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  • promoter
  • Exendin-4 stimulated cyclin A2 promoter activity via the cAMP-cAMP response element binding protein pathway. (diabetesjournals.org)
  • However, electrophoretic mobility shift assays indicate that knockdown of endogenous RASSF1A in HB2 and HeLa cells leads to a reduction in the binding capacity of p120 E4F to the cyclin A2 promoter, whereas in the A549 clone stably expressing RASSF1A the binding capacity is increased. (aacrjournals.org)
  • In the process of searching for regulatory factors of endoreduplication, the promoter of an Arabidopsis thaliana cyclin A gene, CYCA2;3 , was revealed to be active in developing trichomes during the termination period of endoreduplication as well as in proliferating tissues. (plantcell.org)
  • In cancers, loss of expression of genes occurs about 10 times more frequently by transcription silencing (caused by epigenetic promoter hypermethylation of CpG islands) than by mutations. (wikipedia.org)
  • CDKs
  • The structure of human Cdk2 revealed that CDKs have a modified ATP-binding site that can be regulated by cyclin binding. (wikipedia.org)
  • CDK4
  • Here, we generated T cells expressing a mutation-specific transgenic T cell receptor (TCR) to target different immunogenic mutations in cyclin-dependent kinase 4 (CDK4) that naturally occur in human melanoma. (jci.org)
  • Mutations
  • In a syngeneic HLA-A2-transgenic mouse model of large established tumors, we found that both mutations differed dramatically as targets for TCR-modified T cells in vivo. (jci.org)
  • Double homozygous missense mutations of DACH1 and BMP4 occurred in a patient with bilateral cystic dysplasia. (wikipedia.org)
  • Residues
  • Without cyclin, a flexible loop called the activation loop or T-loop blocks the cleft, and the position of several key amino acid residues is not optimal for ATP-binding. (wikipedia.org)
  • Entry
  • Crucial for the Entry of the virus is the EPH receptor A2 and a few Integrins, whose identity has yet to be confirmed. (wikipedia.org)
  • cancer
  • This virus causes Kaposi's sarcoma, a cancer commonly occurring in AIDS patients, as well as primary effusion lymphoma, some types of multicentric Castleman's disease and KSHV inflammatory cytokine syndrome. (wikipedia.org)
  • In 2012, about 528,000 new cases and 266,000 deaths occurred from cervical cancer worldwide. (wikipedia.org)
  • In the United States, about 27,000 cases of cancer due to HPV occur each year. (wikipedia.org)