• When someone has a substance-use disorder in addition to a mental health diagnosis (like depression, trauma, or anxiety), it's known as having a 'co-occurring disorder,' and it complicates the process of diagnosing and treating the whole patient. (psychtimes.com)
  • The purpose of this funding opportunity announcement (FOA) is to support the development of new therapeutic approaches for individuals with Opioid Use Disorder (OUD) and co-occurring mental disorders (COMD). (nih.gov)
  • Opioid Use Disorder (OUD) and co-occurring mental disorders (COMD) frequently are present in a single individual, and yet they take separate paths in the therapeutics development process https://www.nimh.nih.gov/health/topics/substance-use-and-mental-health . (nih.gov)
  • In this disorder, the paralysis of your limbs doesn't occur during REM sleep and you act out your dreams physically. (healthline.com)
  • Raymond Vernon divided products into three categories based on their stage in the product life cycle and how they behave in the international trade market: New Product Maturing Product Standardized Product There are five stages in a product's life cycle in respect to the Product Life Cycle Theory: Introduction Growth Maturity Saturation Abandonment The location of production depends on the stage of the cycle. (wikipedia.org)
  • What are the 5 stages of menstrual cycle? (yourfastadvices.com)
  • What are the stages of ovarian cycle? (yourfastadvices.com)
  • The ovarian cycle may be divided into three stages: the follicular phase, ovulation, and the luteal phase. (yourfastadvices.com)
  • There are five stages of a cat's heat (also known as estrus) cycle, so we'll go over these in order to better understand the entire process. (catster.com)
  • Sleep normally occurs in several stages. (medlineplus.gov)
  • People normally cycle through the three stages of NREM sleep (stages N1 through N3), usually followed by a brief interval of REM sleep, every 90 to 120 minutes or several times every night. (msdmanuals.com)
  • People normally cycle through distinct stages of sleep every 90 to 120 minutes during the night: three stages of nonrapid eye movement sleep (N) and one stage of rapid eye movement (REM) sleep. (msdmanuals.com)
  • THOUSAND OAKS, Calif.--(BUSINESS WIRE)--Dec. 10, 2004-- Amgen Inc. (Nasdaq:AMGN), the world's largest biotechnology company, today announced that new data from a Phase 3 study show that the majority of neutropenic complications occur in the first cycle of chemotherapy treatment for breast cancer patients who are not administered Neulasta(R) (pegfilgrastim). (amgen.com)
  • 3. An important phenomenon of CVD in developing countries is the trend of complications occurring at younger ages. (who.int)
  • The solar cycle , also known as the solar magnetic activity cycle , sunspot cycle , or Schwabe cycle , is a nearly periodic 11-year change in the Sun 's activity measured in terms of variations in the number of observed sunspots on the Sun's surface . (wikipedia.org)
  • Over the period of a solar cycle, levels of solar radiation and ejection of solar material, the number and size of sunspots , solar flares , and coronal loops all exhibit a synchronized fluctuation from a period of minimum activity to a period of a maximum activity back to a period of minimum activity. (wikipedia.org)
  • The idea of a cyclical solar cycle was first hypothesized by Christian Horrebow based on his regular observations of sunspots made between 1761 and 1776 from the Rundetaarn observatory in Copenhagen , Denmark . (wikipedia.org)
  • [4] The solar cycle however would not be clearly identified until 1843 when Samuel Heinrich Schwabe noticed a periodic variation in the average number of sunspots after 17 years of solar observations. (wikipedia.org)
  • Other sleep disorders , such as restless legs syndrome, narcolepsy , or hypersomnia can also occur. (medlineplus.gov)
  • In addition to acute viral encephalitis, other less established and more unusual manifestations of viral infections include progressive neurologic disorders, such as postinfectious encephalomyelitis (such as may occur after measles or Nipah virus encephalitis) and conditions such as postpoliomyelitis syndrome, which has been considered by some to be as a persistent manifestation of poliovirus infection. (medscape.com)
  • The pattern of the reproductive cycle appears to relate to the harsh environment in which the camels live (Novoa, 1970). (fao.org)
