepatic glucose output by inhibiting pancreatic insulin release and, possibly, through an extrapancreatic effect, as well as decreases cellular glucose uptake. (medscape.com)
- Make changes to a patient's insulin regimen (e.g., insulin strength, manufacturer, type, injection site or method of administration) under close medical supervision with increased frequency of blood glucose monitoring. (nih.gov)
Inhibits1
- Octreotide acts primarily on somatostatin receptor subtypes II and V. It also inhibits growth hormone secretion and has a multitude of other endocrine and nonendocrine effects, including inhibition of glucagon, vasoactive intestinal peptides (VIP), and gastrointestinal peptides. (medscape.com)
Varices3
- About 65.1% of the patients had severe anemia but only 60 (48.8%) received blood transfusion in the ED. Amongst those with h/o esophageal varices 7(41.2%) did not receive octreotide. (researchsquare.com)
- Because varices are typically associated with significant hepatic disease, evaluation for possible coagulopathy is important. (msdmanuals.com)
- If the varices are due to alcohol consumption, continuing to drink increases the risk of bleeding. (healthline.com)
Ascites1
- This along with increase splanchnic blood flow leads to formation of ascites. (epainassist.com)
Adipose tissue2
- This agent accelerates hepatic glycogenolysis and lipolysis in adipose tissue by stimulating cyclic AMP (cAMP) synthesis via adenylyl cyclase and enhancing phosphorylase kinase activity. (medscape.com)
- To provide a reliable assessment of hepatic, muscle, and adipose tissue insulin sensitivity across a physiologic range of plasma insulin concentrations, investigators used a 3-stage hyperinsulinemic euglycemic pancreatic clamp to control portal and systemic plasma insulin concentrations. (ajmc.com)
Inhibitors1
- The differentiating, immunomodulating and cytostatic properties of these molecules contributed to this result, together with the antiproliferative effect of somatostatin, octreotide, and prolactin inhibitors. (beatingcancercenter.com)
Insulin secretion2
- Although, diazoxide has a very limited role in treating hypoglycemia, it can help improve symptoms of hypoglycemia caused by increased insulin secretion in patients awaiting surgery or those with nonresectable disease and may be indicated in some cases of insulinoma or overdosage with oral (PO) hypoglycemic agents. (medscape.com)
- Researchers also "infused octreotide during the clamp procedure to block endogenous insulin secretion in order to ensure that similar portal vein insulin concentrations were achieved before and after weight loss. (ajmc.com)
Symptoms3
- Symptoms partially improved, until his finger swelling began. (hss.edu)
- Pejorative events were defined as side effects due to therapy, relapse in clinical symptoms, tumor progression, tumor laboratory marker increase, and death. (snmjournals.org)
- Although there is no single benzodiazepine that has been proven to be more effective than others, consideration should always be given to agents with a rapid onset, longer duration of action to prevent breakthrough symptoms and lesser dependence on hepatic metabolism [9] . (pharmaceutical-journal.com)
Acromegaly2
- The long-acting somatostatin analogue octreotide is used either as an adjuvant or primary therapy to lower GH levels in patients with acromegaly and may also induce pituitary tumor shrinkage. (endocrine-abstracts.org)
- This observational study shows that treatment outcomes of biochemically-uncontrolled acromegaly patients improve with directed care, particularly for those that initially present untreated. (biomedcentral.com)
Splanchnic2
- Octreotide a direct splanchnic vasoconstrictor can also be used. (epainassist.com)
- 12 Octreotide induces potent splanchnic vasoconstriction, which may be mediated in part by inhibition of glucagon release. (ectrx.org)
Induces2
- GH produces direct metabolic effects and induces hepatic insulin-like growth factor (IGF)-1 production. (biomedcentral.com)
- I/R injury, through the liberation of radical oxygen species and the activation of inflammatory pathways, induces cellular injury and mi-crocirculatory damage, which translate to organ dysfunc-tion, morbidity, and increased health care costs [7, 8]. (123dok.net)
Metastases4
- Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
- There is inadequate information to document the effectiveness of PEI as an alternative to surgical resection for the treatment of hepatic metastases. (aetna.com)
- Hepatic artery embolization is effective only in patients with large liver metastases but has no impact on extrahepatic disease ( 4 ). (snmjournals.org)
- We describe a patient with an ACTH-producing carcinoma of the pituitary with refractory Cushing's disease and hepatic metastases. (biomedcentral.com)
Scintigraphy3
- We have mentioned octreotide scintigraphy and positron emission tomography (using a radioactive medium). (theranostics.sg)
- Biochemical response and positive octreotide scintigraphy predicted objective response. (cancerindex.org)
- Positive octreotide scintigraphy and biochemical response predict objective response. (cancerindex.org)
Insufficiency1
- A commercial diet high in protein or formulated for dogs with hepatic insufficiency with an added "body-building" amino acid concentrate can be used. (msdvetmanual.com)
Somatostatin receptor1
- Octreotide may be used in diazoxide-unresponsive patients but is often ineffective because of down-regulation of the somatostatin receptor, and it carries a risk of causing necrotizing enterocolitis and death. (medscape.com)
Fibrosis1
- As there is fibrosis of liver, there is usually difficult passage of flow of blood through the liver and thus this leads to increase in portal pressure. (epainassist.com)
Mortality3