  • Therefore, unweighted frequencies of certain reproductive conditions may differ slightly in this survey cycle compared to survey cycles prior to 2007. (cdc.gov)
  • Two reproductive phases occur in the cephalopod host. (britannica.com)
  • What phase usually occurs around day 14 of the cycle? (yourfastadvices.com)
  • This cycle usually occurs in the late fall and through winter, which is when the fertility cycle decreases because of the longer days. (catster.com)
  • Female cats will have multiple cycles throughout the breeding season , which will differ depending on where they are geographically located, the temperature, and how many daylight hours there are. (catster.com)
  • Over the course of a night, you go through multiple cycles of REM and non-REM sleep. (healthline.com)
  • To investigate these fluctuations within a saturated aquifer system, we monitored a carbon-stimulated in situ Geobacter population while iron reduction was occurring, using 16S rRNA abundances and high-resolution tandem mass spectrometry proteome measurements. (umass.edu)
  • Across a 40-day period where Fe(III) reduction was occurring, fluctuations in protein expression reflected changes in anabolic versus catabolic reactions, with increased levels of biosynthesis occurring soon after acetate arrival in the aquifer. (umass.edu)
  • It has been argued that a necessary condition for stick-slip cycles are a reduction in frictional strength with increasing sliding velocity after sufficient sliding has eliminated the memory of the sliding history 18 . (nature.com)
  • By combining in situ and satellite observations with model simulations, Weiqing Han and collaborators recently investigated the sea level Height EXtreme (HEX) events and co-occurring Marine heatwaves, dubbed Compound Height-Heat EXtreme (CHHEX) events, along Indonesian coasts of the Indian Ocean since the 1960s, particular since 1993 when satellite altimetry data have become available. (issibern.ch)
  • However, it is possible to predict the times of the year when exceptional high tides are most likely to occur. (canadianunderwriter.ca)
  • Chronic cases are more likely to occur following infection in infancy and early childhood, while less than 5% of chronic cases occur after acquiring the virus as an adult. (medicalnewstoday.com)
  • Manual stimulation of the cervix for 15 minutes did not induce ovulation, although luteinization of the mature Graafian follicle occurred (Musa and Abusina, 1978). (fao.org)
  • Ovulation occurs 30-48 hours following copulation (Chen and Yuan, 1979). (fao.org)
  • This stage occurs when the female cat has not ovulated, which only results when the male mates with the female. (catster.com)
  • This stage occurs more in the first part of the night. (healthline.com)
  • Acute hepatitis B describes when the infection first occurs, and symptoms only last a few weeks. (medicalnewstoday.com)
  • Compounding this difficulty is the substantial evidence that neurological changes can occur as a result of substance use, depending on frequency, duration and severity, among other factors. (psychtimes.com)
  • The Product Life Cycle Theory is an economic theory that was developed by Raymond Vernon in response to the failure of the Heckscher-Ohlin model to explain the observed pattern of international trade. (wikipedia.org)
  • The theory suggests that early in a product's life-cycle all the parts and labor associated with that product come from the area where it was invented. (wikipedia.org)
  • According to International Product Life Cycle theory there are five phases which describe how a product matures and declines as a result of internationalization: Local Innovation Overseas Innovation Maturity World Wide Imitation Reversal This is where the new product is introduced to the market, the customers are unaware about the product. (wikipedia.org)
  • When many potential new customers have bought the product, it enters the next stage In the maturity stage of the Product life cycle, the product is widely known and many consumers own it. (wikipedia.org)
  • In the maturity phase of the product life cycle, demand levels off and sales volume increases at a slower rate. (wikipedia.org)
  • What is the life cycle of the hepatitis B virus? (medicalnewstoday.com)
  • The virus's life cycle involves entering liver cells and producing new virus cells to trigger infections in other liver cells. (medicalnewstoday.com)
  • The life cycle of HBV involves entering liver cells, where the virus replicates and then attempts to cause infection in other liver cells. (medicalnewstoday.com)
  • We are focused on our partner profitability, and we are continuing to innovate and drive programs that drive increased profitability on the front end [and] back end, as well as life-cycle incentives. (crn.com)
  • The San Jose, Calif.-based company is prioritizing a focus on life cycle, usage and adoption, Yuskaitis said. (crn.com)
  • As the name implies, at some time in the life cycle a chordate possesses a stiff, dorsal supporting rod (the notochord). (britannica.com)
  • Rhombozoans have an even more complex life cycle. (britannica.com)
  • Hospitalization and the use of intravenous anti-infectives in breast cancer patients were also significantly lower in the group receiving Neulasta in the first and subsequent cycles of chemotherapy. (amgen.com)
  • Patients in the placebo arm not only experienced significantly more neutropenic events than patients in the Neulasta arm, but more than 65 percent of these events occurred in the first cycle of treatment, emphasizing the importance of early protection," said Dr. Vogel. (amgen.com)
  • Breast cancer patients (Stage 1-4, ECOG performance of 0-2) receiving 100 mg/m(2) docetaxel every three weeks for up to four cycles were randomized to receive either 6 mg Neulasta (n=463) or placebo (n=465) once-per-cycle on the day after docetaxel administration for up to four cycles. (amgen.com)
  • Specifically, in the first cycle, one percent of patients in the Neulasta arm (2/463) developed febrile neutropenia compared with 11 percent of patients in the placebo arm (52/465). (amgen.com)
  • Neulasta was also associated with a significantly lower incidence of hospitalizations with one percent of patients requiring hospitalization (5/463) in the first cycle versus nine percent of patients receiving placebo (43/465). (amgen.com)
  • One percent of patients in the Neulasta arm (5/463) required intravenous anti-infectives in the first cycle versus six percent of patients in the placebo arm (30/465). (amgen.com)
  • In addition, in cycles two through four, less than one percent of patients in the Neulasta arm (1/458) developed febrile neutropenia compared with six percent of patients in the placebo arm (26/454). (amgen.com)
  • During these cycles, less than one percent of patients in the Neulasta arm (1/458) were hospitalized versus five percent in the placebo arm (21/454). (amgen.com)
  • Less than one percent of patients in the Neulasta arm (3/458) required intravenous anti-infectives in the subsequent cycles compared to four percent in the placebo arm (19/454). (amgen.com)
  • We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
  • Most changes were subtle, but frequently the genes with altered expression were involved in basal cellular functions such as cell division, cell cycle regulation, apoptosis and cell signalling. (lu.se)
  • The study found that administering Neulasta beginning in the first and subsequent cycles of chemotherapy reduced the rate of infection, as manifested by febrile neutropenia (low white blood cell count with fever), by more than 90 percent. (amgen.com)
  • This study suggests that Neulasta used in first and subsequent cycles of chemotherapy achieves maximum clinical benefit. (amgen.com)
  • It follows that if we understand the characteristics of the different phases, we can estimate where we are in the credit cycle. (24hgold.com)
  • The credit cycle can be broken down into the following phases: post-crisis stabilisation, recovery, expansion and finally crisis. (24hgold.com)
  • Solar (sun spot) cycle. (answers.com)
  • For the 28-year cycle of the calendar, see Solar cycle (calendar) . (wikipedia.org)
  • The prediction for solar cycle 24 gave a smoothed sunspot number maximum of about 69 in the late Summer of 2013. (wikipedia.org)
  • The magnetic field of the Sun flips during each solar cycle, with the flip occurring when the solar cycle is near its maximum. (wikipedia.org)
  • After two solar cycles, the Sun's magnetic field returns to its original state, completing what is known as a Hale cycle . (wikipedia.org)
  • Solar activity, driven by both the solar cycle and transient aperiodic processes, governs the environment of interplanetary space by creating space weather and impacting space- and ground-based technologies as well as the Earth's atmosphere and also possibly climate fluctuations on scales of centuries and longer. (wikipedia.org)
  • Understanding and predicting the solar cycle remains one of the grand challenges in astrophysics with major ramifications for space science and the understanding of magnetohydrodynamic phenomena elsewhere in the universe. (wikipedia.org)