- Preliminary data suggested an increased mortality in a French cohort after childhood somatropin treatment compared to the French reference population1. (endocrine-abstracts.org)
- Early allograft dysfunction (EAD) is another complication of LT, and it may result in increased rates of mortality and morbidity. (ectrx.org)
- In terms of mortality and re-bleeding rates, there seem to be no difference between terlipressin, somatotatin and octreotide ( Seo et al, 2014 ). (derangedphysiology.com)
Lipolysis1
- After a few hours of fasting, insulin levels fall, and increased lipolysis creates free fatty acids and glycerol. (medscape.com)
Tumor growth1
- In conclusion, on top of its harmful early impact on organ function, I/R injury is linked to increased tumor growth. (123dok.net)
Pancreatic4
- Surgery is the only treatment that can cure pancreatic adenocarcinoma, and may also be done to improve quality of life without the potential for cure. (wikipedia.org)
- Laboratory analysis revealed a mild increase in total bilirubin, and abdominal ultrasound revealed a pancreatic mass and several hepatic masses. (hss.edu)
- Biopsy of the pancreatic and hepatic masses were positive for an acinar cell carcinoma. (hss.edu)
- Treatment with nonsteroidal anti-inflammatory drugs, steroids, and high doses of intravenous octreotide, an octapeptide inhibitor of pancreatic hormones, has been reported, although it is usually ineffective [3]. (hss.edu)
Variceal1
- Lack of difference among terlipressin, somatostatin, and octreotide in the control of acute gastroesophageal variceal hemorrhage. (derangedphysiology.com)
Artery1
- Pre-operative hepatic artery chemoembolization followed by orthotopic liver transplantation for HCC. (aetna.com)
Acute1
- It may cause hyperthermia and bronchospasm and is contraindicated in acute pelvic inflammatory, cardiac, renal, pulmonary or hepatic disease. (biologydiscussion.com)
Intrahepatic1
- Due to increase intrahepatic resistance there is increase in portal pressure. (epainassist.com)
Intravenous1
- On November 28, aggressive intravenous (IV) fluid hydration, IV octreotide,* 2016, members of the Bay Area Mycological Society notified and IV silibinin. (cdc.gov)
Transjugular1
- During angiography, a catheter is placed selectively via either the transjugular or transfemoral route into the hepatic vein to measure portal pressure. (medscape.com)
Lipase1
- This included routine chemistries, which ruled out any development of either renal or hepatic disease and included normal lipase and thyroid function test results and a normal complete blood count (CBC). (silverchair.com)
Concentrations1
- Clinical features include anorexia, weight loss, lethargy, polyuria/polydipsia (PU/PD), mild nonregenerative anemia, marked increases in alkaline phosphatase (ALP) and moderate increases in ALT and AST, hyperglycemia, decreased plasma amino acid concentrations (by 50% of normal), hypoalbuminemia, and increased total serum bile acid (TSBA) concentrations. (msdvetmanual.com)
Pituitary1
- Therefore, we performed a meta-analysis to thoroughly assess the current literature on the effect of octreotide on pituitary tumor shrinkage. (endocrine-abstracts.org)
Decrease1
- Due to the absence in the literature of findings of previous complete objective responses of glioblastoma to the usual treatments, we believe it is useful to report our case, which shows that it is possible to increase the efficacy and decrease the toxicity of the current oncotherapy for glioblastoma by combining it with the DBM (Di Bella Method) biological therapy. (beatingcancercenter.com)
Diazoxide1
- 5] Severe cases of congenital HI may be unresponsive to either diazoxide or octreotide and require intensive management with tube feedings, near-total pancreatectomy, or partial pancreatectomy. (medscape.com)
Veins1
- Veins begin to dilate and swell as a result of increased blood flow. (healthline.com)
Doses1
- The patient had recently been under the care of an endocrinologist in another city who had added the oral agents to her insulin regimen and aggressively increased her insulin doses, seemingly to no avail. (silverchair.com)
Reduce2
- Octreotide, by preventing emptying of the gallbladder, might reduce received reports of only a few mushroom poisoning cases per recirculation of amatoxins in bile to the liver. (cdc.gov)
- This study showed that octreotide infusion in the first 3 days after liver transplant could improve renal and allograft function and reduce infection and length of hospital stay. (ectrx.org)
Significantly1
- Do not significantly increase grapefruit juice intake while taking diltiazem, or avoid grapefruit juice if possible. (pdr.net)
Circulation1
- Hepatic ischemia-reperfusion (Recruit) harm is really a pathological problem started by simply disturbed hepatic circulation Biopsia líquida as well as high following reperfusion, which is one of the most lethal pitfalls in hard working liver transplantation along with other liver surgical treatments. (mglurpathway.com)
Prevalence1
- It also increases the prevalence of diabetic retinopathy. (fitnesshacks.org)
Infections1
- The high rates regarding hepatic biotransformation might be a possible explanation for the low severe accumulation regarding triclosan after Transfusion-transmissible infections mouth intake. (mglurpathway.com)
Function3
- Evaluate hematopoietic, cardiovascular (monitor BP), hepatic and renal function periodically. (oncologynurseadvisor.com)
- Other considerations prior to medication administration include documentation of adequate renal function with Cr and BUN levels, documentation of adequate hepatic function with ALT and TBil levels, and documentation of adequate hematological and immune function with platelet and WBC count. (unboundmedicine.com)
- Therapeutic strategies tackling I/R injury could not only improve post-surgical organ function, but also allow a reduction in the risk of cancer recurrence. (123dok.net)