  • Solar cycles have an average duration of about 11 years. (wikipedia.org)
  • In 1852, Rudolf Wolf designated the first numbered solar cycle to have started in February 1755 based on Schwabe's and other observations. (wikipedia.org)
  • Performance specification: Solar power system for compression-cycle vaccine refrigerator or combined refrigerator and water- pack freezer. (who.int)
  • Type-examination protocol: Solar power system for compression-cycle vaccine refrigerator or combined refrigerator and water-pack freezer. (who.int)
  • Quality assurance protocol: Solar power system for compression-cycle vaccine refrigerator or combined refrigerator and water-pack freezer. (who.int)
  • Among immunodeficient individuals, toxoplasmosis most often occurs in those with defects of T-cell-mediated immunity, such as those with hematologic malignancies, bone marrow and solid organ transplants, or acquired immunodeficiency syndrome ( AIDS ).In most immunocompetent individuals, primary or chronic (latent) T gondii infection is asymptomatic. (medscape.com)
  • Infection can occur by ingestion of oocysts following the handling of contaminated soil or cat litter or through the consumption of contaminated water or food sources (eg, unwashed garden vegetables). (medscape.com)
  • [ 5 ] Transmission of tachyzoites to the fetus can occur via the placenta following primary maternal infection. (medscape.com)
  • Rarely, infection by tachyzoites occurs from ingestion of unpasteurized milk or by direct entry into the bloodstream through a blood transfusion or laboratory accident. (medscape.com)
  • Ovarian cycle activity was fully described by Musa (1979). (fao.org)
  • This passion for "Delayed Direct Instruction" is intrinsic to the inquiry learning cycle and its efficacy in helping students develop conceptual models for understanding is outlined in the literature. (cyclesoflearning.com)
  • Because sex differences occur in food choices and weight management behaviors (18-20), a secondary objective was to explore sex differences in the specific strategies used and the barriers encountered to increase our understanding of weight management in restaurant settings. (cdc.gov)
  • In other words, the cycle of growth and recessions is due to instability in the private sector and this is generally believed by state planners and central bankers. (24hgold.com)
  • When this hormone is affected, the growth cycle of hair also gets affected badly. (thewashingtonnote.com)
  • Each time when new hair growth occurs, they have to be sewn again. (thewashingtonnote.com)
  • Hair growth occurs within the hair follicle. (healthline.com)
  • While microbial activities in environmental systems play a key role in the utilization and cycling of essential elements and compounds, microbial activity and growth frequently fluctuates in response to environmental stimuli and perturbations. (umass.edu)
  • While the individual HEX-alone events are mainly driven by enhanced northwesterly winds associated with the Indian and/or Australian monsoons from December to March, CHHEXs occur in May-June and November-December mainly in years when negative Indian Ocean Dipole (IOD) and La Niña, the negative phase of the El Niño - Southern Oscillation (ENSO), co-occur. (issibern.ch)
  • When they co-occur, the intensified equatorial westerly winds and longshore northwesterly winds drive the HEX and CHHEX events. (issibern.ch)
  • tag arrived so use sleep if you have to wait for events and don't want to burn to much cycles, but don't use it for silly delayed output effects! (php.net)
  • 10 9 apoptotic events occurring per day in human adult tissues, it is surprisingly difficult to histologically detect apoptotic cells due to the rapid recognition and clearance of apoptotic cells. (nature.com)
  • Relatively small diurnal events occur during the melt season, whilst during winter there are larger multi-day events related to positive degree days. (nature.com)
  • All events will be run according to current USA Cycling rules and regulations , published event formats and eligibility rules, and information in the communiqués. (usacycling.org)
  • The timing of any credit crisis is set by the rate at which the credit cycle progresses. (24hgold.com)
  • The purpose of this article is to establish where we are in the global credit cycle, and to estimate from that the likely time-scale to the next credit crisis. (24hgold.com)
  • During her estrous cycle, a female cat is receptive towards males for a period anywhere from 3-7 days (with 6-7 days being the average length of time). (catster.com)
  • However, the entire estrous cycle could last up to three weeks, so we'll go into how the heat cycle works and what you can expect during this time. (catster.com)
  • Date and time The date and time the event occurred. (ifttt.com)
  • To generate exceptional high tides, both astronomical and meteorological tides must occur at the same time. (canadianunderwriter.ca)
  • Proliferation and cell cycle progression of the serum-free cultures closely mimicked that of serum-dependent cells. (lu.se)
  • This cycle was created to explain how animal tissues oxidized carbohydrates. (brighthub.com)
  • These seem to occur in eleven-year cycles? (answers.com)
  • What seems to occur during eleven year cycles? (answers.com)
  • In stray and feral cats, anestrus is quite prevalent, but because indoor cats live in an environment with artificial lights, they are more prone to going through the heat cycle all year . (catster.com)
  • In Russia the domesticated Bactrian was found to be polyoestrus, having oestrus cycles all the year round (Bosaev, 1938). (fao.org)
  • Equinox tides arrive twice a year around March 20 and Sept. 22 (plus or minus a week because of the spring/neap cycle). (canadianunderwriter.ca)
  • Please refer to the NHANES website for additional information for the NHANES 2017-March 2020 pre-pandemic data, and for the previous 2017-2018 public use data file with specific weights for that 2-year cycle. (cdc.gov)
  • For those who reported month of menarche in their birth month, it was not possible to discern which year of age menarche occurred. (cdc.gov)
  • This allows each member of the asset team to share common data and provide the feedback required to improve planning cycle times and operational performance. (halliburton.com)
  • The sleep cycle is repeated several times during the night. (medlineplus.gov)
  • This query returns a list of times when your GE Dryer finished a cycle. (ifttt.com)
  • Two pyruvic acid molecules are produced from glycolysis, requiring the Krebs cycle to occur two times per glucose molecule. (brighthub.com)
  • Helmets, in good condition, conforming with USA Cycling Policy I: Helmets must be worn at all times while on the bike, including warm-up and warm-down. (usacycling.org)
  • This process occurs once per release cycle, starting at or near the branch day. (fedoraproject.org)
  • If 'process down,' a panic, or a watchdog timeout occurs on the master XSCF during maintenance using the addfru(8) or replacefru(8) command, XSCF master/standby switching may occur. (fujitsu.com)
  • One small 2013 review found that it's most often a harmless physiological phenomenon that occurs with REM sleep and dreaming. (healthline.com)
  • In Galveston, a similar phenomenon occurred. (cdc.gov)
  • The virus moves to the nucleus of the liver cell, which is where DNA processes occur in a cell. (medicalnewstoday.com)
  • Most cats can start their first heat cycle as early as 4 months of age, but the average age tends to be somewhere around 5-9 months. (catster.com)
  • These results indicate that limited membrane permeabilization occurs in blebs and apoptotic bodies before secondary necrosis, leading to acute and localized release of immunomodulatory proteins during the early phase of active apoptotic membrane blebbing. (nature.com)
  • In both groups, chromatin (the material that comprises chromosomes) elimination occurs during early cleavage divisions from the cell line that will give rise to somatic cells (cells that do not produce gametes). (britannica.com)
  • Androgenic alopecia can occur in both males and females however male pattern baldness is associated with the development of this condition in males. (thewashingtonnote.com)
  • amplifi cation occurs in peridomestic birds and Culex spp. (cdc.gov)
  • They occur world-wide, and seem to be part of a pattern not yet fully understood. (answers.com)
  • Results indicated that force enhancement but not torque enhancement occurs in SSC conditions. (auburn.edu)
  • In this section we will perform further ideal cycle analysis to express the thrust and fuel efficiency of engines in terms of useful design variables, including design limits, flight conditions, and design choices. (mit.edu)
  • A platform event filter (PEF) can trigger an action and generate an alert when a critical hardware-related event occurs. (cisco.com)
  • For each PEF, you can choose the action to be taken (or take no action) when a platform event occurs. (cisco.com)
  • You can also choose to generate and send an alert when a platform event occurs. (cisco.com)
  • Selects the desired system action when this event occurs. (cisco.com)
  • Vascular risks: Stop Gemmily if a thrombotic event occurs. (drugs.com)
  • The initial event in the replicative cycle of a virus is its interaction with receptors present on the surface of a cell. (medscape.com)
  • The distinction is important, because a business cycle by its name suggests it emanates from business. (24hgold.com)
  • Though endometriosis may occur when a person starts having periods, the majority of people do not receive a diagnosis until they are between the ages of 30-40 years old. (medicalnewstoday.com)
  • Both groups are very widely distributed wherever appropriate hosts occur in shallow-bottom environments of the sea. (britannica.com)
  • Which phase of the uterine cycle occurs during days 6 13? (yourfastadvices.com)
  • At which stage of the uterine cycle does the menstrual phase occur? (yourfastadvices.com)
  • Question 3 Explanation: The menstrual phase occurs at the very beginning of the uterine cycle. (yourfastadvices.com)
  • The transition from one phase to another is somewhat arbitrary, and each cycle differs in length and character. (24hgold.com)
  • This phase occurs before the actual cycle begins. (brighthub.com)
  • The pesticide killed fleas, and the cycle of transmission was broken. (cdc.gov)
  • In Galveston, we believe the rat-associated cycle of transmission has changed to one involving opossums and their fleas. (cdc.gov)
  • Although the exact mode of transmission is unknown, recent findings suggest a role for some aquatic insects in the transmission cycle. (who.int)
  • Where do ice ages occur? (answers.com)
  • Though it can occur at nearly any age, most people receive a diagnosis between the ages of 30-40 years old . (medicalnewstoday.com)
  • power-cycle -The server is power cycled. (cisco.com)
  • LDC is not up Configuration variable setting will not persist after a reset or power cycle. (fujitsu.com)
  • This is the first cycle, which can last about 2 days. (catster.com)
  • The estrus cycle can last anywhere from 2 to 19 days but generally averages about 6 or 7 days. (catster.com)
  • This cycle can last 13 to 18 days until proestrus begins the cycle again. (catster.com)
  • He reports a 28-day cycles in which pollicles mature in 6 days maintaining their size for 13 days, then regress in 8 days. (fao.org)
  • The spring/neap cycle is about 15 days. (canadianunderwriter.ca)
  • Affymetrix micro-array technology was used to identify gene expression alterations that had occurred during the adaptation. (lu.se)
  • This is untrue, because cycles of business activity have their origin in the expansion and contraction of credit, whose origin in turn is in central banks' monetary policy and fractional reserve banking. (24hgold.com)
  • Cycles of credit are then manifest in variations of business activity. (24hgold.com)
  • With sound money, that is to say money that neither expands nor contracts, cycles in business activity cannot exist, except for plagues and wars which interrupt the balances between money-hoarding, saving and consumption. (24hgold.com)
  • SLEV activity is restricted to the Western Hemi- lecular detection assays and virus isolation in Vero cells, as sphere and outbreaks have occurred in North America previously described ( 12 ). (cdc.gov)
  • Later work completed by Krebs showed that this cycle is not exclusive to only animals, but that almost all aerobic cells have it. (brighthub.com)
  • In Chapter 3 we represented a gas turbine engine using a Brayton cycle and derived expressions for efficiency and work as functions of the temperature at various points in the cycle. (mit.edu)
  • On the 14th day of the cycle, the pituitary gland secretes a hormone that causes the ovary to release the matured egg cell. (yourfastadvices.com)
  • People don't think in terms of the credit cycle, wrongly believing it is a business cycle. (24hgold.com)
  • If you're like me (a child of the "duck and cover" era), it has probably occurred to you that we shouldn't be living in a world full of nuclear weapons (and people willing to pull the trigger). (urbansurvival.com)
  • So, if the female doesn't mate and isn't impregnated while in the estrus cycle, she will enter into interestrus. (catster.com)
  • This particular cycle only occurs when the female cat has ovulated, which is when she has mated with an unneutered male. (catster.com)